Recent Advances in ω-Transaminase-Mediated Biocatalysis for the Enantioselective Synthesis of Chiral Amines

Covalently immobilized Trp60Cys mutant of ω-transaminase from Chromobacterium violaceum for kinetic resolution of racemic amines in batch and continuous-flow modes

(2018) Emese Abaházi et al.   BIOCHEMICAL ENGINEERING JOURNAL

Biosynthesis of the Nylon 12 Monomer, ω-Aminododecanoic Acid with Novel CYP153A, AlkJ, and ω-TA Enzymes

(2018) Md. Murshidul Ahsan et al.   Biotechnology Journal

Transaminases for chiral amine synthesis

(2018) Andrew Gomm et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Editorial overview: Biocatalysis and biotransformation: The golden age of biocatalysis

(2018) Nicholas J Turner et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Multienzyme Cascade Reactions—Status and Recent Advances

(2018) Josef M. Sperl et al.   ACS Catalysis

Biosynthesis of the Nylon 12 Monomer, ω-Aminododecanoic Acid with Novel CYP153A, AlkJ, and ω-TA Enzymes

(2018) Md. Murshidul Ahsan et al.   Biotechnology Journal

A Novel highly thermostable branched-chain amino acid aminotransferase from the crenarchaeon Vulcanisaeta moutnovskia

(2017) Tatiana N. Stekhanova et al.   ENZYME AND MICROBIAL TECHNOLOGY

Transaminase biocatalysis: optimization and application

(2017) Fei Guo et al.   GREEN CHEMISTRY

Stereoselective amination of racemic sec-alcohols through sequential application of laccases and transaminases

(2017) Lía Martínez-Montero et al.   GREEN CHEMISTRY

A metagenomics approach for new biocatalyst discovery: application to transaminases and the synthesis of allylic amines

(2017) Damien Baud et al.   GREEN CHEMISTRY

Biocatalytic transamination with near-stoichiometric inexpensive amine donors mediated by bifunctional mono- and di-amine transaminases

(2017) James L. Galman et al.   GREEN CHEMISTRY

Immobilization of R -ω-transaminase on MnO 2 nanorods for catalyzing the conversion of ( R )-1-phenylethylamine

(2017) Jian Sun et al.   JOURNAL OF BIOTECHNOLOGY

The fourth wave of biocatalysis is approaching

(2017) Uwe T. Bornscheuer   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES

Characterization of a ( R )-selective amine transaminase from Fusarium oxysporum

(2017) Shuaihua Gao et al.   PROCESS BIOCHEMISTRY

Development of a miniaturized packed bed reactor with ω -transaminase immobilized in LentiKats ®

(2017) Marijan Bajić et al.   PROCESS BIOCHEMISTRY

Surfactant-mediated permeabilization of Pseudomonas putida KT2440 and use of the immobilized permeabilized cells in biotransformation

(2017) Mahesh D. Patil et al.   PROCESS BIOCHEMISTRY

Asymmetric synthesis of serinol-monoesters catalyzed by amine transaminases

(2017) Ingrid C.R. Costa et al.   TETRAHEDRON-ASYMMETRY

Amine transaminases in chiral amines synthesis: recent advances and challenges

(2017) Erica E. Ferrandi et al.   WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY

Biocatalysis in the Pharmaceutical Industry: The Need for Speed

(2017) Matthew D. Truppo   ACS Medicinal Chemistry Letters

Enzyme Cascades in Whole Cells for the Synthesis of Chiral Cyclic Amines

(2017) Lorna J. Hepworth et al.   ACS Catalysis

Discovery, Engineering, and Synthetic Application of Transaminase Biocatalysts

(2017) Iustina Slabu et al.   ACS Catalysis

Explaining Operational Instability of Amine Transaminases: Substrate-Induced Inactivation Mechanism and Influence of Quaternary Structure on Enzyme–Cofactor Intermediate Stability

(2017) Tim Börner et al.   ACS Catalysis

Biosynthesis of Medium- to Long-Chain α,ω-Diols from Free Fatty Acids Using CYP153A Monooxygenase, Carboxylic Acid Reductase, and E. coli Endogenous Aldehyde Reductases

(2017) Md Ahsan et al.   Catalysts

Characterization of Four New Distinct ω-Transaminases from Pseudomonas putida NBRC 14164 for Kinetic Resolution of Racemic Amines and Amino Alcohols

(2016) Hua-Lei Wu et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Enzymatic network for production of ether amines from alcohols

(2016) Cyntia M. Palacio et al.   BIOTECHNOLOGY AND BIOENGINEERING

Biotransformation of β-keto nitriles to chiral (S)-β-amino acids using nitrilase and ω-transaminase

(2016) Sam Mathew et al.   BIOTECHNOLOGY LETTERS

A New Generation of Smart Amine Donors for Transaminase-Mediated Biotransformations

(2016) Andrew Gomm et al.   CHEMISTRY-A EUROPEAN JOURNAL

Highly engineered biocatalysts for efficient small molecule pharmaceutical synthesis

(2016) Jim Lalonde   CURRENT OPINION IN BIOTECHNOLOGY

Biochemical characterization of thermostable ω-transaminase from Sphaerobacter thermophilus and its application for producing aromatic β- and γ-amino acids

(2016) Sam Mathew et al.   ENZYME AND MICROBIAL TECHNOLOGY

Thermodynamics of the alanine aminotransferase reaction

(2016) Matthias Voges et al.   FLUID PHASE EQUILIBRIA

An improved process for biocatalytic asymmetric amine synthesis by in situ product removal using a supported liquid membrane

(2016) Gustav Rehn et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Stabilization of an amine transaminase for biocatalysis

(2016) Shan Chen et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Identification of (S)-selective transaminases for the asymmetric synthesis of bulky chiral amines

(2016) Ioannis V. Pavlidis et al.   Nature Chemistry

Protein-engineering of an amine transaminase for the stereoselective synthesis of a pharmaceutically relevant bicyclic amine

(2016) Martin S. Weiß et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Substrate screening of amino transaminase for the synthesis of a sitagliptin intermediate

(2016) Anwei Hou et al.   TETRAHEDRON

Biocatalytic Transamination for the Asymmetric Synthesis of Pyridylalkylamines. Structural and Activity Features in the Reactivity of Transaminases

(2016) María López-Iglesias et al.   ACS Catalysis

Constructing Biocatalytic Cascades: In Vitro and in Vivo Approaches to de Novo Multi-Enzyme Pathways

(2016) Scott P. France et al.   ACS Catalysis

Rational Design of a (S)-Selective-Transaminase for Asymmetric Synthesis of (1S)-1-(1,1′-biphenyl-2-yl)ethanamine

(2016) Daniel F. A. R. Dourado et al.   ACS Catalysis

Cellulose as an efficient matrix for lipase and transaminase immobilization

(2016) Stefânia P. de Souza et al.   RSC Advances

Identification of novel thermostable ω-transaminase and its application for enzymatic synthesis of chiral amines at high temperature

(2016) Sam Mathew et al.   RSC Advances

Active-Site Engineering of ω-Transaminase for Production of Unnatural Amino Acids Carrying a Side Chain Bulkier than an Ethyl Substituent

(2015) Sang-Woo Han et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Identification of novel thermostable taurine–pyruvate transaminase from Geobacillus thermodenitrificans for chiral amine synthesis

(2015) Yujie Chen et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

One-step purification and immobilization of his-tagged protein via Ni2+-functionalized Fe3O4@polydopamine magnetic nanoparticles

(2015) Jianbing Yang et al.   BIOTECHNOLOGY AND BIOPROCESS ENGINEERING

Engineering the Active Site of the Amine Transaminase fromVibrio fluvialisfor the Asymmetric Synthesis of Aryl-Alkyl Amines and Amino Alcohols

(2015) Alberto Nobili et al.   ChemCatChem

The Industrial Age of Biocatalytic Transamination

(2015) Michael Fuchs et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

A system for ω-transaminase mediated (R)-amination using l-alanine as an amine donor

(2015) N. Richter et al.   GREEN CHEMISTRY

Biocatalytic cascade reactions for asymmetric synthesis of aliphatic amino acids in a biphasic reaction system

(2015) Eul-Soo Park et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Characterization of a novel amine transaminase from Halomonas elongata

(2015) Lorenzo Cerioli et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Immobilisation of ω-transaminase for industrial application: Screening and characterisation of commercial ready to use enzyme carriers

(2015) Watson Neto et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Stereoselective Cascade to C3-Methylated Strictosidine Derivatives Employing Transaminases and Strictosidine Synthases

(2015) Eva-Maria Fischereder et al.   ACS Catalysis

Cutting Short the Asymmetric Synthesis of the Ramatroban Precursor by Employing ω-Transaminases

(2014) Eduardo Busto et al.   ADVANCED SYNTHESIS & CATALYSIS

Enhancing Thermostability and Organic Solvent Tolerance of ω-Transaminase through Global Incorporation of Fluorotyrosine

(2014) Kanagavel Deepankumar et al.   ADVANCED SYNTHESIS & CATALYSIS

Chiral Amine Synthesis Using ω-Transaminases: An Amine Donor that Displaces Equilibria and Enables High-Throughput Screening

(2014) Anthony P. Green et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Recent advances in biocatalyst discovery, development and applications

(2014) Guang Yang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Engineering Transaminase for Stability Enhancement and Site-Specific Immobilization through Multiple Noncanonical Amino Acids Incorporation

(2014) Kanagavel Deepankumar et al.   ChemCatChem

Recent achievements in developing the biocatalytic toolbox for chiral amine synthesis

(2014) Hannes Kohls et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

The substrate specificity, enantioselectivity and structure of the (R)-selective amine : pyruvate transaminase fromNectria haematococca

(2014) Christopher Sayer et al.   FEBS Journal

Immobilization of (R)- and (S)-amine transaminases on chitosan support and their application for amine synthesis using isopropylamine as donor

(2014) H. Mallin et al.   JOURNAL OF BIOTECHNOLOGY

Development of a Concise, Asymmetric Synthesis of a Smoothened Receptor (SMO) Inhibitor: Enzymatic Transamination of a 4-Piperidinone with Dynamic Kinetic Resolution

(2014) Zhihui Peng et al.   ORGANIC LETTERS

Structural studies ofPseudomonasandChromobacteriumω-aminotransferases provide insights into their differing substrate specificity

(2013) Christopher Sayer et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

A model to assess the feasibility of shifting reaction equilibrium by acetone removal in the transamination of ketones using 2-propylamine

(2013) Pär Tufvesson et al.   BIOTECHNOLOGY AND BIOENGINEERING

One-pot one-step deracemization of amines using ω-transaminases

(2013) Giyoung Shin et al.   CHEMICAL COMMUNICATIONS

Characterization and multi-step transketolase-ω-transaminase bioconversions in an immobilized enzyme microreactor (IEMR) with packed tube

(2013) Amanatuzzakiah Abdul Halim et al.   JOURNAL OF BIOTECHNOLOGY

A Practical Method for the Synthesis of Highly Enantioenriched trans-1,2-Amino Alcohols

(2013) James A. Birrell et al.   ORGANIC LETTERS

Process Development of C–N Cross-Coupling and Enantioselective Biocatalytic Reactions for the Asymmetric Synthesis of Niraparib

(2013) Cheol K. Chung et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Asymmetric Preparation of prim-, sec-, and tert-Amines Employing Selected Biocatalysts

(2013) Wolfgang Kroutil et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Biocatalytic Approaches to the Synthesis of Enantiomerically Pure Chiral Amines

(2013) Diego Ghislieri et al.   TOPICS IN CATALYSIS

Recent Developments of Cascade Reactions Involving ω-Transaminases

(2013) Robert C. Simon et al.   ACS Catalysis

Strategies for Stabilization of Enzymes in Organic Solvents

(2013) Veronika Stepankova et al.   ACS Catalysis

Immobilization of Escherichia coli containing ω-transaminase activity in LentiKats®

(2012) Max Cárdenas-Fernández et al.   BIOTECHNOLOGY PROGRESS

Immobilization of two (R)-Amine Transaminases on an Optimized Chitosan Support for the Enzymatic Synthesis of Optically Pure Amines

(2012) Hendrik Mallin et al.   ChemCatChem

Revealing the Structural Basis of Promiscuous Amine Transaminase Activity

(2012) Fabian Steffen-Munsberg et al.   ChemCatChem

Development of an Immobilized Transaminase Capable of Operating in Organic Solvent

(2012) Matthew D. Truppo et al.   ChemCatChem

Connecting Unexplored Protein Crystal Structures to Enzymatic Function

(2012) Fabian Steffen-Munsberg et al.   ChemCatChem

ω-Transaminase-catalyzed kinetic resolution of chiral amines using l-threonine as an amino acceptor precursor

(2012) M. Shaheer Malik et al.   GREEN CHEMISTRY

Activity and stability of different immobilized preparations of recombinant E. coli cells containing ω-transaminase

(2012) Gustav Rehn et al.   PROCESS BIOCHEMISTRY

Redesigning and characterizing the substrate specificity and activity of Vibrio fluvialis aminotransferase for the synthesis of imagabalin

(2012) K. S. Midelfort et al.   PROTEIN ENGINEERING DESIGN & SELECTION

ω-Transaminases for the Production of Optically Pure Amines and Unnatural Amino Acids

(2012) Sam Mathew et al.   ACS Catalysis

Amination of benzylic and cinnamic alcohols via a biocatalytic, aerobic, oxidation–transamination cascade

(2012) Michael Fuchs et al.   RSC Advances

Sitagliptin Manufacture: A Compelling Tale of Green Chemistry, Process Intensification, and Industrial Asymmetric Catalysis

(2011) Aman A. Desai   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Industrial biotransformations in the synthesis of building blocks leading to enantiopure drugs

(2011) D. Muñoz Solano et al.   BIORESOURCE TECHNOLOGY

Purification and Characterization of a Novel (S)-Enantioselective Transaminase fromPseudomonas fluorescensKNK08-18 for the Synthesis of Optically Active Amines

(2011) Noriyuki ITO et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

New opportunities for biocatalysis: driving the synthesis of chiral chemicals

(2011) Gao-Wei Zheng et al.   CURRENT OPINION IN BIOTECHNOLOGY

Immobilised enzyme microreactor for screening of multi-step bioconversions: Characterisation of a de novo transketolase-ω-transaminase pathway to synthesise chiral amino alcohols

(2011) S. Matosevic et al.   JOURNAL OF BIOTECHNOLOGY

Necessary and sufficient conditions for the asymmetric synthesis of chiral amines using ω-aminotransferases

(2010) Joo-Hyun Seo et al.   BIOTECHNOLOGY AND BIOENGINEERING

Biocatalytic Asymmetric Synthesis of Chiral Amines from Ketones Applied to Sitagliptin Manufacture

(2010) C. K. Savile et al.   SCIENCE

ω-Transaminases for the synthesis of non-racemic α-chiral primary amines

(2010) Dominik Koszelewski et al.   TRENDS IN BIOTECHNOLOGY

Biocatalytic Routes to Optically Active Amines

(2009) Matthias Höhne et al.   ChemCatChem

Deracemisation of α-Chiral Primary Amines by a One-Pot, Two-Step Cascade Reaction Catalysed by ω-Transaminases

(2009) Dominik Koszelewski et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Immobilization of ω-transaminases by encapsulation in a sol–gel/celite matrix

(2009) Dominik Koszelewski et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Deracemization of Mexiletine Biocatalyzed by ω-Transaminases

(2009) Dominik Koszelewski et al.   ORGANIC LETTERS

A Protection Strategy Substantially Enhances Rate and Enantioselectivity in ω-Transaminase-Catalyzed Kinetic Resolutions

(2008) Matthias Höhne et al.   ADVANCED SYNTHESIS & CATALYSIS

Preparation of (R)-Amines from Racemic Amines with an (S)-Amine Transaminase fromBacillus megaterium

(2008) Ronald L. Hanson et al.   ADVANCED SYNTHESIS & CATALYSIS