期刊
FRONTIERS IN PHARMACOLOGY
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fphar.2021.685011
关键词
DUBs; post-translational modifications; phosphorylation; ubiquitination; sumoylation; acetylation; oxidation; hydroxylation
资金
- Youth Project of Beijing Natural Science Foundation [5214027]
- National Key R&D Program of China [2016YFC0906002]
- Beijing Institute of Technology Innovative Talents Science and Technology [3160012211907]
- National Natural Science Foundation of China [31770827, 21736002, 31961133015]
- Beijing Institute of Technology Young Backbone Teacher Start-up Fund [3160012221905]
- Beijing Institute of Technology Research Fund Program for Young Scholars
Post-translational modifications like ubiquitination play crucial roles in regulating biological processes in eukaryotes, with DUBs being key enzymes that control ubiquitin-related pathways. Dysregulation of DUBs can lead to various diseases. Phosphorylation is the most extensively studied post-translational modification of DUBs, influencing their function and activity.
Post-translational modifications such as ubiquitination play important regulatory roles in several biological processes in eukaryotes. This process could be reversed by deubiquitinating enzymes (DUBs), which remove conjugated ubiquitin molecules from target substrates. Owing to their role as essential enzymes in regulating all ubiquitin-related processes, the abundance, localization, and catalytic activity of DUBs are tightly regulated. Dysregulation of DUBs can cause dramatic physiological consequences and a variety of disorders such as cancer, and neurodegenerative and inflammatory diseases. Multiple factors, such as transcription and translation of associated genes, and the presence of accessory domains, binding proteins, and inhibitors have been implicated in several aspects of DUB regulation. Beyond this level of regulation, emerging studies show that the function of DUBs can be regulated by a variety of post-translational modifications, which significantly affect the abundance, localization, and catalytic activity of DUBs. The most extensively studied post-translational modification of DUBs is phosphorylation. Besides phosphorylation, ubiquitination, SUMOylation, acetylation, oxidation, and hydroxylation are also reported in DUBs. In this review, we summarize the current knowledge on the regulatory effects of post-translational modifications of DUBs.
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