标题
The Role of Mammalian Target of Rapamycin (mTOR) in Insulin Signaling
作者
关键词
-
出版物
Nutrients
Volume 9, Issue 11, Pages 1176
出版商
MDPI AG
发表日期
2017-10-27
DOI
10.3390/nu9111176
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Interferon alpha impairs insulin production in human beta cells via endoplasmic reticulum stress
- (2017) Angela Lombardi et al. JOURNAL OF AUTOIMMUNITY
- mTOR controls ChREBP transcriptional activity and pancreatic β cell survival under diabetic stress
- (2017) Gia Cac Chau et al. JOURNAL OF CELL BIOLOGY
- Autophagy in the liver: functions in health and disease
- (2017) Takashi Ueno et al. Nature Reviews Gastroenterology & Hepatology
- mTORC2 Puts Its Shoulder to Krebs’ Wheel
- (2016) Sebastian I. Arriola Apelo et al. MOLECULAR CELL
- The Emerging Role of Branched-Chain Amino Acids in Insulin Resistance and Metabolism
- (2016) Mee-Sup Yoon Nutrients
- Leucyl-tRNA Synthetase Activates Vps34 in Amino Acid-Sensing mTORC1 Signaling
- (2016) Mee-Sup Yoon et al. Cell Reports
- mTOR coordinates protein synthesis, mitochondrial activity and proliferation
- (2015) Masahiro Morita et al. CELL CYCLE
- mTORC2 promotes type I insulin-like growth factor receptor and insulin receptor activation through the tyrosine kinase activity of mTOR
- (2015) Yancun Yin et al. CELL RESEARCH
- Rapid Mitogenic Regulation of the mTORC1 Inhibitor, DEPTOR, by Phosphatidic Acid
- (2015) Mee-Sup Yoon et al. MOLECULAR CELL
- Nutrient-sensing mechanisms and pathways
- (2015) Alejo Efeyan et al. NATURE
- A Positive Feedback Loop between Akt and mTORC2 via SIN1 Phosphorylation
- (2015) Guang Yang et al. Cell Reports
- Sestrins Function as Guanine Nucleotide Dissociation Inhibitors for Rag GTPases to Control mTORC1 Signaling
- (2014) Min Peng et al. CELL
- Spatial Control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome
- (2014) Suchithra Menon et al. CELL
- Mitophagy mechanisms and role in human diseases
- (2014) Matthew Redmann et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Making new contacts: the mTOR network in metabolism and signalling crosstalk
- (2014) Mitsugu Shimobayashi et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Stoichiometry and assembly of mTOR complexes revealed by single-molecule pulldown
- (2014) Ankur Jain et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Sestrins Interact with GATOR2 to Negatively Regulate the Amino-Acid-Sensing Pathway Upstream of mTORC1
- (2014) Lynne Chantranupong et al. Cell Reports
- Regulation of PIK3C3/VPS34 complexes by MTOR in nutrient stress-induced autophagy
- (2013) Hai-Xin Yuan et al. Autophagy
- Molecular and Genetic Crosstalks between mTOR and ERRα Are Key Determinants of Rapamycin-Induced Nonalcoholic Fatty Liver
- (2013) Cédric Chaveroux et al. Cell Metabolism
- The multifaceted role of mTORC1 in the control of lipid metabolism
- (2013) Stéphane J H Ricoult et al. EMBO REPORTS
- mTOR complex 2 phosphorylates IMP1 cotranslationally to promote IGF2 production and the proliferation of mouse embryonic fibroblasts
- (2013) N. Dai et al. GENES & DEVELOPMENT
- Recruitment of folliculin to lysosomes supports the amino acid–dependent activation of Rag GTPases
- (2013) Constance S. Petit et al. JOURNAL OF CELL BIOLOGY
- Insulin signaling, resistance, and metabolic syndrome: insights from mouse models into disease mechanisms
- (2013) Shaodong Guo JOURNAL OF ENDOCRINOLOGY
- The Folliculin Tumor Suppressor Is a GAP for the RagC/D GTPases That Signal Amino Acid Levels to mTORC1
- (2013) Zhi-Yang Tsun et al. MOLECULAR CELL
- ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase
- (2013) Ryan C. Russell et al. NATURE CELL BIOLOGY
- Signal integration by mTORC1 coordinates nutrient input with biosynthetic output
- (2013) Christian C. Dibble et al. NATURE CELL BIOLOGY
- A Tumor Suppressor Complex with GAP Activity for the Rag GTPases That Signal Amino Acid Sufficiency to mTORC1
- (2013) L. Bar-Peled et al. SCIENCE
- Amino Acid Deprivation Inhibits TORC1 Through a GTPase-Activating Protein Complex for the Rag Family GTPase Gtr1
- (2013) N. Panchaud et al. Science Signaling
- MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB
- (2012) Jose A. Martina et al. Autophagy
- Regulation of the Hippo-YAP Pathway by G-Protein-Coupled Receptor Signaling
- (2012) Fa-Xing Yu et al. CELL
- Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1
- (2012) Liron Bar-Peled et al. CELL
- mTOR Signaling in Growth Control and Disease
- (2012) Mathieu Laplante et al. CELL
- Hepatic mTORC2 Activates Glycolysis and Lipogenesis through Akt, Glucokinase, and SREBP1c
- (2012) Asami Hagiwara et al. Cell Metabolism
- Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2
- (2012) K. D. Copps et al. DIABETOLOGIA
- A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB
- (2012) Carmine Settembre et al. EMBO JOURNAL
- Major involvement of mTOR in the PPARγ-induced stimulation of adipose tissue lipid uptake and fat accretion
- (2012) Pierre-Gilles Blanchard et al. JOURNAL OF LIPID RESEARCH
- mTOR Complex 2 Regulates Proper Turnover of Insulin Receptor Substrate-1 via the Ubiquitin Ligase Subunit Fbw8
- (2012) Sung Jin Kim et al. MOLECULAR CELL
- TBC1D7 Is a Third Subunit of the TSC1-TSC2 Complex Upstream of mTORC1
- (2012) Christian C. Dibble et al. MOLECULAR CELL
- YAP mediates crosstalk between the Hippo and PI(3)K–TOR pathways by suppressing PTEN via miR-29
- (2012) Karen Tumaneng et al. NATURE CELL BIOLOGY
- Insulin stimulation of SREBP-1c processing in transgenic rat hepatocytes requires p70 S6-kinase
- (2012) J. L. Owen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A Dynamic Network Model of mTOR Signaling Reveals TSC-Independent mTORC2 Regulation
- (2012) P. Dalle Pezze et al. Science Signaling
- The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis
- (2012) A. Roczniak-Ferguson et al. Science Signaling
- Role of S6K1 in regulation of SREBP1c expression in the liver
- (2011) Shuying Li et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Activation of mTORC2 by Association with the Ribosome
- (2011) Vittoria Zinzalla et al. CELL
- mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway
- (2011) Timothy R. Peterson et al. CELL
- mTOR signaling: PLD takes center stage
- (2011) Yuting Sun et al. CELL CYCLE
- mTOR complex 2 signaling and functions
- (2011) Won Jun Oh et al. CELL CYCLE
- Akt Stimulates Hepatic SREBP1c and Lipogenesis through Parallel mTORC1-Dependent and Independent Pathways
- (2011) Jessica L. Yecies et al. Cell Metabolism
- Rictor/mTORC2 Is Essential for Maintaining a Balance Between β-Cell Proliferation and Cell Size
- (2011) Yanyun Gu et al. DIABETES
- Phosphatidic Acid Activates Mammalian Target of Rapamycin Complex 1 (mTORC1) Kinase by Displacing FK506 Binding Protein 38 (FKBP38) and Exerting an Allosteric Effect
- (2011) Mee-Sup Yoon et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Class III PI-3-kinase activates phospholipase D in an amino acid–sensing mTORC1 pathway
- (2011) Mee-Sup Yoon et al. JOURNAL OF CELL BIOLOGY
- l-Arginine is essential for pancreatic β-cell functional integrity, metabolism and defense from inflammatory challenge
- (2011) Mauricio S Krause et al. JOURNAL OF ENDOCRINOLOGY
- Rac1 Regulates the Activity of mTORC1 and mTORC2 and Controls Cellular Size
- (2011) Abdelhafid Saci et al. MOLECULAR CELL
- The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal
- (2011) Bin Zhao et al. NATURE CELL BIOLOGY
- AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
- (2011) Joungmok Kim et al. NATURE CELL BIOLOGY
- The mammalian target of rapamycin regulates cholesterol biosynthetic gene expression and exhibits a rapamycin-resistant transcriptional profile
- (2011) B. T. Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling
- (2011) P. P. Hsu et al. SCIENCE
- The emerging role of autophagy in the pathophysiology of diabetes mellitus
- (2010) Claudio D. Gonzalez et al. Autophagy
- Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids
- (2010) Yasemin Sancak et al. CELL
- Irs1 Serine 307 Promotes Insulin Sensitivity in Mice
- (2010) Kyle D. Copps et al. Cell Metabolism
- Fat Cell-Specific Ablation of Rictor in Mice Impairs Insulin-Regulated Fat Cell and Whole-Body Glucose and Lipid Metabolism
- (2010) A. Kumar et al. DIABETES
- Mammalian Target of Rapamycin Complex 1 Suppresses Lipolysis, Stimulates Lipogenesis, and Promotes Fat Storage
- (2010) P. Chakrabarti et al. DIABETES
- Chronic Rapamycin Treatment Causes Glucose Intolerance and Hyperlipidemia by Upregulating Hepatic Gluconeogenesis and Impairing Lipid Deposition in Adipose Tissue
- (2010) V. P. Houde et al. DIABETES
- Role of autophagy in β-cell function and mass
- (2010) K. Y. Hur et al. DIABETES OBESITY & METABOLISM
- mTORC1 Inhibition via Rapamycin Promotes Triacylglycerol Lipolysis and Release of Free Fatty Acids in 3T3-L1 Adipocytes
- (2010) Ghada A. Soliman et al. LIPIDS
- Structure of the Human mTOR Complex I and Its Implications for Rapamycin Inhibition
- (2010) Calvin K. Yip et al. MOLECULAR CELL
- Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1
- (2010) Katrin Düvel et al. MOLECULAR CELL
- Unknown
- (2010) Anita Ost et al. MOLECULAR MEDICINE
- mTORC1 controls fasting-induced ketogenesis and its modulation by ageing
- (2010) Shomit Sengupta et al. NATURE
- Autophagy and Metabolism
- (2010) J. D. Rabinowitz et al. SCIENCE
- Amino acid-sensing mTOR signaling is involved in modulation of lipolysis by chronic insulin treatment in adipocytes
- (2009) Chongben Zhang et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance
- (2009) Christopher B. Newgard et al. Cell Metabolism
- mTOR and the control of whole body metabolism
- (2009) Pazit Polak et al. CURRENT OPINION IN CELL BIOLOGY
- Raptor Binds the SAIN (Shc and IRS-1 NPXY Binding) Domain of Insulin Receptor Substrate-1 (IRS-1) and Regulates the Phosphorylation of IRS-1 at Ser-636/639 by mTOR
- (2009) Alexandros Tzatsos JOURNAL OF BIOLOGICAL CHEMISTRY
- A Phosphorylation Cascade Controls the Degradation of Active SREBP1
- (2009) Maria T. Bengoechea-Alonso et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- TOR complex 2: a signaling pathway of its own
- (2009) Nadine Cybulski et al. TRENDS IN BIOCHEMICAL SCIENCES
- Loss of Autophagy Diminishes Pancreatic β Cell Mass and Function with Resultant Hyperglycemia
- (2008) Hye Seung Jung et al. Cell Metabolism
- SREBP Activity Is Regulated by mTORC1 and Contributes to Akt-Dependent Cell Growth
- (2008) Thomas Porstmann et al. Cell Metabolism
- Amino Acids Activate mTOR Complex 1 via Ca2+/CaM Signaling to hVps34
- (2008) Pawan Gulati et al. Cell Metabolism
- Autophagy Is Important in Islet Homeostasis and Compensatory Increase of Beta Cell Mass in Response to High-Fat Diet
- (2008) Chie Ebato et al. Cell Metabolism
- S6K Directly Phosphorylates IRS-1 on Ser-270 to Promote Insulin Resistance in Response to TNF-α Signaling through IKK2
- (2008) Jin Zhang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Regulation of mTORC1 and mTORC2 Complex Assembly by Phosphatidic Acid: Competition with Rapamycin
- (2008) A. Toschi et al. MOLECULAR AND CELLULAR BIOLOGY
- The TSC1-TSC2 Complex Is Required for Proper Activation of mTOR Complex 2
- (2008) J. Huang et al. MOLECULAR AND CELLULAR BIOLOGY
- Interplay and Effects of Temporal Changes in the Phosphorylation State of Serine-302, -307, and -318 of Insulin Receptor Substrate-1 on Insulin Action in Skeletal Muscle Cells
- (2008) Cora Weigert et al. MOLECULAR ENDOCRINOLOGY
- Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2
- (2008) Jinhua Wu et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1
- (2008) Y. Sancak et al. SCIENCE
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search