Brown and beige fat: development, function and therapeutic potential

MicroRNA-133 Controls Brown Adipose Determination in Skeletal Muscle Satellite Cells by Targeting Prdm16

(2013) Hang Yin et al.   Cell Metabolism

Beyond the Sympathetic Tone: The New Brown Fat Activators

(2013) Francesc Villarroya et al.   Cell Metabolism

A Classical Brown Adipose Tissue mRNA Signature Partly Overlaps with Brite in the Supraclavicular Region of Adult Humans

(2013) Naja Zenius Jespersen et al.   Cell Metabolism

EBF2 Determines and Maintains Brown Adipocyte Identity

(2013) Sona Rajakumari et al.   Cell Metabolism

Vascular endothelial growth factor is important for brown adipose tissue development and maintenance

(2013) Mandrita Bagchi et al.   FASEB JOURNAL

Adaptive thermogenesis in adipocytes: Is beige the new brown?

(2013) J. Wu et al.   GENES & DEVELOPMENT

Brown-fat paucity due to impaired BMP signalling induces compensatory browning of white fat

(2013) Tim J. Schulz et al.   NATURE

Bi-directional interconversion of brite and white adipocytes

(2013) Matthias Rosenwald et al.   NATURE CELL BIOLOGY

Characterization of the adipocyte cellular lineage in vivo

(2013) Ryan Berry et al.   NATURE CELL BIOLOGY

Evidence for two types of brown adipose tissue in humans

(2013) Martin E Lidell et al.   NATURE MEDICINE

Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat

(2013) Aaron M Cypess et al.   NATURE MEDICINE

miR-133a Regulates Adipocyte Browning In Vivo

(2013) Weiyi Liu et al.   PLoS Genetics

Pref-1 in brown adipose tissue: specific involvement in brown adipocyte differentiation and regulatory role of C/EBPδ

(2012) Jordi Armengol et al.   BIOCHEMICAL JOURNAL

Functional characterization of UCP1 in mammalian HEK293 cells excludes mitochondrial uncoupling artefacts and reveals no contribution to basal proton leak

(2012) Martin Jastroch et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Pharmacological and nutritional agents promoting browning of white adipose tissue

(2012) M. Luisa Bonet et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Brown Remodeling of White Adipose Tissue by SirT1-Dependent Deacetylation of Pparγ

(2012) Li Qiang et al.   CELL

BMP8B Increases Brown Adipose Tissue Thermogenesis through Both Central and Peripheral Actions

(2012) Andrew J. Whittle et al.   CELL

TRPV4 Is a Regulator of Adipose Oxidative Metabolism, Inflammation, and Energy Homeostasis

(2012) Li Ye et al.   CELL

Mechanism of Fatty-Acid-Dependent UCP1 Uncoupling in Brown Fat Mitochondria

(2012) Andriy Fedorenko et al.   CELL

Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human

(2012) Jun Wu et al.   CELL

PPARγ agonists Induce a White-to-Brown Fat Conversion through Stabilization of PRDM16 Protein

(2012) Haruya Ohno et al.   Cell Metabolism

PTEN Loss in the Myf5 Lineage Redistributes Body Fat and Reveals Subsets of White Adipocytes that Arise from Myf5 Precursors

(2012) Joan Sanchez-Gurmaches et al.   Cell Metabolism

In Vivo Identification of Bipotential Adipocyte Progenitors Recruited by β3-Adrenoceptor Activation and High-Fat Feeding

(2012) Yun-Hee Lee et al.   Cell Metabolism

Pten Positively Regulates Brown Adipose Function, Energy Expenditure, and Longevity

(2012) Ana Ortega-Molina et al.   Cell Metabolism

Loss of Perivascular Adipose Tissue on Peroxisome Proliferator–Activated Receptor-γ Deletion in Smooth Muscle Cells Impairs Intravascular Thermoregulation and Enhances Atherosclerosis

(2012) Lin Chang et al.   CIRCULATION

Adipose Tissue Overexpression of Vascular Endothelial Growth Factor Protects Against Diet-Induced Obesity and Insulin Resistance

(2012) I. Elias et al.   DIABETES

A Novel Therapeutic Approach to Treating Obesity through Modulation of TGFβ Signaling

(2012) Alan Koncarevic et al.   ENDOCRINOLOGY

Resistance to Obesity by Repression ofVEGFGene Expression through Induction of Brown-Like Adipocyte Differentiation

(2012) Xiaodan Lu et al.   ENDOCRINOLOGY

Beige differentiation of adipose depots in mice lacking prolactin receptor protects against high-fat-diet-induced obesity

(2012) Julien Auffret et al.   FASEB JOURNAL

Mice lacking δ-opioid receptors resist the development of diet-induced obesity

(2012) Traci A. Czyzyk et al.   FASEB JOURNAL

GRK2 contribution to the regulation of energy expenditure and brown fat function

(2012) Rocio Vila-Bedmar et al.   FASEB JOURNAL

FGF21 regulates PGC-1  and browning of white adipose tissues in adaptive thermogenesis

(2012) f. M. Fisher et al.   GENES & DEVELOPMENT

Low Density Lipoprotein (LDL) Receptor-related Protein 6 (LRP6) Regulates Body Fat and Glucose Homeostasis by Modulating Nutrient Sensing Pathways and Mitochondrial Energy Expenditure

(2012) Wenzhong Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Brown adipose tissue regulates glucose homeostasis and insulin sensitivity

(2012) Kristin I. Stanford et al.   JOURNAL OF CLINICAL INVESTIGATION

Secreted frizzled-related protein 5 suppresses adipocyte mitochondrial metabolism through WNT inhibition

(2012) Hiroyuki Mori et al.   JOURNAL OF CLINICAL INVESTIGATION

Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes

(2012) Marica Bordicchia et al.   JOURNAL OF CLINICAL INVESTIGATION

The adipose organ of obesity-prone C57BL/6J mice is composed of mixed white and brown adipocytes

(2012) A. Vitali et al.   JOURNAL OF LIPID RESEARCH

Genome-Wide Profiling of Peroxisome Proliferator-Activated Receptor   in Primary Epididymal, Inguinal, and Brown Adipocytes Reveals Depot-Selective Binding Correlated with Gene Expression

(2012) M. S. Siersbaek et al.   MOLECULAR AND CELLULAR BIOLOGY

Blockade of the Activin Receptor IIB Activates Functional Brown Adipogenesis and Thermogenesis by Inducing Mitochondrial Oxidative Metabolism

(2012) B. Fournier et al.   MOLECULAR AND CELLULAR BIOLOGY

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

(2012) Pontus Boström et al.   NATURE

MyomiR-133 regulates brown fat differentiation through Prdm16

(2012) Mirko Trajkovski et al.   NATURE CELL BIOLOGY

Retinaldehyde dehydrogenase 1 regulates a thermogenic program in white adipose tissue

(2012) Florian W Kiefer et al.   NATURE MEDICINE

Sarcolipin is a newly identified regulator of muscle-based thermogenesis in mammals

(2012) Naresh C Bal et al.   NATURE MEDICINE

Human BAT Possesses Molecular Signatures That Resemble Beige/Brite Cells

(2012) Louis Z. Sharp et al.   PLoS One

Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor  

(2012) W. Wei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dichotomous effects of VEGF-A on adipose tissue dysfunction

(2012) K. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Development of insulin resistance in mice lacking PGC-1  in adipose tissues

(2012) S. Kleiner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeted deletion of thioesterase superfamily member 1 promotes energy expenditure and protects against obesity and insulin resistance

(2012) Y. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Essential Role for miR-196a in Brown Adipogenesis of White Fat Progenitor Cells

(2012) Masaki Mori et al.   PLOS BIOLOGY

Ablation of ghrelin receptor reduces adiposity and improves insulin sensitivity during aging by regulating fat metabolism in white and brown adipose tissues

(2011) Ligen Lin et al.   AGING CELL

Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice

(2011) Paul J. Meakin et al.   BIOCHEMICAL JOURNAL

Protection from Obesity and Diabetes by Blockade of TGF-β/Smad3 Signaling

(2011) Hariom Yadav et al.   Cell Metabolism

The Arrestin Domain-Containing 3 Protein Regulates Body Mass and Energy Expenditure

(2011) Parth Patwari et al.   Cell Metabolism

Orexin Is Required for Brown Adipose Tissue Development, Differentiation, and Function

(2011) Dyan Sellayah et al.   Cell Metabolism

Insulin Resistance, Hyperglycemia, and Atherosclerosis

(2011) Karin E. Bornfeldt et al.   Cell Metabolism

The Adipocyte-Expressed Forkhead Transcription Factor Foxc2 Regulates Metabolism Through Altered Mitochondrial Function

(2011) M. E. Lidell et al.   DIABETES

Inhibition of myostatin protects against diet-induced obesity by enhancing fatty acid oxidation and promoting a brown adipose phenotype in mice

(2011) C. Zhang et al.   DIABETOLOGIA

Ablation of the transcriptional regulator Id1 enhances energy expenditure, increases insulin sensitivity, and protects against age and diet induced insulin resistance, and hepatosteatosis

(2011) Ande Satyanarayana et al.   FASEB JOURNAL

Thermogenic Activation Induces FGF21 Expression and Release in Brown Adipose Tissue

(2011) Elayne Hondares et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inactivation of the Mitochondrial Carrier SLC25A25 (ATP-Mg2+/PiTransporter) Reduces Physical Endurance and Metabolic Efficiency in Mice

(2011) Rea P. Anunciado-Koza et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Peroxisome Proliferator-activated Receptor α (PPARα) Induces PPARγ Coactivator 1α (PGC-1α) Gene Expression and Contributes to Thermogenic Activation of Brown Fat

(2011) Elayne Hondares et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High Prevalence of Brown Adipose Tissue in Adult Humans

(2011) Paul Lee et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Protein kinase Cβ deficiency attenuates obesity syndrome ofob/obmice by promoting white adipose tissue remodeling

(2011) Wei Huang et al.   JOURNAL OF LIPID RESEARCH

Unknown

(2011) Dionysios Chartoumpekis et al.   MOLECULAR MEDICINE

Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis

(2011) Khoa D. Nguyen et al.   NATURE

Brown adipose tissue activity controls triglyceride clearance

(2011) Alexander Bartelt et al.   NATURE MEDICINE

Relation of B-Type Natriuretic Peptide Levels to Body Mass Index After Comprehensive Lifestyle Changes

(2010) Nita Chainani-Wu et al.   AMERICAN JOURNAL OF CARDIOLOGY

The emergence of cold-induced brown adipocytes in mouse white fat depots is determined predominantly by white to brown adipocyte transdifferentiation

(2010) G. Barbatelli et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Improved glucose control and reduced body fat mass in free fatty acid receptor 2-deficient mice fed a high-fat diet

(2010) Mikael Bjursell et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Uncoupling protein 1 expression and high-fat diets

(2010) Tobias Fromme et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Uncoupling protein-1 is not leaky

(2010) Irina G. Shabalina et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Hepatic FGF21 Expression Is Induced at Birth via PPARα in Response to Milk Intake and Contributes to Thermogenic Activation of Neonatal Brown Fat

(2010) Elayne Hondares et al.   Cell Metabolism

ATF4 regulates lipid metabolism and thermogenesis

(2010) Chunxia Wang et al.   CELL RESEARCH

Inducible lineage tracing of Pax7-descendant cells reveals embryonic origin of adult satellite cells

(2010) Christoph Lepper et al.   GENESIS

Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice

(2010) Patrick Seale et al.   JOURNAL OF CLINICAL INVESTIGATION

Orexin neurons are indispensable for stress-induced thermogenesis in mice

(2010) Wei Zhang et al.   JOURNAL OF PHYSIOLOGY-LONDON

The Predicted Effects of Chronic Obesity in Middle Age on Medicare Costs and Mortality

(2010) Liming Cai et al.   MEDICAL CARE

Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARγ by Cdk5

(2010) Jang Hyun Choi et al.   NATURE

Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance

(2010) Miguel López et al.   NATURE MEDICINE

Identification of inducible brown adipocyte progenitors residing in skeletal muscle and white fat

(2010) T. J. Schulz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cyclooxygenase-2 Controls Energy Homeostasis in Mice by de Novo Recruitment of Brown Adipocytes

(2010) A. Vegiopoulos et al.   SCIENCE

The economic impact of obesity in the United States

(2010) Ross Hammond et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Twist-1 Is a PPARδ-Inducible, Negative-Feedback Regulator of PGC-1α in Brown Fat Metabolism

(2009) Dongning Pan et al.   CELL

The Protein Kinase IKKɛ Regulates Energy Balance in Obese Mice

(2009) Shian-Huey Chiang et al.   CELL

Proteome Differences between Brown and White Fat Mitochondria Reveal Specialized Metabolic Functions

(2009) Francesca Forner et al.   Cell Metabolism

Hypoxia-Independent Angiogenesis in Adipose Tissues during Cold Acclimation

(2009) Yuan Xue et al.   Cell Metabolism

UCP1 Ablation Induces Obesity and Abolishes Diet-Induced Thermogenesis in Mice Exempt from Thermal Stress by Living at Thermoneutrality

(2009) Helena M. Feldmann et al.   Cell Metabolism

High Incidence of Metabolically Active Brown Adipose Tissue in Healthy Adult Humans: Effects of Cold Exposure and Adiposity

(2009) M. Saito et al.   DIABETES

Cannabinoid type 1 receptor blockade induces transdifferentiation towards a brown fat phenotype in white adipocytes

(2009) N. Perwitz et al.   DIABETES OBESITY & METABOLISM

Skin-specific Deletion of Stearoyl-CoA Desaturase-1 Alters Skin Lipid Composition and Protects Mice from High Fat Diet-induced Obesity

(2009) Harini Sampath et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deletion of Tumor Necrosis Factor-α Receptor 1 (TNFR1) Protects against Diet-induced Obesity by Means of Increased Thermogenesis

(2009) Talita Romanatto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chronic Peroxisome Proliferator-activated Receptor γ (PPARγ) Activation of Epididymally Derived White Adipocyte Cultures Reveals a Population of Thermogenically Competent, UCP1-containing Adipocytes Molecularly Distinct from Classic Brown Adipocytes

(2009) Natasa Petrovic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential roles of NHERF1, NHERF2, and PDZK1 in regulating CFTR-mediated intestinal anion secretion in mice

(2009) Anurag Kumar Singh et al.   JOURNAL OF CLINICAL INVESTIGATION

Mice lacking Pctp /StarD2 exhibit increased adaptive thermogenesis and enlarged mitochondria in brown adipose tissue

(2009) Hye Won Kang et al.   JOURNAL OF LIPID RESEARCH

C/EBP  and the Corepressors CtBP1 and CtBP2 Regulate Repression of Select Visceral White Adipose Genes during Induction of the Brown Phenotype in White Adipocytes by Peroxisome Proliferator-Activated Receptor   Agonists

(2009) C. Vernochet et al.   MOLECULAR AND CELLULAR BIOLOGY

Initiation of myoblast to brown fat switch by a PRDM16–C/EBP-β transcriptional complex

(2009) Shingo Kajimura et al.   NATURE

Functional Brown Adipose Tissue in Healthy Adults

(2009) Kirsi A. Virtanen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cold-Activated Brown Adipose Tissue in Healthy Men

(2009) Wouter D. van Marken Lichtenbelt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Identification and Importance of Brown Adipose Tissue in Adult Humans

(2009) Aaron M. Cypess et al.   NEW ENGLAND JOURNAL OF MEDICINE

Increased muscle PGC-1  expression protects from sarcopenia and metabolic disease during aging

(2009) T. Wenz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human Multipotent Adipose-Derived Stem Cells Differentiate into Functional Brown Adipocytes

(2009) Christian Elabd et al.   STEM CELLS

Reduced adiposity and improved insulin sensitivity in obese mice with antisense suppression of 4E-BP2 expression

(2008) Xing Xian Yu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Heart Disease and Stroke Statistics—2009 Update

(2008) et al.   CIRCULATION

Fibroblast Growth Factor 21 Reverses Hepatic Steatosis, Increases Energy Expenditure, and Improves Insulin Sensitivity in Diet-Induced Obese Mice

(2008) J. Xu et al.   DIABETES

Peroxisome Proliferator-Activated Receptor-γ-Mediated Positive Energy Balance in the Rat Is Associated with Reduced Sympathetic Drive to Adipose Tissues and Thyroid Status

(2008) William T. Festuccia et al.   ENDOCRINOLOGY

Fibroblast Growth Factor 21 Corrects Obesity in Mice

(2008) Tamer Coskun et al.   ENDOCRINOLOGY

Noradrenergic parenchymal nerve fiber branching after cold acclimatisation correlates with brown adipocyte density in mouse adipose organ

(2008) I. Murano et al.   JOURNAL OF ANATOMY

Liver X Receptor   Is a Transcriptional Repressor of the Uncoupling Protein 1 Gene and the Brown Fat Phenotype

(2008) H. Wang et al.   MOLECULAR AND CELLULAR BIOLOGY

A Functional Interaction between RIP140 and PGC-1  Regulates the Expression of the Lipid Droplet Protein CIDEA

(2008) M. Hallberg et al.   MOLECULAR AND CELLULAR BIOLOGY

T3-mediated expression of PGC-1α via a far upstream located thyroid hormone response element

(2008) Anne Wulf et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

PRDM16 controls a brown fat/skeletal muscle switch

(2008) Patrick Seale et al.   NATURE

New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure

(2008) Yu-Hua Tseng et al.   NATURE

Attainment of Brown Adipocyte Features in White Adipocytes of Hormone-Sensitive Lipase Null Mice

(2008) Kristoffer Ström et al.   PLoS One

Up-Regulation of Mitochondrial Activity and Acquirement of Brown Adipose Tissue-Like Property in the White Adipose Tissue of Fsp27 Deficient Mice

(2008) Shen Yon Toh et al.   PLoS One

FOXC2 controls Ang-2 expression and modulates angiogenesis, vascular patterning, remodeling, and functions in adipose tissue

(2008) Y. Xue et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA