Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis

Human Brown Adipocyte Thermogenesis Is Driven by β2-AR Stimulation

(2020) Denis P. Blondin et al.   Cell Metabolism

Opposing Actions of Adrenocorticotropic Hormone and Glucocorticoids on UCP1-Mediated Respiration in Brown Adipocytes

(2019) Katharina Schnabl et al.   Frontiers in Physiology

The brown adipose tissue glucagon receptor is functional but not essential for control of energy homeostasis in mice

(2019) Jacqueline L. Beaudry et al.   Molecular Metabolism

Illuminating G-Protein-Coupling Selectivity of GPCRs

(2019) Asuka Inoue et al.   CELL

Selective activation of Gs signaling in adipocytes causes striking metabolic improvements in mice

(2019) Lei Wang et al.   Molecular Metabolism

Adipocyte Gs but not Gi signaling regulates whole-body glucose homeostasis

(2019) Alexandre Caron et al.   Molecular Metabolism

Peptide/Receptor Co-evolution Explains the Lipolytic Function of the Neuropeptide TLQP-21

(2019) Bhavani S. Sahu et al.   Cell Reports

Physiological roles of the GIP receptor in murine brown adipose tissue

(2019) Jacqueline L. Beaudry et al.   Molecular Metabolism

Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis

(2018) Elahu G. Sustarsic et al.   Cell Metabolism

Towards a better understanding of the cannabinoid-related orphan receptors GPR3, GPR6, and GPR12

(2018) Paula Morales et al.   DRUG METABOLISM REVIEWS

Non-adrenergic control of lipolysis and thermogenesis in adipose tissues

(2018) Katharina Braun et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Accumulation of succinate controls activation of adipose tissue thermogenesis

(2018) Evanna L. Mills et al.   NATURE

Intact innervation is essential for diet-induced recruitment of brown adipose tissue

(2018) Alexander W. Fischer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Secretin-Activated Brown Fat Mediates Prandial Thermogenesis to Induce Satiation

(2018) Yongguo Li et al.   CELL

Inhibition of Mevalonate Pathway Prevents Adipocyte Browning in Mice and Men by Affecting Protein Prenylation

(2018) Miroslav Balaz et al.   Cell Metabolism

Thermal stress induces glycolytic beige fat formation via a myogenic state

(2018) Yong Chen et al.   NATURE

Adipocyte Expression of SLC19A1 Links DNA Hypermethylation to Adipose Tissue Inflammation and Insulin Resistance

(2017) Paul Petrus et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Novel Pharmacological Probes Reveal ABHD5 as a Locus of Lipolysis Control in White and Brown Adipocytes

(2017) Elizabeth A. Rondini et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The neuropeptide TLQP-21 opposes obesity via C3aR1-mediated enhancement of adrenergic-induced lipolysis

(2017) Cheryl Cero et al.   Molecular Metabolism

Characterization of immortalized human brown and white pre-adipocyte cell models from a single donor

(2017) Lasse K. Markussen et al.   PLoS One

Brown Adipose Tissue Activation Is Linked to Distinct Systemic Effects on Lipid Metabolism in Humans

(2016) Maria Chondronikola et al.   Cell Metabolism

Role of Brown Fat in Lipoprotein Metabolism and Atherosclerosis

(2016) Geerte Hoeke et al.   CIRCULATION RESEARCH

Brown adipose tissue as a secretory organ

(2016) Francesc Villarroya et al.   Nature Reviews Endocrinology

The Gq signalling pathway inhibits brown and beige adipose tissue

(2016) Katarina Klepac et al.   Nature Communications

Bmp4 Promotes a Brown to White-like Adipocyte Shift

(2016) Salvatore Modica et al.   Cell Reports

Stress-induced activation of brown adipose tissue prevents obesity in conditions of low adaptive thermogenesis

(2016) Maria Razzoli et al.   Molecular Metabolism

A Creatine-Driven Substrate Cycle Enhances Energy Expenditure and Thermogenesis in Beige Fat

(2015) Lawrence Kazak et al.   CELL

Endogenous and Synthetic ABHD5 Ligands Regulate ABHD5-Perilipin Interactions and Lipolysis in Fat and Muscle

(2015) Matthew A. Sanders et al.   Cell Metabolism

Activation of Human Brown Adipose Tissue by a β3-Adrenergic Receptor Agonist

(2015) Aaron M. Cypess et al.   Cell Metabolism

PRDM16 binds MED1 and controls chromatin architecture to determine a brown fat transcriptional program

(2015) Matthew J. Harms et al.   GENES & DEVELOPMENT

The Activation Mechanism of Glycoprotein Hormone Receptors with Implications in the Cause and Therapy of Endocrine Diseases

(2015) Antje Brüser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Brown and beige fat in humans: thermogenic adipocytes that control energy and glucose homeostasis

(2015) Labros Sidossis et al.   JOURNAL OF CLINICAL INVESTIGATION

Clonal analyses and gene profiling identify genetic biomarkers of the thermogenic potential of human brown and white preadipocytes

(2015) Ruidan Xue et al.   NATURE MEDICINE

iRNA-seq: computational method for genome-wide assessment of acute transcriptional regulation from total RNA-seq data

(2015) Jesper Grud Skat Madsen et al.   NUCLEIC ACIDS RESEARCH

Anti-obesity and metabolic efficacy of the β3-adrenergic agonist, CL316243, in mice at thermoneutrality compared to 22°C

(2015) Cuiying Xiao et al.   Obesity

Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development

(2015) Jimmy F. P. Berbée et al.   Nature Communications

Mice lacking GPR3 receptors display late-onset obese phenotype due to impaired thermogenic function in brown adipose tissue

(2015) Grzegorz Godlewski et al.   Scientific Reports

RNA-Seq and Mass-Spectrometry-Based Lipidomics Reveal Extensive Changes of Glycerolipid Pathways in Brown Adipose Tissue in Response to Cold

(2015) Ann-Britt Marcher et al.   Cell Reports

An siRNA-based method for efficient silencing of gene expression in mature brown adipocytes

(2015) Marie S. Isidor et al.   Adipocyte

IRF4 Is a Key Thermogenic Transcriptional Partner of PGC-1α

(2014) Xingxing Kong et al.   CELL

What We Talk About When We Talk About Fat

(2014) Evan D. Rosen et al.   CELL

Brown adipose tissue takes up plasma triglycerides mostly after lipolysis

(2014) P. Padmini S. J. Khedoe et al.   JOURNAL OF LIPID RESEARCH

Adenosine activates brown adipose tissue and recruits beige adipocytes via A2A receptors

(2014) Thorsten Gnad et al.   NATURE

Whole-Exome Sequencing of 2,000 Danish Individuals and the Role of Rare Coding Variants in Type 2 Diabetes

(2013) Kirk E. Lohmueller et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Beyond the Sympathetic Tone: The New Brown Fat Activators

(2013) Francesc Villarroya et al.   Cell Metabolism

A Classical Brown Adipose Tissue mRNA Signature Partly Overlaps with Brite in the Supraclavicular Region of Adult Humans

(2013) Naja Zenius Jespersen et al.   Cell Metabolism

Cold acclimation recruits human brown fat and increases nonshivering thermogenesis

(2013) Anouk A.J.J. van der Lans et al.   JOURNAL OF CLINICAL INVESTIGATION

Bi-directional interconversion of brite and white adipocytes

(2013) Matthias Rosenwald et al.   NATURE CELL BIOLOGY

Development of small-molecule inhibitors targeting adipose triglyceride lipase

(2013) Nicole Mayer et al.   Nature Chemical Biology

Brown and beige fat: development, function and therapeutic potential

(2013) Matthew Harms et al.   NATURE MEDICINE

miR-155 regulates differentiation of brown and beige adipocytes via a bistable circuit

(2013) Yong Chen et al.   Nature Communications

UCP1 in Brite/Beige Adipose Tissue Mitochondria Is Functionally Thermogenic

(2013) Irina G. Shabalina et al.   Cell Reports

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human

(2012) Jun Wu et al.   CELL

FAT SIGNALS - Lipases and Lipolysis in Lipid Metabolism and Signaling

(2012) Rudolf Zechner et al.   Cell Metabolism

Adipose Tissue MicroRNAs as Regulators of CCL2 Production in Human Obesity

(2012) E. Arner et al.   DIABETES

Lipolytic Products Activate Peroxisome Proliferator-activated Receptor (PPAR) α and δ in Brown Adipocytes to Match Fatty Acid Oxidation with Supply

(2012) Emilio P. Mottillo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Brown adipose tissue activity controls triglyceride clearance

(2011) Alexander Bartelt et al.   NATURE MEDICINE

An Autocrine Lactate Loop Mediates Insulin-Dependent Inhibition of Lipolysis through GPR81

(2010) Kashan Ahmed et al.   Cell Metabolism

Sympathetic and sensory innervation of brown adipose tissue

(2010) T J Bartness et al.   INTERNATIONAL JOURNAL OF OBESITY

Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

(2010) Sven Heinz et al.   MOLECULAR CELL

The N-terminal domain of GPR61, an orphan G-protein-coupled receptor, is essential for its constitutive activity

(2008) Masaru Toyooka et al.   JOURNAL OF NEUROSCIENCE RESEARCH