Thymic stromal lymphopoietin induces adipose loss through sebum hypersecretion

Targeted deletion of the TSLP receptor reveals cellular mechanisms that promote type 2 airway inflammation

(2020) Hiroki Kabata et al.   Mucosal Immunology

Homeostatic Control of Sebaceous Glands by Innate Lymphoid Cells Regulates Commensal Bacteria Equilibrium

(2019) Tetsuro Kobayashi et al.   CELL

Niche-Specific Factors Dynamically Regulate Sebaceous Gland Stem Cells in the Skin

(2019) Natalia A. Veniaminova et al.   DEVELOPMENTAL CELL

Hippo-mediated suppression of IRS2/AKT signaling prevents hepatic steatosis and liver cancer

(2018) Sun-Hye Jeong et al.   JOURNAL OF CLINICAL INVESTIGATION

Immunotopographical Differences of Human Skin

(2018) Gabriella Béke et al.   Frontiers in Immunology

Thymic Stromal Lymphopoietin Isoforms, Inflammatory Disorders, and Cancer

(2018) Gilda Varricchi et al.   Frontiers in Immunology

The atopic march: current insights into skin barrier dysfunction and epithelial cell-derived cytokines

(2017) Hongwei Han et al.   IMMUNOLOGICAL REVIEWS

Skin-derived TSLP systemically expands regulatory T cells

(2017) Theresa M. Leichner et al.   JOURNAL OF AUTOIMMUNITY

Sebaceous Gland-Rich Skin Is Characterized by TSLP Expression and Distinct Immune Surveillance Which Is Disturbed in Rosacea

(2017) Zsolt Dajnoki et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Holocrine Secretion of Sebum Is a Unique DNase2-Dependent Mode of Programmed Cell Death

(2017) Heinz Fischer et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The Expression of the Short Isoform of Thymic Stromal Lymphopoietin in the Colon Is Regulated by the Nuclear Receptor Peroxisome Proliferator Activated Receptor-Gamma and Is Impaired during Ulcerative Colitis

(2017) Anthony Martin Mena et al.   Frontiers in Immunology

Distinct roles of short and long thymic stromal lymphopoietin isoforms in house dust mite-induced asthmatic airway epithelial barrier disruption

(2016) Hangming Dong et al.   Scientific Reports

Activated Type 2 Innate Lymphoid Cells Regulate Beige Fat Biogenesis

(2015) Min-Woo Lee et al.   CELL

Antigen- and Cytokine-Driven Accumulation of Regulatory T Cells in Visceral Adipose Tissue of Lean Mice

(2015) Dmitriy Kolodin et al.   Cell Metabolism

Dichotomy of short and long thymic stromal lymphopoietin isoforms in inflammatory disorders of the bowel and skin

(2015) Giulia Fornasa et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Eosinophils and Type 2 Cytokine Signaling in Macrophages Orchestrate Development of Functional Beige Fat

(2014) Yifu Qiu et al.   CELL

The importance of TSLP in allergic disease and its role as a potential therapeutic target

(2014) Antonella Cianferoni et al.   Expert Review of Clinical Immunology

Exposure to food allergens through inflamed skin promotes intestinal food allergy through the thymic stromal lymphopoietin–basophil axis

(2014) Mario Noti et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Intradermal Administration of Thymic Stromal Lymphopoietin Induces a T Cell- and Eosinophil-Dependent Systemic Th2 Inflammatory Response

(2014) H. K. Jessup et al.   JOURNAL OF IMMUNOLOGY

Basophils Promote Innate Lymphoid Cell Responses in Inflamed Skin

(2014) Brian S. Kim et al.   JOURNAL OF IMMUNOLOGY

The short form of TSLP is constitutively translated in human keratinocytes and has characteristics of an antimicrobial peptide

(2014) L Bjerkan et al.   Mucosal Immunology

Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity

(2014) Jonathan R. Brestoff et al.   NATURE

The Epidemiology of Obesity: A Big Picture

(2014) Adela Hruby et al.   PHARMACOECONOMICS

Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages

(2013) Ari B. Molofsky et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Homologous recombination into the eosinophil peroxidase locus generates a strain of mice expressing Cre recombinase exclusively in eosinophils

(2013) Alfred D. Doyle et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Thymic stromal lymphopoietin–elicited basophil responses promote eosinophilic esophagitis

(2013) Mario Noti et al.   NATURE MEDICINE

TSLP Elicits IL-33-Independent Innate Lymphoid Cell Responses to Promote Skin Inflammation

(2013) B. S. Kim et al.   Science Translational Medicine

Loss of Claudins 2 and 15 From Mice Causes Defects in Paracellular Na+ Flow and Nutrient Transport in Gut and Leads to Death from Malnutrition

(2012) Masami Wada et al.   GASTROENTEROLOGY

Functions of thymic stromal lymphopoietin in immunity and disease

(2012) Yanlu Zhang et al.   IMMUNOLOGIC RESEARCH

Thymic stromal lymphopoietin (TSLP)-induced polyclonal B-cell activation and autoimmunity are mediated by CD4+ T cells and IL-4

(2012) M. Iseki et al.   INTERNATIONAL IMMUNOLOGY

Long TSLP transcript expression and release of TSLP induced by TLR ligands and cytokines in human keratinocytes

(2012) Yang Xie et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

TSLP Produced by Keratinocytes Promotes Allergen Sensitization through Skin and Thereby Triggers Atopic March in Mice

(2012) Juan Manuel Leyva-Castillo et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The Emerging Role of Peptides and Lipids as Antimicrobial Epidermal Barriers and Modulators of Local Inflammation

(2012) N.K. Brogden et al.   SKIN PHARMACOLOGY AND PHYSIOLOGY

TSLP Expression: Cellular Sources, Triggers, and Regulatory Mechanisms

(2012) Toshiro Takai   ALLERGOLOGY INTERNATIONAL

TSLP enhances the function of helper type 2 cells

(2011) Masayuki Kitajima et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Thymic stromal lymphopoietin exerts antimicrobial activities

(2011) Andreas Sonesson et al.   EXPERIMENTAL DERMATOLOGY

Eosinophils Sustain Adipose Alternatively Activated Macrophages Associated with Glucose Homeostasis

(2011) D. Wu et al.   SCIENCE

Sensing the outside world: TSLP regulates barrier immunity

(2010) Steven F Ziegler et al.   NATURE IMMUNOLOGY

Protease and Protease-Activated Receptor-2 Signaling in the Pathogenesis of Atopic Dermatitis

(2010) Sang Eun Lee et al.   YONSEI MEDICAL JOURNAL

Thymic Stromal Lymphopoietin Induces Chemotactic and Prosurvival Effects in Eosinophils

(2009) Chun K. Wong et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Skin-specific Deletion of Stearoyl-CoA Desaturase-1 Alters Skin Lipid Composition and Protects Mice from High Fat Diet-induced Obesity

(2009) Harini Sampath et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epidermal Barrier Dysfunction in Atopic Dermatitis

(2009) Michael J. Cork et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Sebum Free Fatty Acids Enhance the Innate Immune Defense of Human Sebocytes by Upregulating β-Defensin-2 Expression

(2009) Teruaki Nakatsuji et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

(2009) Markus Feuerer et al.   NATURE MEDICINE

Thymic stromal lymphopoietin overproduced by keratinocytes in mouse skin aggravates experimental asthma

(2009) Z. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Skin-Derived TSLP Triggers Progression from Epidermal-Barrier Defects to Asthma

(2009) Shadmehr Demehri et al.   PLOS BIOLOGY

Functional Analysis of the Thymic Stromal Lymphopoietin Variants in Human Bronchial Epithelial Cells

(2008) Michishige Harada et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Sebocytes Express Functional Cathelicidin Antimicrobial Peptides and Can Act to Kill Propionibacterium Acnes

(2008) Dong-Youn Lee et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY