Agonist-specific voltage-dependent gating of lysosomal two-pore Na+ channels

A pharmacological master key mechanism that unlocks the selectivity filter gate in K+ channels

(2019) Marcus Schewe et al.   SCIENCE

Structural mechanisms of phospholipid activation of the human TPC2 channel

(2019) Ji She et al.   eLife

Monoamine transporters: structure, intrinsic dynamics and allosteric regulation

(2019) Mary Hongying Cheng et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Phosphatidylinositol-3,5-bisphosphate lipid-binding-induced activation of the human two-pore channel 2

(2018) Sonja A. Kirsch et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Structural insights into the voltage and phospholipid activation of the mammalian TPC1 channel

(2018) Ji She et al.   NATURE

The lysosome as a cellular centre for signalling, metabolism and quality control

(2018) Rosalie E. Lawrence et al.   NATURE CELL BIOLOGY

Lysosomal Ion Channels as Decoders of Cellular Signals

(2018) Ping Li et al.   TRENDS IN BIOCHEMICAL SCIENCES

Tuning the ion selectivity of two-pore channels

(2017) Jiangtao Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Non-canonical Voltage-Sensing Mechanism Controls Gating in K2P K+ Channels

(2016) Marcus Schewe et al.   CELL

A molecular mechanism to regulate lysosome motility for lysosome positioning and tubulation

(2016) Xinran Li et al.   NATURE CELL BIOLOGY

TPC2 controls pigmentation by regulating melanosome pH and size

(2016) Andrea L. Ambrosio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of lysosomal ion homeostasis by channels and transporters

(2016) Jian Xiong et al.   Science China-Life Sciences

MCOLN1 is a ROS sensor in lysosomes that regulates autophagy

(2016) Xiaoli Zhang et al.   Nature Communications

A melanosomal two-pore sodium channel regulates pigmentation

(2016) Nicholas W. Bellono et al.   Scientific Reports

Lysosomal Physiology

(2015) Haoxing Xu et al.   Annual Review of Physiology

TPC: the NAADP discovery channel?: Figure 1

(2015) Anthony J. Morgan et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

TMEM175 Is an Organelle K + Channel Regulating Lysosomal Function

(2015) Chunlei Cang et al.   CELL

BK Channels Alleviate Lysosomal Storage Diseases by Providing Positive Feedback Regulation of Lysosomal Ca2+ Release

(2015) Qi Cao et al.   DEVELOPMENTAL CELL

Expression of Ca2+-permeable two-pore channels rescues NAADP signalling in TPC-deficient cells

(2015) M. Ruas et al.   EMBO JOURNAL

Structure of the voltage-gated two-pore channel TPC1 from Arabidopsis thaliana

(2015) Jiangtao Guo et al.   NATURE

Up-regulation of lysosomal TRPML1 channels is essential for lysosomal adaptation to nutrient starvation

(2015) Wuyang Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment

(2015) Yasuteru Sakurai et al.   SCIENCE

Function and dysfunction of two-pore channels

(2015) Sandip Patel   Science Signaling

Intracellular sphingosine releases calcium from lysosomes

(2015) Doris Höglinger et al.   eLife

Function and dysfunction of two-pore channels

(2015) Sandip Patel   Science Signaling

Convergent regulation of the lysosomal two-pore channel-2 by Mg2+, NAADP, PI(3,5)P2 and multiple protein kinases

(2014) A. Jha et al.   EMBO JOURNAL

The voltage-gated sodium channel TPC1 confers endolysosomal excitability

(2014) Chunlei Cang et al.   Nature Chemical Biology

Inhibition of acid sphingomyelinase by tricyclic antidepressants and analogons

(2014) Nadine Beckmann et al.   Frontiers in Physiology

Phosphatidylinositol 3,5-bisphosphate: Low abundance, high significance

(2013) Amber J. McCartney et al.   BIOESSAYS

mTOR Regulates Lysosomal ATP-Sensitive Two-Pore Na+ Channels to Adapt to Metabolic State

(2013) Chunlei Cang et al.   CELL

TPC Proteins Are Phosphoinositide- Activated Sodium-Selective Ion Channels in Endosomes and Lysosomes

(2012) Xiang Wang et al.   CELL

Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calcium release

(2012) Dongbiao Shen et al.   Nature Communications

Molecular mechanisms of endolysosomal Ca2+signalling in health and disease

(2011) Anthony J. Morgan et al.   BIOCHEMICAL JOURNAL

Photoaffinity Labeling of Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) Targets in Mammalian Cells

(2011) Yaping Lin-Moshier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Photoaffinity Labeling of High Affinity Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP)-Binding Proteins in Sea Urchin Egg

(2011) Timothy F. Walseth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Multiplex Calcium Assay for Identification of GPCR Agonists and Antagonists

(2010) Ke Liu et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Purified TPC Isoforms Form NAADP Receptors with Distinct Roles for Ca2+ Signaling and Endolysosomal Trafficking

(2010) Margarida Ruas et al.   CURRENT BIOLOGY

Ion Channel Voltage Sensors: Structure, Function, and Pathophysiology

(2010) William A. Catterall   NEURON

A small-molecule scaffold induces autophagy in primary neurons and protects against toxicity in a Huntington disease model

(2010) A. S. Tsvetkov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PI(3,5)P2 controls membrane trafficking by direct activation of mucolipin Ca2+ release channels in the endolysosome

(2010) Xian-ping Dong et al.   Nature Communications

Essential requirement for two-pore channel 1 in NAADP-mediated calcium signaling

(2009) Eugen Brailoiu et al.   JOURNAL OF CELL BIOLOGY

NAADP mobilizes calcium from acidic organelles through two-pore channels

(2009) Peter J. Calcraft et al.   NATURE

The two-pore channel TPCN2 mediates NAADP-dependent Ca2+-release from lysosomal stores

(2009) Xiangang Zong et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Gating at the selectivity filter in cyclic nucleotide-gated channels

(2008) J. E. Contreras et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA