Direct neuronal reprogramming: Fast forward from new concepts toward therapeutic approaches

Ferroptosis: mechanisms, biology and role in disease

(2021) Xuejun Jiang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Regeneration of Functional Neurons After Spinal Cord Injury via in situ NeuroD1-Mediated Astrocyte-to-Neuron Conversion

(2021) Brendan Puls et al.   Frontiers in Cell and Developmental Biology

In vivo reprogramming of NG2 glia enables adult neurogenesis and functional recovery following spinal cord injury

(2021) Wenjiao Tai et al.   Cell Stem Cell

Fully defined human pluripotent stem cell-derived microglia and tri-culture system model C3 production in Alzheimer’s disease

(2021) Sudha R. Guttikonda et al.   NATURE NEUROSCIENCE

Neurog2 directly converts astrocytes into functional neurons in midbrain and spinal cord

(2021) Fei Liu et al.   Cell Death & Disease

Molecular Mechanisms Underlying Ascl1-Mediated Astrocyte-to-Neuron Conversion

(2021) Zhiping Rao et al.   Stem Cell Reports

In vivo chemical reprogramming of astrocytes into neurons

(2021) Yantao Ma et al.   Cell Discovery

Induced Neurons for Disease Modeling and Repair: A Focus on Non-fibroblastic Cell Sources in Direct Reprogramming

(2021) Kathryn M. Kim et al.   Frontiers in Bioengineering and Biotechnology

Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer’s patients

(2021) Jerome Mertens et al.   Cell Stem Cell

The roles of Polycomb repressive complexes in mammalian development and cancer

(2021) Andrea Piunti et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Astrocytes and neurons share region-specific transcriptional signatures that confer regional identity to neuronal reprogramming

(2021) Álvaro Herrero-Navarro et al.   Science Advances

Molecular diversity of diencephalic astrocytes reveals adult astrogenesis regulated by Smad4

(2021) Stefanie Ohlig et al.   EMBO JOURNAL

Molecular logic of cellular diversification in the mouse cerebral cortex

(2021) Daniela J. Di Bella et al.   NATURE

Molecular architecture of the developing mouse brain

(2021) Gioele La Manno et al.   NATURE

Heterogeneity of neurons reprogrammed from spinal cord astrocytes by the proneural factors Ascl1 and Neurogenin2

(2021) J. Kempf et al.   Cell Reports

Post-Translational Modifications of Deubiquitinating Enzymes: Expanding the Ubiquitin Code

(2021) Yanfeng Wang et al.   Frontiers in Pharmacology

Revisiting astrocyte to neuron conversion with lineage tracing in vivo

(2021) Lei-Lei Wang et al.   CELL

Reprogramming reactive glia into interneurons reduces chronic seizure activity in a mouse model of mesial temporal lobe epilepsy

(2021) Célia Lentini et al.   Cell Stem Cell

NeuroD1 induces microglial apoptosis and cannot induce microglia-to-neuron cross-lineage reprogramming

(2021) Yanxia Rao et al.   NEURON

Clarifying the ability of NeuroD1 to convert mouse microglia into neurons

(2021) Taito Matsuda et al.   NEURON

A decade of questions about the fluidity of cell identity

(2020) Giacomo Masserdotti et al.   NATURE

Genetic aberrations in iPSCs are introduced by a transient G1/S cell cycle checkpoint deficiency

(2020) Ryoko Araki et al.   Nature Communications

Gene therapy conversion of striatal astrocytes into GABAergic neurons in mouse models of Huntington’s disease

(2020) Zheng Wu et al.   Nature Communications

Identification of region-specific astrocyte subtypes at single cell resolution

(2020) Mykhailo Y. Batiuk et al.   Nature Communications

Glia-to-Neuron Conversion by CRISPR-CasRx Alleviates Symptoms of Neurological Disease in Mice

(2020) Haibo Zhou et al.   CELL

Transplanted Embryonic Neurons Improve Functional Recovery by Increasing Activity in Injured Cortical Circuits

(2020) Evgenia Andreoli et al.   CEREBRAL CORTEX

Pro-neuronal activity of Myod1 due to promiscuous binding to neuronal genes

(2020) Qian Yi Lee et al.   NATURE CELL BIOLOGY

Astrocyte layers in the mammalian cerebral cortex revealed by a single-cell in situ transcriptomic map

(2020) Omer Ali Bayraktar et al.   NATURE NEUROSCIENCE

Two-Parameter Mobility Assessments Discriminate Diverse Regulatory Factor Behaviors in Chromatin

(2020) Jonathan Lerner et al.   MOLECULAR CELL

Reversing a model of Parkinson’s disease with in situ converted nigral neurons

(2020) Hao Qian et al.   NATURE

Pluripotent Stem Cell Therapies for Parkinson Disease: Present Challenges and Future Opportunities

(2020) Tae Wan Kim et al.   Frontiers in Cell and Developmental Biology

Pioneer Transcription Factors Initiating Gene Network Changes

(2020) Kenneth S. Zaret   Annual Review of Genetics

Deconstructing Stepwise Fate Conversion of Human Fibroblasts to Neurons by MicroRNAs

(2020) Kitra Cates et al.   Cell Stem Cell

Pseudotyped lentiviral vectors for tract-targeting and application for the functional control of selective neural circuits

(2020) Shigeki Kato et al.   JOURNAL OF NEUROSCIENCE METHODS

Robust Myelination of Regenerated Axons Induced by Combined Manipulations of GPR17 and Microglia

(2020) Jing Wang et al.   NEURON

Gene regulatory networks controlling vertebrate retinal regeneration

(2020) Thanh Hoang et al.   SCIENCE

Direct Reprogramming of Human Fetal- and Stem Cell-Derived Glial Progenitor Cells into Midbrain Dopaminergic Neurons

(2020) Sara Nolbrant et al.   Stem Cell Reports

EpiMogrify Models H3K4me3 Data to Identify Signaling Molecules that Improve Cell Fate Control and Maintenance

(2020) Uma S. Kamaraj et al.   Cell Systems

CRISPR-Mediated Induction of Neuron-Enriched Mitochondrial Proteins Boosts Direct Glia-to-Neuron Conversion

(2020) Gianluca L. Russo et al.   Cell Stem Cell

Rapid evolution of blood-brain-barrier-penetrating AAV capsids by RNA-driven biopanning

(2020) Mathieu Nonnenmacher et al.   Molecular Therapy-Methods & Clinical Development

Systemic AAV vectors for widespread and targeted gene delivery in rodents

(2019) Rosemary C. Challis et al.   Nature Protocols

Pioneer Factor NeuroD1 Rearranges Transcriptional and Epigenetic Profiles to Execute Microglia-Neuron Conversion

(2019) Taito Matsuda et al.   NEURON

Region-Restrict Astrocytes Exhibit Heterogeneous Susceptibility to Neuronal Reprogramming

(2019) Xin Hu et al.   Stem Cell Reports

Direct Neuronal Reprogramming Reveals Unknown Functions for Known Transcription Factors

(2019) Gaia Colasante et al.   Frontiers in Neuroscience

Proneural factors Ascl1 and Neurog2 contribute to neuronal subtype identities by establishing distinct chromatin landscapes

(2019) Begüm Aydin et al.   NATURE NEUROSCIENCE

An integrative method to predict signalling perturbations for cellular transitions

(2019) Gaia Zaffaroni et al.   NUCLEIC ACIDS RESEARCH

Chemical modulation of transcriptionally enriched signaling pathways to optimize the conversion of fibroblasts into neurons

(2019) Joseph Herdy et al.   eLife

Targeted removal of epigenetic barriers during transcriptional reprogramming

(2019) Valentin Baumann et al.   Nature Communications

In vivo direct reprogramming of glial linage to mature neurons after cerebral ischemia

(2019) Toru Yamashita et al.   Scientific Reports

A NeuroD1 AAV-Based Gene Therapy for Functional Brain Repair after Ischemic Injury through In Vivo Astrocyte-to-Neuron Conversion

(2019) Yu-Chen Chen et al.   MOLECULAR THERAPY

Cell-type-specific profiling of brain mitochondria reveals functional and molecular diversity

(2019) Caroline Fecher et al.   NATURE NEUROSCIENCE

Inducing Different Neuronal Subtypes from Astrocytes in the Injured Mouse Cerebral Cortex

(2019) Nicola Mattugini et al.   NEURON

A systematic capsid evolution approach performed in vivo for the design of AAV vectors with tailored properties and tropism

(2019) Marcus Davidsson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

bHLH transcription factors in neural development, disease, and reprogramming

(2018) Daniel J. Dennis et al.   BRAIN RESEARCH

MicroRNAs Overcome Cell Fate Barrier by Reducing EZH2-Controlled REST Stability during Neuronal Conversion of Human Adult Fibroblasts

(2018) Seong Won Lee et al.   DEVELOPMENTAL CELL

Whole-organism clone tracing using single-cell sequencing

(2018) Anna Alemany et al.   NATURE

Neuronal atlas of the dorsal horn defines its architecture and links sensory input to transcriptional cell types

(2018) Martin Häring et al.   NATURE NEUROSCIENCE

Direct pericyte-to-neuron reprogramming via unfolding of a neural stem cell-like program

(2018) Marisa Karow et al.   NATURE NEUROSCIENCE

Striatal neurons directly converted from Huntington’s disease patient fibroblasts recapitulate age-associated disease phenotypes

(2018) Matheus B. Victor et al.   NATURE NEUROSCIENCE

Randomized Trial of Verubecestat for Mild-to-Moderate Alzheimer’s Disease

(2018) Michael F. Egan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Layer-specific morphological and molecular differences in neocortical astrocytes and their dependence on neuronal layers

(2018) Darin Lanjakornsiripan et al.   Nature Communications

The Aging Astrocyte Transcriptome from Multiple Regions of the Mouse Brain

(2018) Matthew M. Boisvert et al.   Cell Reports

Mitochondrial Aging Defects Emerge in Directly Reprogrammed Human Neurons due to Their Metabolic Profile

(2018) Yongsung Kim et al.   Cell Reports

Local and global influences on protein turnover in neurons and glia

(2018) Aline R Dörrbaum et al.   eLife

Molecular Architecture of the Mouse Nervous System

(2018) Amit Zeisel et al.   CELL

A stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenation

(2018) Chao Sheng et al.   Nature Communications

E proteins sharpen neurogenesis by modulating proneural bHLH transcription factors’ activity in an E-box-dependent manner

(2018) Gwenvael Le Dréau et al.   eLife

Role of Mitochondria in Ferroptosis

(2018) Minghui Gao et al.   MOLECULAR CELL

Shared and distinct transcriptomic cell types across neocortical areas

(2018) Bosiljka Tasic et al.   NATURE

Molecular and Functional Properties of Regional Astrocytes in the Adult Brain

(2017) Lydie Morel et al.   JOURNAL OF NEUROSCIENCE

Stimulation of functional neuronal regeneration from Müller glia in adult mice

(2017) Nikolas L. Jorstad et al.   NATURE

Human iPS cell-derived dopaminergic neurons function in a primate Parkinson’s disease model

(2017) Tetsuhiro Kikuchi et al.   NATURE

Myt1l safeguards neuronal identity by actively repressing many non-neuronal fates

(2017) Moritz Mall et al.   NATURE

Induction of functional dopamine neurons from human astrocytes in vitro and mouse astrocytes in a Parkinson's disease model

(2017) Pia Rivetti di Val Cervo et al.   NATURE BIOTECHNOLOGY

Electromagnetized gold nanoparticles mediate direct lineage reprogramming into induced dopamine neurons in vivo for Parkinson's disease therapy

(2017) Junsang Yoo et al.   Nature Nanotechnology

Cell-specific and region-specific transcriptomics in the multiple sclerosis model: Focus on astrocytes

(2017) Noriko Itoh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rapid Chromatin Switch in the Direct Reprogramming of Fibroblasts to Neurons

(2017) Orly L. Wapinski et al.   Cell Reports

Lineage Reprogramming of Astroglial Cells from Different Origins into Distinct Neuronal Subtypes

(2017) Malek Chouchane et al.   Stem Cell Reports

Direct Reprogramming of Resident NG2 Glia into Neurons with Properties of Fast-Spiking Parvalbumin-Containing Interneurons

(2017) Maria Pereira et al.   Stem Cell Reports

Alzheimer’s disease: experimental models and reality

(2016) Eleanor Drummond et al.   ACTA NEUROPATHOLOGICA

Molecular Diversity of Midbrain Development in Mouse, Human, and Stem Cells

(2016) Gioele La Manno et al.   CELL

Restoration of Visual Function by Enhancing Conduction in Regenerated Axons

(2016) Fengfeng Bei et al.   CELL

Identification and Successful Negotiation of a Metabolic Checkpoint in Direct Neuronal Reprogramming

(2016) Sergio Gascón et al.   Cell Stem Cell

Direct neuronal reprogramming: learning from and for development

(2016) Giacomo Masserdotti et al.   DEVELOPMENT

Direct lineage reprogramming via pioneer factors; a detour through developmental gene regulatory networks

(2016) Samantha A. Morris   DEVELOPMENT

Transplanted embryonic neurons integrate into adult neocortical circuits

(2016) Susanne Falkner et al.   NATURE

Dissecting direct reprogramming from fibroblast to neuron using single-cell RNA-seq

(2016) Barbara Treutlein et al.   NATURE

C/EBPα creates elite cells for iPSC reprogramming by upregulating Klf4 and increasing the levels of Lsd1 and Brd4

(2016) Bruno Di Stefano et al.   NATURE CELL BIOLOGY

A predictive computational framework for direct reprogramming between human cell types

(2016) Owen J L Rackham et al.   NATURE GENETICS

Adult mouse cortical cell taxonomy revealed by single cell transcriptomics

(2016) Bosiljka Tasic et al.   NATURE NEUROSCIENCE

Functional diversity of astrocytes in neural circuit regulation

(2016) Lucile Ben Haim et al.   NATURE REVIEWS NEUROSCIENCE

In vivo reprogramming reactive glia into iPSCs to produce new neurons in the cortex following traumatic brain injury

(2016) Xiang Gao et al.   Scientific Reports

Direct Lineage Reprogramming Reveals Disease-Specific Phenotypes of Motor Neurons from Human ALS Patients

(2016) Meng-Lu Liu et al.   Cell Reports

MyT1 Counteracts the Neural Progenitor Program to Promote Vertebrate Neurogenesis

(2016) Francisca F. Vasconcelos et al.   Cell Reports

The p53 Pathway Controls SOX2-Mediated Reprogramming in the Adult Mouse Spinal Cord

(2016) Lei-Lei Wang et al.   Cell Reports

Maintenance of age in human neurons generated by microRNA-based neuronal conversion of fibroblasts

(2016) Christine J Huh et al.   eLife

Small Molecules Modulate Chromatin Accessibility to Promote NEUROG2-Mediated Fibroblast-to-Neuron Reprogramming

(2016) Derek K. Smith et al.   Stem Cell Reports

Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets

(2015) Evan Z. Macosko et al.   CELL

Adult Neural Stem Cells from the Subventricular Zone Give Rise to Reactive Astrocytes in the Cortex after Stroke

(2015) Maryam Faiz et al.   Cell Stem Cell

Successful Function of Autologous iPSC-Derived Dopamine Neurons following Transplantation in a Non-Human Primate Model of Parkinson’s Disease

(2015) Penelope J. Hallett et al.   Cell Stem Cell

Rapid Conversion of Fibroblasts into Functional Forebrain GABAergic Interneurons by Direct Genetic Reprogramming

(2015) Gaia Colasante et al.   Cell Stem Cell

Transcriptional Mechanisms of Proneural Factors and REST in Regulating Neuronal Reprogramming of Astrocytes

(2015) Giacomo Masserdotti et al.   Cell Stem Cell

Direct Conversion of Normal and Alzheimer’s Disease Human Fibroblasts into Neuronal Cells by Small Molecules

(2015) Wenxiang Hu et al.   Cell Stem Cell

Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects

(2015) Jerome Mertens et al.   Cell Stem Cell

Small-Molecule-Driven Direct Reprogramming of Mouse Fibroblasts into Functional Neurons

(2015) Xiang Li et al.   Cell Stem Cell

How to make a midbrain dopaminergic neuron

(2015) E. Arenas et al.   DEVELOPMENT

Gbx2 is essential for maintaining thalamic neuron identity and repressing habenular characters in the developing thalamus

(2015) Chatterjee Mallika et al.   DEVELOPMENTAL BIOLOGY

NeuroD1 reprograms chromatin and transcription factor landscapes to induce the neuronal program

(2015) A. Pataskar et al.   EMBO JOURNAL

(Patho-)physiological relevance of PINK1-dependent ubiquitin phosphorylation

(2015) F. C. Fiesel et al.   EMBO REPORTS

Reactive astrocytes as neural stem or progenitor cells: In vivo lineage, In vitro potential, and Genome-wide expression analysis

(2015) Magdalena Götz et al.   GLIA

Ascl1 Converts Dorsal Midbrain Astrocytes into Functional Neurons In Vivo

(2015) Y. Liu et al.   JOURNAL OF NEUROSCIENCE

Monosynaptic Circuit Tracing with Glycoprotein-Deleted Rabies Viruses

(2015) E. M. Callaway et al.   JOURNAL OF NEUROSCIENCE

Area-Specific Reestablishment of Damaged Circuits in the Adult Cerebral Cortex by Cortical Neurons Derived from Mouse Embryonic Stem Cells

(2015) Kimmo A. Michelsen et al.   NEURON

Enhanced Rejuvenation in Induced Pluripotent Stem Cell-Derived Neurons Compared with Directly Converted Neurons from an Aged Mouse

(2015) Yuanyuan Yang et al.   STEM CELLS AND DEVELOPMENT

Cell cycle and p53 gate the direct conversion of human fibroblasts to dopaminergic neurons

(2015) Houbo Jiang et al.   Nature Communications

Conversion of MyoD to a Neurogenic Factor: Binding Site Specificity Determines Lineage

(2015) Abraham P. Fong et al.   Cell Reports

In Vivo Reprogramming of Striatal NG2 Glia into Functional Neurons that Integrate into Local Host Circuitry

(2015) Olof Torper et al.   Cell Reports

Molecular and cellular development of spinal cord locomotor circuitry

(2015) Daniel C. Lu et al.   Frontiers in Molecular Neuroscience

Monosynaptic Tracing using Modified Rabies Virus Reveals Early and Extensive Circuit Integration of Human Embryonic Stem Cell-Derived Neurons

(2015) Shane Grealish et al.   Stem Cell Reports

Direct Conversion of Fibroblasts into Functional Astrocytes by Defined Transcription Factors

(2015) Massimiliano Caiazzo et al.   Stem Cell Reports

SOX2 Reprograms Resident Astrocytes into Neural Progenitors in the Adult Brain

(2015) Wenze Niu et al.   Stem Cell Reports

The BET Family Member BRD4 Interacts with OCT4 and Regulates Pluripotency Gene Expression

(2015) Tao Wu et al.   Stem Cell Reports

The Cell Biology of Neurogenesis: Toward an Understanding of the Development and Evolution of the Neocortex

(2014) Elena Taverna et al.   Annual Review of Cell and Developmental Biology

CellNet: Network Biology Applied to Stem Cell Engineering

(2014) Patrick Cahan et al.   CELL

Nonstochastic Reprogramming from a Privileged Somatic Cell State

(2014) Shangqin Guo et al.   CELL

Generation of Multipotent Induced Neural Crest by Direct Reprogramming of Human Postnatal Fibroblasts with a Single Transcription Factor

(2014) Yong Jun Kim et al.   Cell Stem Cell

Direct Reprogramming of Human Fibroblasts to Functional and Expandable Hepatocytes

(2014) Pengyu Huang et al.   Cell Stem Cell

The phosphorylation status of Ascl1 is a key determinant of neuronal differentiation and maturation in vivo and in vitro

(2014) F. R. Ali et al.   DEVELOPMENT

Transduction efficiency of neurons and glial cells by AAV-1, -5, -9, -rh10 and -hu11 serotypes in rat spinal cord following contusion injury

(2014) H A Petrosyan et al.   GENE THERAPY

The Ink4a/Arf Locus Is a Barrier to Direct Neuronal Transdifferentiation

(2014) J. D. Price et al.   JOURNAL OF NEUROSCIENCE

Enhancers Are Major Targets for Murine Leukemia Virus Vector Integration

(2014) S. S. De Ravin et al.   JOURNAL OF VIROLOGY

A mesoscale connectome of the mouse brain

(2014) Seung Wook Oh et al.   NATURE

Regulation of microRNA biogenesis

(2014) Minju Ha et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Generation of Human Striatal Neurons by MicroRNA-Dependent Direct Conversion of Fibroblasts

(2014) Matheus B. Victor et al.   NEURON

A latent neurogenic program in astrocytes regulated by Notch signaling in the mouse

(2014) J. P. Magnusson et al.   SCIENCE

In vivo conversion of astrocytes to neurons in the injured adult spinal cord

(2014) Zhida Su et al.   Nature Communications

Isl1 Directly Controls a Cholinergic Neuronal Identity in the Developing Forebrain and Spinal Cord by Forming Cell Type-Specific Complexes

(2014) Hyong-Ho Cho et al.   PLoS Genetics

Generation of Induced Neuronal Cells by the Single Reprogramming Factor ASCL1

(2014) Soham Chanda et al.   Stem Cell Reports

Sox2-Mediated Conversion of NG2 Glia into Induced Neurons in the Injured Adult Cerebral Cortex

(2014) Christophe Heinrich et al.   Stem Cell Reports

Hierarchical Mechanisms for Direct Reprogramming of Fibroblasts to Neurons

(2013) Orly L. Wapinski et al.   CELL

Direct Conversion of Fibroblasts to Neurons by Reprogramming PTB-Regulated MicroRNA Circuits

(2013) Yuanchao Xue et al.   CELL

The BAF Complex Interacts with Pax6 in Adult Neural Progenitors to Establish a Neurogenic Cross-Regulatory Transcriptional Network

(2013) Jovica Ninkovic et al.   Cell Stem Cell

Reprogramming Fibroblasts into Bipotential Hepatic Stem Cells by Defined Factors

(2013) Bing Yu et al.   Cell Stem Cell

Reactive Glia in the Injured Brain Acquire Stem Cell Properties in Response to Sonic Hedgehog

(2013) Swetlana Sirko et al.   Cell Stem Cell

In Vivo Direct Reprogramming of Reactive Glial Cells into Functional Neurons after Brain Injury and in an Alzheimer’s Disease Model

(2013) Ziyuan Guo et al.   Cell Stem Cell

Asymmetric activation of Dll4-Notch signaling by Foxn4 and proneural factors activates BMP/TGF  signaling to specify V2b interneurons in the spinal cord

(2013) K. Misra et al.   DEVELOPMENT

Protective astrogenesis from the SVZ niche after injury is controlled by Notch modulator Thbs4

(2013) Eric J. Benner et al.   NATURE

In vivo reprogramming of astrocytes to neuroblasts in the adult brain

(2013) Wenze Niu et al.   NATURE CELL BIOLOGY

Generation of induced neurons via direct conversion in vivo

(2013) O. Torper et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Environmental impact on direct neuronal reprogramming in vivo in the adult brain

(2013) Andrew Grande et al.   Nature Communications

Small molecules enable neurogenin 2 to efficiently convert human fibroblasts into cholinergic neurons

(2013) Meng-Lu Liu et al.   Nature Communications

DNA methylation age of human tissues and cell types

(2013) Steve Horvath   GENOME BIOLOGY

Direct Conversion of Fibroblasts into Stably Expandable Neural Stem Cells

(2012) Marc Thier et al.   Cell Stem Cell

Reprogramming of Pericyte-Derived Cells of the Adult Human Brain into Induced Neuronal Cells

(2012) Marisa Karow et al.   Cell Stem Cell

Post-translational modification of Ngn2 differentially affects transcription of distinct targets to regulate the balance between progenitor maintenance and differentiation

(2012) C. Hindley et al.   DEVELOPMENT

GSK3 Temporally Regulates Neurogenin 2 Proneural Activity in the Neocortex

(2012) S. Li et al.   JOURNAL OF NEUROSCIENCE

SoxC Transcription Factors Are Required for Neuronal Differentiation in Adult Hippocampal Neurogenesis

(2012) L. Mu et al.   JOURNAL OF NEUROSCIENCE

Small molecules enable highly efficient neuronal conversion of human fibroblasts

(2012) Julia Ladewig et al.   NATURE METHODS

Direct conversion of mouse fibroblasts to self-renewing, tripotent neural precursor cells

(2012) E. Lujan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A kinase inhibitor screen identifies small-molecule enhancers of reprogramming and iPS cell generation

(2012) Zhonghan Li et al.   Nature Communications

Direct Reprogramming of Adult Human Fibroblasts to Functional Neurons under Defined Conditions

(2011) Rajesh Ambasudhan et al.   Cell Stem Cell

Direct Lineage Conversion of Terminally Differentiated Hepatocytes to Functional Neurons

(2011) Samuele Marro et al.   Cell Stem Cell

Conversion of Mouse and Human Fibroblasts into Functional Spinal Motor Neurons

(2011) Esther Y. Son et al.   Cell Stem Cell

Cell cycle-regulated multi-site phosphorylation of Neurogenin 2 coordinates cell cycling with differentiation during neurogenesis

(2011) F. Ali et al.   DEVELOPMENT

MicroRNA-mediated conversion of human fibroblasts to neurons

(2011) Andrew S. Yoo et al.   NATURE

Direct generation of functional dopaminergic neurons from mouse and human fibroblasts

(2011) Massimiliano Caiazzo et al.   NATURE

Induction of human neuronal cells by defined transcription factors

(2011) Zhiping P. Pang et al.   NATURE

Efficient Conversion of Astrocytes to Functional Midbrain Dopaminergic Neurons Using a Single Polycistronic Vector

(2011) Russell C. Addis et al.   PLoS One

Direct conversion of human fibroblasts to dopaminergic neurons

(2011) U. Pfisterer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transplanted Hypothalamic Neurons Restore Leptin Signaling and Ameliorate Obesity in db/db Mice

(2011) A. Czupryn et al.   SCIENCE

Rewiring the brain with cell transplantation in Parkinson's disease

(2011) Afsaneh Gaillard et al.   TRENDS IN NEUROSCIENCES

Direct Reprogramming of Fibroblasts into Functional Cardiomyocytes by Defined Factors

(2010) Masaki Ieda et al.   CELL

Direct conversion of fibroblasts to functional neurons by defined factors

(2010) Thomas Vierbuchen et al.   NATURE

Directing Astroglia from the Cerebral Cortex into Subtype Specific Functional Neurons

(2010) Christophe Heinrich et al.   PLOS BIOLOGY

Involvement of Ngn2, Tbr and NeuroD proteins during postnatal olfactory bulb neurogenesis

(2009) Laurent Roybon et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling

(2009) Stuart M Chambers et al.   NATURE BIOTECHNOLOGY

miR-124 regulates adult neurogenesis in the subventricular zone stem cell niche

(2009) Li-Chun Cheng et al.   NATURE NEUROSCIENCE

Neurod1 is essential for the survival and maturation of adult-born neurons

(2009) Zhengliang Gao et al.   NATURE NEUROSCIENCE

A robust and high-throughput Cre reporting and characterization system for the whole mouse brain

(2009) Linda Madisen et al.   NATURE NEUROSCIENCE

Retinoid Signaling and Neurogenin2 Function Are Coupled for the Specification of Spinal Motor Neurons through a Chromatin Modifier CBP

(2009) Seunghee Lee et al.   NEURON

NeuroD1 induces terminal neuronal differentiation in olfactory neurogenesis

(2009) C. Boutin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular dissection of reactive astrogliosis and glial scar formation

(2009) Michael V. Sofroniew   TRENDS IN NEUROSCIENCES

miRNAs are essential for survival and differentiation of newborn neurons but not for expansion of neural progenitors during early neurogenesis in the mouse embryonic neocortex

(2008) D. De Pietri Tonelli et al.   DEVELOPMENT

GFAPpromoter elements required for region-specific and astrocyte-specific expression

(2008) Youngjin Lee et al.   GLIA

In vivo reprogramming of adult pancreatic exocrine cells to β-cells

(2008) Qiao Zhou et al.   NATURE

Small-molecule activation of neuronal cell fate

(2008) Jay W Schneider et al.   Nature Chemical Biology

Origin and progeny of reactive gliosis: A source of multipotent cells in the injured brain

(2008) A. Buffo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA