☆ 4.6 Article

Association between genetic polymorphisms of Toll-like receptor 2 (TLR2) and schizophrenia in the Korean population

GENE (2013)

期刊

GENE

卷 526, 期 2, 页码 182-186

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ELSEVIER SCIENCE BV

DOI: 10.1016/j.gene.2013.04.058

关键词

Immunological dysregulation; Schizophrenia; TLR2 gene; Poor concentration

类别

Genetics & Heredity

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Immunological dysregulation has been suggested to be involved in the pathogenesis of schizophrenia. Accumulating evidences further implicate that activated inflammatory processes may be particularly relevant for the precipitation of negative and cognitive symptoms of schizophrenia. Toll-like receptor 2 (TLR2) plays an important role in innate immunity by sensing a variety of pathogens and inducing an acquired immunity. In the present study, we investigated whether the coding region of single nucleotide polymorphisms (SNPs) of the TLR2 gene was associated with schizophrenia as well as with clinical symptoms in schizophrenia patients. The study population consisted of 286 Korean schizophrenia patients and 305 Korean control subjects. The assessment of the Scale for the Assessment of Negative Symptoms was used to evaluate the negative symptoms of schizophrenia; the operational criteria checklist was used to measure general psychopathology. We selected two cSNPs [rs3804099 (Asn199Asn) and rs3804100 (Ser450Ser)] considering their heterozygosity and minor allele frequency. SNP genotyping was conducted using direct sequencing. We did not find any significant associations between SNPs and schizophrenia in the genotype and allelic frequencies. On the other hand, in the analysis of cognitive symptoms, rs3804099 showed significant differences in schizophrenia patients with poor concentration in the dominant model (TC/CC vs. TT, p = 0.0099). Also, rs3804100 showed a significant association with poor concentration in the co-dominant (TC vs. TT, p = 0.014) and the dominant models (TC/CC vs. IT, p = 0.0035). We obtained no significant support for the association of the TLR2 gene with susceptibility to schizophrenia in the Korean population. However, our results provide possibility that C allele of rs3804099 and rs3804100 may be associated with poor concentration in schizophrenia patients. Further studies with larger samples are required to confirm our results. (C) 2013 Elsevier B.V. All rights reserved.

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Whole transcriptome analysis reveals dysregulation of molecular networks in schizophrenia

Jinfeng Yang, Qing Long, Yunqiao Zhang, Yilin Liu, Jie Wu, Xinling Zhao, Xu You, Xiaoyan Li, Jiewei Liu, Zhaowei Teng, Yong Zeng, Xiong-Jian Luo

Summary: In this study, we investigated the regulatory relationships between different types of transcripts and altered molecular networks in schizophrenia (SCZ) by quantifying mRNAs, lncRNAs, miRNAs, and circRNAs simultaneously. We identified 807 dysregulated genes that showed differential expression in SCZ cases compared with controls. Network-based analysis revealed dysregulation of molecular networks in SCZ. Integration of the transcriptome data with published data allowed for the identification of promising SCZ candidate genes. Our findings suggest that dysregulated molecular networks and regulatory relationships between different types of transcripts may contribute to the development of SCZ.

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