Local hyperthermia therapy induces browning of white fat and treats obesity

Kdm2a deficiency in macrophages enhances thermogenesis to protect mice against HFD-induced obesity by enhancing H3K36me2 at the Pparg locus

(2021) Longmin Chen et al.   CELL DEATH AND DIFFERENTIATION

Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis

(2021) Olivia Sveidahl Johansen et al.   CELL

Adipocyte iron levels impinge on a fat-gut crosstalk to regulate intestinal lipid absorption and mediate protection from obesity

(2021) Zhuzhen Zhang et al.   Cell Metabolism

Adhesion-mediated mechanosignaling forces mitohormesis

(2021) Kevin M. Tharp et al.   Cell Metabolism

Fever supports CD8+ effector T cell responses by promoting mitochondrial translation

(2021) David O’Sullivan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Thymic stromal lymphopoietin induces adipose loss through sebum hypersecretion

(2021) Ruth Choa et al.   SCIENCE

Febrile Temperature Critically Controls the Differentiation and Pathogenicity of T Helper 17 Cells

(2020) Xiaohu Wang et al.   IMMUNITY

Aifm2, a NADH Oxidase, Supports Robust Glycolysis and Is Required for Cold- and Diet-Induced Thermogenesis

(2020) Hai P. Nguyen et al.   MOLECULAR CELL

Single-Cell RNA Profiling Reveals Adipocyte to Macrophage Signaling Sufficient to Enhance Thermogenesis

(2020) Felipe Henriques et al.   Cell Reports

Fever Promotes T Lymphocyte Trafficking via a Thermal Sensory Pathway Involving Heat Shock Protein 90 and α4 Integrins

(2019) ChangDong Lin et al.   IMMUNITY

Astaxanthin but not quercetin preserves mitochondrial integrity and function, ameliorates oxidative stress, and reduces heat-induced skeletal muscle injury

(2019) Tianzheng Yu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Thermal and cardiovascular responses and thermal sensation during hot-water bathing and the influence of room temperature

(2019) Yuta Masuda et al.   JOURNAL OF THERMAL BIOLOGY

Innervation of thermogenic adipose tissue via a calsyntenin 3β–S100b axis

(2019) Xing Zeng et al.   NATURE

The endocrine function of adipose tissues in health and cardiometabolic disease

(2019) Ludger Scheja et al.   Nature Reviews Endocrinology

Nuclear hnRNPA2B1 initiates and amplifies the innate immune response to DNA viruses

(2019) Lei Wang et al.   SCIENCE

Versatile Polydopamine Platforms: Synthesis and Promising Applications for Surface Modification and Advanced Nanomedicine

(2019) Wei Cheng et al.   ACS Nano

NLRP3 Inflammasome Mediates White Adipose Tissue Browning After Burn

(2019) Roohi Vinaik et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The clinical potential of circulating microRNAs in obesity

(2019) Chenbo Ji et al.   Nature Reviews Endocrinology

Inhibiting Heat Shock Factor 1 in Cancer: A Unique Therapeutic Opportunity

(2019) Bushu Dong et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Heat Shock Protein 72 Regulates Hepatic Lipid Accumulation

(2018) Ashley E. Archer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Abdominal subcutaneous adipose tissue: a favorable adipose depot for diabetes?

(2018) Peizhu Chen et al.   Cardiovascular Diabetology

CalR : A Web-Based Analysis Tool for Indirect Calorimetry Experiments

(2018) Amir I. Mina et al.   Cell Metabolism

FGF21 gene therapy as treatment for obesity and insulin resistance

(2018) Veronica Jimenez et al.   EMBO Molecular Medicine

Ablation of endothelial VEGFR1 improves metabolic dysfunction by inducing adipose tissue browning

(2018) Takahiro Seki et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Role of hyperglycaemia in the relationship between serum osteocalcin levels and relative skeletal muscle index

(2018) Yiting Xu et al.   CLINICAL NUTRITION

Adipocyte-secreted BMP8b mediates adrenergic-induced remodeling of the neuro-vascular network in adipose tissue

(2018) Vanessa Pellegrinelli et al.   Nature Communications

The transcriptional regulator of the chaperone response HSF1 controls hepatic bioenergetics and protein homeostasis

(2017) Aijun Qiao et al.   JOURNAL OF CELL BIOLOGY

UCP1-independent signaling involving SERCA2b-mediated calcium cycling regulates beige fat thermogenesis and systemic glucose homeostasis

(2017) Kenji Ikeda et al.   NATURE MEDICINE

Regulation of heat shock transcription factors and their roles in physiology and disease

(2017) Rocio Gomez-Pastor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Abnormal degradation of the neuronal stress-protective transcription factor HSF1 in Huntington’s disease

(2017) Rocio Gomez-Pastor et al.   Nature Communications

Mitochondrial Stress Restores the Heat Shock Response and Prevents Proteostasis Collapse during Aging

(2017) Johnathan Labbadia et al.   Cell Reports

Optical visualisation of thermogenesis in stimulated single-cell brown adipocytes

(2017) Rókus Kriszt et al.   Scientific Reports

Alternatively Activated Macrophages Drive Browning of White Adipose Tissue in Burns

(2017) Abdikarim Abdullahi et al.   ANNALS OF SURGERY

Multi-responsive photothermal-chemotherapy with drug-loaded melanin-like nanoparticles for synergetic tumor ablation

(2016) Xinyu Wang et al.   BIOMATERIALS

Capsaicin induces browning of white adipose tissue and counters obesity by activating TRPV1 channel-dependent mechanisms

(2016) Padmamalini Baskaran et al.   BRITISH JOURNAL OF PHARMACOLOGY

A widespread sequence-specific mRNA decay pathway mediated by hnRNPs A1 and A2/B1

(2016) Rene Geissler et al.   GENES & DEVELOPMENT

Passive heat therapy improves cutaneous microvascular function in sedentary humans via improved nitric oxide-dependent dilation

(2016) Vienna E. Brunt et al.   JOURNAL OF APPLIED PHYSIOLOGY

Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1

(2016) Edward T. Chouchani et al.   NATURE

Structure of human heat-shock transcription factor 1 in complex with DNA

(2016) Tobias Neudegger et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Protein-RNA Networks Regulated by Normal and ALS-Associated Mutant HNRNPA2B1 in the Nervous System

(2016) Fernando J. Martinez et al.   NEURON

HSF1: Guardian of Proteostasis in Cancer

(2016) Chengkai Dai et al.   TRENDS IN CELL BIOLOGY

The transcriptional coactivator PGC1α protects against hyperthermic stress via cooperation with the heat shock factor HSF1

(2016) L Xu et al.   Cell Death & Disease

Structure of human heat-shock transcription factor 1 in complex with DNA

(2016) Tobias Neudegger et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

IER5 generates a novel hypo-phosphorylated active form of HSF1 and contributes to tumorigenesis

(2016) Yoshinori Asano et al.   Scientific Reports

Effects of Obesity Related Genetic Variations on Visceral and Subcutaneous Fat Distribution in a Chinese Population

(2016) Tao Wang et al.   Scientific Reports

Adrenergically stimulated blood flow in brown adipose tissue is not dependent on thermogenesis

(2015) Gustavo Abreu-Vieira et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

A Creatine-Driven Substrate Cycle Enhances Energy Expenditure and Thermogenesis in Beige Fat

(2015) Lawrence Kazak et al.   CELL

HNRNPA2B1 Is a Mediator of m6A-Dependent Nuclear RNA Processing Events

(2015) Claudio R. Alarcón et al.   CELL

Celastrol Protects against Obesity and Metabolic Dysfunction through Activation of a HSF1-PGC1α Transcriptional Axis

(2015) Xinran Ma et al.   Cell Metabolism

Burn Induces Browning of the Subcutaneous White Adipose Tissue in Mice and Humans

(2015) David Patsouris et al.   Cell Reports

Association Between Sauna Bathing and Fatal Cardiovascular and All-Cause Mortality Events

(2015) Tanjaniina Laukkanen et al.   JAMA Internal Medicine

What We Talk About When We Talk About Fat

(2014) Evan D. Rosen et al.   CELL

Ablation of PRDM16 and Beige Adipose Causes Metabolic Dysfunction and a Subcutaneous to Visceral Fat Switch

(2014) Paul Cohen et al.   CELL

Biphasic Effect of Melanocortin Agonists on Metabolic Rate and Body Temperature

(2014) Beth Lute et al.   Cell Metabolism

Mitohormesis

(2014) Jeanho Yun et al.   Cell Metabolism

A Smooth Muscle-Like Origin for Beige Adipocytes

(2014) Jonathan Z. Long et al.   Cell Metabolism

Polydopamine and Its Derivative Materials: Synthesis and Promising Applications in Energy, Environmental, and Biomedical Fields

(2014) Yanlan Liu et al.   CHEMICAL REVIEWS

HSF-1-mediated cytoskeletal integrity determines thermotolerance and life span

(2014) N. A. Baird et al.   SCIENCE

A Classical Brown Adipose Tissue mRNA Signature Partly Overlaps with Brite in the Supraclavicular Region of Adult Humans

(2013) Naja Zenius Jespersen et al.   Cell Metabolism

The impact of winter cold weather on acute myocardial infarctions in Portugal

(2013) João Vasconcelos et al.   ENVIRONMENTAL POLLUTION

Brown and beige fat: development, function and therapeutic potential

(2013) Matthew Harms et al.   NATURE MEDICINE

Fat cells directly sense temperature to activate thermogenesis

(2013) L. Ye et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Brown adipose tissue volume in healthy lean south Asian adults compared with white Caucasians: a prospective, case-controlled observational study

(2013) Leontine E H Bakker et al.   Lancet Diabetes & Endocrinology

HSF1 Drives a Transcriptional Program Distinct from Heat Shock to Support Highly Malignant Human Cancers

(2012) Marc L. Mendillo et al.   CELL

Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human

(2012) Jun Wu et al.   CELL

Inverse Relationship between Serum Osteocalcin Levels and Visceral Fat Area in Chinese Men

(2012) Yuqian Bao et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The adipose organ of obesity-prone C57BL/6J mice is composed of mixed white and brown adipocytes

(2012) A. Vitali et al.   JOURNAL OF LIPID RESEARCH

Thermal Imaging to Assess Age-Related Changes of Skin Temperature within the Supraclavicular Region Co-Locating with Brown Adipose Tissue in Healthy Children

(2012) Michael E. Symonds et al.   JOURNAL OF PEDIATRICS

Fast gapped-read alignment with Bowtie 2

(2012) Ben Langmead et al.   NATURE METHODS

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

(2012) Guangchuang Yu et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Development of insulin resistance in mice lacking PGC-1  in adipose tissues

(2012) S. Kleiner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Opposite effects of statins on mitochondria of cardiac and skeletal muscles: a ‘mitohormesis’ mechanism involving reactive oxygen species and PGC-1

(2011) Jamal Bouitbir et al.   EUROPEAN HEART JOURNAL

Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis

(2011) Khoa D. Nguyen et al.   NATURE

Integrative genomics viewer

(2011) James T Robinson et al.   NATURE BIOTECHNOLOGY

A guide to analysis of mouse energy metabolism

(2011) Matthias H Tschöp et al.   NATURE METHODS

Genome-Wide Profiling of H3K56 Acetylation and Transcription Factor Binding Sites in Human Adipocytes

(2011) Kinyui Alice Lo et al.   PLoS One

β3 Receptors: role in cardiometabolic disorders

(2011) Shraddha V. Bhadada et al.   Therapeutic Advances in Endocrinology and Metabolism

The emergence of cold-induced brown adipocytes in mouse white fat depots is determined predominantly by white to brown adipocyte transdifferentiation

(2010) G. Barbatelli et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Warm SPA-induced hyperthermia confers protection to rats against airway inflammation evoked by capsaicin and substance P

(2010) Yaw-Syan Fu et al.   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

A Recurring Problem With the Analysis of Energy Expenditure in Genetic Models Expressing Lean and Obese Phenotypes

(2010) A. A. Butler et al.   DIABETES

Compromised respiratory adaptation and thermoregulation in aging and age-related diseases

(2009) Sic L. Chan et al.   AGEING RESEARCH REVIEWS

Hypothalamic Orexin Stimulates Feeding-Associated Glucose Utilization in Skeletal Muscle via Sympathetic Nervous System

(2009) Tetsuya Shiuchi et al.   Cell Metabolism

Functional Brown Adipose Tissue in Healthy Adults

(2009) Kirsi A. Virtanen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cold-Activated Brown Adipose Tissue in Healthy Men

(2009) Wouter D. van Marken Lichtenbelt et al.   NEW ENGLAND JOURNAL OF MEDICINE

HSP70 and Constitutively Active HSF1 Mediate Protection Against CDCrel-1-mediated Toxicity

(2008) Alisha E Jung et al.   MOLECULAR THERAPY

HSP72 protects against obesity-induced insulin resistance

(2008) J. Chung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Model-based Analysis of ChIP-Seq (MACS)

(2008) Yong Zhang et al.   GENOME BIOLOGY