A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance

Metabolite profiling in plasma and tissues of ob/ob and db/db mice identifies novel markers of obesity and type 2 diabetes

(2015) Pieter Giesbertz et al.   DIABETOLOGIA

Hepatic insulin signalling is dispensable for suppression of glucose output by insulin in vivo

(2015) Paul M. Titchenell et al.   Nature Communications

Metabolomic Analysis of the Skeletal Muscle of Mice Overexpressing PGC-1α

(2015) Yukino Hatazawa et al.   PLoS One

Endothelial PGC-1α Mediates Vascular Dysfunction in Diabetes

(2014) Naoki Sawada et al.   Cell Metabolism

β-Aminoisobutyric Acid Induces Browning of White Fat and Hepatic β-Oxidation and Is Inversely Correlated with Cardiometabolic Risk Factors

(2014) Lee D. Roberts et al.   Cell Metabolism

Analysis of Skeletal Muscle Gene Expression Patterns and the Impact of Functional Capacity in Patients With Systolic Heart Failure

(2014) Daniel E. Forman et al.   JOURNAL OF CARDIAC FAILURE

The many roles of PGC-1α in muscle — recent developments

(2014) Mun Chun Chan et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Ectopic Fat in Insulin Resistance, Dyslipidemia, and Cardiometabolic Disease

(2014) Gerald I. Shulman   NEW ENGLAND JOURNAL OF MEDICINE

Disconnecting Mitochondrial Content from Respiratory Chain Capacity in PGC-1-Deficient Skeletal Muscle

(2013) Glenn C. Rowe et al.   Cell Reports

Real-Time Noninvasive Imaging of Fatty Acid Uptake in Vivo

(2012) Amy H. Henkin et al.   ACS Chemical Biology

Vascular endothelial hyperpermeability induces the clinical symptoms of Clarkson disease (the systemic capillary leak syndrome)

(2012) Z. Xie et al.   BLOOD

Interplay between Lipids and Branched-Chain Amino Acids in Development of Insulin Resistance

(2012) Christopher B. Newgard   Cell Metabolism

Metabolite profiles and the risk of developing diabetes

(2011) Thomas J Wang et al.   NATURE MEDICINE

Vascular endothelial growth factor B controls endothelial fatty acid uptake

(2010) Carolina E. Hagberg et al.   NATURE

A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance

(2009) Christopher B. Newgard et al.   Cell Metabolism

HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1α

(2008) Zoltan Arany et al.   NATURE

Paradoxical effects of increased expression of PGC-1  on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism

(2008) C. S. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA