Article
Neurosciences
Yu-Hua Hu, Bao-Hua Jiao, Cheng-Ye Wang, Jian-Liang Wu
Summary: RIP2 is involved in TMZ resistance through the regulation of the NF-κB/MGMT signaling pathway. Interference with NF-κB or MGMT activity may be a novel strategy for treating RIP2-positive TMZ-resistant glioma.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Multidisciplinary Sciences
Jugal Kishore Das, Yijie Ren, Anil Kumar, Hao-Yun Peng, Liqing Wang, Xiaofang Xiong, Robert C. Alaniz, Paul de Figueiredo, Xingcong Ren, Xiaoqi Liu, Alexey G. Ryazonov, Jin-Ming Yang, Jianxun Song
Summary: eEF-2K plays a critical role in regulating the fate and function of CD8(+) T cells. Loss of eEF-2K leads to increased proliferation but decreased survival of CD8(+) T cells, along with premature senescence and exhaustion. eEF-2K deficiency also affects the metabolic activity of CD8(+) T cells and the effectiveness of CAR-T therapy against cancer.
Article
Oncology
Xin Liu, Shenglin Zhang, Yi Dong, Yunpeng Xie, Qingshan Li
Summary: Gliomas, the most common primary brain tumors in adults, present clinical challenges due to their infiltrative growth patterns and high relapse tendencies. This study identified SENP1 as an upregulated SUMOylation regulator in gliomas and demonstrated its association with poor prognoses. Mechanistically, SENP1 inhibited SIRT1 expression through de-SUMOylation, leading to the activation of NF-kappa B and promotion of glioma cell malignant phenotype. This suggests that SENP1-mediated de-SUMOylation of SIRT1 could have therapeutic implications for gliomas.
EXPERIMENTAL CELL RESEARCH
(2023)
Article
Medicine, Research & Experimental
Ting Zhao, Jianming Zeng, Yujie Xu, Zhongping Su, Yulong Chong, Tao Ling, Haozhe Xu, Hui Shi, Minggao Zhu, Qi Mo, Xiaoying Huang, Yingchang Li, Xiaoren Zhang, Hongbin Ni, Qiang You
Summary: This study reveals that CHI3L1 is overexpressed in glioma and plays a crucial role in tumor progression. It enhances the NF-kappa B signaling pathway and interacts with ACTN4 and NFKB1. Additionally, CHI3L1 reprograms the tumor microenvironment and contributes to M2 macrophage polarization. It is also positively correlated with the expression of immune checkpoints and remodels the TME to an immunosuppressive phenotype.
Article
Oncology
Yu-Zhou Chang, Rui-Chao Chai, Bo Pang, Xin Chang, Song Yuan An, Ke-Nan Zhang, Tao Jiang, Yong-Zhi Wang
Summary: The study confirmed the role of METTL3 in IDH-wildtype gliomas, promoting malignant progression by enhancing the stability of MALAT1.
Article
Pharmacology & Pharmacy
Wenbin Pei, Xiaojian Huang, Bowei Ni, Rui Zhang, Guangyi Niu, Hongbo You
Summary: In this study, it was found that Alantolactone (ALT) could alleviate IL-1 beta-induced inflammatory responses, protect cartilage from damage, and promote impaired autophagy through inhibiting the STAT3 and NF-kappa B signal pathways, suggesting a promising therapeutic effect for osteoarthritis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Minjun Yao, Caihua Zhang, Lingzhi Ni, Xiaoxiao Ji, Jianqiao Hong, Yazhou Chen, Jie Wang, Congsun Li, Jiyan Lin, Tingting Lu, Yihao Sheng, Menghao Sun, Mingmin Shi, Chenhe Zhou, Xunzi Cai
Summary: This study demonstrated for the first time the protective medicinal efficacy of cepharanthine (CEP) in osteoarthritis. CEP suppressed inflammation and increased protein expression in joint tissues while restoring cellular autophagy. The mouse model confirmed the therapeutic potential of CEP in osteoarthritis treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Savina Apolloni, Paola Fabbrizio, Susanna Amadio, Giulia Napoli, Mattia Freschi, Francesca Sironi, Paolo Pevarello, Paola Tarroni, Chiara Liberati, Caterina Bendotti, Cinzia Volonte
Summary: Amyotrophic lateral sclerosis (ALS) is a neuroinflammatory disease where the role of P2X7 receptor has been highlighted, and the novel P2X7 antagonist AXX71 shows potential therapeutic value in ALS by targeting microglia-related proinflammatory markers and autophagy during the early symptomatic phase of the disease. This suggests that P2X7 modulation could be further explored as a therapeutic strategy in preclinical studies and applied in ALS clinical trials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Qin He, Yiting Cai, Jiani Huang, Xiaoying He, Wei Han, Wei Chen
Summary: This study found that autophagic activity was decreased in human pterygium tissues, and activating autophagy can slow down the fibrotic process of pterygium, while blocking autophagy exacerbates this process.
JOURNAL OF MOLECULAR CELL BIOLOGY
(2023)
Article
Chemistry, Medicinal
Xue-Yi Wu, Tian Wang, Hui-Xin Hu, Kan Zhang, Yu Zhao, Bao-Bing Zhao, Hong-Xiang Lou, Xiao-Ning Wang, Tao Shen
Summary: Rhamnazin (RN) is a flavonol compound extracted from Physalis alkekengi L. var. franchetii, which has been used in traditional Chinese medicine for treating pulmonary diseases. This study reveals that RN activates the Nrf2 pathway and effectively alleviates oxidative stress and inflammation in pulmonary disorders. The therapeutic effects of RN are associated with inhibition of NF-κB and promotion of cell autophagy.
PHYTOTHERAPY RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Bingwu Liu, Xinfeng Yan, Zuojia Hou, Lei Zhang, Duwen Zhang
Summary: Bupivacaine inhibits colorectal cancer proliferation by suppressing cell viability, promoting apoptosis and autophagy, regulating the NF-kappa B signaling pathway, demonstrating potential therapeutic effects.
Article
Neurosciences
Xiao-Liang Wang, Bao-Hua Jiao, Jian-Liang Wu, Jian-Kai Yang, Yu-Hua Hu, Kai Cui
Summary: This study investigates the role of RIP2 in regulating the stemness of glioma cells and their resistance to chemotherapy. RIP2 was found to mediate resistance to temozolomide by activating the NF-kappa B pathway and upregulating the expression of CD133 and SOX-2, both of which are involved in stemness maintenance. Targeting the RIP2/NF-kappa B pathway may be a potential therapeutic strategy for temozolomide-resistant gliomas.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Nani Wang, Pingcui Xu, Renjie Wu, Xuping Wang, Yongjun Wang, Dan Shou, Yan Zhang
Summary: Timosaponin BII alleviates high glucose-induced oxidative stress and apoptosis in osteoblasts by activating autophagy through inhibiting the mTOR/NF kappa B signaling pathway.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Hongbo You, Rui Zhang, Lingying Wang, Qiyong Pan, Zekai Mao, Xiaojian Huang
Summary: Osteoarthritis (OA) is a major cause of cartilage pain and limited mobility in middle-aged and elderly individuals, with inflammation-induced cartilage degeneration playing a key role. Shikimic acid (SA) has been found to have significant anti-inflammatory effects and potential therapeutic effects for OA by suppressing IL-1 beta-induced pathways.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yunshan Zhang, Min Zhu, Jun Pan, Qunnan Qiu, Xinyu Tong, Xiaolong Hu, Chengliang Gong
Summary: It was found that BmCPV can produce vcircRNA_000048, which encodes a vsp21 to suppress viral replication. Vsp21 inhibits viral replication by inducing autophagy and activating the NF-κB signaling pathway. Vsp21 enhances the ubiquitination and degradation of phospho-IκB-α by interacting with UCH.
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2023)