Ketoisocaproic acid, a metabolite of leucine, suppresses insulin-stimulated glucose transport in skeletal muscle cells in a BCAT2-dependent manner

Pharmacological inhibition of S6K1 increases glucose metabolism and Akt signalling in vitro and in diet-induced obese mice

(2016) Michael Shum et al.   DIABETOLOGIA

Effects of intraduodenal infusion of the branched-chain amino acid leucine on ad libitum eating, gut motor and hormone functions, and glycemia in healthy men

(2015) Robert E Steinert et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

A Nutritional Formula Enriched With Arginine, Zinc, and Antioxidants for the Healing of Pressure Ulcers

(2015) Emanuele Cereda et al.   ANNALS OF INTERNAL MEDICINE

Metabolite profiling in plasma and tissues of ob/ob and db/db mice identifies novel markers of obesity and type 2 diabetes

(2015) Pieter Giesbertz et al.   DIABETOLOGIA

Protein–Leucine Fed Dose Effects on Muscle Protein Synthesis after Endurance Exercise

(2015) DAVID S. ROWLANDS et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Pharmacogenetic influence of eNOS gene variant on endothelial and glucose metabolism responses to L-arginine supplementation: Post hoc analysis of the L-arginine trial

(2015) Lucilla D. Monti et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Leucine facilitates the insulin-stimulated glucose uptake and insulin signaling in skeletal muscle cells: involving mTORC1 and mTORC2

(2014) Hui Liu et al.   AMINO ACIDS

Protein Ingestion Induces Muscle Insulin Resistance Independent of Leucine-Mediated mTOR Activation

(2014) Gordon I. Smith et al.   DIABETES

Impaired Adiponectin Signaling Contributes to Disturbed Catabolism of Branched-Chain Amino Acids in Diabetic Mice

(2014) Kun Lian et al.   DIABETES

High dietary protein intake, reducing or eliciting insulin resistance?

(2014) A Rietman et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Branched-chain amino acids in metabolic signalling and insulin resistance

(2014) Christopher J. Lynch et al.   Nature Reviews Endocrinology

Leucine supplementation of a low-protein mixed macronutrient beverage enhances myofibrillar protein synthesis in young men: a double-blind, randomized trial

(2013) Tyler A Churchward-Venne et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Cooperation between brain and islet in glucose homeostasis and diabetes

(2013) Michael W. Schwartz et al.   NATURE

Dietary protein – its role in satiety, energetics, weight loss and health

(2012) Margriet S. Westerterp-Plantenga et al.   BRITISH JOURNAL OF NUTRITION

Emerging Perspectives on Essential Amino Acid Metabolism in Obesity and the Insulin-Resistant State

(2012) Sean H. Adams   Advances in Nutrition

Skeletal muscle protein synthesis and the abundance of the mRNA translation initiation repressor PDCD4 are inversely regulated by fasting and refeeding in rats

(2011) Sana Zargar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

An amino acid mixture enhances insulin-stimulated glucose uptake in isolated rat epitrochlearis muscle

(2011) Maximilian Kleinert et al.   JOURNAL OF APPLIED PHYSIOLOGY

Dietary Leucine - An Environmental Modifier of Insulin Resistance Acting on Multiple Levels of Metabolism

(2011) Yazmin Macotela et al.   PLoS One

Insulin resistance, lipotoxicity, type 2 diabetes and atherosclerosis: the missing links. The Claude Bernard Lecture 2009

(2010) R. A. DeFronzo   DIABETOLOGIA

Transamination Is Required for α-Ketoisocaproate but Not Leucine to Stimulate Insulin Secretion

(2010) Yingsheng Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Leucine and α-Ketoisocaproic Acid, but Not Norleucine, Stimulate Skeletal Muscle Protein Synthesis in Neonatal Pigs

(2010) Jeffery Escobar et al.   JOURNAL OF NUTRITION

Role of Reactive Oxygen Species in the Progression of Type 2 Diabetes and Atherosclerosis

(2010) Hideaki Kaneto et al.   MEDIATORS OF INFLAMMATION

Amino acids influence the glucose uptake through GLUT4 in CHO-K1 cells under high glucose conditions

(2010) Radhakrishnan Selvi et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Dietary Protein, Weight Loss, and Weight Maintenance

(2009) M.S. Westerterp-Plantenga et al.   Annual Review of Nutrition

A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance

(2009) Christopher B. Newgard et al.   Cell Metabolism

Leucine modulates contraction- and insulin-stimulated glucose transport and upstream signaling events in rat skeletal muscle

(2009) Nobumasa Iwanaka et al.   JOURNAL OF APPLIED PHYSIOLOGY

Decreased enzyme activity and contents of hepatic branched-chain α-keto acid dehydrogenase complex subunits in a rat model for type 2 diabetes mellitus

(2009) Gustavo Bajotto et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

High protein diets decrease total and abdominal fat and improve CVD risk profile in overweight and obese men and women with elevated triacylglycerol

(2009) P.M. Clifton et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Skeletal muscle insulin resistance: role of inflammatory cytokines and reactive oxygen species

(2007) Yongzhong Wei et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY