期刊
JOURNAL OF NEUROSCIENCE
卷 32, 期 9, 页码 3067-3080出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.4679-11.2012
关键词
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资金
- Technical University Munich
- European Science Foundation [DFG 858/6-2]
- Marie Curie Excellence Team
- European Union
- Bavarian Research Network on Adult Neural Stem Cells
- Helmholtz Alliance for Mental Health in an Ageing Society
- Bundesministerium fur Bildung und Forschung (BMBF) Network
- European Commission (Network of European Neuroscience Institutes) [LSHM-CT-2005-19063]
- Deutsche Forschungsgemeinschaft [BE 4182/2-2]
- BMBF network
Neural stem cells (NSCs) generate new hippocampal dentate granule neurons throughout adulthood. The genetic programs controlling neuronal differentiation of adult NSCs are only poorly understood. Here we show that, in the adult mouse hippocampus, expression of the SoxC transcription factors Sox4 and Sox11 is initiated around the time of neuronal commitment of adult NSCs and is maintained in immature neurons. Overexpression of Sox4 and Sox11 strongly promotes in vitro neurogenesis from adult NSCs, whereas ablation of Sox4/Sox11 prevents in vitro and in vivo neurogenesis from adult NSCs. Moreover, we demonstrate that SoxC transcription factors target the promoters of genes that are induced on neuronal differentiation of adult NSCs. Finally, we show that reprogramming of astroglia into neurons is dependent on the presence of SoxC factors. These data identify SoxC proteins as essential contributors to the genetic network controlling neuronal differentiation in adult neurogenesis and neuronal reprogramming of somatic cells.
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