Article
Multidisciplinary Sciences
Kanae Matsuda-Ito, Taito Matsuda, Kinichi Nakashima
Summary: NeuroD1 expression level plays a crucial role in neuronal reprogramming. Low expression fails to induce neuronal conversion, while elevated expression significantly improves reprogramming efficiency. Even under conditions where NeuroD1 expression is too low to induce effective conversion, combined expression with other RFs facilitates the breaking down of cellular barriers and induces neuronal reprogramming.
SCIENTIFIC REPORTS
(2022)
Letter
Neurosciences
Yanxia Rao, Bo Peng
Summary: The debate on NeuroD1-induced microglia-to-neuron conversion has recently been addressed. A study published in Neuron demonstrates that NeuroD1 is unable to induce such conversion. However, researchers who observed the conversion responded, claiming that the failure to observe it in vitro was due to low NeuroD1 expression efficiency. The authors of the original study refute this claim, stating that their NeuroD1 expression level was comparable to the other study, or even higher.
Article
Plant Sciences
Hazel McLellan, Petra C. Boevink, Paul R. J. Birch
Summary: Recent research has shown that disrupting the interaction between pathogen effectors and their host target proteins can decrease infection. With the identification of more effector-target pairs and the exposure of their structures and interaction surfaces, it may soon be possible to genetically modify plants to become nonhosts.
TRENDS IN PLANT SCIENCE
(2023)
Article
Neurosciences
Tiantian Guo, Xinjia Pan, Guangtong Jiang, Denghong Zhang, Jinghui Qi, Lin Shao, Zhanxiang Wang, Huaxi Xu, Yingjun Zhao
Summary: The strategy of converting astroglia into neurons through regulating the PTBP1 gene has failed to show successful results in mouse models of Alzheimer's disease and Parkinson's disease, and cannot reverse pathological and cognitive deficits.
JOURNAL OF NEUROSCIENCE
(2022)
Review
Chemistry, Multidisciplinary
Hanjun Ryu, Sang-Woo Kim
Summary: Pyroelectric energy harvesting systems have gained attention for their potential applications as power generators, utilizing pyroelectric nanogenerators for low-power sensors. The development progress includes an overview of the pyroelectric effect, with detailed reviews of polymer and ceramic materials-based PyNGs. Challenges and prospects regarding PyNGs are also described.
Article
Multidisciplinary Sciences
Yuting Chen, Eriona Hysolli, Anlu Chen, Stephen Casper, Songlei Liu, Kevin Yang, Chenli Liu, George Church
Summary: This study demonstrates the first application of whole-genome recoding technology in human cells, achieving successful conversion of TAG to TAA for 33 essential genes via a single transfection. It also reveals off-target events in gene exons and introduces a computational tool called GRIT for recoding, showcasing the feasibility of recoding and highly multiplex editing in mammalian cells.
NATURE COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Ying Chen, John Man Tak Chu, Raymond Chuen Chung Chang, Gordon Tin Chun Wong
Summary: The complement system plays a crucial role in the central nervous system beyond immunity, impacting neurodevelopment and neurodegenerative diseases. Proper activation of the complement system is essential for maintaining normal brain function, but overactivation or dysregulation may lead to synaptic dysfunction and excessive pro-inflammatory responses. Targeting complement factors shows therapeutic potential for neurodegenerative conditions.
Article
Immunology
Florian Mayrhofer, Angela M. M. Hanson, Manuel F. F. Navedo, Yang K. K. Xiang, Athena M. M. Soulika, Wenbin Deng, Olga V. V. Chechneva
Summary: Material transfer is an important way for cells to exchange information and resources. It has been found that neurons in the mouse central nervous system can receive nuclear and ribosomal material from Sox10-lineage cells. This transfer of material is region dependent, develops during postnatal brain maturation, and responds dynamically to LPS-induced neuroinflammation in adult mice. These findings have potential implications for understanding and modulating neuronal function, as well as treating neurological disorders.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Neurosciences
Valerie A. Wagner, Guorui Deng, Kristin E. Claflin, McKenzie L. Ritter, Huxing Cui, Pablo Nakagawa, Curt D. Sigmund, Lisa L. Morselli, Justin L. Grobe, Anne E. Kwitek
Summary: Using single-nucleus RNA sequencing, we observed changes in gene expression patterns of AT(1)R subtypes in AgRP neurons of the arcuate nucleus during DOCA-salt treatment, which is associated with blood pressure and metabolism regulation. Additionally, activation of microglia in the brain was found. These findings provide important insights into the physiological and pathophysiological significance of different subtypes of neuronal and glial cells.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Engineering, Biomedical
Werner E. G. Muller, Meik Neufurth, Ingo Lieberwirth, Shunfeng Wang, Heinz C. Schroder, Xiaohong Wang
Summary: This article investigates the morphological transformation of inorganic polyphosphates and their impact on cell functions. The study reveals the significant influence of calcium ions and pH on the formation of polyP nanoparticles and coacervates. Characterization and functional studies provide insights into the physiological activity and cellular uptake mechanism of polyP in different forms.
MATERIALS TODAY BIO
(2022)
Article
Acoustics
Alain Destexhe, Luc Foubert
Summary: The study introduces a method to convert neural signals into sound sequences that precisely reflect the sequences of events, by quantifying wave motifs in the signal to generate sound envelopes. This method is demonstrated using sleep delta waves in human EEG, allowing for personalized sound sequences specific to an individual's EEG to be synthesized.
JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
(2022)
Editorial Material
Biochemistry & Molecular Biology
Zane B. Andrews
Summary: Neural circuits play a role in regulating food intake by responding to internal hunger and hedonic cues. This study used a hunger discrimination task and genetic manipulation to identify circuits involved in driving food intake.
Article
Chemistry, Applied
Andrea Vera-Loor, Panagiota Rigou, Nathalie Marlin, Gerard Mortha, Alain Dufresne
Summary: Microfibrillated cellulose (MFC) is a promising cellulosic material that has shown great potential in various industries. However, there is still a need to improve its processing techniques to increase production volumes and reduce costs.
CARBOHYDRATE POLYMERS
(2022)
Article
Multidisciplinary Sciences
Ipek Akol, Annalisa Izzo, Fabian Gather, Stefanie Strack, Stefanie Heidrich, Darren O. Hailin, Alejandro Villarreal, Christine Hacker, Tudor Rauleac, Chiara Bella, Andre Fischer, Thomas Manke, Tanja Vogel
Summary: Forkhead box G1 (FOXG1) plays important roles in neuronal differentiation and maintaining excitatory/inhibitory balance in the network. In this study, the authors investigated how FOXG1 impacts neuronal maturation at the chromatin level in the mouse hippocampus. They found that FOXG1 regulates transcription, binds to enhancer regions, and alters the epigenetic landscape. FOXG1 and NEUROD1 act cooperatively to control neuronal maturation, and the chromatin alterations affect synaptogenesis and axonogenesis. This study provides insights into the multimodality of FOXG1 functions and suggests epigenetic drugs as potential therapeutic options for neuronal dysfunction.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biochemistry & Molecular Biology
Olga Bocharova, Narayan P. Pandit, Kara Molesworth, Aidan Fisher, Olga Mychko, Natallia Makarava, Ilia Baskakov
Summary: The study found that the 5XFAD genotype did not protect mice against HSV-1 infection, and the tropisms of HSV-1 were not affected by the genotype. 5XFAD mice with abundant A β aggregates showed slightly better survival rates. Additionally, HSV-1 viral particles were excluded from brain areas with high densities of A β aggregates, partially due to the phagocytic activity of reactive microglia.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
