Article
Chemistry, Medicinal
Elizaveta A. Dutysheva, Irina A. Utepova, Maria A. Trestsova, Alexander S. Anisimov, Valery N. Charushin, Oleg N. Chupakhin, Boris A. Margulis, Irina Guzhova, Vladimir F. Lazarev
Summary: Chemicals that induce the synthesis of heat shock proteins have been shown to improve neuronal survival and provide neuroprotective effects in the pathogenesis of Alzheimer's disease.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Anne-Cathrine S. Vogt, Gary T. Jennings, Mona O. Mohsen, Monique Vogel, Martin F. Bachmann
Summary: Alzheimer's disease is the most common form of dementia and is responsible for 60-70% of cases. The number of people with dementia is expected to triple by 2050 due to an aging population. Currently, there are only symptomatic treatments available, making it crucial to develop novel therapeutic strategies to prevent or delay the onset of Alzheimer's disease. This mini-review focuses on the understanding of Alzheimer's disease pathobiology and discusses current immunomodulating therapies targeting amyloid-beta protein.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Medicinal
Weimin Qiu, Hui Liu, Yijun Liu, Xin Lu, Lei Wang, Yanyu Hu, Feng Feng, Qi Li, Haopeng Sun
Summary: Alzheimer's disease (AD) is a difficult to treat progressive neurodegenerative disease characterized by the accumulation of amyloid beta (A beta) plaques in the brain. A beta interacts with various receptors on the plasma membrane and mediates signaling pathways that contribute to the development of AD. Despite ongoing research, there are currently no effective medications for AD. This review discusses the importance of A beta in the pathogenesis of AD, recent progress in targeting A beta-related receptors and compounds, and the challenges and opportunities in developing effective therapies for AD.
MEDICINAL RESEARCH REVIEWS
(2023)
Article
Immunology
Longfei Xu, Mingzhe Li, Aili Wei, Miaomiao Yang, Chao Li, Ran Liu, Yuejun Zheng, Yuxin Chen, Zixi Wang, Kun Wang, Tianhui Wang
Summary: Moderate exercise promotes the clearance of beta-amyloid and hyperphosphorylated Tau protein in AD mice by activating the PI3K/Akt signaling pathway, leading to improved cognitive ability and reduced pathological changes.
JOURNAL OF NEUROINFLAMMATION
(2022)
Review
Cell Biology
Felipe P. Perez, Joseph P. Bandeira, Cristina N. Perez Chumbiauca, Debomoy K. Lahiri, Jorge Morisaki, Maher Rizkalla
Summary: This article provides a multidimensional sequence of events describing the interaction between electromagnetic field stimulation and biological systems. It explores the effects of repeated electromagnetic stimulation on RNA and its subsequent impact on cell processes and disease prevention. The research is based on mathematical models, experiments, and studies, indicating the potential of low-frequency electromagnetic field stimulation in treating age-related diseases.
JOURNAL OF BIOMEDICAL SCIENCE
(2022)
Article
Biotechnology & Applied Microbiology
Akiko Amano, Nobuo Sanjo, Wataru Araki, Yasutaka Anraku, Makoto Nakakido, Etsuro Matsubara, Takami Tomiyama, Tetsuya Nagata, Kouhei Tsumoto, Kazunori Kataoka, Takanori Yokota
Summary: Researchers developed polymeric nanomicelles capable of passing through the blood-brain barrier to deliver specific antibodies to the brain. The administration of 6H4 antibody fragments in polymeric nanomicelles for 10 weeks significantly reduced the amounts of toxic A beta species in the brain and inhibited the formation of A beta plaques. Behavioral analysis also showed an improvement in spatial reference memory in mice with Alzheimer's disease.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Elena Tamagno, Michela Guglielmotto, Valeria Vasciaveo, Massimo Tabaton
Summary: The pathogenesis of Alzheimer's disease involves the accumulation of beta amyloid and vulnerability of the brain to oxidative stress, which are linked to each other. It is difficult to determine which comes first, Aβ or oxidative stress. Evidence suggests that oxidative stress occurs early in the development of Alzheimer's disease and plays a crucial role in the manifestation of clinical and pathological symptoms.
Article
Biochemistry & Molecular Biology
Willy Smeralda, Marc Since, Julien Cardin, Sophie Corvaisier, Sophie Lecomte, Christophe Cullin, Aurelie Malzert-Freon
Summary: The study focused on the molecular interactions between the amyloid beta peptide associated with Alzheimer's disease and biological membranes, developing simple liposomal formulations mimicking neuronal cell membranes. Characterization of interactions through a multiparametric procedure laid the methodological foundation for developing an original model describing interactions between A beta peptide and lipids.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Biochemistry & Molecular Biology
Lucia Gallego Villarejo, Lisa Bachmann, David Marks, Maite Brachthaeuser, Alexander Geidies, Thorsten Mueller
Summary: Intracellular amyloid beta (iAβ) plays a crucial role in neurodegeneration and serves as a pathological marker. Modulating iAβ through pharmacological treatment has shown beneficial effects on cognitive properties. Future research should focus on the impact of viral infections on iAβ generation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Erica Caballero, Elena Hernando-Perez, Victor Tapias, Maria Calvo-Rodriguez, Carlos Villalobos, Lucia Nunez
Summary: The Aβ oligomers in Alzheimer's disease promote calcium influx by amyloid channels and NMDA receptors, leading to excitotoxicity and neuron degeneration.
Review
Biochemistry & Molecular Biology
Yuanxin Zhao, Buhan Liu, Jian Wang, Long Xu, Sihang Yu, Jiaying Fu, Xiaoyu Yan, Jing Su
Summary: Neuroinflammation mediated by microglia is a common feature in neurodegenerative diseases. The accumulation of Aβ and tau proteins can disrupt the metabolism of microglia, leading to neuroinflammation.
Article
Clinical Neurology
Lei Liu, Hyunchang Kwak, Trebor L. Lawton, Shan-Xue Jin, Angela L. Meunier, Yifan Dang, Beth Ostaszewski, Alison C. Pietras, Andrew M. Stern, Dennis J. Selkoe
Summary: The study developed a new method for detecting and quantifying soluble oligomers of amyloid beta protein in human plasma. The method is highly sensitive, cost-effective, and suitable for high throughput analysis.
ALZHEIMERS & DEMENTIA
(2022)
Article
Nutrition & Dietetics
Won Seok Lee, Hae-June Lee, Ji Yeong Yang, Hye-Lim Shin, Sik-Won Choi, Jong-Ki Kim, Woo Duck Seo, Eun Ho Kim
Summary: Oat seedling extract (OSE) has been found to have antioxidant activity and a specific mechanism for combating Alzheimer's disease (AD), providing neuroprotective effects against neurodegeneration, synaptic dysfunction, and neuroinflammation.
Review
Biochemistry & Molecular Biology
Bibiana C. Mota, Magdalena Sastre
Summary: PGC1 alpha plays a crucial role in neurodegenerative disorders, especially in Alzheimer's disease. Overexpression of PGC1 alpha can reduce A beta generation, potentially serving as a novel therapeutic avenue for AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Scott Ayton, Ashley Bush
Summary: Alzheimer's disease is a major disease without preventative or disease modifying therapy, and current drugs targeting amyloid beta have been unsuccessful in slowing cognitive decline. Debate is ongoing about whether to continue anti-A beta therapy or pursue alternative targets. The need for disease modifying AD therapies has become one of the highest priorities in all of medicine due to the growing burden of the disease on patients, families, and healthcare budgets.
AGEING RESEARCH REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Rajanish Giri, Taniya Bhardwaj, Meenakshi Shegane, Bhuvaneshwari R. Gehi, Prateek Kumar, Kundlik Gadhave, Christopher J. Oldfield, Vladimir N. Uversky
Summary: The emergence of SARS-CoV-2, leading to COVID-19, has become a global public health emergency. Research shows that the SARS-CoV-2 proteome exhibits significant levels of structural order, with functionally important intrinsically disordered protein regions playing a crucial role in viral infectivity and pathogenicity.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Review
Chemistry, Medicinal
Kundlik Gadhave, Deepak Kumar, Vladimir N. Uversky, Rajanish Giri
Summary: The exact molecular mechanisms associated with Alzheimer's disease remain a mystery, making the utilization of signaling pathways as potential drug targets limited. It is necessary to find correlations and cross-talk between these pathways and establish different therapeutic targets for a better understanding of the biological events responsible for AD-related neurodegeneration. Consideration should be given to the central role of autophagy in AD and its interplay with other pathways as the finest therapeutic strategy.
MEDICINAL RESEARCH REVIEWS
(2021)
Article
Oncology
Elina Khatoon, Kishore Banik, Choudhary Harsha, Bethsebie Lalduhsaki Sailo, Krishan Kumar Thakur, Amrita Devi Khwairakpam, Rajesh Vikkurthi, Thengujam Babita Devi, Subash C. Gupta, Ajaikumar B. Kunnumakkara
Summary: Despite advances in cancer treatment, drug resistance remains a major challenge. Phytochemicals have emerged as potential chemosensitizing agents due to their multitargeted properties and low toxicity.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sahabuddin Ahmed, Samir Ranjan Panda, Mohit Kwatra, Bidya Dhar Sahu, V. G. M. Naidu
Summary: Activation of NLRP3 inflammasome plays a crucial role in neurodegenerative diseases, and understanding the bidirectional signaling involved in this process is key for treatment. This study investigated the role of LPS, H2O2, and PA in NLRP3 inflammasome-driven neurodegeneration and found that targeting damaged mitochondria and scavenging free radicals could potentially limit microglial activation and support neuronal survival in PD.
ACS CHEMICAL NEUROSCIENCE
(2022)
Review
Chemistry, Medicinal
Kishore Banik, Elina Khatoon, Choudhary Harsha, Varsha Rana, Dey Parama, Krishan Kumar Thakur, Anupam Bishayee, Ajaikumar B. Kunnumakkara
Summary: This article evaluates the therapeutic potential and mechanisms of action of WOG against different cancers. Studies have shown that WOG has immense therapeutic potential against various cancers by regulating cell signaling pathways, and its combination with chemotherapeutic drugs improves treatment efficacy. Further human trials are needed to validate these findings and establish the clinical efficacy of WOG for cancer prevention and treatment.
PHYTOTHERAPY RESEARCH
(2022)
Meeting Abstract
Oncology
A. B. Kunnumakkara, K. K. Thakur
ANNALS OF ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Bhuvaneshwari R. Gehi, Kundlik Gadhave, Vladimir N. Uversky, Rajanish Giri
Summary: This study investigated the presence of intrinsic disorder in proteins of the oxidative stress-induced JNK signaling cascade. It was found that most proteins in this pathway contain disordered regions, with scaffold proteins and transcription factors having the highest levels of intrinsic disorder. Additionally, the study characterized the molecular recognition features, posttranslational modification sites, and short linear motifs associated with the predicted disordered regions in these proteins.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Medicine, Research & Experimental
Devivasha Bordoloi, Choudhary Harsha, Ganesan Padmavathi, Kishore Banik, Bethsebie Lalduhsaki Sailo, Nand Kishor Roy, Sosmitha Girisa, Krishan Kumar Thakur, Amrita Devi Khwairakpam, Arunachalam Chinnathambi, Tahani Awad Alahmadi, Sulaiman Ali Alharbi, Mehdi Shakibaei, Ajaikumar B. Kunnumakkara
Summary: Lung cancer is a major cause of cancer-related deaths in men and one of the deadliest cancers in women. This study identifies the protein TIPE3 as a biomarker for lung cancer, showing significant upregulation in lung cancer tissues. Knockout of TIPE3 is found to reduce the proliferation, survival, and migration of lung cancer cells, and arrests the G2 phase of the cell cycle through inactivation of multiple signaling pathways. The study also reveals the positive regulation of TIPE3 in tobacco-induced lung cancer.
Article
Multidisciplinary Sciences
Parmandeep Kaur, Sandip Ghosh, Arghya Bhowmick, Kundlik Gadhave, Satabdi Datta, Abhrajyoti Ghosh, Neha Garg, Roop L. Mahajan, Biswarup Basu, Diptiman Choudhury
Summary: This study reports the development and application of Bacterioboat as a drug carrier suitable for oral administration. It demonstrates high drug loading, sustained release, and stability, leading to improved shrinkage of solid tumors, enhanced life expectancy, and reduced side effects.
Article
Plant Sciences
Eswara Rao Puppala, Sunepjungla L. Aochenlar, P. A. Shantanu, Sahabuddin Ahmed, Arun Kumar Jannu, Aishwarya Jala, Sai Sudha Yalamarthi, Roshan M. Borkar, Dinesh Mani Tripathi, V. G. M. Naidu
Summary: This study explored the anti-ulcerative properties of perillyl alcohol (POH) on stress aggravated ulcerative colitis. The results showed that POH reversed oxidative stress and inflammatory response by inhibiting TLR4/NF-kB pathway and IL-6/JAK2/STAT3 pathway, leading to a decrease in pro-inflammatory cytokines. It also improved the physiological and histological changes of ulcerative colitis, and increased the mobility time and neurotransmitters while decreasing cortisol in mice brains.
Article
Multidisciplinary Sciences
Gal Manella, Nityanand Bolshette, Marina Golik, Gad Asher
Summary: In our study of how circadian clocks integrate multiple signals, we found that there are diverse and complex modes of integration. The responses are often non-linear and cannot be predicted from the individual signal response. We also observed that some signals have dominance in resetting the clock phase and that the clock is sensitive to relative levels of the signal. These findings contribute to a better understanding of the functioning and resetting mechanisms of circadian clocks.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Immunology
Kiran K. Dayananda, Sahabuddin Ahmed, Daniel Wang, Baruh Polis, Rafiad Islam, Arie Kaffman
Summary: Early life adversity affects the hippocampus in various mammalian species. There are two models (cumulative model and dimensional model) to explain the relationship between early adversity and later development. This study found that exposure to limited bedding and unpredictable postnatal stress impairs microglia-mediated synaptic pruning in the hippocampus and affects their function negatively.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Environmental Sciences
Samir Ranjan Panda, Vishal Balu Chaudhari, Sahabuddin Ahmed, Mohit Kwatra, Aishwarya Jala, Srikanth Ponneganti, Sharad D. Pawar, Roshan M. Borkar, Pawan Sharma, V. G. M. Naidu
Summary: Exposure to PM2.5 can disrupt the gut microbiome and lead to neuroinflammation and neurodegeneration through the gut-brain axis. PAHs, organic compounds in PM2.5, may contribute to this process. Melatonin has been shown to regulate the microbiome and reduce inflammation in the gut and brain. In this study, melatonin treatment was found to inhibit microglial activation and colonic inflammation in cells exposed to PM2.5, and alleviate neuroinflammation and neurodegeneration in mice exposed to PM2.5.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2023)
Article
Parasitology
Sunidhi Sharma, Vanshita Goel, Pawandeep Kaur, Kundlik Gadhave, Neha Garg, Lachhman Das Singla, Diptiman Choudhury
Summary: Targeted delivery for anthelmintic treatment has not been achieved, resulting in the need for excessive drug dose and leading to side effects and therapeutic resistance. This study developed biocompatible albendazole-loaded solid lipid nanoparticles with sustained-release properties, which enhanced the bioavailability of the drug and showed potential as an effective anthelmintic drug delivery vehicle.
EXPERIMENTAL PARASITOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Nitin Sharma, Kundlik Gadhave, Prateek Kumar, Rajanish Giri
Summary: The transactivation domain of the Adenovirus Early region 1A (E1A) oncoprotein is a disordered protein that interacts with various human cell transcriptional co-activators. This study investigated the folding behavior of the E1A peptide and its interactions with the transcriptional adaptor zinc finger 2 (TAZ2). The results show that the folding of E1A is temperature and solution dependent, and it undergoes helical transitions in alcohol and osmolyte solutions. Additionally, the study observed that E1A can form amyloid-like aggregates that are toxic to mammalian cells.
CURRENT RESEARCH IN STRUCTURAL BIOLOGY
(2022)
