Article
Biochemistry & Molecular Biology
Sho Koyasu, Shoichiro Horita, Keisuke Saito, Minoru Kobayashi, Hiroshi Ishikita, Christalle C. T. Chow, Gouki Kambe, Shigeto Nishikawa, Toshi Menju, Akiyo Morinibu, Yasushi Okochi, Yoshiaki Tabuchi, Yasuhito Onodera, Norihiko Takeda, Hiroshi Date, Gregg L. Semenza, Ester M. Hammond, Hiroshi Harada
Summary: p53 deficiency triggers the activation of HIF-1 and ZBTB2 plays a crucial role in this process. ZBTB2 promotes invasion and growth of p53-deficient cancers and is associated with poor prognosis in lung cancer patients. ZBTB2 N-terminus-mimetic polypeptides inhibit ZBTB2 activity and suppress tumor aggressiveness.
Review
Cell Biology
Nasim Kheshtchin, Jamshid Hadjati
Summary: Hypoxia, a common characteristic of solid tumors, contributes to different aspects of tumor progression and limits the efficacy of immunotherapies. Developing new immunotherapy strategies involving therapeutic targeting of HIF-1 molecules associated with hypoxia may enhance the clinical effectiveness of immunotherapy. Targeting hypoxia presents a potential opportunity to improve the clinical benefit of cancer immunotherapy.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Environmental Sciences
Xianping Huang, Weihe Zhou, Yuefeng Zhang
Summary: The research revealed that in a hypoxic microenvironment, YY1 interacts with HIF-1 alpha to regulate the stemness of lung cancer cells.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Oncology
Kreon Koukoulas, Antonis Giakountis, Angeliki Karagiota, Martina Samiotaki, George Panayotou, George Simos, Ilias Mylonis
Summary: ERK-mediated phosphorylation of HIF-1 alpha enhances its interaction with NPM1, which influences the transcriptional activation of HIF-1 target genes. NPM1 and HIF-1 co-regulate genes enriched in different cancer types, and their expression correlates with hypoxic tumor status and patient prognosis.
MOLECULAR ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Maciej Jaskiewicz, Adrianna Moszynska, Jaroslaw Kroliczewski, Aleksandra Cabaj, Sylwia Bartoszewska, Agata Charzynska, Magda Gebert, Michal Dabrowski, James F. Collawn, Rafal Bartoszewski
Summary: HIF is a transcription factor that activates the adaptive hypoxic response during low oxygen levels. HIF-1 and HIF-2 mediate this response in a sequential manner, but their transcriptional profiles differ and the transition between them is not well understood.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2022)
Article
Biochemistry & Molecular Biology
Yangsook Song Green, Maria C. Ferreira dos Santos, Daniel Fuja, Ethan Reichert, Alexandre R. Campos, Sophie J. Cowman, Karen Acuna Pilarte, Jessica Kohan, Sheryl R. Tripp, Elizabeth A. Leibold, Deepika Sirohi, Neeraj Agarwal, Xiaohui Liu, Mei Yee Koh
Summary: This study found that targeting ISCA2 protein can reduce HIF-1/2 alpha protein levels and inhibit the development of clear cell renal cell carcinoma (ccRCC) by inducing ferroptosis. ISCA2 inhibition not only decreases HIF-2 alpha protein levels by blocking IRE-dependent translation, but can also reduce HIF-1 alpha translation at higher concentrations through unknown mechanisms. Additionally, ISCA2 inhibition triggers the iron starvation response, leading to iron/metals overload and cell death.
Article
Oncology
Pedro P. Cunha, David Bargiela, Eleanor Minogue, Lena C. M. Krause, Laura Barbieri, Carolin Brombach, Milos Gojkovic, Emilia Marklund, Sandra Pietsch, Iosifina Foskolou, Cristina M. Branco, Pedro Veli, Randall S. Johnson
Summary: Nitric oxide (NO), produced by NO synthases (NOS1-3), regulates neurotransmission, vascular permeability, and immune function. While myeloid cell-derived NO suppresses T-cell responses, the role of NO synthesis in T cells themselves remains unclear. The study demonstrates that significant amounts of NO are synthesized in activated human and murine CD8 T cells. In a mouse model with T cell-specific deletion of Nos2 expression, tumor growth is accelerated. Genetic deletion of Nos2 in murine T cells alters effector differentiation, reduces tumor infiltration, and inhibits recall responses and adoptive cell transfer function. These findings highlight the critical role of endogenous NO production in T cell-mediated tumor immunity.
CANCER IMMUNOLOGY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Yong Zhang, Li Jiang, Nianqun Qin, Mi Cao, Xiujuan Liang, Rensheng Wang
Summary: This study reveals that under hypoxic conditions, hCINAP regulates the migration and EMT of cervical cancer cells through the Akt-mTOR signaling pathway, while also inhibiting hypoxia-induced p53-dependent apoptosis. This suggests that hCINAP may play essential roles in cervical cancer metastasis and could be a potential target for the treatment of cervical cancer.
BIOCHEMISTRY AND CELL BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Xiaowei Wu, Minjie Li, Ying Li, Yu Deng, Shun Ke, Fan Li, Yujin Wang, Shuchang Zhou
Summary: The study demonstrated that FGF11 acts as an oncogene in non-small cell lung cancer, while miR-525-5p may negatively regulate FGF11. Targeting FGF11 and HIF-1 alpha could serve as novel strategies for the treatment of NSCLC.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Thuy-Hang Nguyen, Stephanie Conotte, Alexandra Belayew, Anne-Emilie Decleves, Alexandre Legrand, Alexandra Tassin
Summary: Muscular dystrophies are genetic degenerative muscle disorders characterized by muscle wasting, often accompanied by respiratory impairments and hypoxemia. Hypoxic stress activates compensatory mechanisms, with HIF-1α playing a key role. Alterations in HIF-1α in muscle may impact the pathophysiology of muscular dystrophies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Yafei Zhang, Hongwei Lu, Hong Ji, Yiming Li
Summary: This study investigated the role of hypoxia-inducible factor-1 alpha (HIF-1 alpha) and p53 in mucosal apoptosis in portal hypertensive gastropathy (PHG). The results showed that HIF-1 alpha and p53 were significantly upregulated in the gastric mucosa of PHG patients and animal models, and inhibition of these molecules could attenuate apoptosis. It was also found that HIF-1 alpha regulated the p53-induced mucosal epithelial apoptotic signaling pathway. Therefore, HIF-1 alpha and p53 may be potential therapeutic targets for PHG.
DIGESTIVE AND LIVER DISEASE
(2023)
Article
Oncology
Chaojie Li, Nannan Yang, Zhijin Chen, Ning Xia, Qungang Shan, Ziyin Wang, Jian Lu, Mingyi Shang, Zhongmin Wang
Summary: Our study revealed that Tie1 is upregulated in a hypoxic environment in non-small cell lung carcinoma (NSCLC) cells, promoting stemness and resistance to cisplatin. Silencing Tie1 reduced stemness properties and increased sensitivity to cisplatin, suggesting its role in tumorigenesis and drug resistance in NSCLC. Additionally, Tie1 expression was induced by hypoxia in an HIF-1 alpha-dependent manner, further supporting its involvement in promoting stemness and drug resistance in NSCLC.
CANCER CELL INTERNATIONAL
(2021)
Article
Biotechnology & Applied Microbiology
Xiao-Yi Chen, Qian-Long Wang, Wei-Xue Huang, Long-Wei Li, Lan-Cong Liu, Yi Yang, You-Jiao Wu, Shan-Shan Song, Hao Ma, Hua Zhou, Pei Luo
Summary: This study aimed to analyze and evaluate the dynamic changes in HIF-1 alpha concentration in serum exosomes during bacterial peritonitis. A new colorimetric method to quantitate these changes was established. The results showed that the serum exosomal HIF-1 alpha levels increased in the early stage of bacterial peritonitis, reached a peak at 24-48 hours, and then gradually decreased. Intervention treatment reduced the abdominal infection extent, HIF-1 alpha concentration in serum exosomes, and the serum pro-inflammatory factors levels. These findings suggest that serum exosomal HIF-1 alpha can be used as a biomarker for predicting and monitoring the pathological process of bacterial peritonitis.
Article
Immunology
Ju-Won Jang, Sojin Park, Eun-Yi Moon
Summary: B cells may be regulated by crosstalk between HIF-1 alpha and Nrf2 through ROS-mediated Syk activation, where HIF-1 alpha levels might control Nrf2 levels and vice versa, possibly associated with Syk phosphorylation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Dong Zhao, Shanliang Zheng, Xingwen Wang, Hao Liu, Kunming Zhao, Li Li, Ying Hu
Summary: In certain tumors, iASPP plays a crucial role in the activation of HIF-1α. Inhibition of iASPP can slow down tumor growth, reduce angiogenesis, increase tumor necrosis, and decrease glycolysis dependent on HIF-1α. Mechanistically, iASPP directly binds VHL and prevents its binding to HIF-1α, leading to the stabilization of HIF-1α.