标题
Insulin Receptor Isoforms in Physiology and Disease: An Updated View
作者
关键词
-
出版物
ENDOCRINE REVIEWS
Volume 38, Issue 5, Pages 379-431
出版商
The Endocrine Society
发表日期
2017-06-20
DOI
10.1210/er.2017-00073
参考文献
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- Memory enhancement: consolidation, reconsolidation and insulin-like growth factor 2
- (2012) Cristina M. Alberini et al. TRENDS IN NEUROSCIENCES
- Impaired thermogenesis and adipose tissue development in mice with fat-specific disruption of insulin and IGF-1 signalling
- (2012) Jeremie Boucher et al. Nature Communications
- HMGA1 is a novel downstream nuclear target of the insulin receptor signaling pathway
- (2012) Eusebio Chiefari et al. Scientific Reports
- Tumor suppressive microRNA-1 mediated novel apoptosis pathways through direct inhibition of splicing factor serine/arginine-rich 9 (SRSF9/SRp30c) in bladder cancer
- (2011) Hirofumi Yoshino et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Receptor-isoform-selective insulin analogues give tissue-preferential effects
- (2011) Sara G. Vienberg et al. BIOCHEMICAL JOURNAL
- Dual IGF-I/II-Neutralizing Antibody MEDI-573 Potently Inhibits IGF Signaling and Tumor Growth
- (2011) J. Gao et al. CANCER RESEARCH
- Dual IGF-1R/InsR Inhibitor BMS-754807 Synergizes with Hormonal Agents in Treatment of Estrogen-Dependent Breast Cancer
- (2011) X. Hou et al. CANCER RESEARCH
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- (2011) Jussi Pihlajamäki et al. Cell Metabolism
- Analysis of MiR-195 and MiR-497 Expression, Regulation and Role in Breast Cancer
- (2011) D. Li et al. CLINICAL CANCER RESEARCH
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- (2011) A. Abbas et al. DIABETES
- Insulin Restores Gestational Diabetes Mellitus-Reduced Adenosine Transport Involving Differential Expression of Insulin Receptor Isoforms in Human Umbilical Vein Endothelium
- (2011) F. Westermeier et al. DIABETES
- Further Exploration of the Relationship Between Insulin Glargine and Incident Cancer: A retrospective cohort study of older Medicare patients
- (2011) N. E. Morden et al. DIABETES CARE
- Risk of cancer in patients on insulin glargine and other insulin analogues in comparison with those on human insulin: results from a large population-based follow-up study
- (2011) R. Ruiter et al. DIABETOLOGIA
- Plasma Distribution and Signaling Activities of IGF-II Precursors
- (2011) Alicia G. Marks et al. ENDOCRINOLOGY
- Dissociation of the insulin receptor from caveolae during TNFα-induced insulin resistance and its recovery byd-PDMP
- (2011) Junji Sekimoto et al. FEBS LETTERS
- Decorin Antagonizes IGF Receptor I (IGF-IR) Function by Interfering with IGF-IR Activity and Attenuating Downstream Signaling
- (2011) Renato V. Iozzo et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Effect of Intranasal Insulin on Cognitive Function: A Systematic Review
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- Epithelial-Mesenchymal Transition Predicts Sensitivity to the Dual IGF-1R/IR Inhibitor OSI-906 in Hepatocellular Carcinoma Cell Lines
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- Research Resource: New and Diverse Substrates for the Insulin Receptor Isoform A Revealed by Quantitative Proteomics After Stimulation With IGF-II or Insulin
- (2011) Alaide Morcavallo et al. MOLECULAR ENDOCRINOLOGY
- MicroRNAs 103 and 107 regulate insulin sensitivity
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- A hepatocyte growth factor receptor (Met)−insulin receptor hybrid governs hepatic glucose metabolism
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- Upregulation of the Insulin Receptor and Type I Insulin-Like Growth Factor Receptor Are Early Events in Hepatocarcinogenesis
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- Obesity related hyperinsulinaemia and hyperglycaemia and cancer development
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- Over-accumulation of nuclear IGF-1 receptor in tumor cells requires elevated expression of the receptor and the SUMO-conjugating enzyme Ubc9
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- Up-regulation and subcellular localization of hnRNP A2/B1 in the development of hepatocellular carcinoma
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- The expression and role of hybrid insulin/insulin-like growth factor receptor type 1 in endometrial carcinoma cells
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- Differential Mechanisms of Acquired Resistance to Insulin-like Growth Factor-I Receptor Antibody Therapy or to a Small-Molecule Inhibitor, BMS-754807, in a Human Rhabdomyosarcoma Model
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- Insulin-Mediated Acceleration of Breast Cancer Development and Progression in a Nonobese Model of Type 2 Diabetes
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- Blockade of Furin Activity and Furin-Induced Tumor Cells Malignant Phenotypes By The Chemically Synthesized Human Furin Prodomain
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- Direct Recruitment of Insulin Receptor and ERK Signaling Cascade to Insulin-Inducible Gene Loci
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- Age-related changes in insulin receptor mRNA and protein expression in genetically obese Zucker rats
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- Insulin Resistance Predicts Mortality in Nondiabetic Individuals in the U.S.
- (2010) K. J. Ausk et al. DIABETES CARE
- Hepatocyte Growth Factor and Clinical Diabetes in Postmenopausal Women
- (2010) S. N. Rajpathak et al. DIABETES CARE
- Insulin analogues differently activate insulin receptor isoforms and post-receptor signalling
- (2010) L. Sciacca et al. DIABETOLOGIA
- Tumor Necrosis Factor-α (TNF-α) Inhibits Insulin-like Growth Factor-I (IGF-I) Activities in Human Trophoblast Cell Cultures Through IGF-I/Insulin Hybrid Receptors
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- Silencing of the Insulin Receptor Isoform A Favors Formation of Type 1 Insulin-Like Growth Factor Receptor (IGF-IR) Homodimers and Enhances Ligand-Induced IGF-IR Activation and Viability of Human Colon Carcinoma Cells
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- Insulin Receptor (IR) Pathway Hyperactivity in IGF-IR Null Cells and Suppression of Downstream Growth Signaling Using the Dual IGF-IR/IR Inhibitor, BMS-754807
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- Muscleblind-like 1 (Mbnl1) Promotes Insulin Receptor Exon 11 Inclusion via Binding to a Downstream Evolutionarily Conserved Intronic Enhancer
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- Insulin and Insulin-like Growth Factor-1 Receptors Act as Ligand-specific Amplitude Modulators of a Common Pathway Regulating Gene Transcription
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- A novel domain of caveolin-2 that controls nuclear targeting: regulation of insulin-specific ERK activation and nuclear translocation by caveolin-2
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- Insulin Receptor Isoforms and Insulin-Like Growth Factor Receptor in Human Follicular Cell Precursors from Papillary Thyroid Cancer and Normal Thyroid
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- Insulin is a potent myeloma cell growth factor through insulin/IGF-1 hybrid receptor activation
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- Compensatory Insulin Receptor (IR) Activation on Inhibition of Insulin-Like Growth Factor-1 Receptor (IGF-1R): Rationale for Cotargeting IGF-1R and IR in Cancer
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- G protein-coupled receptors: novel targets for drug discovery in cancer
- (2010) Rosamaria Lappano et al. NATURE REVIEWS DRUG DISCOVERY
- In Vitro Metabolic and Mitogenic Signaling of Insulin Glargine and Its Metabolites
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- Structural resolution of a tandem hormone-binding element in the insulin receptor and its implications for design of peptide agonists
- (2010) B. J. Smith et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Insulin receptor functionally enhances multistage tumor progression and conveys intrinsic resistance to IGF-1R targeted therapy
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- A Kinase-Independent Role for Unoccupied Insulin and IGF-1 Receptors in the Control of Apoptosis
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- Insulin-Like Growth Factor-1 Receptor Expression Masks the Antiinflammatory and Glucose Uptake Capacity of Insulin in Vascular Smooth Muscle Cells
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- Prolonged tyrosine kinase activation of insulin receptor by pY27-caveolin-2
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- Intrinsic expression of host genes and intronic miRNAs in prostate carcinoma cells
- (2009) Kavleen Sikand et al. Cancer Cell International
- Synchronization in G0/G1 enhances the mitogenic response of cells overexpressing the human insulin receptor A isoform to insulin
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- Glucose binds to the insulin receptor affecting the mutual affinity of insulin and its receptor
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- Insulin analogues display IGF-I-like mitogenic and anti-apoptotic activities in cultured cancer cells
- (2009) Doron Weinstein et al. DIABETES-METABOLISM RESEARCH AND REVIEWS
- Does diabetes therapy influence the risk of cancer?
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- Insulin glargine use and short-term incidence of malignancies—a population-based follow-up study in Sweden
- (2009) J. M. Jonasson et al. DIABETOLOGIA
- Use of insulin glargine and cancer incidence in Scotland: a study from the Scottish Diabetes Research Network Epidemiology Group
- (2009) H. M. Colhoun et al. DIABETOLOGIA
- The influence of glucose-lowering therapies on cancer risk in type 2 diabetes
- (2009) C. J. Currie et al. DIABETOLOGIA
- Risk of malignancies in patients with diabetes treated with human insulin or insulin analogues: a cohort study
- (2009) L. G. Hemkens et al. DIABETOLOGIA
- Insulin Receptor Isoforms and Insulin Receptor/Insulin-Like Growth Factor Receptor Hybrids in Physiology and Disease
- (2009) Antonino Belfiore et al. ENDOCRINE REVIEWS
- Analysis of signaling pathways related to cell proliferation stimulated by insulin analogs in human mammary epithelial cell lines
- (2009) Ashish Shukla et al. ENDOCRINE-RELATED CANCER
- Diabetes and cancer
- (2009) Paolo Vigneri et al. ENDOCRINE-RELATED CANCER
- Selective Response to InsulinVersusInsulin-Like Growth Factor-I and -II and Up-Regulation of Insulin Receptor Splice Variant B in the Differentiated Mouse Mammary Epithelium
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- Insulin-Like Growth Factor Type 1 Receptor and Insulin Receptor Isoform Expression and Signaling in Mammary Epithelial Cells
- (2009) Anne M. Rowzee et al. ENDOCRINOLOGY
- Differential Signaling Activation by Insulin and Insulin-Like Growth Factors I and II upon Binding to Insulin Receptor Isoform A
- (2009) Antonella Sacco et al. ENDOCRINOLOGY
- Time-dependent regulation of muscle caveolin activation and insulin signalling in response to high-fat diet
- (2009) Ana Gómez-Ruiz et al. FEBS LETTERS
- Human aortic smooth muscle cells are insulin resistant at the receptor level but sensitive to IGF1 and IGF2
- (2009) S I Chisalita et al. JOURNAL OF MOLECULAR ENDOCRINOLOGY
- Insulin/IGF-1 hybrid receptor expression on human platelets: consequences for the effect of insulin on platelet function
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- Type 2 diabetes mellitus after gestational diabetes: a systematic review and meta-analysis
- (2009) Leanne Bellamy et al. LANCET
- Autophagy-Mediated Insulin Receptor Down-Regulation Contributes to Endoplasmic Reticulum Stress-Induced Insulin Resistance
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- HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer
- (2009) Charles J. David et al. NATURE
- The human insulin receptor mRNA contains a functional internal ribosome entry segment
- (2009) Keith A. Spriggs et al. NUCLEIC ACIDS RESEARCH
- Crosstalk in Met receptor oncogenesis
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- Activation of the insulin receptor (IR) by insulin and a synthetic peptide has different effects on gene expression in IR-transfected L6 myoblasts
- (2008) Maja Jensen et al. BIOCHEMICAL JOURNAL
- High-Affinity Insulin Binding: Insulin Interacts with Two Receptor Ligand Binding Sites†
- (2008) Linda Whittaker et al. BIOCHEMISTRY
- Addiction to Elevated Insulin-like Growth Factor I Receptor and Initial Modulation of the AKT Pathway Define the Responsiveness of Rhabdomyosarcoma to the Targeting Antibody
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- Phosphorylated Insulin-Like Growth Factor-I/Insulin Receptor Is Present in All Breast Cancer Subtypes and Is Related to Poor Survival
- (2008) J. H. Law et al. CANCER RESEARCH
- Insulin-like Growth Factor-I-Dependent Up-regulation of ZEB1 Drives Epithelial-to-Mesenchymal Transition in Human Prostate Cancer Cells
- (2008) T. R. Graham et al. CANCER RESEARCH
- Hepatic Insulin Resistance Is Sufficient to Produce Dyslipidemia and Susceptibility to Atherosclerosis
- (2008) Sudha B. Biddinger et al. Cell Metabolism
- -Cell Dysfunction in Subjects With Impaired Glucose Tolerance and Early Type 2 Diabetes: Comparison of Surrogate Markers With First-Phase Insulin Secretion From an Intravenous Glucose Tolerance Test
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- A potential role for skeletal muscle caveolin-1 as an insulin sensitivity modulator in ageing-dependent non-obese type 2 diabetes: studies in a new mouse model
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- Insulin sensitivity measured by the euglycaemic insulin clamp and proinsulin levels as predictors of stroke in elderly men
- (2008) B. Wiberg et al. DIABETOLOGIA
- Akt2 Regulation of Cdc2-Like Kinases (Clk/Sty), Serine/Arginine-Rich (SR) Protein Phosphorylation, and Insulin-Induced Alternative Splicing of PKCβII Messenger Ribonucleic Acid
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- Changes in insulin and IGF-I receptor expression during differentiation of human preadipocytes
- (2008) Karolina Bäck et al. GROWTH HORMONE & IGF RESEARCH
- Grb10/Nedd4-mediated multiubiquitination of the insulin-like growth factor receptor regulates receptor internalization
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- Normal Values of Circulating Insulin-Like Growth Factor-I Bioactivity in the Healthy Population: Comparison with Five Widely Used IGF-I Immunoassays
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- Potentially important microRNA cluster on chromosome 17p13.1 in primary peritoneal carcinoma
- (2008) Richard J Flavin et al. MODERN PATHOLOGY
- SRp20 and CUG-BP1 Modulate Insulin Receptor Exon 11 Alternative Splicing
- (2008) S. Sen et al. MOLECULAR AND CELLULAR BIOLOGY
- Suppression of non-small cell lung tumor development by the let-7 microRNA family
- (2008) M. S. Kumar et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Functionally significant insulin-like growth factor I receptor mutations in centenarians
- (2008) Y. Suh et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Insulin receptor expression by human prostate cancers
- (2008) Michael E. Cox et al. PROSTATE
- Lin-28 interaction with the Let-7 precursor loop mediates regulated microRNA processing
- (2008) M. A. Newman et al. RNA
- Hyper-insulinaemia and cancer, meta-analyses of epidemiological studies
- (2008) Paola Pisani ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
- Proliferative effects of insulin analogues on mammary epithelial cells
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- Insulin-Like Signaling, Nutrient Homeostasis, and Life Span
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- N-linked glycans of the human insulin receptor and their distribution over the crystal structure
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