Bidirectional Ca2+signaling occurs between the endoplasmic reticulum and acidic organelles

Triggering of Ca2+signals by NAADP-gated two-pore channels: a role for membrane contact sites?

(2012) Sandip Patel et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The luminal Ca2+ chelator, TPEN, inhibits NAADP-induced Ca2+ release

(2012) Anthony J. Morgan et al.   CELL CALCIUM

Membrane Potential Regulates Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) Dependence of the pH- and Ca2+-sensitive Organellar Two-pore Channel TPC1

(2012) Volodymyr Rybalchenko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lysosomal calcium homeostasis defects, not proton pump defects, cause endo-lysosomal dysfunction in PSEN-deficient cells

(2012) Katrijn Coen et al.   JOURNAL OF CELL BIOLOGY

Direct mobilisation of lysosomal Ca 2+ triggers complex Ca 2+ signals

(2012) Bethan S. Kilpatrick et al.   JOURNAL OF CELL SCIENCE

Lysosomes shape Ins(1,4,5) P 3 -evoked Ca 2+ signals by selectively sequestering Ca 2+ released from the endoplasmic reticulum

(2012) Cristina I. López-Sanjurjo et al.   JOURNAL OF CELL SCIENCE

Molecular mechanisms of endolysosomal Ca2+signalling in health and disease

(2011) Anthony J. Morgan et al.   BIOCHEMICAL JOURNAL

NAADP influences excitation–contraction coupling by releasing calcium from lysosomes in atrial myocytes

(2011) Thomas P. Collins et al.   CELL CALCIUM

Sea urchin eggs in the acid reign

(2011) Anthony J. Morgan   CELL CALCIUM

Semaphorin and Eph Receptor Signaling Guide a Series of Cell Movements for Ventral Enclosure in C. elegans

(2011) Richard Ikegami et al.   CURRENT BIOLOGY

NAADP mediates ATP-induced Ca2+signals in astrocytes

(2011) Miquel Barceló-Torns et al.   FEBS LETTERS

Calcium- and polyphosphate-containing acidic granules of sea urchin eggs are similar to acidocalcisomes, but are not the targets for NAADP

(2010) Isabela B. Ramos et al.   BIOCHEMICAL JOURNAL

Purified TPC Isoforms Form NAADP Receptors with Distinct Roles for Ca2+ Signaling and Endolysosomal Trafficking

(2010) Margarida Ruas et al.   CURRENT BIOLOGY

An NAADP-gated Two-pore Channel Targeted to the Plasma Membrane Uncouples Triggering from Amplifying Ca2+Signals

(2010) Eugen Brailoiu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Calcium-mobilizing Messenger Nicotinic Acid Adenine Dinucleotide Phosphate Participates in Sperm Activation by Mediating the Acrosome Reaction

(2010) Sridhar R. Vasudevan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Ecto-enzyme CD38 Is a Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) Synthase That Couples Receptor Activation to Ca2+Mobilization from Lysosomes in Pancreatic Acinar Cells

(2010) François Cosker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TPC2 Is a Novel NAADP-sensitive Ca2+Release Channel, Operating as a Dual Sensor of Luminal pH and Ca2+

(2010) Samantha J. Pitt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insulin receptor signaling for the proliferation of pancreatic β-cells: Involvement of Ca2+second messengers, IP3, NAADP and cADPR

(2010) Asif Iqbal Shawl et al.   Islets

An Ancestral Deuterostome Family of Two-pore Channels Mediates Nicotinic Acid Adenine Dinucleotide Phosphate-dependent Calcium Release from Acidic Organelles

(2009) Eugen Brailoiu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Essential requirement for two-pore channel 1 in NAADP-mediated calcium signaling

(2009) Eugen Brailoiu et al.   JOURNAL OF CELL BIOLOGY

NAADP mobilizes calcium from acidic organelles through two-pore channels

(2009) Peter J. Calcraft et al.   NATURE

Identification of a chemical probe for NAADP by virtual screening

(2009) Edmund Naylor et al.   Nature Chemical Biology

The two-pore channel TPCN2 mediates NAADP-dependent Ca2+-release from lysosomal stores

(2009) Xiangang Zong et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Imaging the quantal substructure of single IP3R channel activity during Ca2+ puffs in intact mammalian cells

(2009) I. F. Smith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NAADP-mediated channel ‘chatter’ in neurons of the rat medulla oblongata

(2008) G. Cristina Brailoiu et al.   BIOCHEMICAL JOURNAL

Ca2+ Signaling Occurs via Second Messenger Release from Intraorganelle Synthesis Sites

(2008) Lianne C. Davis et al.   CURRENT BIOLOGY

Generation of Nicotinic Acid Adenine Dinucleotide Phosphate and Cyclic ADP-Ribose by Glucagon-Like Peptide-1 Evokes Ca2+ Signal That Is Essential for Insulin Secretion in Mouse Pancreatic Islets

(2008) B.-J. Kim et al.   DIABETES

Calcium dynamics in bovine adrenal medulla chromaffin cell secretory granules

(2008) Jaime SantoDomingo et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Regulation of Nuclear Ca2+Signaling by Translocation of the Ca2+Messenger Synthesizing Enzyme ADP-ribosyl Cyclase during Neuronal Depolarization

(2008) Stéphanie Bezin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Investigating cADPR and NAADP in intact and broken cell preparations

(2008) Anthony J. Morgan et al.   METHODS

Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium

(2008) Emyr Lloyd-Evans et al.   NATURE MEDICINE