标题
Roles and Mechanisms of the Protein Quality Control System in Alzheimer’s Disease
作者
关键词
-
出版物
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 23, Issue 1, Pages 345
出版商
MDPI AG
发表日期
2021-12-29
DOI
10.3390/ijms23010345
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Current druggable targets for therapeutic control of Alzheimer's disease
- (2021) Girdhari Lal Gupta et al. Contemporary Clinical Trials
- Iron Homeostasis Disorder and Alzheimer’s Disease
- (2021) Yu Peng et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Activating transcription factor 6 reduces Aβ1–42 and restores memory in Alzheimer’s disease model mice
- (2020) Yayun Du et al. INTERNATIONAL JOURNAL OF NEUROSCIENCE
- Molecular Mechanisms of ER Stress and UPR in the Pathogenesis of Alzheimer’s Disease
- (2020) Md. Sahab Uddin et al. MOLECULAR NEUROBIOLOGY
- Pathogenesis and promising therapeutics of Alzheimer disease through eIF2α pathway and correspondent kinases
- (2020) Reza Moradi Majd et al. METABOLIC BRAIN DISEASE
- Treatment Combinations for Alzheimer’s Disease: Current And Future Pharmacotherapy Options
- (2019) Jeffrey L. Cummings et al. JOURNAL OF ALZHEIMERS DISEASE
- Manual Acupuncture Regulates Behavior and Cerebral Blood Flow in the SAMP8 Mouse Model of Alzheimer’s Disease
- (2019) Ning Ding et al. Frontiers in Neuroscience
- Learning and memory deficits and Alzheimer's disease-like changes in mice after chronic exposure to microcystin-LR
- (2019) Jing Wang et al. JOURNAL OF HAZARDOUS MATERIALS
- Present Algorithms and Future Treatments for Alzheimer’s Disease
- (2019) George T. Grossberg et al. JOURNAL OF ALZHEIMERS DISEASE
- Emerging roles of long non-coding RNAs in the pathogenesis of Alzheimer’s disease
- (2019) Francesca Cortini et al. AGEING RESEARCH REVIEWS
- Exploring the relationship between physical activity, beta-amyloid and tau: A narrative review
- (2019) Belinda M. Brown et al. AGEING RESEARCH REVIEWS
- An update on the interactions between Alzheimer's disease, autophagy and inflammation
- (2019) Mehmet Bostancıklıoğlu GENE
- Molecular chaperones biochemistry and role in neurodegenerative diseases
- (2019) Ali Chaari INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
- Endo-lysosomal pathway and ubiquitin-proteasome system dysfunction in Alzheimer's disease pathogenesis
- (2019) Jiqing Cao et al. NEUROSCIENCE LETTERS
- Atf6α impacts cell number by influencing survival, death and proliferation
- (2019) Rohit B. Sharma et al. Molecular Metabolism
- The cholinergic system in the pathophysiology and treatment of Alzheimer’s disease
- (2018) Harald Hampel et al. BRAIN
- Development of Piperazinediones as dual inhibitor for treatment of Alzheimer's disease
- (2018) Devendra Kumar et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Sulforaphane Upregulates the Heat Shock Protein Co-Chaperone CHIP and Clears Amyloid-β and Tau in a Mouse Model of Alzheimer's Disease
- (2018) Siyoung Lee et al. MOLECULAR NUTRITION & FOOD RESEARCH
- Hyperphosphorylated Truncated Protein Tau Induces Caspase-3 Independent Apoptosis-Like Pathway in the Alzheimer's Disease Cellular Model
- (2018) Monika Zilkova et al. JOURNAL OF ALZHEIMERS DISEASE
- Autophagy in Aging and Alzheimer's Disease: Pathologic or Protective?
- (2018) Aaron Barnett et al. JOURNAL OF ALZHEIMERS DISEASE
- Regulation of proteasome assembly and activity in health and disease
- (2018) Adrien Rousseau et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Overexpression of Ubiquilin-1 Alleviates Alzheimer’s Disease-Caused Cognitive and Motor Deficits and Reduces Amyloid-β Accumulation in Mice
- (2017) Oludotun O. Adegoke et al. JOURNAL OF ALZHEIMERS DISEASE
- Targeting psychologic stress signaling pathways in Alzheimer’s disease
- (2017) Hunter S. Futch et al. Molecular Neurodegeneration
- Amyloid-β42 clearance and neuroprotection mediated by X-box binding protein 1 signaling decline with aging in the Drosophila brain
- (2017) María S. Marcora et al. NEUROBIOLOGY OF AGING
- Modulation of hippocampal synapse maturation by activity-regulated E3 ligase via non-canonical pathway
- (2017) Pushpa Kumari et al. NEUROSCIENCE
- Cadmium disrupts autophagic flux by inhibiting cytosolic Ca 2+ -dependent autophagosome-lysosome fusion in primary rat proximal tubular cells
- (2017) Fei Liu et al. TOXICOLOGY
- Control of mitochondrial biogenesis and function by the ubiquitin–proteasome system
- (2017) Piotr Bragoszewski et al. Open Biology
- Impaired retrograde transport of axonal autophagosomes contributes to autophagic stress in Alzheimer’s disease neurons
- (2017) Prasad Tammineni et al. eLife
- Modifications and Trafficking of APP in the Pathogenesis of Alzheimer’s Disease
- (2017) Xin Wang et al. Frontiers in Molecular Neuroscience
- Interplay of endoplasmic reticulum stress and autophagy in neurodegenerative disorders
- (2016) Yu Cai et al. Autophagy
- On the linkage between the ubiquitin-proteasome system and the mitochondria
- (2016) Gilad Lehmann et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- The unfolded protein response: mechanisms and therapy of neurodegeneration
- (2016) Heather L. Smith et al. BRAIN
- Inhibition of endoplasmic reticulum stress-activated IRE1α-TRAF2-caspase-12 apoptotic pathway is involved in the neuroprotective effects of telmisartan in the rotenone rat model of Parkinson's disease
- (2016) Qiang Tong et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Cathepsin D as a therapeutic target in Alzheimer’s disease
- (2016) Fabio Di Domenico et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- The ubiquitin proteasomal system: a potential target for the management of Alzheimer's disease
- (2016) Kundlik Gadhave et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Cathepsin B Improves ß-Amyloidosis and Learning and Memory in Models of Alzheimer’s Disease
- (2016) Christine M Embury et al. Journal of Neuroimmune Pharmacology
- 3D culture models of Alzheimer’s disease: a road map to a “cure-in-a-dish”
- (2016) Se Hoon Choi et al. Molecular Neurodegeneration
- The Ubiquitin-Proteasome System: Potential Therapeutic Targets for Alzheimer’s Disease and Spinal Cord Injury
- (2016) Bing Gong et al. Frontiers in Molecular Neuroscience
- PERK inhibition prevents tau-mediated neurodegeneration in a mouse model of frontotemporal dementia
- (2015) Helois Radford et al. ACTA NEUROPATHOLOGICA
- Treatment for Alzheimer’s disease: has anything changed?
- (2015) Louise Waite Australian Prescriber
- Comparison between different D-Dimer cutoff values to assess the individual risk of recurrent venous thromboembolism: analysis of results obtained in the DULCIS study
- (2015) G. Palareti et al. International Journal of Laboratory Hematology
- Degradation of gamma secretase activating protein by the ubiquitin-proteasome pathway
- (2015) Jin Chu et al. JOURNAL OF NEUROCHEMISTRY
- Regulation of human MAPT gene expression
- (2015) Marie-Laure Caillet-Boudin et al. Molecular Neurodegeneration
- Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling
- (2015) Natura Myeku et al. NATURE MEDICINE
- Proteostasis and aging
- (2015) Susmita Kaushik et al. NATURE MEDICINE
- Partial restoration of protein synthesis rates by the small molecule ISRIB prevents neurodegeneration without pancreatic toxicity
- (2015) M Halliday et al. Cell Death & Disease
- Acute ER stress regulates amyloid precursor protein processing through ubiquitin-dependent degradation
- (2015) Eun Sun Jung et al. Scientific Reports
- The small molecule ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assembly
- (2015) Carmela Sidrauski et al. eLife
- The involvement of BDNF, NGF and GDNF in aging and Alzheimer's disease
- (2015) Josiane Budni et al. Aging and Disease
- Alzheimer disease: Epidemiology, diagnostic criteria, risk factors and biomarkers
- (2014) Christiane Reitz et al. BIOCHEMICAL PHARMACOLOGY
- The role of endoplasmic reticulum in amyloid precursor protein processing and trafficking: Implications for Alzheimer's disease
- (2014) A.I. Plácido et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- The unfolded protein response as a target for cancer therapy
- (2014) Anika Nagelkerke et al. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
- PERK mediates eIF2α phosphorylation responsible for BACE1 elevation, CREB dysfunction and neurodegeneration in a mouse model of Alzheimer's disease
- (2014) Latha Devi et al. NEUROBIOLOGY OF AGING
- A major role for Tau in neuronal DNA and RNA protection in vivo under physiological and hyperthermic conditions
- (2014) Marie Violet et al. Frontiers in Cellular Neuroscience
- Cab45S inhibits the ER stress-induced IRE1-JNK pathway and apoptosis via GRP78/BiP
- (2014) L Chen et al. Cell Death & Disease
- Meta-analysis of Ubiquilin1 gene polymorphism and Alzheimer’s disease risk
- (2014) Yingying Jia MEDICAL SCIENCE MONITOR
- Mass Spectrometry Assessment of Ubiquitin Carboxyl-Terminal Hydrolase L1 Partitioning between Soluble and Particulate Brain Homogenate Fractions
- (2013) Junjun Chen et al. ANALYTICAL CHEMISTRY
- A mathematical model of the unfolded protein stress response reveals the decision mechanism for recovery, adaptation and apoptosis
- (2013) Kamil Erguler et al. BMC Systems Biology
- Molecular Mechanism Aspect of ER Stress in Alzheimer's Disease: Current Approaches and Future Strategies
- (2013) Niloufar Ansari et al. CURRENT DRUG TARGETS
- Cellular and molecular mechanisms underlying axon formation, growth, and branching
- (2013) Tommy L. Lewis et al. JOURNAL OF CELL BIOLOGY
- Autophagy Modulation for Alzheimer’s Disease Therapy
- (2013) Xi-Chen Zhu et al. MOLECULAR NEUROBIOLOGY
- The Ubiquitin–Proteasome System in Retinal Health and Disease
- (2013) Laura Campello et al. MOLECULAR NEUROBIOLOGY
- Suppression of eIF2α kinases alleviates Alzheimer's disease–related plasticity and memory deficits
- (2013) Tao Ma et al. NATURE NEUROSCIENCE
- Relationship between amyloid-beta and the ubiquitin–proteasome system in Alzheimer’s disease
- (2013) Liang Hong et al. NEUROLOGICAL RESEARCH
- Autophagy in Human Health and Disease
- (2013) Augustine M.K. Choi et al. NEW ENGLAND JOURNAL OF MEDICINE
- The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression
- (2013) Wafa B’chir et al. NUCLEIC ACIDS RESEARCH
- Regulation of Autophagy Via PERK-eIF2α Effectively Relieve the Radiation Myelitis Induced by Iodine-125
- (2013) Zuozhang Yang et al. PLoS One
- Ubiquilin-1 and protein quality control in Alzheimer disease
- (2013) Amina El Ayadi et al. Prion
- Tau degradation: The ubiquitin–proteasome system versus the autophagy-lysosome system
- (2013) Min Jae Lee et al. PROGRESS IN NEUROBIOLOGY
- Oral Treatment Targeting the Unfolded Protein Response Prevents Neurodegeneration and Clinical Disease in Prion-Infected Mice
- (2013) J. A. Moreno et al. Science Translational Medicine
- The unfolded protein response in Alzheimer’s disease
- (2013) Víctor Hugo Cornejo et al. Seminars in Immunopathology
- Autophagic/lysosomal dysfunction in Alzheimer’s disease
- (2013) Miranda E Orr et al. Alzheimers Research & Therapy
- Biochemistry and Cell Biology of Tau Protein in Neurofibrillary Degeneration
- (2013) E.-M. Mandelkow et al. Cold Spring Harbor Perspectives in Medicine
- The Synaptic Accumulation of Hyperphosphorylated Tau Oligomers in Alzheimer Disease Is Associated With Dysfunction of the Ubiquitin-Proteasome System
- (2012) Hwan-Ching Tai et al. AMERICAN JOURNAL OF PATHOLOGY
- Endoplasmic Reticulum Stress and Type 2 Diabetes
- (2012) Sung Hoon Back et al. Annual Review of Biochemistry
- Ubiquitin and Proteasomes in Transcription
- (2012) Fuqiang Geng et al. Annual Review of Biochemistry
- Transmissible Proteins: Expanding the Prion Heresy
- (2012) Claudio Soto CELL
- Neuronal autophagy and neurodegenerative diseases
- (2012) Jin H. Son et al. EXPERIMENTAL AND MOLECULAR MEDICINE
- Emerging regulatory mechanisms in ubiquitin-dependent cell cycle control
- (2012) A. Mocciaro et al. JOURNAL OF CELL SCIENCE
- The role of ubiquitylation in receptor endocytosis and endosomal sorting
- (2012) K. Haglund et al. JOURNAL OF CELL SCIENCE
- Endoplasmic reticulum dysfunction in neurological disease
- (2012) Benoit D Roussel et al. LANCET NEUROLOGY
- Calpain 2 Activated through N-Methyl-D-Aspartic Acid Receptor Signaling Cleaves CPEB3 and Abrogates CPEB3-Repressed Translation in Neurons
- (2012) C.-F. Wang et al. MOLECULAR AND CELLULAR BIOLOGY
- Sustained translational repression by eIF2α-P mediates prion neurodegeneration
- (2012) Julie A. Moreno et al. NATURE
- The unfolded protein response: controlling cell fate decisions under ER stress and beyond
- (2012) Claudio Hetz NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Preventing Alzheimer's Disease
- (2012) D. J. Selkoe SCIENCE
- Selective destruction of abnormal proteins by ubiquitin-mediated protein quality control degradation
- (2012) Eric K. Fredrickson et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Membrane Trafficking Pathways in Alzheimer's Disease
- (2012) Lawrence Rajendran et al. TRAFFIC
- Cyclic AMP response element-binding protein (CREB) phosphorylation: A mechanistic marker in the development of memory enhancing Alzheimer's disease therapeutics
- (2011) R. Scott Bitner BIOCHEMICAL PHARMACOLOGY
- Calcium channel blocking as a therapeutic strategy for Alzheimer's disease: The case for isradipine
- (2011) Thimmappa S. Anekonda et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- The role of the ubiquitin proteasome system in Alzheimer's disease
- (2011) Beat M Riederer et al. EXPERIMENTAL BIOLOGY AND MEDICINE
- Autophagy deregulation in neurodegenerative diseases - recent advances and future perspectives
- (2011) Zelda H. Cheung et al. JOURNAL OF NEUROCHEMISTRY
- In Vivo Microdialysis Reveals Age-Dependent Decrease of Brain Interstitial Fluid Tau Levels in P301S Human Tau Transgenic Mice
- (2011) K. Yamada et al. JOURNAL OF NEUROSCIENCE
- Alzheimer's disease
- (2011) Clive Ballard et al. LANCET
- Resolving controversies on the path to Alzheimer's therapeutics
- (2011) Dennis J Selkoe NATURE MEDICINE
- Autophagy failure in Alzheimer's disease—locating the primary defect
- (2011) Ralph A. Nixon et al. NEUROBIOLOGY OF DISEASE
- The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation
- (2011) P. Walter et al. SCIENCE
- Alzheimer's Disease: The Challenge of the Second Century
- (2011) D. M. Holtzman et al. Science Translational Medicine
- Amyloid-β Peptide Is a Substrate of the Human 20S Proteasome
- (2010) Xiaobei Zhao et al. ACS Chemical Neuroscience
- Too much of a good thing is bad: proteasome inhibition induces stressed hearts to fail
- (2010) L. Carrier CARDIOVASCULAR RESEARCH
- Ubiquitin Enzymes, Ubiquitin and Proteasome Activity in Blood Mononuclear Cells of MCI, Alzheimer and Parkinson Patients
- (2010) C. Ullrich et al. Current Alzheimer Research
- A Caspase Cleaved Form of Tau Is Preferentially Degraded through the Autophagy Pathway
- (2010) Philip J. Dolan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Protein homeostasis and aging in neurodegeneration
- (2010) Peter M. Douglas et al. JOURNAL OF CELL BIOLOGY
- Ubiquitin carboxy-terminal hydrolase L1 (UCHL1) S18Y polymorphism in Alzheimer's disease
- (2010) Madeleine Zetterberg et al. Molecular Neurodegeneration
- Autophagy Dysfunction in Alzheimer’s Disease
- (2010) Liang Li et al. Neurodegenerative Diseases
- ADDLs and the signaling web that leads to Alzheimer’s disease
- (2010) Grant A. Krafft et al. NEUROPHARMACOLOGY
- Activation of PERK Signaling Attenuates Aβ-Mediated ER Stress
- (2010) Do Yeon Lee et al. PLoS One
- Ubiquitin carboxyl-terminal hydrolase L1 is required for maintaining the structure and function of the neuromuscular junction
- (2010) F. Chen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Autophagy in neurodegenerative disorders: pathogenic roles and therapeutic implications
- (2010) Rebecca Banerjee et al. TRENDS IN NEUROSCIENCES
- Lysosomal Dysfunction Promotes Cleavage and Neurotoxicity of Tau In Vivo
- (2010) Vikram Khurana et al. PLoS Genetics
- Alzheimer’s Disease Amyloid β-Protein and Synaptic Function
- (2009) Tomas Ondrejcak et al. NEUROMOLECULAR MEDICINE
- Autophagic-lysosomal perturbation enhances tau aggregation in transfectants with induced wild-type tau expression
- (2008) Tadanori Hamano et al. EUROPEAN JOURNAL OF NEUROSCIENCE
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started