标题
p53 Signaling on Microenvironment and Its Contribution to Tissue Chemoresistance
作者
关键词
-
出版物
Membranes
Volume 12, Issue 2, Pages 202
出版商
MDPI AG
发表日期
2022-02-10
DOI
10.3390/membranes12020202
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Cancer Stemness: p53 at the Wheel
- (2021) Dishari Ghatak et al. Frontiers in Oncology
- Mutant p53 promotes RCP-dependent chemoresistance coinciding with increased delivery of P-glycoprotein to the plasma membrane
- (2021) Vinaya Phatak et al. Cell Death & Disease
- Extracellular Matrix Proteins Confer Cell Adhesion-Mediated Drug Resistance Through Integrin αv in Glioblastoma Cells
- (2021) Qi Yu et al. Frontiers in Cell and Developmental Biology
- Cooperation between oncogenic Ras and wild-type p53 stimulates STAT non-cell autonomously to promote tumor radioresistance
- (2021) Yong-Li Dong et al. Communications Biology
- Co-evolution of matrisome and adaptive adhesion dynamics drives ovarian cancer chemoresistance
- (2021) Elina A. Pietilä et al. Nature Communications
- Cancer Cells Shuttle Extracellular Vesicles Containing Oncogenic Mutant p53 Proteins to the Tumor Microenvironment
- (2021) Bibek Bhatta et al. Cancers
- PAK1 Mediates Bone Marrow Stromal Cell-Induced Drug Resistance in Acute Myeloid Leukemia via ERK1/2 Signaling Pathway
- (2021) Banban Li et al. Frontiers in Cell and Developmental Biology
- A Different Facet of p53 Function: Regulation of Immunity and Inflammation During Tumor Development
- (2021) Di Shi et al. Frontiers in Cell and Developmental Biology
- Bidirectional tumor/stroma crosstalk promotes metastasis in mesenchymal colorectal cancer
- (2020) Sarah Ouahoud et al. ONCOGENE
- Cancer-Specific Loss of p53 Leads to a Modulation of Myeloid and T Cell Responses
- (2020) Julianna Blagih et al. Cell Reports
- p53’s Extended Reach: The Mutant p53 Secretome
- (2020) Evangelos Pavlakis et al. Biomolecules
- The p53/MDM2/MDMX-targeted therapies—a clinical synopsis
- (2020) Liren Jiang et al. Cell Death & Disease
- Regulation of Integrin Subunit Alpha 2 by miR-135b-5p Modulates Chemoresistance in Gastric Cancer
- (2020) Qi Wang et al. Frontiers in Oncology
- Recent Synthetic Approaches towards Small Molecule Reactivators of p53
- (2020) Jerson L. Silva et al. Biomolecules
- Altered RNA Splicing by Mutant p53 Activates Oncogenic RAS Signaling in Pancreatic Cancer
- (2020) Luisa F. Escobar-Hoyos et al. CANCER CELL
- Targeting cellular senescence in cancer and aging: roles of p53 and its isoforms
- (2020) Jessica Beck et al. CARCINOGENESIS
- Exosomal microRNA‑146a derived from mesenchymal stem cells increases the sensitivity of ovarian cancer cells to docetaxel and taxane via a LAMC2‑mediated PI3K/Akt axis
- (2020) Liya Qiu et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- Beta 1 integrin signaling mediates pancreatic ductal adenocarcinoma resistance to MEK inhibition
- (2020) Arthur Brannon et al. Scientific Reports
- Extracellular Vesicles: Messengers of p53 in Tumor–Stroma Communication and Cancer Metastasis
- (2020) Evangelos Pavlakis et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Gain-of-function hot spot mutant p53R248Q regulation of integrin/FAK/ERK signaling in esophageal squamous cell carcinoma
- (2020) Valen Zhuoyou Yu et al. Translational Oncology
- Autocrine IL-6/STAT3 signaling aids development of acquired drug resistance in Group 3 medulloblastoma
- (2020) Lakshana Sreenivasan et al. Cell Death & Disease
- An FBXW7-ZEB2 axis links EMT and tumour microenvironment to promote colorectal cancer stem cells and chemoresistance
- (2019) Ningning Li et al. Oncogenesis
- Chronic TGF-β exposure drives stabilized EMT, tumor stemness, and cancer drug resistance with vulnerability to bitopic mTOR inhibition
- (2019) Yoko Katsuno et al. Science Signaling
- The tumor as organizer model
- (2019) Jinyang Li et al. SCIENCE
- Intra-Tumoral Metabolic Zonation and Resultant Phenotypic Diversification Are Dictated by Blood Vessel Proximity
- (2019) Saran Kumar et al. Cell Metabolism
- Mutant p53 amplifies a dynamin-1/APPL1 endosome feedback loop that regulates recycling and migration
- (2019) Ashley M. Lakoduk et al. JOURNAL OF CELL BIOLOGY
- Bioengineered scaffolds for 3D culture demonstrate extracellular matrix-mediated mechanisms of chemotherapy resistance in glioblastoma
- (2019) Weikun Xiao et al. MATRIX BIOLOGY
- Tumor microenvironment-driven non-cell-autonomous resistance to antineoplastic treatment
- (2019) Yidi Qu et al. Molecular Cancer
- HIF inactivation of p53 in Ovarian Cancer Can be Reversed by Topotecan, Restoring Cisplatin and Paclitaxel Sensitivity
- (2019) Basmina Parmakhtiar et al. MOLECULAR CANCER RESEARCH
- Intertumoral heterogeneity in patient-specific drug sensitivities in treatment-naïve glioblastoma
- (2019) Erlend Skaga et al. BMC CANCER
- Exosomal micro RNA s derived from colon cancer cells promote tumor progression by suppressing fibroblast TP 53 expression
- (2019) Shunsuke Yoshii et al. CANCER SCIENCE
- Modeling the regulation of p53 activation by HIF‐1 upon hypoxia
- (2019) Ping Wang et al. FEBS LETTERS
- Tumor-associated macrophages in tumor metastasis: biological roles and clinical therapeutic applications
- (2019) Yuxin Lin et al. Journal of Hematology & Oncology
- Hypoxia Induces Drug Resistance in Colorectal Cancer through the HIF-1α/miR-338-5p/IL-6 Feedback Loop
- (2019) Ke Xu et al. MOLECULAR THERAPY
- Integrated Analysis of TP53 Gene and Pathway Alterations in The Cancer Genome Atlas
- (2019) Lawrence A. Donehower et al. Cell Reports
- The Δ133p53β isoform promotes an immunosuppressive environment leading to aggressive prostate cancer
- (2019) Marina Kazantseva et al. Cell Death & Disease
- Highlights in Resistance Mechanism Pathways for Combination Therapy
- (2019) Delou et al. Cells
- CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan
- (2019) Claire Vennin et al. Nature Communications
- Upregulation of Epithelial-To-Mesenchymal Transition Markers and P2X7 Receptors Is Associated to Increased Invasiveness Caused by P2X7 Receptor Stimulation in Human Glioblastoma Stem Cells
- (2019) Sihana Ziberi et al. Cells
- Elevation of the TP53 isoform Δ133p53β in glioblastomas: an alternative to mutant p53 in promoting tumour development
- (2018) Marina Kazantseva et al. JOURNAL OF PATHOLOGY
- Diverse genetic-driven immune landscapes dictate tumor progression through distinct mechanisms
- (2018) Marco Bezzi et al. NATURE MEDICINE
- Hypoxia-induced exosomes contribute to a more aggressive and chemoresistant ovarian cancer phenotype: a novel mechanism linking STAT3/Rab proteins
- (2018) Kalpana Deepa Priya Dorayappan et al. ONCOGENE
- Mutant p53 gain of function underlies high expression levels of colorectal cancer stem cells markers
- (2018) Hilla Solomon et al. ONCOGENE
- Altered p53 functionality in cancer-associated fibroblasts contributes to their cancer-supporting features
- (2018) Sharathchandra Arandkar et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Small-molecule MDM2 antagonists attenuate the senescence-associated secretory phenotype
- (2018) Christopher D. Wiley et al. Scientific Reports
- LGR5, a novel functional glioma stem cell marker, promotes EMT by activating the Wnt/β-catenin pathway and predicts poor survival of glioma patients
- (2018) Jin Zhang et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Phenotypic Basis for Matrix Stiffness-Dependent Chemoresistance of Breast Cancer Cells to Doxorubicin
- (2018) M. Hunter Joyce et al. Frontiers in Oncology
- Extracellular Vesicles Released by Glioblastoma Cells Stimulate Normal Astrocytes to Acquire a Tumor-Supportive Phenotype Via p53 and MYC Signaling Pathways
- (2018) S. Hallal et al. MOLECULAR NEUROBIOLOGY
- p53 mutants cooperate with HIF-1 in transcriptional regulation of extracellular matrix components to promote tumor progression
- (2018) Ivano Amelio et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mutant p53s generate pro-invasive niches by influencing exosome podocalyxin levels
- (2018) David Novo et al. Nature Communications
- Antagonistic Effects of p53 and HIF1A on microRNA-34a Regulation of PPP1R11 and STAT3 and Hypoxia-induced Epithelial to Mesenchymal Transition in Colorectal Cancer Cells
- (2017) Huihui Li et al. GASTROENTEROLOGY
- The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration
- (2017) Birgit Ritschka et al. GENES & DEVELOPMENT
- Targeting Tumor Adaption to Chronic Hypoxia: Implications for Drug Resistance, and How It Can Be Overcome
- (2017) et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Drug Resistance Driven by Cancer Stem Cells and Their Niche
- (2017) Marta Prieto-Vila et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Senescence-associated reprogramming promotes cancer stemness
- (2017) Maja Milanovic et al. NATURE
- Packaging and transfer of mitochondrial DNA via exosomes regulate escape from dormancy in hormonal therapy-resistant breast cancer
- (2017) Pasquale Sansone et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The role of MDM2 and MDM4 in breast cancer development and prevention
- (2017) Sue Haupt et al. Journal of Molecular Cell Biology
- Treatment-Induced Mutagenesis and Selective Pressures Sculpt Cancer Evolution
- (2017) Subramanian Venkatesan et al. Cold Spring Harbor Perspectives in Medicine
- Matrix stiffness induces epithelial–mesenchymal transition and promotes chemoresistance in pancreatic cancer cells
- (2017) A J Rice et al. Oncogenesis
- Mutant p53 promotes tumor progression and metastasis by the endoplasmic reticulum UDPase ENTPD5
- (2016) Fotini Vogiatzi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Extracellular matrix stiffness causes systematic variations in proliferation and chemosensitivity in myeloid leukemias
- (2016) Jae-Won Shin et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The role of p53 in cancer drug resistance and targeted chemotherapy
- (2016) Karin Hientz et al. Oncotarget
- Oncogenic Mutant p53 Gain of Function Nourishes the Vicious Cycle of Tumor Development and Cancer Stem-Cell Formation
- (2016) Yoav Shetzer et al. Cold Spring Harbor Perspectives in Medicine
- Regulation of Cellular Metabolism and Hypoxia by p53
- (2016) Timothy J. Humpton et al. Cold Spring Harbor Perspectives in Medicine
- TP53 drives invasion through expression of its Δ133p53β variant
- (2016) Gilles Gadea et al. eLife
- The Enrichment of Survivin in Exosomes from Breast Cancer Cells Treated with Paclitaxel Promotes Cell Survival and Chemoresistance
- (2016) Bridget Kreger et al. Cancers
- Novel p53 target genes secreted by the liver are involved in non-cell-autonomous regulation
- (2015) M Charni et al. CELL DEATH AND DIFFERENTIATION
- Cycling hypoxia induces chemoresistance through the activation of reactive oxygen species-mediated B-cell lymphoma extra-long pathway in glioblastoma multiforme
- (2015) Wei-Ling Chen et al. Journal of Translational Medicine
- Matrix stiffness drives epithelial–mesenchymal transition and tumour metastasis through a TWIST1–G3BP2 mechanotransduction pathway
- (2015) Spencer C. Wei et al. NATURE CELL BIOLOGY
- p53 orchestrates between normal differentiation and cancer
- (2015) Noa Rivlin et al. SEMINARS IN CANCER BIOLOGY
- Mutant p53 promotes ovarian cancer cell adhesion to mesothelial cells via integrin β4 and Akt signals
- (2015) Jong-Gyu Lee et al. Scientific Reports
- Transcriptome Analysis of Individual Stromal Cell Populations Identifies Stroma-Tumor Crosstalk in Mouse Lung Cancer Model
- (2015) Hyejin Choi et al. Cell Reports
- Short Hairpin RNA-Mediated Fibronectin Knockdown Delays Tumor Growth in a Mouse Glioma Model
- (2015) Sadhak Sengupta et al. NEOPLASIA
- Exosome Transfer from Stromal to Breast Cancer Cells Regulates Therapy Resistance Pathways
- (2014) Mirjam C. Boelens et al. CELL
- p53: The barrier to cancer stem cell formation
- (2014) Ronit Aloni-Grinstein et al. FEBS LETTERS
- The aggregation of mutant p53 produces prion-like properties in cancer
- (2014) Luciana P Rangel et al. Prion
- Endothelial Interleukin-6 Defines the Tumorigenic Potential of Primary Human Cancer Stem Cells
- (2014) Sudha Krishnamurthy et al. STEM CELLS
- Prion-like aggregation of mutant p53 in cancer
- (2014) Jerson L. Silva et al. TRENDS IN BIOCHEMICAL SCIENCES
- Autophagic degradation of the inhibitory p53 isoform Δ133p53α as a regulatory mechanism for p53-mediated senescence
- (2014) Izumi Horikawa et al. Nature Communications
- Glioblastoma cells inhibit astrocytic p53-expression favoring cancer malignancy
- (2014) D Biasoli et al. Oncogenesis
- Activation of p53 pathway by Nutlin-3a inhibits the expression of the therapeutic target α5 integrin in colon cancer cells
- (2013) Hana Janouskova et al. CANCER LETTERS
- Trp53 Inactivation in the Tumor Microenvironment Promotes Tumor Progression by Expanding the Immunosuppressive Lymphoid-like Stromal Network
- (2013) G. Guo et al. CANCER RESEARCH
- Critical Role of STAT3 in IL-6–Mediated Drug Resistance in Human Neuroblastoma
- (2013) Tasnim Ara et al. CANCER RESEARCH
- Non-Cell-Autonomous Tumor Suppression by p53
- (2013) Amaia Lujambio et al. CELL
- Mutational landscape and significance across 12 major cancer types
- (2013) Cyriac Kandoth et al. NATURE
- Microenvironmental regulation of tumor progression and metastasis
- (2013) Daniela F Quail et al. NATURE MEDICINE
- p53 regulates mesenchymal stem cell-mediated tumor suppression in a tumor microenvironment through immune modulation
- (2013) Y Huang et al. ONCOGENE
- Investigating the Link between Molecular Subtypes of Glioblastoma, Epithelial-Mesenchymal Transition, and CD133 Cell Surface Protein
- (2013) Hadi Zarkoob et al. PLoS One
- p53 Aggregates Penetrate Cells and Induce the Co-Aggregation of Intracellular p53
- (2013) Karolyn J. Forget et al. PLoS One
- Dual role of p53 amyloid formation in cancer; loss of function and gain of toxicity
- (2012) Cristian A. Lasagna-Reeves et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Hypoxic enhancement of exosome release by breast cancer cells
- (2012) Hamish W King et al. BMC CANCER
- p53-Mediated Senescence Impairs the Apoptotic Response to Chemotherapy and Clinical Outcome in Breast Cancer
- (2012) James G. Jackson et al. CANCER CELL
- Integrin 5 1 Plays a Critical Role in Resistance to Temozolomide by Interfering with the p53 Pathway in High-Grade Glioma
- (2012) H. Janouskova et al. CANCER RESEARCH
- A CXCL1 Paracrine Network Links Cancer Chemoresistance and Metastasis
- (2012) Swarnali Acharyya et al. CELL
- Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion
- (2012) Ravid Straussman et al. NATURE
- The p53 isoform, Δ133p53α, stimulates angiogenesis and tumour progression
- (2012) H Bernard et al. ONCOGENE
- Mutant p53 enhances MET trafficking and signalling to drive cell scattering and invasion
- (2012) P A J Muller et al. ONCOGENE
- Role of stromal cell-mediated Notch signaling in CLL resistance to chemotherapy
- (2012) A H Nwabo Kamdje et al. Blood Cancer Journal
- Delayed caspase-8 activation and enhanced integrin β1-activated FAK underpins anoikis in oesophageal carcinoma cells harbouring mt p53-R175H
- (2011) Stephanie Fanucchi et al. CELL BIOLOGY INTERNATIONAL
- SASP mediates chemoresistance and tumor-initiating-activity of mesothelioma cells
- (2011) C Canino et al. ONCOGENE
- Reciprocal influence of the p53 and the hypoxic pathways
- (2011) A Sermeus et al. Cell Death & Disease
- The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression
- (2010) Jean-Philippe Coppé et al. Annual Review of Pathology-Mechanisms of Disease
- A role for p53 in the regulation of extracellular matrix metalloproteinase inducer in human cancer cells
- (2010) Hua Zhu et al. CANCER BIOLOGY & THERAPY
- P53-induced microRNA-107 inhibits HIF-1 and tumor angiogenesis
- (2010) M. Yamakuchi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Negative Regulation of 4 Integrin Transcription by Homeodomain-Interacting Protein Kinase 2 and p53 Impairs Tumor Progression
- (2009) G. Bon et al. CANCER RESEARCH
- Mutant p53 Drives Invasion by Promoting Integrin Recycling
- (2009) Patricia A.J. Muller et al. CELL
- Integrins
- (2009) Malgorzata Barczyk et al. CELL AND TISSUE RESEARCH
- Crosstalk to Stromal Fibroblasts Induces Resistance of Lung Cancer to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors
- (2009) W. Wang et al. CLINICAL CANCER RESEARCH
- Cancer stem cell marker CD133+ tumour cells and clinical outcome in rectal cancer
- (2009) Qi Wang et al. HISTOPATHOLOGY
- Attenuated p53 activation in tumour-associated stromal cells accompanies decreased sensitivity to etoposide and vincristine
- (2008) A C Dudley et al. BRITISH JOURNAL OF CANCER
- Effects of lentivirus-mediated HIF-1α knockdown on hypoxia-related cisplatin resistance and their dependence on p53 status in fibrosarcoma cells
- (2008) J Hao et al. CANCER GENE THERAPY
- The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells
- (2008) Sendurai A. Mani et al. CELL
- Senescence of Activated Stellate Cells Limits Liver Fibrosis
- (2008) Valery Krizhanovsky et al. CELL
- Cancer Stem Cell Analysis and Clinical Outcome in Patients with Glioblastoma Multiforme
- (2008) R. Pallini et al. CLINICAL CANCER RESEARCH
- Caveolin-1-dependent 1 integrin endocytosis is a critical regulator of fibronectin turnover
- (2008) F. Shi et al. JOURNAL OF CELL SCIENCE
- Cancer cells suppress p53 in adjacent fibroblasts
- (2008) J Bar et al. ONCOGENE
- Drug-Selected Human Lung Cancer Stem Cells: Cytokine Network, Tumorigenic and Metastatic Properties
- (2008) Vera Levina et al. PLoS One
- Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor
- (2008) Jean-Philippe Coppé et al. PLOS BIOLOGY
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