Insulin action at a molecular level – 100 years of progress

High Brown Fat Activity Correlates With Cardiovascular Risk Factor Levels Cross-Sectionally and Subclinical Atherosclerosis at 5-Year Follow-Up

(2020) Juho Raiko et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Insulin and epidermal growth factor receptor family members share parallel activation mechanisms

(2020) Kathryn M. Ferguson et al.   PROTEIN SCIENCE

Roles of the PI3K/AKT/mTOR signalling pathways in neurodegenerative diseases and tumours

(2020) Fei Xu et al.   Cell and Bioscience

A Cell-Autonomous Signature of Dysregulated Protein Phosphorylation Underlies Muscle Insulin Resistance in Type 2 Diabetes

(2020) Thiago M. Batista et al.   Cell Metabolism

TAZ couples Hippo/Wnt signalling and insulin sensitivity through Irs1 expression

(2019) Jun-Ha Hwang et al.   Nature Communications

Insulin signaling in the hippocampus and amygdala regulates metabolism and neurobehavior

(2019) Marion Soto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PGC1A regulates the IRS1:IRS2 ratio during fasting to influence hepatic metabolism downstream of insulin

(2019) Aurèle Besse-Patin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vascular Smooth Muscle Cells Contribute to Atherosclerosis Immunity

(2019) Desheng Hu et al.   Frontiers in Immunology

Intranasal Targeting of Hypothalamic PTP1B and TCPTP Reinstates Leptin and Insulin Sensitivity and Promotes Weight Loss in Obesity

(2019) Garron T. Dodd et al.   Cell Reports

Nonalcoholic Fatty Liver Disease, Insulin Resistance, and Ceramides

(2019) Varman T. Samuel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Homozygous receptors for insulin and not IGF-1 accelerate intimal hyperplasia in insulin resistance and diabetes

(2019) Qian Li et al.   Nature Communications

Muscle-liver substrate fluxes in exercising humans and potential effects on hepatic metabolism

(2019) Chunxiu Hu et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The integrative biology of type 2 diabetes

(2019) Michael Roden et al.   NATURE

Saturated fatty acids-induced miR-424–5p aggravates insulin resistance via targeting insulin receptor in hepatocytes

(2018) Kyung-Ho Min et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Reducing insulin via conditional partial gene ablation in adults reverses diet-induced weight gain

(2018) Melissa M. Page et al.   FASEB JOURNAL

Visualization of ligand-induced transmembrane signaling in the full-length human insulin receptor

(2018) Theresia Gutmann et al.   JOURNAL OF CELL BIOLOGY

Inactivating hepatic follistatin alleviates hyperglycemia

(2018) Rongya Tao et al.   NATURE MEDICINE

Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums

(2018) Steven E. Arnold et al.   Nature Reviews Neurology

Identification of microRNA that represses IRS-1 expression in liver

(2018) Kaoru Ono et al.   PLoS One

How ligand binds to the type 1 insulin-like growth factor receptor

(2018) Yibin Xu et al.   Nature Communications

Diet, Genetics, and the Gut Microbiome Drive Dynamic Changes in Plasma Metabolites

(2018) Shiho Fujisaka et al.   Cell Reports

The UPR Activator ATF6 Responds to Proteotoxic and Lipotoxic Stress by Distinct Mechanisms

(2018) Arvin B. Tam et al.   DEVELOPMENTAL CELL

Targeting FXR and FGF19 to Treat Metabolic Diseases—Lessons Learned From Bariatric Surgery

(2018) Nadejda Bozadjieva et al.   DIABETES

Suppression of insulin feedback enhances the efficacy of PI3K inhibitors

(2018) Benjamin D. Hopkins et al.   NATURE

Structure of the insulin receptor–insulin complex by single-particle cryo-EM analysis

(2018) Giovanna Scapin et al.   NATURE

Mechanisms of Insulin Action and Insulin Resistance

(2018) Max C. Petersen et al.   PHYSIOLOGICAL REVIEWS

Exercise-Induced Changes in Visceral Adipose Tissue Mass Are Regulated by IL-6 Signaling: A Randomized Controlled Trial

(2018) Anne-Sophie Wedell-Neergaard et al.   Cell Metabolism

FoxO Transcription Factors are Critical Regulators of Diabetes-Related Muscle Atrophy

(2018) Brian T. O’Neill et al.   DIABETES

Metformin increases glucose uptake and acts renoprotectively by reducing SHIP2 activity

(2018) Zydrune Polianskyte-Prause et al.   FASEB JOURNAL

MicroRNAs as Regulators of Insulin Signaling: Research Updates and Potential Therapeutic Perspectives in Type 2 Diabetes

(2018) Laura Nigi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Regulation of glucose uptake and inflammation markers by FOXO1 and FOXO3 in skeletal muscle

(2018) Leonidas S. Lundell et al.   Molecular Metabolism

Insulin Receptor Isoforms in Physiology and Disease: An Updated View

(2017) Antonino Belfiore et al.   ENDOCRINE REVIEWS

Fibroblast Growth Factor 21—Metabolic Role in Mice and Men

(2017) Harald Staiger et al.   ENDOCRINE REVIEWS

Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signaling

(2017) Samir Softic et al.   JOURNAL OF CLINICAL INVESTIGATION

FoxO integration of insulin signaling with glucose and lipid metabolism

(2017) Sojin Lee et al.   JOURNAL OF ENDOCRINOLOGY

Training alters the distribution of perilipin proteins in muscle following acute free fatty acid exposure

(2017) S. O. Shepherd et al.   JOURNAL OF PHYSIOLOGY-LONDON

Insulin action and resistance in obesity and type 2 diabetes

(2017) Michael P Czech   NATURE MEDICINE

Unraveling the Regulation of Hepatic Metabolism by Insulin

(2017) Paul M. Titchenell et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Domain-dependent effects of insulin and IGF-1 receptors on signalling and gene expression

(2017) Weikang Cai et al.   Nature Communications

Induction of miR-96 by Dietary Saturated Fatty Acids Exacerbates Hepatic Insulin Resistance through the Suppression of INSR and IRS-1

(2017) Won-Mo Yang et al.   PLoS One

Linking the Human Gut Microbiome to Inflammatory Cytokine Production Capacity

(2016) Melanie Schirmer et al.   CELL

Direct Hepatocyte Insulin Signaling Is Required for Lipogenesis but Is Dispensable for the Suppression of Glucose Production

(2016) Paul M. Titchenell et al.   Cell Metabolism

Insulin Signaling and Heart Failure

(2016) Christian Riehle et al.   CIRCULATION RESEARCH

Lipodystrophy Due to Adipose Tissue–Specific Insulin Receptor Knockout Results in Progressive NAFLD

(2016) Samir Softic et al.   DIABETES

Differential Roles of Insulin and IGF-1 Receptors in Adipose Tissue Development and Function

(2016) Jeremie Boucher et al.   DIABETES

Role of Dietary Fructose and Hepatic De Novo Lipogenesis in Fatty Liver Disease

(2016) Samir Softic et al.   DIGESTIVE DISEASES AND SCIENCES

Serine 302 Phosphorylation of Mouse Insulin Receptor Substrate 1 (IRS1) Is Dispensable for Normal Insulin Signaling and Feedback Regulation by Hepatic S6 Kinase

(2016) Kyle D. Copps et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insulin and IGF-1 receptors regulate FoxO-mediated signaling in muscle proteostasis

(2016) Brian T. O’Neill et al.   JOURNAL OF CLINICAL INVESTIGATION

Antibiotic effects on gut microbiota and metabolism are host dependent

(2016) Shiho Fujisaka et al.   JOURNAL OF CLINICAL INVESTIGATION

The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux

(2016) Varman T. Samuel et al.   JOURNAL OF CLINICAL INVESTIGATION

Human gut microbes impact host serum metabolome and insulin sensitivity

(2016) Helle Krogh Pedersen et al.   NATURE

Acetate mediates a microbiome–brain–β-cell axis to promote metabolic syndrome

(2016) Rachel J. Perry et al.   NATURE

Brain Insulin Resistance at the Crossroads of Metabolic and Cognitive Disorders in Humans

(2016) Stephanie Kullmann et al.   PHYSIOLOGICAL REVIEWS

Interactions between host genetics and gut microbiome in diabetes and metabolic syndrome

(2016) Siegfried Ussar et al.   Molecular Metabolism

MiR-126 Suppresses the Glucose-Stimulated Proliferation via IRS-2 in INS-1 β Cells

(2016) Hong Tao et al.   PLoS One

Insulin/receptor binding: The last piece of the puzzle?

(2015) Pierre De Meyts   BIOESSAYS

Treatment of Obesity with Celastrol

(2015) Junli Liu et al.   CELL

Hepatic Acetyl CoA Links Adipose Tissue Inflammation to Hepatic Insulin Resistance and Type 2 Diabetes

(2015) Rachel J. Perry et al.   CELL

Roux-en-Y Gastric Bypass and Vertical Banded Gastroplasty Induce Long-Term Changes on the Human Gut Microbiome Contributing to Fat Mass Regulation

(2015) Valentina Tremaroli et al.   Cell Metabolism

Interactions between Gut Microbiota, Host Genetics and Diet Modulate the Predisposition to Obesity and Metabolic Syndrome

(2015) Siegfried Ussar et al.   Cell Metabolism

Contribution of Gut Bacteria to Lipid Levels: Figure.

(2015) Hooman Allayee et al.   CIRCULATION RESEARCH

The gut microbiome in health and in disease

(2015) Andrew B. Shreiner et al.   CURRENT OPINION IN GASTROENTEROLOGY

Influence of the human intestinal microbiome on obesity and metabolic dysfunction

(2015) Herbert Tilg et al.   CURRENT OPINION IN PEDIATRICS

Obesity-induced miR-15b is linked causally to the development of insulin resistance through the repression of the insulin receptor in hepatocytes

(2015) Won-Mo Yang et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Is Acetylation a Metabolic Rheostat that Regulates Skeletal Muscle Insulin Action?

(2015) Samuel LaBarge et al.   MOLECULES AND CELLS

Obesity and Aging

(2015) Gérard N. Bischof et al.   PSYCHOSOMATIC MEDICINE

Protein Tyrosine Phosphatases in Hypothalamic Insulin and Leptin Signaling

(2015) Zhong-Yin Zhang et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

FoxO1 integrates direct and indirect effects of insulin on hepatic glucose production and glucose utilization

(2015) InSug O-Sullivan et al.   Nature Communications

Differential Role of Insulin/IGF-1 Receptor Signaling in Muscle Growth and Glucose Homeostasis

(2015) Brian T. O’Neill et al.   Cell Reports

A Positive Feedback Loop between Akt and mTORC2 via SIN1 Phosphorylation

(2015) Guang Yang et al.   Cell Reports

Shades of Brown: A Model for Thermogenic Fat

(2015) Jon Dempersmier et al.   Frontiers in Endocrinology

MiRNA-145 is involved in the development of resistin-induced insulin resistance in HepG2 cells

(2014) Fengyun Wen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Insulin Action in Brain Regulates Systemic Metabolism and Brain Function

(2014) A. Kleinridders et al.   DIABETES

IRS2 integrates insulin/IGF1 signalling with metabolism, neurodegeneration and longevity

(2014) M. F. White   DIABETES OBESITY & METABOLISM

Saturated fatty acid-induced miR-195 impairs insulin signaling and glycogen metabolism in HepG2 cells

(2014) Won-Mo Yang et al.   FEBS LETTERS

Role of the Microbiome in Energy Regulation and Metabolism

(2014) Max Nieuwdorp et al.   GASTROENTEROLOGY

Insulin and Metabolic Stress Stimulate Multisite Serine/Threonine Phosphorylation of Insulin Receptor Substrate 1 and Inhibit Tyrosine Phosphorylation

(2014) Nancy J. Hançer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Myostatin Induces Insulin Resistance via Casitas B-Lineage Lymphoma b (Cblb)-mediated Degradation of Insulin Receptor Substrate 1 (IRS1) Protein in Response to High Calorie Diet Intake

(2014) Sabeera Bonala et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The microbiome revolution

(2014) Martin J. Blaser   JOURNAL OF CLINICAL INVESTIGATION

A complex role for adipose tissue macrophages

(2014) Shannon M. Reilly et al.   Nature Reviews Endocrinology

Exercise as an anti-inflammatory therapy for rheumatic diseases—myokine regulation

(2014) Fabiana B. Benatti et al.   Nature Reviews Rheumatology

Regulation of host weight gain and lipid metabolism by bacterial bile acid modification in the gut

(2014) S. A. Joyce et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Skeletal muscle glucose metabolism and inflammation in the development of the metabolic syndrome

(2014) André Marette et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

The absence of insulin signaling in the heart induces changes in potassium channel expression and ventricular repolarization

(2013) Angelica Lopez-Izquierdo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The Effects of Salsalate on Glycemic Control in Patients With Type 2 Diabetes

(2013) Allison B. Goldfine   ANNALS OF INTERNAL MEDICINE

miR-135a targets IRS2 and regulates insulin signaling and glucose uptake in the diabetic gastrocnemius skeletal muscle

(2013) Priyanka Agarwal et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

TNF-α Mediates PKR-Dependent Memory Impairment and Brain IRS-1 Inhibition Induced by Alzheimer’s β-Amyloid Oligomers in Mice and Monkeys

(2013) Mychael V. Lourenco et al.   Cell Metabolism

Direct Autocrine Action of Insulin on  -Cells: Does It Make Physiological Sense?

(2013) C. J. Rhodes et al.   DIABETES

Sirt3 Regulates Metabolic Flexibility of Skeletal Muscle Through Reversible Enzymatic Deacetylation

(2013) E. Jing et al.   DIABETES

Biomarkers for Type 2 Diabetes and Impaired Fasting Glucose Using a Nontargeted Metabolomics Approach

(2013) C. Menni et al.   DIABETES

The gut microbiome as novel cardio-metabolic target: the time has come!

(2013) S. Vinje et al.   EUROPEAN HEART JOURNAL

mTOR complex 2 phosphorylates IMP1 cotranslationally to promote IGF2 production and the proliferation of mouse embryonic fibroblasts

(2013) N. Dai et al.   GENES & DEVELOPMENT

Nerve Growth Factor Receptor TrkA, a New Receptor in Insulin Signaling Pathway in PC12 Cells

(2013) Thangiah Geetha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crosstalk between mTOR complexes

(2013) Jianling Xie et al.   NATURE CELL BIOLOGY

The role of hepatokines in metabolism

(2013) Norbert Stefan et al.   Nature Reviews Endocrinology

The global NAFLD epidemic

(2013) Rohit Loomba et al.   Nature Reviews Gastroenterology & Hepatology

Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice

(2013) V. K. Ridaura et al.   SCIENCE

Analysis of In Vitro Insulin-Resistance Models and Their Physiological Relevance to In Vivo Diet-Induced Adipose Insulin Resistance

(2013) Kinyui Alice Lo et al.   Cell Reports

Irs2 and Irs4 synergize in non-LepRb neurons to control energy balance and glucose homeostasis

(2013) Marianna Sadagurski et al.   Molecular Metabolism

MG53′s new identity

(2013) Jennifer R Levy et al.   Skeletal Muscle

Adipose tissue expandability, lipotoxicity and the metabolic syndrome

(2013) Antonio Vidal-Puig   Endocrinologia y Nutricion

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Mechanisms for Insulin Resistance: Common Threads and Missing Links

(2012) Varman T. Samuel et al.   CELL

Hyperinsulinemia Drives Diet-Induced Obesity Independently of Brain Insulin Production

(2012) Arya E. Mehran et al.   Cell Metabolism

Insulin Resistance in the Defense against Obesity

(2012) Alan R. Saltiel   Cell Metabolism

Interplay between Lipids and Branched-Chain Amino Acids in Development of Insulin Resistance

(2012) Christopher B. Newgard   Cell Metabolism

Constitutive STAT3 Phosphorylation Contributes to Skeletal Muscle Insulin Resistance in Type 2 Diabetes

(2012) F. Mashili et al.   DIABETES

Acylcarnitines

(2012) Marieke G. Schooneman et al.   DIABETES

Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2

(2012) K. D. Copps et al.   DIABETOLOGIA

Integrating Metabolism and Longevity Through Insulin and IGF1 Signaling

(2012) Marianna Sadagurski et al.   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

PTP1B and TCPTP - nonredundant phosphatases in insulin signaling and glucose homeostasis

(2012) Tony Tiganis   FEBS Journal

Identification of the Degradation Determinants of Insulin Receptor Substrate 1 for Signaling Cullin-RING E3 Ubiquitin Ligase 7-mediated Ubiquitination

(2012) Xinsong Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial Protein Acylation and Intermediary Metabolism: Regulation by Sirtuins and Implications for Metabolic Disease

(2012) John C. Newman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers

(2012) Theresa R. Bomfim et al.   JOURNAL OF CLINICAL INVESTIGATION

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

(2012) Konrad Talbot et al.   JOURNAL OF CLINICAL INVESTIGATION

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

(2012)   NATURE GENETICS

Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1

(2012) Mingjian Lu et al.   NATURE MEDICINE

PI3K signalling: the path to discovery and understanding

(2012) Bart Vanhaesebroeck et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Transcriptional Coactivators p/CIP and SRC-1 Control Insulin Resistance through IRS1 in Obesity Models

(2012) Zhiyong Wang et al.   PLoS One

Mitochondrial sirtuins: regulators of protein acylation and metabolism

(2012) Wenjuan He et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Gut microbiota and diabetes: from pathogenesis to therapeutic perspective

(2011) Rémy Burcelin et al.   ACTA DIABETOLOGICA

The Lin28/let-7 Axis Regulates Glucose Metabolism

(2011) Hao Zhu et al.   CELL

Impaired Insulin Signaling in Endothelial Cells Reduces Insulin-Induced Glucose Uptake by Skeletal Muscle

(2011) Tetsuya Kubota et al.   Cell Metabolism

Akt signalling in health and disease

(2011) Ingeborg Hers et al.   CELLULAR SIGNALLING

Specific Glucose-Induced Control of Insulin Receptor Substrate-2 Expression Is Mediated via Ca 2+ -Dependent Calcineurin/NFAT Signaling in Primary Pancreatic Islet β-Cells

(2011) Damien Demozay et al.   DIABETES

Preferential Fat Deposition in SubcutaneousVersusVisceral Depots Is Associated with Insulin Sensitivity

(2011) Tracey McLaughlin et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Gut microbiome, obesity, and metabolic dysfunction

(2011) Herbert Tilg et al.   JOURNAL OF CLINICAL INVESTIGATION

IRS2 increases mitochondrial dysfunction and oxidative stress in a mouse model of Huntington disease

(2011) Marianna Sadagurski et al.   JOURNAL OF CLINICAL INVESTIGATION

Insulin receptor substrate 2 is a negative regulator of memory formation

(2011) E. E. Irvine et al.   LEARNING & MEMORY

Regulation of glucose homeostasis through a XBP-1–FoxO1 interaction

(2011) Yingjiang Zhou et al.   NATURE MEDICINE

Phosphoproteomic Analysis Identifies Grb10 as an mTORC1 Substrate That Negatively Regulates Insulin Signaling

(2011) Y. Yu et al.   SCIENCE

Transcription factor AP-2β: A negative regulator of IRS-1 gene expression

(2010) Xiangning Meng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Irs1 Serine 307 Promotes Insulin Sensitivity in Mice

(2010) Kyle D. Copps et al.   Cell Metabolism

Loss of Insulin Signaling in Vascular Endothelial Cells Accelerates Atherosclerosis in Apolipoprotein E Null Mice

(2010) Christian Rask-Madsen et al.   Cell Metabolism

Insulin Receptor Substrates Irs1 and Irs2 Coordinate Skeletal Muscle Growth and Metabolism via the Akt and AMPK Pathways

(2010) Y. C. Long et al.   MOLECULAR AND CELLULAR BIOLOGY

SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation

(2010) Matthew D. Hirschey et al.   NATURE

Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin

(2010) William L Holland et al.   NATURE MEDICINE

α-Hydroxybutyrate Is an Early Biomarker of Insulin Resistance and Glucose Intolerance in a Nondiabetic Population

(2010) Walter E. Gall et al.   PLoS One

Resistin induces insulin resistance, but does not affect glucose output in rat-derived hepatocytes

(2009) Feng Liu et al.   ACTA PHARMACOLOGICA SINICA

Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice

(2009) Richard Killick et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Reduced IGF-1 Signaling Delays Age-Associated Proteotoxicity in Mice

(2009) Ehud Cohen et al.   CELL

A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance

(2009) Christopher B. Newgard et al.   Cell Metabolism

Human IL6 enhances leptin action in mice

(2009) M. Sadagurski et al.   DIABETOLOGIA

Neuronal IGF-1 resistance reduces Aβ accumulation and protects against premature death in a model of Alzheimer’s disease

(2009) Susanna Freude et al.   FASEB JOURNAL

The Irs1 Branch of the Insulin Signaling Cascade Plays a Dominant Role in Hepatic Nutrient Homeostasis

(2009) S. Guo et al.   MOLECULAR AND CELLULAR BIOLOGY

Glucose Effects on Beta-Cell Growth and Survival Require Activation of Insulin Receptors and Insulin Receptor Substrate 2

(2009) A. Assmann et al.   MOLECULAR AND CELLULAR BIOLOGY

The autocrine and paracrine roles of adipokines

(2009) Kalypso Karastergiou et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Foxo1 integrates insulin signaling with mitochondrial function in the liver

(2009) Zhiyong Cheng et al.   NATURE MEDICINE

Identification and Importance of Brown Adipose Tissue in Adult Humans

(2009) Aaron M. Cypess et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inactivation of Hepatic Foxo1 by Insulin Signaling Is Required for Adaptive Nutrient Homeostasis and Endocrine Growth Regulation

(2008) Xiaocheng C. Dong et al.   Cell Metabolism

Hepatic Insulin Resistance Is Sufficient to Produce Dyslipidemia and Susceptibility to Atherosclerosis

(2008) Sudha B. Biddinger et al.   Cell Metabolism

Dephosphorylation of Translation Initiation Factor 2α Enhances Glucose Tolerance and Attenuates Hepatosteatosis in Mice

(2008) Seiichi Oyadomari et al.   Cell Metabolism

Dynamic Functional Relay between Insulin Receptor Substrate 1 and 2 in Hepatic Insulin Signaling during Fasting and Feeding

(2008) Naoto Kubota et al.   Cell Metabolism

Beneficial Effects of Subcutaneous Fat Transplantation on Metabolism

(2008) Thien T. Tran et al.   Cell Metabolism

Endoplasmic Reticulum Stress Markers Are Associated with Obesity in Nondiabetic Subjects

(2008) Neeraj K. Sharma et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The CUL7 E3 Ubiquitin Ligase Targets Insulin Receptor Substrate 1 for Ubiquitin-Dependent Degradation

(2008) Xinsong Xu et al.   MOLECULAR CELL

Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling

(2008) Aileen M. Moloney et al.   NEUROBIOLOGY OF AGING

The insulin receptor: a prototype for dimeric, allosteric membrane receptors?

(2008) Pierre De Meyts   TRENDS IN BIOCHEMICAL SCIENCES