Editorial Material
Cell Biology
Hyun Jung Hwang, Yoon Ki Kim
Summary: LC3B plays a crucial role in autophagy by binding to RNA and facilitating the degradation of mRNA.
Article
Oncology
Xiao-Hui Song, Xiao-Yan Liao, Xu-Ying Zheng, Jia-Qian Liu, Zhe-Wei Zhang, Li-Na Zhang, Yong-Bin Yan
Summary: Cancer cells reprogram gene expression profiles to support continuous growth, proliferation, and metastasis. Dysregulation of the human deadenylases Ccr4a/b and Caf1a/b is observed in various types of cancers, and depletion of these enzymes inhibits cell proliferation and tumorigenicity. Targeting global RNA metabolism may offer a potential novel strategy for cancer treatment.
Article
Mathematics
Tamara Antonova, Roman Dmytryshyn, Vitaliy Goran
Summary: This paper establishes an analytical extension of the ratios of Lauricella-Saran hypergeometric functions F-K to the corresponding branched continued fractions. The results are further validated through numerical experiments.
Article
Food Science & Technology
Alessandra Cimbalo, Manuel Alonso-Garrido, Guillermina Font, Massimo Frangiamone, Lara Manyes
Summary: Enniatins (ENs) are depsipeptide mycotoxins produced by Fusarium fungi known for their ability to modulate cell membrane permeability, disrupt ionic gradients, induce oxidative stress, and alter gene expression related to electron transport chain in mitochondria. ENs can lead to mitochondrial disorders and affect intestinal barrier function by causing oxidative stress.
Article
Psychology, Educational
Susie Kim
Summary: Recent research identified grammatical criterial features for each CEFR proficiency level, but further investigation is needed to understand how English learners with different first language backgrounds use these features. While the use of criterial features became more frequent and widespread as proficiency levels increased, there were low frequencies of these features overall. Furthermore, discrepancies between criterial level and learner proficiency were observed, highlighting the potential influence of first language, test and task type, and rating on the study findings.
LANGUAGE ASSESSMENT QUARTERLY
(2021)
Article
Biochemistry & Molecular Biology
Alexandra S. Silchenko, Anatoly I. Kalinovsky, Sergey A. Avilov, Roman S. Popov, Pavel S. Dmitrenok, Ekaterina A. Chingizova, Ekaterina S. Menchinskaya, Elena G. Panina, Vadim G. Stepanov, Vladimir I. Kalinin, Valentin A. Stonik
Summary: Seven new monosulfated triterpene glycosides, named djakonoviosides A (1), A(1) (2), A(2) (3), and B-1-B-4 (4-7), were isolated from the far eastern sea cucumber Cucumaria djakonovi. These compounds have different carbohydrate chains and aglycones, exhibiting significant membranolytic actions against human cell lines, particularly the triple-negative MDA-MB-231 breast cancer cells. The presence of new aglycones in C. djakonovi and the shared glycoside patterns among different Cucumaria species highlight the importance of these glycosides as chemotaxonomic markers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Hamza Amine, Nina Ripin, Sahil Sharma, Georg Stoecklin, Frederic H. Allain, Bertrand Seraphin, Fabienne Mauxion
Summary: Antiproliferative BTG/Tob proteins interact directly with the CAF1 deadenylase subunit of the CCR4-NOT complex, requiring conserved motifs boxA and boxB. BTG1 and BTG2 associate with PRMT1 through boxC motif, and also contact PABPC1. In the context of an APRO domain, boxC motif is necessary and sufficient for interaction with PABPC1, but not required for BTG2 association with PRMT1.
Article
Mathematics
Nuh Durna, Rabia Kilic
Summary: This paper investigates various spectral properties of the upper triangular double band matrix in the sequence space, including spectrum, fine spectrum, approximate point spectrum, defect spectrum, and compression spectrum.
COMMUNICATIONS FACULTY OF SCIENCES UNIVERSITY OF ANKARA-SERIES A1 MATHEMATICS AND STATISTICS
(2022)
Article
Biochemical Research Methods
Dig Bijay Mahat, Hojoong Kwak, Gregory T. Booth, Iris H. Jonkers, Charles G. Danko, Ravi K. Patel, Colin T. Waters, Katie Munson, Leighton J. Core, John T. Lis
Article
Biochemistry & Molecular Biology
Norah L. Smith, Ravi K. Patel, Arnold Reynaldi, Jennifer K. Grenier, Jocelyn Wang, Neva B. Watson, Kito Nzingha, Kristel J. Yee Mon, Seth A. Peng, Andrew Grimson, Miles P. Davenport, Brian D. Rudd
Article
Plant Sciences
Cameron Johnson, Liza J. Conrad, Ravi Patel, Sarah Anderson, Chenxin Li, Andy Pereira, Venkatesan Sundaresan
Article
Plant Sciences
Mukesh Jain, Gopal Misra, Ravi K. Patel, Pushp Priya, Shalu Jhanwar, Aamir W. Khan, Niraj Shah, Vikas K. Singh, Rohini Garg, Ganga Jeena, Manju Yadav, Chandra Kant, Priyanka Sharma, Gitanjali Yadav, Sabhyata Bhatia, Akhilesh K. Tyagi, Debasis Chattopadhyay
Article
Multidisciplinary Sciences
Mohit Verma, Vinay Kumar, Ravi K. Patel, Rohini Garg, Mukesh Jain
Article
Immunology
Lauren M. Webb, Oyebola O. Oyesola, Simon P. Fruh, Lena Kamynina, Katherine M. Still, Ravi K. Patel, Seth A. Peng, Rebecca L. Cubitt, Andrew Grimson, Jennifer K. Grenier, Tajie H. Harris, Charles G. Danko, Elia D. Tait Wojno
JOURNAL OF EXPERIMENTAL MEDICINE
(2019)
Article
Developmental Biology
Priti Singh, Ravi K. Patel, Nathan Palmer, Jennifer K. Grenier, Darius Paduch, Philipp Kaldis, Andrew Grimson, John C. Schimenti
Article
Biochemistry & Molecular Biology
Ravi K. Patel, Jessica D. West, Ya Jiang, Elizabeth A. Fogarty, Andrew Grimson
NUCLEIC ACIDS RESEARCH
(2020)
Article
Cell Biology
Kristel J. Yee Mon, Hongya Zhu, Ciaran W. P. Daly, Luyen T. Vu, Norah L. Smith, Ravi Patel, David J. Topham, Kristin Scheible, Kondwani Jambo, Minh T. N. Le, Brian D. Rudd, Andrew Grimson
Summary: MicroRNAs (miRNAs) play a critical role in regulating the CD8+ T cell response to infection, with miR-29 acting as a developmental switch controlling the balance between effector response and memory generation in neonates and adults.
Article
Medicine, General & Internal
Al Ozonoff, Joanna Schaenman, Naresh Doni Jayavelu, Carly E. Milliren, Carolyn S. Calfee, Charles B. Cairns, Monica Kraft, Lindsey R. Baden, Albert C. Shaw, Florian Krammer, Harm van Bakel, Denise A. Esserman, Shanshan Liu, Ana Fernandez Sesma, Viviana Simon, David A. Hafler, Ruth R. Montgomery, Steven H. Kleinstein, Ofer Levy, Christian Bime, Elias K. Haddad, David J. Erle, Bali Pulendran, Kari C. Nadeau, Mark M. Davis, Catherine L. Hough, William B. Messer, Nelson I. Agudelo Higuita, Jordan P. Metcalf, Mark A. Atkinson, Scott C. Brakenridge, David Corry, Farrah Kheradmand, Lauren I. R. Ehrlich, Esther Melamed, Grace A. McComsey, Rafick Sekaly, Joann Diray-Arce, Bjoern Peters, Alison D. Augustine, Elaine F. Reed, Matthew C. Altman, Patrice M. Becker, Nadine Rouphael, IMPACC Study Grp
Summary: This study aims to better understand the association between characteristics of COVID-19 patients and their outcomes. It found that risk factors such as age, Hispanic ethnicity, elevated baseline creatinine or troponin levels, baseline lymphopenia, presence of infiltrate by chest imaging, and high SARS-CoV2 viral load were associated with prolonged hospitalization or death. Female sex was the only risk factor associated with post-acute sequalae of COVID-19 (PASC). The findings provide important insights for patient management and prognosis improvement.
Article
Medicine, Research & Experimental
Elise Marsan, Dmitry Velmeshev, Arren Ramsey, Ravi K. Patel, Jiasheng Zhang, Mark Koontz, Madeline G. Andrews, Martina de Majo, Cristina Mora, Jessica Blumenfeld, Alissa N. Li, Salvatore Spina, Lea T. Grinberg, William W. Seeley, Bruce L. Miller, Erik M. Ullian, Matthew F. Krummel, Arnold R. Kriegstein, Eric J. Huang
Summary: Mutations in the GRN gene are a major cause of FTLD. Comparative single-cell transcriptomics in mice and FTLD-GRN patients revealed a conserved astroglial pathology characterized by upregulated GJA1, AQP4, and APOE, and downregulated SLC1A2, leading to synaptic degeneration. This astroglial toxicity was confirmed in cell cultures and cortical organoids, suggesting its potential role in neurodegeneration in FTLD-GRN.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Meeting Abstract
Immunology
Neva B. Watson, Ravi K. Patel, Oyebola O. Oyesola, Nathan Laniewski, Norah L. Smith, Kristel Yee Mon, Cybelle Tabilas, Ciaran Daly, Jessica D. West, Vu Tien Luyen, Viviana I. Maymi, Kito Nzingha, Samantha P. Wesnak, Kristin M. Scheible, Elia D. Tait Wojno, Andrew W. Grimson, Brian D. Rudd
JOURNAL OF IMMUNOLOGY
(2021)
Article
Oncology
Victoria E. Wang, Bradley W. Blaser, Ravi K. Patel, Gregory K. Behbehani, Arjun A. Rao, Blythe Durbin-Johnson, Tommy Jiang, Aaron C. Logan, Matthew Settles, Gabriel N. Mannis, Rebecca Olin, Lloyd E. Damon, Thomas G. Martin, Peter H. Sayre, Karin M. Gaensler, Emma McMahon, Michael Flanders, Vivian Weinberg, Chun J. Ye, David P. Carbone, Pamela N. Munster, Gabriela K. Fragiadakis, Frank McCormick, Charalambos Andreadis
Summary: This study demonstrates the favorable safety profile and promising clinical activity of ficlatuzumab and cytarabine in high-risk AML, supporting further investigation of this combination in a randomized trial. It also shows the utility of a novel application using multiplexed single-cell analyses to detect on-target activity and identify biomarkers of response.
BLOOD CANCER DISCOVERY
(2021)
Meeting Abstract
Immunology
Neva B. Watson, Seth Peng, Kito Nzingha, Jocelyn Wang, Jennifer K. Grenier, Norah L. Smith, Ravi K. Patel, Andrew W. Grimson, Brian D. Rudd
JOURNAL OF IMMUNOLOGY
(2017)