Article
Multidisciplinary Sciences
Birte Niemann, Saskia Haufs-Brusberg, Laura Puetz, Martin Feickert, Michelle Y. Jaeckstein, Anne Hoffmann, Jelena Zurkovic, Markus Heine, Eva-Maria Trautmann, Christa E. Mueller, Anke Toenjes, Christian Schlein, Azin Jafari, Holger K. Eltzschig, Thorsten Gnad, Matthias Bluher, Natalie Krahmer, Peter Kovacs, Joerg Heeren, Alexander Pfeifer
Summary: This study reveals that inosine, a metabolite released during apoptosis, enhances the thermogenic program in healthy adipocytes and regulates energy expenditure. The equilibrative nucleoside transporter 1 (ENT1) controls inosine levels in brown adipose tissue, affecting thermogenic capacity. In humans, a loss of function mutation in ENT1 is associated with lower body mass index and reduced odds of obesity.
Review
Endocrinology & Metabolism
Okamatsu-Ogura Yuko, Masayuki Saito
Summary: The article provides an overview of brown adipose tissue (BAT), including its functions in health and diseases, the development of inducible thermogenic adipocytes (beige adipocytes), the diversity of thermogenic mechanisms, and BAT's influence on peripheral tissues and systemic homeostasis.
DIABETES & METABOLISM JOURNAL
(2021)
Article
Biology
Muhammad Hamza Bokhari, Carina Halleskog, Alice Aslund, Nathalie Boulet, Eva Casadesus Rendos, Jasper Martin Anton de Jong, Robert Csikasz, Ez-Zoubir Amri, Irina Shabalina, Tore Bengtsson
Summary: The study demonstrates the crucial role of UCP1 protein in the thermogenesis of murine brown and brite adipocytes. The use of isothermal microcalorimetry is established as a sensitive and accurate technique for measuring this heat-producing response.
COMMUNICATIONS BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Chad C. Doucette, Davide Barteselli, Daniel C. Nguyen, Sophia Blanchard, Mason Pelletier, Devesh Kesharwani, Ed Jachimowicz, Su Su, Michele Karolak, Aaron C. Brown
Summary: In this study, an optogenetic approach was used to activate UCP1-dependent thermogenesis in brown adipocytes. This system allows for precise, chemical free, temporal control of UCP1-dependent thermogenesis, which can contribute to our understanding of brown adipocyte biology and the development of therapies for obesity-related disorders.
Article
Endocrinology & Metabolism
Patrick Lundgren, Prateek V. Sharma, Lenka Dohnalova, Kyle Coleman, Giulia T. Uhr, Susanna Kircher, Lev Litichevskiy, Klaas Bahnsen, Helene C. Descamps, Christina Demetriadou, Jacqueline Chan, Karthikeyani Chellappa, Timothy O. Cox, Yael Heyman, Sarshan R. Pather, Clarissa Shoffler, Christopher Petucci, Ophir Shalem, Arjun Raj, Joseph A. Baur, Nathaniel W. Snyder, Kathryn E. Wellen, Maayan Levy, Patrick Seale, Mingyao Li, Christoph A. Thaiss
Summary: Transient cold exposure leads to sustained transcriptional and metabolic adaptations in brown adipose tissue, improving thermogenic responses to subsequent cold encounters. This response is driven by a lipogenic subpopulation of brown adipocytes, which produce acylcarnitines to enhance the thermogenic response.
Article
Endocrinology & Metabolism
Patrick Lundgren, Prateek V. Sharma, Lenka Dohnalova, Kyle Coleman, Giulia T. Uhr, Susanna Kircher, Lev Litichevskiy, Klaas Bahnsen, Helene C. Descamps, Christina Demetriadou, Jacqueline Chan, Karthikeyani Chellappa, Timothy O. Cox, Yael Heyman, Sarshan R. Pather, Clarissa Shoffler, Christopher Petucci, Ophir Shalem, Arjun Raj, Joseph A. Baur, Nathaniel W. Snyder, Kathryn E. Wellen, Maayan Levy, Patrick Seale, Mingyao Li, Christoph A. Thaiss
Summary: Transient cold exposure leads to sustained transcriptional and metabolic adaptations in brown adipose tissue, improving thermogenic responses to subsequent cold encounters. These adaptations are driven by a lipogenic subpopulation of brown adipocytes located around Ucp1hi adipocytes, and are associated with the production of acylcarnitines.
Article
Multidisciplinary Sciences
Qiqiao Du, Jieyu Wu, Carina Fischer, Takahiro Seki, Xu Jing, Juan Gao, Xingkang He, Kayoko Hosaka, Le Tong, Akihiro Yasue, Masato Miyake, Mitsuaki Sobajima, Seiichi Oyadomari, Xiaoting Sun, Yunlong Yang, Qinjun Zhou, Minghua Ge, Wei Tao, Shuzhong Yao, Yihai Cao
Summary: This study demonstrates that the mass and functions of brown adipose tissue (BAT) in adult animals can be controlled by manipulating BAT adipocyte differentiation in vivo. Inhibition of PDGFR alpha leads to an increase in brown adipocyte numbers and the formation of enlarged BAT. The study also shows that megaBAT significantly improves global metabolism, insulin sensitivity, high-fat-diet-induced obesity, and diabetes.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Haopeng Xiao, Luiz H. M. Bozi, Yizhi Sun, Christopher L. Riley, Vivek M. Philip, Mandy Chen, Jiaming Li, Tian Zhang, Evanna L. Mills, Margo P. Emont, Wenfei Sun, Anita Reddy, Ryan Garrity, Jiani Long, Tobias Becher, Laura Potano Vitas, Dina Laznik-Bogoslavski, Martha Ordonez, Xinyue Liu, Xiong Chen, Yun Wang, Weihai Liu, Nhien Tran, Yitong Liu, Yang Zhang, Aaron M. Cypess, Andrew P. White, Yuchen He, Rebecca Deng, Heiko Schoder, Joao A. Paulo, Mark P. Jedrychowski, Alexander S. Banks, Yu-Hua Tseng, Paul Cohen, Linus T. Tsai, Evan D. Rosen, Samuel Klein, Maria Chondronikola, Fiona E. McAllister, Nick Van Bruggen, Edward L. Huttlin, Bruce M. Spiegelman, Gary A. Churchill, Steven P. Gygi, Edward T. Chouchani
Summary: By studying a genetically diverse cohort of mice, researchers have identified the functional architecture of brown adipose tissue (BAT) proteome and discovered key regulators of BAT. They also found proteins that are associated with protection from or sensitivity to metabolic diseases. These findings provide important insights into the conserved mechanisms of BAT regulation over metabolic physiology.
Article
Food Science & Technology
Stefanie F. Maurer, Sebastian Dieckmann, Jens Lund, Tobias Fromme, Anne Lundby Hess, Cecilia Colson, Louise Kjolbaek, Arne Astrup, Matthew Paul Gillum, Lesli Hingstrup Larsen, Gerhard Liebisch, Ez-Zoubir Amri, Martin Klingenspor
Summary: The study suggests that dietary fish oil supplementation may enhance the recruitment of thermogenic capacity in adipocytes, but does not significantly affect body weight or adiposity.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Endocrinology & Metabolism
Grace Park, John A. Haley, Johnny Le, Su Myung Jung, Timothy P. Fitzgibbons, Ekaterina D. Korobkina, Huawei Li, Shelagh M. Fluharty, Qingbo Chen, Jessica B. Spinelli, Chinmay M. Trivedi, Cholsoon Jang, David A. Guertin
Summary: Adaptive thermogenesis by brown adipose tissue (BAT) plays an important role in dissipating calories as heat and can potentially be used as an anti-obesity target. This study quantified metabolite exchange in BAT and skeletal muscle during cold exposure in mice, revealing unexpected metabolites consumed, released, and shared between organs. Glucose and lactate were found to provide the majority of carbon for adaptive thermogenesis, and cold adaptation triggered different fuel utilization profiles compared to the drug CL316,243. BAT was also found to significantly increase nitrogen uptake during cold adaptation, except for the amino acid glutamine. This study provides valuable insights into the fuel utilization of BAT and its potential implications for future research in this field.
Article
Biochemistry & Molecular Biology
Prasanna K. R. Allu, Esther Paulo, Ambre M. Bertholet, Gavin Situ, Seung-Hwan Lee, Yixuan Wu, Catherine E. Gleason, Bidisha Saha, Ajay Chawla, Biao Wang, David Pearce
Summary: This passage discusses the importance of nonshivering thermogenesis in mammals and its mechanism. The core mechanism involves skin thermoreceptors sensing temperature, nerve signals transmitted to the hypothalamus to generate signals that activate brown adipocytes. In response to mild cold, beta-adrenergic signals not only stimulate fatty acid oxidation but also promote lipogenesis through the mTORC2-Akt signaling module.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Kaja Rupar, Marie S. Isidor, Lidia Argemi-Muntadas, Marina Agueda-Oyarzabal, Kaja Plucinska, Erin L. Brown, Matthias Mattanovich, Simone Bossi, Marco Tozzi, David Tandio, Patricia S. S. Petersen, Tora I. Henriksen, Kajetan Trost, Jacob B. Hansen, Zachary Gerhart-Hines, Soren Nielsen, Thomas Moritz, Brice Emanuelli
Summary: The researchers found that Bsg is negatively associated with obesity and its expression increases in brown adipocytes upon cold acclimation and beta-adrenergic stimulation. They also discovered that Bsg is required for mitochondrial respiration, lipolysis, and Ucp1 transcription in activated brown adipocytes, and Bsg regulates the levels of lactate and acetoacetate in these cells.
Article
Cell Biology
Alba Sabate-Perez, Montserrat Romero, Paula Sanchez-Fernandez-de-Landa, Stefania Carobbio, Michail Mouratidis, David Sala, Pablo Engel, Josep A. Villena, Sam Virtue, Antonio Vidal-Puig, Manuel Palacin, Xavier Testar, Antonio Zorzano
Summary: The study reveals a novel molecular mechanism by which TP53INP2 regulates PPARG activity and brown adipogenesis through autophagy, and demonstrates the importance of TP53INP2 in maintaining thermogenic capacity and preventing lipid accumulation in brown adipose tissue. These findings provide insights into the therapeutic strategies against obesity and its metabolic complications.
Review
Biochemistry & Molecular Biology
Annie Ladoux, Pascal Peraldi, Berengere Chignon-Sicard, Christian Dani
Summary: Adipose tissue is a complex organ consisting of white and brown fat, each with distinct functions. Mature adipocytes are responsible for storing or burning energy, while adipose progenitors play a crucial role in maintaining and expanding the tissue.
Review
Nutrition & Dietetics
Lloyd Noriega, Cheng-Ying Yang, Chih-Hao Wang
Summary: Brown and beige adipocytes have the ability to generate heat and can be activated by various methods. Understanding the molecular mechanisms of their differentiation and function is crucial for developing clinical therapies. Drugs and nutritional interventions can activate these adipocytes while minimizing potential side effects.
