Article
Biology
Alessandra Caruso, Alessandra Gaetano, Sergio Scaccianoce
Summary: CRH plays a role in regulating multiple biological systems, and is also associated with reproduction, neuropsychiatric, gastrointestinal, immune disorders, and tumor development. Further research on the physiological functions of CRH will help determine its role in human diseases and may serve as novel therapeutic targets.
Article
Cardiac & Cardiovascular Systems
Zhao-Fu Sheng, Hua Zhang, Jeffery G. Phaup, PeiRu Zheng, XunLei Kang, Zhenguo Liu, Hui-Ming Chang, Edward T. H. Yeh, Alan Kim Johnson, Hui-Lin Pan, De-Pei Li
Summary: Chronic stress is a known risk factor for the development of hypertension. In this study, it was found that the corticotropin-releasing hormone (CRH) neurons in the central nucleus of the amygdala (CeA) are involved in the autonomic responses to chronic stress. Suppressing CeA-CRH neurons can alleviate chronic stress-induced hypertension and decrease elevated sympathetic outflow. Additionally, chronic stress leads to decreased levels of Kv7.2 and Kv7.3 channels in the CeA, which contribute to the hyperactivity of CeA-CRH neurons.
CARDIOVASCULAR RESEARCH
(2023)
Article
Environmental Sciences
Xue Liu, Jiaqian Feng, Zhijing Jiang, Guangbo Zhang, Xiuwen Xu, Jixiu Wang, Jingwen Yang, Tianming Wang
Summary: In the neuroendocrine system, corticotropin-releasing hormone (CRH) activates CRHRs and plays a vital role in the HPA/HPI axis. Two CRHR1 subtypes, LcCRHR1-1 and LcCRHR1-2, were identified in Larimichthys crocea genome and were found to be highly homologous to known teleost CRHRs. These receptors were found to be localized in the cell membrane and respond to LcCRH by increasing cAMP, Ca2+ and mitogen-activated protein kinase phosphorylation. LcCRHR1s were expressed in various tissues, with high expression in the brain and ovaries, and shown to be specifically localized in ovarian follicle cells. This study suggests that the CRH/CRHR1 system may be involved in the neuroendocrine regulation of reproduction in L. crocea.
FRONTIERS IN MARINE SCIENCE
(2023)
Article
Clinical Neurology
Alexandros N. Vgontzas, Julio Fernandez-Mendoza, Kristina Puzino Lenker, Maria Basta, Edward O. Bixler, George P. Chrousos
Summary: Insomnia, especially when associated with objective sleep disturbance, was found to be related to activation of the hypothalamic-pituitary-adrenal axis. Men with insomnia demonstrated shorter total sleep time and lower sleep efficiency on polysomnography, as well as lower levels of adrenocorticotropic hormone and cortisol after exposure to stress, suggesting a disrupted hypothalamic-pituitary-adrenal axis function in this population.
JOURNAL OF SLEEP RESEARCH
(2022)
Article
Endocrinology & Metabolism
Erin Faught, Mathilakath M. Vijayan
Summary: The study demonstrates that the CRH/CRHR1 system mediates stress-induced hyperactivity, while the temporal activation of cortisol production and associated GR/MR signaling are crucial for prolonging stressor-induced hyperactivity.
NEUROENDOCRINOLOGY
(2022)
Editorial Material
Multidisciplinary Sciences
Ian H. Guldner, Tony Wyss-Coray
Summary: An analysis of mice with tau protein, a key feature of Alzheimer's disease, demonstrates that immune cells work together to cause tau-mediated neurodegeneration, and that existing clinic drugs can combat this decline.
Review
Immunology
Sonal Dubey, Ekta Singh
Summary: Alzheimer's disease (AD) is a major cause of dementia, affecting millions of people worldwide. Oxidative stress is a crucial factor in the induction and progression of AD. Understanding and managing oxidative stress has proven effective in AD treatment, with various natural and synthetic molecules showing promise. Clinical studies also support the use of antioxidants in preventing neurodegeneration in AD. This review summarizes the development of antioxidants for restricting oxidative stress-induced neurodegeneration in AD.
INFLAMMOPHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Dorit Trudler, Swagata Ghatak, Stuart A. Lipton
Summary: Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and Huntington's disease, represent a significant social and economic burden due to increasing prevalence and lack of effective therapies. Lack of reliable models has hindered the development of treatments, but human-induced pluripotent stem cell technology offers a promising alternative to complement animal models for disease modeling and drug discovery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Kazunori Kageyama, Yasumasa Iwasaki, Makoto Daimon
Summary: This review focuses on the molecular mechanisms of CRF regulation in the hypothalamus during stress and stress resilience, highlighting the central role of CRF in regulating the stress response. The involvement of ACTH, glucocorticoids, various regulatory factors, and different CRF receptors in stress resilience are discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Marika Lanza, Rossella Basilotta, Salvatore Cuzzocrea, Maria Bulzomi, Salvatore Oddo, Giovanna Casili, Emanuela Esposito
Summary: The prevalence of obesity worldwide is rapidly increasing and is considered a leading cause of death. Added sugar consumption is one of the main factors contributing to this, as it is associated with a higher risk of obesity, heart disease, diabetes, and brain illnesses such as Alzheimer's disease (AD). Excess sugar can worsen oxidative damage and brain inflammation, which are neuropathological signs of AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Leonid G. Khaspekov
Summary: This review summarizes the role of stress in the pathogenesis of neurodegenerative diseases, focusing on mechanisms such as hyperphosphorylation of tau protein, aggregation of beta-amyloid, and hyperactivation of the hypothalamic-pituitary-adrenal axis. In addition, microglia are involved in the effects of stress on the pathogenesis of neurodegenerative diseases.
BIOCHEMISTRY-MOSCOW
(2021)
Article
Clinical Neurology
Hannah M. Edwards, Clare E. Wallace, Woodrow D. Gardiner, Brookelyn M. Doherty, Ryan T. Harrigan, Kayla M. Yuede, Carla M. Yuede, John R. Cirrito
Summary: The risk of developing Alzheimer's disease is influenced by genetics and environmental factors, such as stress, sleep abnormalities, and traumatic brain injury. Women have a higher risk of Alzheimer's disease compared to men, even after accounting for lifespan differences. Women are more likely to experience high levels of stress. Sex differences in stress response may contribute to the increased risk of Alzheimer's disease in women. In this study, we used microdialysis to measure A beta levels in male and female mice in response to acute stress. We found that A beta levels were altered differently in females compared to males, with females showing significantly increased levels of A beta. This response is mediated through differences in the Corticotrophin Releasing Factor receptor signaling pathway involving beta-arrestin in male and female mice, as male mice lacking beta-arrestin also showed an increase in A beta levels in response to stress, similar to females.
Article
Multidisciplinary Sciences
Shruti Shandilya, Sandeep Kumar, Niraj Kumar Jha, Kavindra Kumar Kesari, Janne Ruokolainen
Summary: Recent studies have shown the significant impact of gut microbiota on brain functions, particularly in oxidative stress and neuroprotection. Gut bacteria metabolites play a crucial role in the pathogenesis of neurodegenerative diseases.
JOURNAL OF ADVANCED RESEARCH
(2022)
Article
Environmental Sciences
Emily S. Barrett, Matthew Corsetti, Drew Day, Sally W. Thurston, Christine T. Loftus, Catherine J. Karr, Kurunthachalam Kannan, Kaja Z. LeWinn, Alicia K. Smith, Roger Smith, Frances A. Tylavsky, Nicole R. Bush, Sheela Sathyanarayana
Summary: Phthalates may disrupt the endocrine pathways in pregnant women, impacting pregnancy outcomes and fetal development. This study found associations between phthalate mixtures and changes in plasma pCRH levels, with differing effects observed among women with gestational diabetes and gestational hypertension.
ENVIRONMENT INTERNATIONAL
(2022)
Review
Geriatrics & Gerontology
Haleh Barmaki, Alireza Nourazarian, Fatemeh Khaki-Khatibi
Summary: This review examines the impact of impaired autophagy on the progression of Alzheimer's disease pathology. Autophagy plays a crucial role in removing abnormal proteins and damaged organelles, but it weakens with aging and disease progression, leading to the accumulation of toxic proteins and neurodegeneration. There are therapeutic strategies to revitalize autophagy, but they face challenges in clinical practice.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Kevin H. Strang, Cara L. Croft, Zachary A. Sorrentino, Paramita Chakrabarty, Todd E. Golde, Benoit I. Giasson
JOURNAL OF BIOLOGICAL CHEMISTRY
(2018)
Article
Neurosciences
Andrew J. Shepherd, Bryan A. Copits, Aaron D. Mickle, Pall Karlsson, Suraj Kadunganattil, Simon Haroutounian, Satya M. Tadinada, Annette D. de Kloet, Manouela V. Valtcheva, Lisa A. McIlvried, Tayler D. Sheahan, Sanjay Jain, Pradipta R. Ray, Yuriy M. Usachev, Gregory Dussor, Eric G. Krause, Theodore J. Price, Robert W. Gereau, Durga P. Mohapatra
JOURNAL OF NEUROSCIENCE
(2018)
Article
Neurosciences
Lei A. Wang, Annette D. de Kloet, Michael D. Smeltzer, Karlena M. Cahill, Helmut Hiller, Erin B. Bruce, David J. Pioquinto, Jacob A. Ludin, Michael J. Katovich, Mohan K. Raizada, Eric G. Krause
Article
Multidisciplinary Sciences
Cara L. Craft, Brenda D. Moore, Yong Ran, Paramita Chakrabarty, Yona Levites, Todd E. Golde, Benoit I. Giasson
Editorial Material
Neurosciences
Hunter S. Futch, Cara L. Croft
JOURNAL OF NEUROSCIENCE
(2018)
Article
Geriatrics & Gerontology
Joseph A. McQuail, Eric G. Krause, Barry Setlow, Deborah A. Scheuer, Jennifer L. Bizon
NEUROBIOLOGY OF AGING
(2018)
Article
Multidisciplinary Sciences
Andrew J. Shepherd, Aaron D. Mickle, Judith P. Golden, Madison R. Mack, Carmen M. Halabi, Annette D. de Kloet, Vijay K. Samineni, Brian S. Kim, Eric G. Krause, Robert W. Gereau, Durga P. Mohapatra
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Immunology
Cara L. Croft, Pedro E. Cruz, Daniel H. Ryu, Carolina Ceballos-Diaz, Kevin H. Strang, Brittany M. Woody, Wen-Lang Lin, Michael Deture, Edgardo Rodriguez-Lebron, Dennis W. Dickson, Paramita Chakrabarty, Yona Levites, Benoit I. Giasson, Todd E. Golde
JOURNAL OF EXPERIMENTAL MEDICINE
(2019)
Article
Neurosciences
Yalun Tan, Sarthak M. Singhal, Scott W. Harden, Karlena M. Cahill, Dan-Tam M. Nguyen, Luis M. Colon-Perez, Todd J. Sahagian, Jeffrey S. Thinschmidt, Annette D. de Kloet, Marcelo Febo, Charles J. Frazier, Eric G. Krause
JOURNAL OF NEUROSCIENCE
(2019)
Article
Immunology
Hunter S. Futch, Karen N. McFarland, Brenda D. Moore, M. Zino Kuhn, Benoit I. Giasson, Thomas B. Ladd, Karen A. Scott, Melanie R. Shapiro, Rachel L. Nosacka, Marshall S. Goodwin, Yong Ran, Pedro E. Cruz, Daniel H. Ryu, Cara L. Croft, Yona Levites, Christopher Janus, Paramita Chakrabarty, Andrew R. Judge, Todd M. Brusko, Annette D. de Kloet, Eric G. Krause, Todd E. Golde
JOURNAL OF EXPERIMENTAL MEDICINE
(2019)
Article
Endocrinology & Metabolism
Dipanwita Pati, Scott W. Harden, Wanhui Sheng, Kyle B. Kelly, Annette D. de Kloet, Eric G. Krause, Charles J. Frazier
JOURNAL OF NEUROENDOCRINOLOGY
(2020)
Review
Neurosciences
C. L. Croft, H. S. Futch, B. D. Moore, T. E. Golde
MOLECULAR NEURODEGENERATION
(2019)
Article
Clinical Neurology
Cara L. Croft, Marshall S. Goodwin, Daniel H. Ryu, Christian B. Lessard, Giancarlo Tejeda, Marc Marrero, Ava R. Vause, Giavanna Paterno, Pedro E. Cruz, Jada Lewis, Benoit I. Giasson, Todd E. Golde
Summary: In tauopathy BSC models, tau inclusions typically form within 12-96 hours and show appreciable turnover with an average half-life of about 1 week when newly formed. As BSCs with inclusions age in culture, turnover of tau inclusions continues but the half-lives increase, indicating that individual tau inclusions can be long-lived structures. The data suggest that tau inclusions are dynamic structures with turnover, rather than permanent 'tombstones'.
ACTA NEUROPATHOLOGICA
(2021)
Article
Biology
Yuxing Xia, Stefan Prokop, Brach M. Bell, Kimberly-Marie M. Gorion, Cara L. Croft, Lith Nasif, Guilian Xu, Cara J. Riffe, Alyssa N. Manaois, Kevin H. Strang, Stephan S. Quintin, Giavanna Paterno, Malu Gamez Tansey, David R. Borchelt, Todd E. Golde, Benoit Giasson
Summary: This study presents a transgenic mouse model with predictable progression of pathogenic tau protein, providing insights into tau pathology in neurodegenerative diseases.
COMMUNICATIONS BIOLOGY
(2022)
Article
Neurosciences
Cara L. Croft, Giavanna Paterno, Ava R. Vause, Lyla A. Rowe, Daniel H. Ryu, Marshall S. Goodwin, Corey A. Moran, Pedro E. Cruz, Benoit I. Giasson, Todd E. Golde
Summary: The study investigates the dynamics of alpha-synuclein accumulation and turnover in neurodegenerative diseases, finding that aggregation, overexpression, phosphorylation, and mutation do not affect alpha-syn dynamics, while exogenous alpha-syn fibril seeds significantly slow turnover.
NPJ PARKINSONS DISEASE
(2022)