Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function
出版年份 2020 全文链接
标题
Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function
作者
关键词
-
出版物
eLife
Volume 9, Issue -, Pages -
出版商
eLife Sciences Publications, Ltd
发表日期
2020-03-13
DOI
10.7554/elife.54712
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- pH-Lemon, a fluorescent protein-based pH reporter for acidic compartments
- (2019) Sandra Burgstaller et al. ACS Sensors
- Structural mechanisms of phospholipid activation of the human TPC2 channel
- (2019) Ji She et al. eLife
- Two-pore channels and disease
- (2018) Sandip Patel et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Phosphatidylinositol-3,5-bisphosphate lipid-binding-induced activation of the human two-pore channel 2
- (2018) Sonja A. Kirsch et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Structural insights into the voltage and phospholipid activation of the mammalian TPC1 channel
- (2018) Ji She et al. NATURE
- mTORC1 controls lysosomal Ca2+release through the two-pore channel TPC2
- (2018) Oluseye A. Ogunbayo et al. Science Signaling
- mTORC1 controls lysosomal Ca2+release through the two-pore channel TPC2
- (2018) Oluseye A. Ogunbayo et al. Science Signaling
- MICU1 imparts the mitochondrial uniporter with the ability to discriminate between Ca2+ and Mn2+
- (2018) Kimberli J. Kamer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mining of Ebola virus entry inhibitors identifies approved drugs as two-pore channel pore blockers
- (2018) Christopher J. Penny et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Synthesis, Anti-varicella-zoster virus and Anti-cytomegalovirus Activity of 4,5-Disubstituted 1,2,3-(1H)-Triazoles
- (2018) Wei-yuan Yuan et al. Medicinal Chemistry
- Patch-clamp technique to characterize ion channels in enlarged individual endolysosomes
- (2017) Cheng-Chang Chen et al. Nature Protocols
- TPC2 polymorphisms associated with a hair pigmentation phenotype in humans result in gain of channel function by independent mechanisms
- (2017) Yu-Kai Chao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Tuning the ion selectivity of two-pore channels
- (2017) Jiangtao Guo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Novel anion receptors for selective recognition of dimethyl phosphinate and carboxylate
- (2017) Dae Hyup Sohn et al. TETRAHEDRON
- TRPM7 kinase activity regulates murine mast cell degranulation
- (2016) Susanna Zierler et al. JOURNAL OF PHYSIOLOGY-LONDON
- 2-Imino 2H-chromene and 2-(phenylimino) 2H-chromene 3-aryl carboxamide derivatives as novel cytotoxic agents: synthesis, biological assay, and molecular docking study
- (2016) Najmeh Edraki et al. Journal of the Iranian Chemical Society
- TPC2 controls pigmentation by regulating melanosome pH and size
- (2016) Andrea L. Ambrosio et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Lysosomal Physiology
- (2015) Haoxing Xu et al. Annual Review of Physiology
- A TRP Channel Senses Lysosome Neutralization by Pathogens to Trigger Their Expulsion
- (2015) Yuxuan Miao et al. CELL
- Expression of Ca2+-permeable two-pore channels rescues NAADP signalling in TPC-deficient cells
- (2015) M. Ruas et al. EMBO JOURNAL
- 3-(3,5-Dimethyl-1H-Pyrazol-1-yl)-3-Oxopropanenitrile as Precursor for Some New Mono-Heterocyclic and Bis-Heterocyclic Compounds
- (2015) Nadia H. Metwally et al. JOURNAL OF HETEROCYCLIC CHEMISTRY
- Physical basis of apparent pore dilation of ATP-activated P2X receptor channels
- (2015) Mufeng Li et al. NATURE NEUROSCIENCE
- Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment
- (2015) Yasuteru Sakurai et al. SCIENCE
- Function and dysfunction of two-pore channels
- (2015) Sandip Patel Science Signaling
- Function and dysfunction of two-pore channels
- (2015) Sandip Patel Science Signaling
- Regulated lysosomal exocytosis mediates cancer progression
- (2015) E. Machado et al. Science Advances
- The phosphoinositide PI(3,5)P2 mediates activation of mammalian but not plant TPC proteins: functional expression of endolysosomal channels in yeast and plant cells
- (2014) Anna Boccaccio et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Convergent regulation of the lysosomal two-pore channel-2 by Mg2+, NAADP, PI(3,5)P2 and multiple protein kinases
- (2014) A. Jha et al. EMBO JOURNAL
- Lysosomal Two-pore Channel Subtype 2 (TPC2) Regulates Skeletal Muscle Autophagic Signaling
- (2014) Pei-Hui Lin et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The voltage-gated sodium channel TPC1 confers endolysosomal excitability
- (2014) Chunlei Cang et al. Nature Chemical Biology
- Reconstituted Human TPC1 Is a Proton-Permeable Ion Channel and Is Activated by NAADP or Ca2+
- (2014) S. J. Pitt et al. Science Signaling
- High susceptibility to fatty liver disease in two-pore channel 2-deficient mice
- (2014) Christian Grimm et al. Nature Communications
- mTOR Regulates Lysosomal ATP-Sensitive Two-Pore Na+ Channels to Adapt to Metabolic State
- (2013) Chunlei Cang et al. CELL
- TRPV1 structures in distinct conformations reveal activation mechanisms
- (2013) Erhu Cao et al. NATURE
- TPC Proteins Are Phosphoinositide- Activated Sodium-Selective Ion Channels in Endosomes and Lysosomes
- (2012) Xiang Wang et al. CELL
- Mechanosynthesis of amides in the total absence of organic solvent from reaction to product recovery
- (2012) Thomas-Xavier Métro et al. CHEMICAL COMMUNICATIONS
- Membrane Potential Regulates Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) Dependence of the pH- and Ca2+-sensitive Organellar Two-pore Channel TPC1
- (2012) Volodymyr Rybalchenko et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Gated regulation of CRAC channel ion selectivity by STIM1
- (2012) Beth A. McNally et al. NATURE
- Understanding the mechanism of IL-1β secretion
- (2011) Gloria Lopez-Castejon et al. CYTOKINE & GROWTH FACTOR REVIEWS
- Transient Receptor Potential Mucolipin 1 (TRPML1) and Two-pore Channels Are Functionally Independent Organellar Ion Channels
- (2011) Soichiro Yamaguchi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Photoaffinity Labeling of Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) Targets in Mammalian Cells
- (2011) Yaping Lin-Moshier et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cell-Permeable Iminocoumarine-Based Fluorescent Dyes for Mitochondria
- (2011) Diliang Guo et al. ORGANIC LETTERS
- Arylpiperazine-containing pyrrole 3-carboxamide derivatives targeting serotonin 5-HT2A, 5-HT2C, and the serotonin transporter as a potential antidepressant
- (2010) Suk Youn Kang et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Small Molecule Activators of TRPML3
- (2010) Christian Grimm et al. CHEMISTRY & BIOLOGY
- Purified TPC Isoforms Form NAADP Receptors with Distinct Roles for Ca2+ Signaling and Endolysosomal Trafficking
- (2010) Margarida Ruas et al. CURRENT BIOLOGY
- An NAADP-gated Two-pore Channel Targeted to the Plasma Membrane Uncouples Triggering from Amplifying Ca2+Signals
- (2010) Eugen Brailoiu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Ecto-enzyme CD38 Is a Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) Synthase That Couples Receptor Activation to Ca2+Mobilization from Lysosomes in Pancreatic Acinar Cells
- (2010) François Cosker et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- TPC2 Is a Novel NAADP-sensitive Ca2+Release Channel, Operating as a Dual Sensor of Luminal pH and Ca2+
- (2010) Samantha J. Pitt et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Characterization of Two-pore Channel 2 (TPCN2)-mediated Ca2+Currents in Isolated Lysosomes
- (2010) Michael Schieder et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Essential requirement for two-pore channel 1 in NAADP-mediated calcium signaling
- (2009) Eugen Brailoiu et al. JOURNAL OF CELL BIOLOGY
- Structure-Based Design, Synthesis, and Characterization of Inhibitors of Human andPlasmodium falciparumDihydroorotate Dehydrogenases†
- (2009) Matthew Davies et al. JOURNAL OF MEDICINAL CHEMISTRY
- NAADP mobilizes calcium from acidic organelles through two-pore channels
- (2009) Peter J. Calcraft et al. NATURE
- The two-pore channel TPCN2 mediates NAADP-dependent Ca2+-release from lysosomal stores
- (2009) Xiangang Zong et al. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- Triflic anhydride-mediated tandem formylation/cyclization of cyanoacetanilides: a concise synthesis of glycocitlone alkaloids
- (2009) Yusuke Kobayashi et al. TETRAHEDRON LETTERS
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started