Insulin/receptor binding: The last piece of the puzzle?

Insulin Receptor Activation with Transmembrane Domain Ligands

(2014) Jongsoon Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protective hinge in insulin opens to enable its receptor engagement

(2014) J. G. Menting et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein painting reveals solvent-excluded drug targets hidden within native protein–protein interfaces

(2014) Alessandra Luchini et al.   Nature Communications

Human insulin analogues modified at the B26 site reveal a hormone conformation that is undetected in the receptor complex

(2014) Lenka Žáková et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Mechanisms of Activation of Receptor Tyrosine Kinases: Monomers or Dimers

(2014) Ichiro Maruyama   Cells

The insulin receptor changes conformation in unforeseen ways on ligand binding: Sharpening the picture of insulin receptor activation

(2013) Colin W. Ward et al.   BIOESSAYS

Structural Integrity of the B24 Site in Human Insulin Is Important for Hormone Functionality

(2013) Lenka Žáková et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural biology: Insulin meets its receptor

(2013) Stevan R. Hubbard   NATURE

How insulin engages its primary binding site on the insulin receptor

(2013) John G. Menting et al.   NATURE

In Memoriam: Guy Dodson (1937–2012)

(2013) Pierre De Meyts   Frontiers in Endocrinology

Similar but different: ligand-induced activation of the insulin and epidermal growth factor receptor families

(2012) Colin W Ward et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

A single ligand is sufficient to activate EGFR dimers

(2012) P. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fine Details of IGF-1R Activation, Inhibition, and Asymmetry Determined by Associated Hydrogen /Deuterium-Exchange and Peptide Mass Mapping

(2011) Damian Houde et al.   STRUCTURE

The Ins and Outs of EGFR Asymmetry

(2010) Daniel J. Leahy   CELL

Structural Basis for Negative Cooperativity in Growth Factor Binding to an EGF Receptor

(2010) Diego Alvarado et al.   CELL

Cell Signaling by Receptor Tyrosine Kinases

(2010) Mark A. Lemmon et al.   CELL

Structural resolution of a tandem hormone-binding element in the insulin receptor and its implications for design of peptide agonists

(2010) B. J. Smith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Implications for the active form of human insulin based on the structural convergence of highly active hormone analogues

(2010) J. Jiracek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis of Allosteric Ligand-Receptor Interactions in the Insulin/Relaxin Peptide Family

(2009) Pierre De Meyts et al.   Annals of the New York Academy of Sciences

Ligand-induced activation of the insulin receptor: a multi-step process involving structural changes in both the ligand and the receptor

(2009) Colin W. Ward et al.   BIOESSAYS

Importance of the Solvent-Exposed Residues of the Insulin B Chain α-Helix for Receptor Binding†

(2008) Tine Glendorf et al.   BIOCHEMISTRY

Insulin Analogues with Modifications at Position B26. Divergence of Binding Affinity and Biological Activity†

(2008) Lenka Žáková et al.   BIOCHEMISTRY

High-Affinity Insulin Binding: Insulin Interacts with Two Receptor Ligand Binding Sites†

(2008) Linda Whittaker et al.   BIOCHEMISTRY

Alanine Scanning of a Putative Receptor Binding Surface of Insulin-like Growth Factor-I

(2008) Lisbeth Gauguin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The insulin receptor: a prototype for dimeric, allosteric membrane receptors?

(2008) Pierre De Meyts   TRENDS IN BIOCHEMICAL SCIENCES