Article
Biology
Julia Stokes, Arielle Freed, Rebecca Bornstein, Kevin N. Su, John Snell, Amanda Pan, Grace X. Sun, Kyung Yeon Park, Sangwook Jung, Hailey Worstman, Brittany M. Johnson, Philip G. Morgan, Margaret M. Sedensky, Simon C. Johnson
Summary: The study shows that volatile anesthetics have unexpected metabolic effects on neonatal mice by depleting b-hydroxybutarate in the blood, while this does not affect adults. The depletion is mediated by citrate accumulation, malonyl-CoA production by acetyl-CoA carboxylase, and inhibition of fatty acid oxidation, leading to reduced metabolic flexibility in adults compared to younger animals.
Review
Biochemistry & Molecular Biology
Ze Yun, Zhiying Zou, Shanfeng Sun, Huilian Che
Summary: This study found that chlorogenic acid improved food allergy by regulating the AMPK/ACC/CPT-1 signaling pathway in the spleen.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Microbiology
Pan Wang, Xin Wang, Ying Yin, Mingliang He, Wei Tan, Wenting Gao, Jianping Wen
Summary: The study found that inactivating the signal transduction protein GlnB can increase the production of ascomycin by enhancing the supply of precursors. Protein co-precipitation experiments and coupled enzyme activity assays revealed that the interaction between GlnB protein and the alpha subunit of acetyl-CoA carboxylase and propionyl-CoA carboxylase inhibited their activities.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Andrea L. Livieri, Facundo Colaccini, Martin A. Hernandez, Gabriela Gago, Hector M. Alvarez, Hugo Gramajo, Eduardo Rodriguez
Summary: In actinomycetes, acyl-CoA carboxylases (ACCs) are biotin-dependent enzymes with diverse structures and functions. Rhodococcus jostii RHA1 was found to have multiple putative ACC domains and subunits. Mutant strains with specific genes disrupted showed the importance of these genes in lipid biosynthesis and growth.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Zahra Hasanpour, Mousa Zarrin, Ahmad Oryan, Mostafa Mohaghegh-Dolatabad, Amir Ahmadpour
Summary: This study aims to validate the impact of feed restriction and the transition period on hepatic genes related to fat metabolism in fat-tailed sheep. The results show that feed restriction does not affect the mRNA abundance of the target genes during both pre- and post-partum periods. However, parturition suppresses the mRNA abundance of these genes. Fat-tailed sheep are well adapted to feed scarcity and have a higher capacity for fat mobilization during negative energy balance.
TROPICAL ANIMAL HEALTH AND PRODUCTION
(2022)
Article
Agriculture, Multidisciplinary
Buli Su, Peixuan Lai, Fan Yang, Anzhang Li, Ming-Rong Deng, Honghui Zhu
Summary: This study developed a novel method to increase the supply of acetyl-CoA in Saccharomyces cerevisiae and improve the production of downstream products. By optimizing metabolic pathways and conducting genetic engineering, the production of mevalonic acid was successfully increased, and further improvement was achieved by dynamically downregulating gene expression. The final strain produced a high yield of lycopene.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Cell Biology
Bolin Cai, Manting Ma, Jing Zhang, Shaofen Kong, Zhen Zhou, Zhenhui Li, Bahareldin Ali Abdalla, Haiping Xu, Xiquan Zhang, Raman Akinyanju Lawal, Qinghua Nie
Summary: This study discovers a long non-coding RNA called ZFP36L2-AS that plays a crucial role in regulating muscle metabolism. It promotes myoblast differentiation while inhibiting myoblast proliferation, and also contributes to intramuscular fat deposition and muscle atrophy.
CELL DEATH & DISEASE
(2022)
Article
Geriatrics & Gerontology
Amy Zheng, Seong Eun Kwak, Jesper B. Birk, Edward B. Arias, Dominic Thorley, Jorgen F. P. Wojtaszewski, Gregory D. Cartee
Summary: This study investigated the impact of caloric restriction (CR) on AMP-activated protein kinase (AMPK) and its substrates in skeletal muscle of older animals. The results revealed that CR significantly increased the phosphorylation of AMPK and several AMPK substrates, suggesting a potential role of AMPK in the antiaging effects of CR.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Review
Biotechnology & Applied Microbiology
Abhisha Sawant Dessai, Poonam Kalhotra, Aaron T. Novickis, Subhamoy Dasgupta
Summary: Metabolic reprogramming is a characteristic of cancer development and metastasis, which involves the modulation of multiple metabolic pathways to support cancer cell growth. The activity of rate-limiting enzymes in these pathways is specifically regulated through transcriptional, translational, and post translational modifications to maintain enhanced activity.
CANCER GENE THERAPY
(2023)
Article
Pharmacology & Pharmacy
Gangadharan Leela Shyni, Kaithathara Francis Sajin, Sivasankaran Nair Mangalam, Kozhiparambil Gopalan Raghu
Summary: TM from Myristica fragrans has shown anti-obesity effects in 3T3-L1 adipocytes by reducing lipid accumulation, promoting lipolysis, and regulating genes and proteins involved in lipid metabolism. It also enhances glucose uptake and increases carnitine palmitoyltransferase levels, suggesting its potential as an anti-obesity therapeutic.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Oncology
Michal Marczyk, Vignesh Gunasekharan, David Casadevall, Tao Qing, Julia Foldi, Raghav Sehgal, Naing Lin Shan, Kim R. M. Blenman, Tess A. O'Meara, Sheila Umlauf, Yulia Surovtseva, Viswanathan Muthusamy, Jesse Rinehart, Rachel J. Perry, Richard Kibbey, Christos Hatzis, Lajos Pusztai
Summary: This study examines the expression patterns of isozymes in cancer and identifies potential therapeutic targets. It shows that the loss of isozyme diversity in cancer can be exploited for anticancer therapy.
Article
Chemistry, Medicinal
Tonghui Huang, Xin Wu, Shirong Yan, Tianya Liu, Xiaoxing Yin
Summary: A series of spiroketopyrazole derivatives were synthesized and evaluated for their anticancer activities as ACC inhibitors. Compound 7j showed the strongest enzyme inhibitory activity, while compound 7m exhibited potent anti-proliferative effects against various cancer cell lines, indicating its potential as a therapeutic agent for hepatocellular carcinoma.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Oncology
Agnes Basseville, Pierre-Christian Violet, Maryam Safari, Carole Sourbier, W. Marston Linehan, Robert W. Robey, Mark Levine, Dan L. Sackett, Susan E. Bates
Summary: This study identifies an association between the RAS-phenotype and sensitivity to histone deacetylase inhibitors in solid tumors. The researchers found that romidepsin treatment depletes acetyl-CoA, leading to metabolic and oxidative stress and ultimately causing death in KRAS-mutant cells. Analysis also revealed a correlation between acetyl-CoA generation pathways and HDACi sensitivity.
Review
Microbiology
John E. Cronan
Summary: This review provides an update on the research of Escherichia coli acetyl-CoA carboxylase (ACC), focusing on the structures, stoichiometry, regulation of ACC activity and expression.
MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS
(2021)
Review
Biochemistry & Molecular Biology
Yuyang Liu, Kivanc Birsoy
Summary: Mitochondria are organelles with their own genomes and unique biochemical reaction networks. They must maintain a specific biochemical environment and coordinate with the host cell's metabolic networks. This coordination involves sensing and controlling metabolites and responding to metabolic stresses. Dysfunction in the regulatory circuits of mitochondrial metabolic sensing and control can lead to metabolic disorders with clinical manifestations. This review discusses the logic and molecular basis of metabolic sensing and control in mitochondria, highlighting gaps in current knowledge that can potentially be addressed with emerging technologies.