Directed Evolution of l-Threonine Aldolase for the Diastereoselective Synthesis of β-Hydroxy-α-amino Acids
出版年份 2021 全文链接
标题
Directed Evolution of l-Threonine Aldolase for the Diastereoselective Synthesis of β-Hydroxy-α-amino Acids
作者
关键词
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出版物
ACS Catalysis
Volume -, Issue -, Pages 3198-3205
出版商
American Chemical Society (ACS)
发表日期
2021-02-26
DOI
10.1021/acscatal.0c04949
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Construction of a Highly Diastereoselective Aldol Reaction System with l-Threonine Aldolase by Computer-Assisted Rational Molecular Modification and Medium Engineering
- (2020) Wenlong Zheng et al. ORGANIC LETTERS
- High-Throughput Screening Method for Directed Evolution and Characterization of Aldol Activity of D-Threonine Aldolase
- (2020) Lei Gong et al. APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
- Improving and Inverting Cβ-Stereoselectivity of Threonine Aldolase via Substrate-Binding-Guided Mutagenesis and a Stepwise Visual Screening
- (2019) Qijia Chen et al. ACS Catalysis
- The Crucial Role of Methodology Development in Directed Evolution of Selective Enzymes
- (2019) Ge Qu et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Comparison of L-Threonine Aldolase Variants in the Aldol and Retro-Aldol Reactions
- (2019) Kateryna Fesko Frontiers in Bioengineering and Biotechnology
- Identification and application of threonine aldolase for synthesis of valuable α-amino, β-hydroxy-building blocks
- (2019) Mathieu Ligibel et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- P450-Catalyzed Regio- and Diastereoselective Steroid Hydroxylation: Efficient Directed Evolution Enabled by Mutability Landscaping
- (2018) Carlos G. Acevedo-Rocha et al. ACS Catalysis
- Exploiting correlated molecular-dynamics networks to counteract enzyme activity–stability trade-off
- (2018) Haoran Yu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Coupled molecular dynamics mediate long- and short-range epistasis between mutations that affect stability and aggregation kinetics
- (2018) Haoran Yu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- An L-threonine transaldolase is required for L-threo-β-hydroxy-α-amino acid assembly during obafluorin biosynthesis
- (2017) Thomas A. Scott et al. Nature Communications
- Threonine aldolases: perspectives in engineering and screening the enzymes with enhanced substrate and stereo specificities
- (2016) Kateryna Fesko APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
- Comparing Different Strategies in Directed Evolution of Enzyme Stereoselectivity: Single- versus Double-Code Saturation Mutagenesis
- (2016) Zhoutong Sun et al. CHEMBIOCHEM
- SAAMBE: Webserver to Predict the Charge of Binding Free Energy Caused by Amino Acids Mutations
- (2016) Marharyta Petukh et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Structure-Guided Triple-Code Saturation Mutagenesis: Efficient Tuning of the Stereoselectivity of an Epoxide Hydrolase
- (2016) Zhoutong Sun et al. ACS Catalysis
- Catalytic Asymmetric Reduction of Difficult-to-Reduce Ketones: Triple-Code Saturation Mutagenesis of an Alcohol Dehydrogenase
- (2016) Zhoutong Sun et al. ACS Catalysis
- Multiparameter Optimization in Directed Evolution: Engineering Thermostability, Enantioselectivity, and Activity of an Epoxide Hydrolase
- (2016) Guangyue Li et al. ACS Catalysis
- Reshaping an Enzyme Binding Pocket for Enhanced and Inverted Stereoselectivity: Use of Smallest Amino Acid Alphabets in Directed Evolution
- (2015) Zhoutong Sun et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Computer-Assisted Rational Modifications to Improve the Thermostability of β-Glucosidase from Penicillium piceum H16
- (2015) Zhiyou Zong et al. BioEnergy Research
- L-allo-Threonine aldolase with an H128Y/S292R mutation fromAeromonas jandaeiDK-39 reveals the structural basis of changes in substrate stereoselectivity
- (2014) Hui-Min Qin et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- On the catalytic mechanism and stereospecificity ofEscherichia colil-threonine aldolase
- (2013) Martino L. di Salvo et al. FEBS Journal
- Gradually accumulating beneficial mutations to improve the thermostability of N-carbamoyl-d-amino acid amidohydrolase by step-wise evolution
- (2011) Dalong Zhang et al. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
- Threonine aldolases—screening, properties and applications in the synthesis of non-proteinogenic β-hydroxy-α-amino acids
- (2010) Nina Dückers et al. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
- Finding better protein engineering strategies
- (2009) Romas J Kazlauskas et al. Nature Chemical Biology
- Improving the thermostability of N-carbamyl-d-amino acid amidohydrolase by error-prone PCR
- (2008) Hong Yu et al. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
- Addressing the Numbers Problem in Directed Evolution
- (2008) Manfred T. Reetz et al. CHEMBIOCHEM
- Four types of threonine aldolases: Similarities and differences in kinetics/thermodynamics
- (2007) Kateryna Fesko et al. JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC
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