The interplay between apoptosis and cellular senescence: Bcl-2 family proteins as targets for cancer therapy

Senolysis by glutaminolysis inhibition ameliorates various age-associated disorders

(2021) Yoshikazu Johmura et al.   SCIENCE

Senolytic Targeting of Bcl-2 Anti-Apoptotic Family Increases Cell Death in Irradiated Sarcoma Cells

(2021) Julie Lafontaine et al.   Cancers

Design and optimisation of dendrimer-conjugated Bcl-2/xL inhibitor, AZD0466, with improved therapeutic index for cancer therapy

(2021) Claire M. Patterson et al.   Communications Biology

Therapy-Induced Senescence Drives Bone Loss

(2020) Zhangting Yao et al.   CANCER RESEARCH

AMG-176, an Mcl-1 antagonist, shows preclinical efficacy in chronic lymphocytic leukemia

(2020) Xue Yi et al.   CLINICAL CANCER RESEARCH

Discovery and Characterization of 2,5-Substituted Benzoic Acid Dual Inhibitors of the Anti-apoptotic Mcl-1 and Bfl-1 Proteins

(2020) Karson J. Kump et al.   JOURNAL OF MEDICINAL CHEMISTRY

Regorafenib Alteration of the BCL-xL/MCL-1 Ratio Provides a Therapeutic Opportunity for BH3-Mimetics in Hepatocellular Carcinoma Models

(2020) Blanca Cucarull et al.   Cancers

BH3 mimetics selectively eliminate chemotherapy-induced senescent cells and improve response in TP53 wild-type breast cancer

(2020) Ashkan Shahbandi et al.   CELL DEATH AND DIFFERENTIATION

Dual targeting of CDK4/6 and BCL2 pathways augments tumor response in estrogen receptor positive breast cancer

(2020) James R Whittle et al.   CLINICAL CANCER RESEARCH

Design, synthesis and biological evaluation of tyrosine derivatives as Mcl-1 inhibitors

(2020) Lulu Liu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Combinatorial inhibition of focal adhesion kinase and BCL-2 enhances anti-leukemia activity of venetoclax in acute myeloid leukemia

(2020) Xiangmeng Wang et al.   MOLECULAR CANCER THERAPEUTICS

Targeting apoptosis in cancer therapy

(2020) Benedito A. Carneiro et al.   Nature Reviews Clinical Oncology

BCL-w: apoptotic and non-apoptotic role in health and disease

(2020) Mariusz L. Hartman et al.   Cell Death & Disease

Discovery of A-1331852, a First-in-Class, Potent and Orally-Bioavailable BCL-XL Inhibitor

(2020) Le Wang et al.   ACS Medicinal Chemistry Letters

Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity

(2020) Yonghan He et al.   Nature Communications

A BET family protein degrader provokes senolysis by targeting NHEJ and autophagy in senescent cells

(2020) Masahiro Wakita et al.   Nature Communications

Senolytic compounds control a distinct fate of androgen receptor agonist- and antagonist-induced cellular senescent LNCaP prostate cancer cells

(2020) Thanakorn Pungsrinont et al.   Cell and Bioscience

Bcl‐2/Bcl‐xl inhibitor APG‐1252‐M1 is a promising therapeutic strategy for gastric carcinoma

(2020) Hanjie Yi et al.   Cancer Medicine

Therapy-Induced Senescence: An “Old” Friend Becomes the Enemy

(2020) Tareq Saleh et al.   Cancers

Insights from In Vivo Studies of Cellular Senescence

(2020) Luis I. Prieto et al.   Cells

Inhibition of Anti-Apoptotic Bcl-2 Proteins in Preclinical and Clinical Studies: Current Overview in Cancer

(2020) Simona D’Aguanno et al.   Cells

Role of p53 in the Regulation of Cellular Senescence

(2020) Mahmut Mijit et al.   Biomolecules

Myeloid cell leukemin-1 inhibitors: a growing arsenal for cancer therapy

(2020) Peng-Ju Zhu et al.   DRUG DISCOVERY TODAY

Preclinical antitumor efficacy of senescence-inducing chemotherapy combined with a nanoSenolytic

(2020) Irene Galiana et al.   JOURNAL OF CONTROLLED RELEASE

DT2216—a Bcl-xL-specific degrader is highly active against Bcl-xL-dependent T cell lymphomas

(2020) Yonghan He et al.   Journal of Hematology & Oncology

Clearance of therapy‐induced senescent tumor cells by the senolytic ABT‐263 via interference with BCL‐X L –BAX interaction

(2020) Tareq Saleh et al.   Molecular Oncology

Senolytic CAR T cells reverse senescence-associated pathologies

(2020) Corina Amor et al.   NATURE

A Senescence-Centric View of Aging: Implications for Longevity and Disease

(2020) M. Borghesan et al.   TRENDS IN CELL BIOLOGY

Shrimp miR-965 induced the human melanoma stem-like cell apoptosis and inhibited their stemness by disrupting the MCL-1-ER stress-XBP1 feedback loop in a cross-species manner

(2020) Wenlin Wu et al.   Stem Cell Research & Therapy

The Premature Senescence in Breast Cancer Treatment Strategy

(2020) Małgorzata Milczarek   Cancers

Senescence and Cancer: A Review of Clinical Implications of Senescence and Senotherapies

(2020) Lynda Wyld et al.   Cancers

Cotargeting BCL-2 and MCL-1 in high-risk B-ALL

(2020) Donia M. Moujalled et al.   Blood Advances

Convergence of therapy-induced senescence (TIS) and EMT in multistep carcinogenesis: current opinions and emerging perspectives

(2020) Mir Mohd Faheem et al.   Cell Death Discovery

Modification of Mcl-1 alternative splicing induces apoptosis and suppresses tumor proliferation in gastric cancer

(2020) Yonghong Li et al.   Aging-US

Peptide and Small Molecule Inhibitors Targeting Myeloid Cell Leukemia 1 (Mcl-1) as Novel Antitumor Agents

(2020) Xing Lu et al.   CURRENT MOLECULAR MEDICINE

The BCL-2 selective inhibitor ABT-199 sensitizes soft tissue sarcomas to proteasome inhibition by a concerted mechanism requiring BAX and NOXA

(2020) Alina Muenchow et al.   Cell Death & Disease

Identification of BCL-XL as highly active survival factor and promising therapeutic target in colorectal cancer

(2020) Anna-Lena Scherr et al.   Cell Death & Disease

Depletion of senescent-like neuronal cells alleviates cisplatin-induced peripheral neuropathy in mice

(2020) Scarlett Acklin et al.   Scientific Reports

Upregulation of Mcl-1S Causes Cell-Cycle Perturbations and DNA Damage Accumulation

(2020) Alena Y. Streletskaia et al.   Frontiers in Cell and Developmental Biology

Pharmacological inactivation of CDK2 inhibits MYC/BCL-XL-driven leukemia in vivo through induction of cellular senescence

(2020) Wesam Bazzar et al.   CELL CYCLE

MCL-1 inhibitors, fast-lane development of a new class of anti-cancer agents

(2020) Arnold Bolomsky et al.   Journal of Hematology & Oncology

Serine-70 phosphorylated Bcl-2 prevents oxidative stress-induced DNA damage by modulating the mitochondrial redox metabolism

(2020) Stephen Jun Fei Chong et al.   NUCLEIC ACIDS RESEARCH

Therapy-induced polyploidization and senescence: Coincidence or interconnection?

(2020) Ewa Sikora et al.   SEMINARS IN CANCER BIOLOGY

Targeting tumor cell senescence and polyploidy as potential therapeutic strategies

(2020) Tareq Saleh et al.   SEMINARS IN CANCER BIOLOGY

Aging-Associated Alterations in Mammary Epithelia and Stroma Revealed by Single-Cell RNA Sequencing

(2020) Carman Man-Chung Li et al.   Cell Reports

Molecular mechanisms and cardiovascular implications of cancer therapy-induced senescence

(2020) Ibrahim Y. Abdelgawad et al.   PHARMACOLOGY & THERAPEUTICS

Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins

(2019) Rumani Singh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Erythropoietin inhibits chemotherapy-induced cell death and promotes a senescence-like state in leukemia cells

(2019) Thuc-Nghi Duc Pham et al.   Cell Death & Disease

Senolytics and senostatics as adjuvant tumour therapy

(2019) Susan Short et al.   EBioMedicine

BCL-2 family isoforms in apoptosis and cancer

(2019) Chloe F. A. Warren et al.   Cell Death & Disease

Recent advances in the development of Mcl-1 inhibitors for cancer therapy

(2019) Alexander W. Hird et al.   PHARMACOLOGY & THERAPEUTICS

Tumor Cell Escape from Therapy-Induced Senescence as a Model of Disease Recurrence after Dormancy

(2019) Tareq Saleh et al.   CANCER RESEARCH

The small molecule Bcl-2/Mcl-1 inhibitor TW-37 shows single-agent cytotoxicity in neuroblastoma cell lines

(2019) Stefanie Klenke et al.   BMC CANCER

Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors That Demonstrate in Vivo Activity in Mouse Xenograft Models of Human Cancer

(2019) Taekyu Lee et al.   JOURNAL OF MEDICINAL CHEMISTRY

From Inhibition to Degradation: Targeting the Anti-apoptotic Protein Myeloid Cell Leukemia 1 (MCL1)

(2019) James William Papatzimas et al.   JOURNAL OF MEDICINAL CHEMISTRY

Senolytic therapies for healthy longevity

(2019) Jan M. van Deursen   SCIENCE

A functional genetic screen defines the AKT-induced senescence signaling network

(2019) Keefe T. Chan et al.   CELL DEATH AND DIFFERENTIATION

The role of senescence in cancer development

(2019) Eleni Mavrogonatou et al.   SEMINARS IN CANCER BIOLOGY

Exploiting interconnected synthetic lethal interactions between PARP inhibition and cancer cell reversible senescence

(2019) Hubert Fleury et al.   Nature Communications

MCL-1 inhibitors – where are we now (2019)?

(2019) Steven Fletcher   EXPERT OPINION ON THERAPEUTIC PATENTS

Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands

(2019) Ziqian Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Modulation of the Apoptosis Gene Bcl-x Function Through Alternative Splicing

(2019) Megan Stevens et al.   Frontiers in Genetics

AZD4573 is a highly selective CDK9 inhibitor that suppresses Mcl-1 and induces apoptosis in hematological cancer cells.

(2019) Justin Cidado et al.   CLINICAL CANCER RESEARCH

Targeting senescent cells in translational medicine

(2019) Marta Paez‐Ribes et al.   EMBO Molecular Medicine

A novel CDK9 inhibitor increases the efficacy of venetoclax (ABT-199) in multiple models of hematologic malignancies

(2019) Darren C. Phillips et al.   LEUKEMIA

A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity

(2019) Sajid Khan et al.   NATURE MEDICINE

Bcl-XL: A multifunctional anti-apoptotic protein

(2019) Mingxue Li et al.   PHARMACOLOGICAL RESEARCH

Transcriptional Silencing of MCL-1 Through Cyclin-Dependent Kinase Inhibition in Acute Myeloid Leukemia

(2019) Raoul Tibes et al.   Frontiers in Oncology

A versatile drug delivery system targeting senescent cells

(2018) Daniel Muñoz‐Espín et al.   EMBO Molecular Medicine

BCL-2 as therapeutic target for hematological malignancies

(2018) Guilherme Fleury Perini et al.   Journal of Hematology & Oncology

Dual inhibition of BCL-XL and MCL-1 is required to induce tumour regression in lung squamous cell carcinomas sensitive to FGFR inhibition

(2018) Clare E. Weeden et al.   ONCOGENE

Regulation of senescence escape by the cdk4–EZH2–AP2M1 pathway in response to chemotherapy

(2018) Mélanie Le Duff et al.   Cell Death & Disease

S55746 is a novel orally active BCL-2 selective and potent inhibitor that impairs hematological tumor growth

(2018) Patrick Casara et al.   Oncotarget

Targeting BCL-2 regulated apoptosis in cancer

(2018) Kirsteen J. Campbell et al.   Open Biology

Cellular Senescence: The Sought or the Unwanted?

(2018) Yu Sun et al.   TRENDS IN MOLECULAR MEDICINE

Sensitizing non-small cell lung cancer to BCL-xL-targeted apoptosis

(2018) Qi Shen et al.   Cell Death & Disease

A Novel MCL-1 Inhibitor Combined with Venetoclax Rescues Venetoclax Resistant Acute Myelogenous Leukemia

(2018) Haley E. Ramsey et al.   Cancer Discovery

miR-93-5p suppresses cellular senescence by directly targeting Bcl-w and p21

(2018) Jae Yeon Choi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The emerging field of senotherapeutic drugs

(2018) Vassilios Myrianthopoulos   Future Medicinal Chemistry

Bcl-2 Inhibition to Overcome Resistance to Chemo- and Immunotherapy

(2018) Marilina García-Aranda et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Targeting BCL-xL improves the efficacy of bromodomain and extra-terminal protein inhibitors in triple-negative breast cancer by eliciting the death of senescent cells

(2018) Sylvia S. Gayle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mTOR kinase leads to PTEN-loss-induced cellular senescence by phosphorylating p53

(2018) Seung Hee Jung et al.   ONCOGENE

Targeting Mcl-1 and other Bcl-2 family member proteins in cancer therapy

(2018) Ryuji Yamaguchi et al.   PHARMACOLOGY & THERAPEUTICS

Dual functions for OVAAL in initiation of RAF/MEK/ERK prosurvival signals and evasion of p27-mediated cellular senescence

(2018) Ben Sang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia

(2018) Adriana E. Tron et al.   Nature Communications

Differential effects of protein kinase C-eta on apoptosis versus senescence

(2018) Alakananda Basu et al.   CELLULAR SIGNALLING

mTOR as Regulator of Lifespan, Aging, and Cellular Senescence: A Mini-Review

(2017) Thomas Weichhart   GERONTOLOGY

APG-1252-12A induces mitochondria-dependent apoptosis through inhibiting the antiapoptotic proteins Bcl-2/Bcl-xl in HL-60 cells

(2017) Jing Wang et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

The Clinical Potential of Senolytic Drugs

(2017) James L. Kirkland et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Metformin Synergizes with BCL-XL/BCL-2 Inhibitor ABT-263 to Induce Apoptosis Specifically in p53-Defective Cancer Cells

(2017) Xinzhe Li et al.   MOLECULAR CANCER THERAPEUTICS

Synergistic action of the MCL-1 inhibitor S63845 with current therapies in preclinical models of triple-negative and HER2-amplified breast cancer

(2017) Delphine Merino et al.   Science Translational Medicine

Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors

(2016) Yi Zhu et al.   AGING CELL

To clear, or not to clear (senescent cells)? That is the question

(2016) Amaia Lujambio   BIOESSAYS

Caspase-3-dependent cleavage of Bcl-xL in the stroma exosomes is required for their uptake by hematological malignant cells

(2016) I. Vardaki et al.   BLOOD

BOK Is a Non-canonical BCL-2 Family Effector of Apoptosis Regulated by ER-Associated Degradation

(2016) Fabien Llambi et al.   CELL

Mcl-1 involvement in mitochondrial dynamics is associated with apoptotic cell death

(2016) Giampaolo Morciano et al.   MOLECULAR BIOLOGY OF THE CELL

The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models

(2016) András Kotschy et al.   NATURE

Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL

(2016) Reut Yosef et al.   Nature Communications

Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse

(2016) Marco Demaria et al.   Cancer Discovery

Loss of a Single Mcl-1 Allele Inhibits MYC-Driven Lymphomagenesis by Sensitizing Pro-B Cells to Apoptosis

(2016) Stephanie Grabow et al.   Cell Reports

Dynamic Bcl-xL (S49) and (S62) Phosphorylation/Dephosphorylation during Mitosis Prevents Chromosome Instability and Aneuploidy in Normal Human Diploid Fibroblasts

(2016) Prasamit Saurav Baruah et al.   PLoS One

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

(2015) Yi Zhu et al.   AGING CELL

Emerging understanding of Bcl-2 biology: Implications for neoplastic progression and treatment

(2015) Cristina Correia et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Inhibition of Mcl-1 with the pan-Bcl-2 family inhibitor (-)BI97D6 overcomes ABT-737 resistance in acute myeloid leukemia

(2015) R. Pan et al.   BLOOD

Phase 1 study of the safety, pharmacokinetics, and antitumour activity of the BCL2 inhibitor navitoclax in combination with rituximab in patients with relapsed or refractory CD20+lymphoid malignancies

(2015) Andrew W. Roberts et al.   BRITISH JOURNAL OF HAEMATOLOGY

Structure-Function Analysis of the Mcl-1 Protein Identifies a Novel Senescence-regulating Domain

(2015) Abeba Demelash et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A phase 2 study of the BH3 mimetic BCL2 inhibitor navitoclax (ABT-263) with or without rituximab, in previously untreated B-cell chronic lymphocytic leukemia

(2015) Thomas J. Kipps et al.   LEUKEMIA & LYMPHOMA

Genomic analysis and selective small molecule inhibition identifies BCL-XL as a critical survival factor in a subset of colorectal cancer

(2015) Haichao Zhang et al.   Molecular Cancer

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

(2015) Jianhui Chang et al.   NATURE MEDICINE

Cellular senescence in aging and age-related disease: from mechanisms to therapy

(2015) Bennett G Childs et al.   NATURE MEDICINE

Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy

(2015) Joel D. Leverson et al.   Science Translational Medicine

Broad targeting of resistance to apoptosis in cancer

(2015) Ramzi M. Mohammad et al.   SEMINARS IN CANCER BIOLOGY

Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax)

(2015) J D Leverson et al.   Cell Death & Disease

Akt inhibition improves irinotecan treatment and prevents cell emergence by switching the senescence response to apoptosis

(2015) Alexandra Vétillard et al.   Oncotarget

Irinotecan treatment and senescence failure promote the emergence of more transformed and invasive cells that depend on anti-apoptotic Mcl-1

(2015) Barbara Jonchère et al.   Oncotarget

A Phase II, Multicenter, Open-Label Study of Obatoclax Mesylate in Patients With Previously Untreated Myelodysplastic Syndromes With Anemia or Thrombocytopenia

(2014) Martha L. Arellano et al.   Clinical Lymphoma Myeloma & Leukemia

Senescence and apoptosis: dueling or complementary cell fates?

(2014) B. G. Childs et al.   EMBO REPORTS

Targeting of MCL-1 kills MYC-driven mouse and human lymphomas even when they bear mutations in p53

(2014) G. L. Kelly et al.   GENES & DEVELOPMENT

A phase I clinical trial of navitoclax, a targeted high-affinity Bcl-2 family inhibitor, in combination with gemcitabine in patients with solid tumors

(2014) James M. Cleary et al.   INVESTIGATIONAL NEW DRUGS

A phase I/II study of the pan Bcl-2 inhibitor obatoclax mesylate plus bortezomib for relapsed or refractory mantle cell lymphoma

(2014) André Goy et al.   LEUKEMIA & LYMPHOMA

Randomized phase II study of carboplatin and etoposide with or without obatoclax mesylate in extensive-stage small cell lung cancer

(2014) Corey J. Langer et al.   LUNG CANCER

Cellular senescence: from physiology to pathology

(2014) Daniel Muñoz-Espín et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Targeting Bcl-2/Bcl-XL Induces Antitumor Activity in Uveal Melanoma Patient-Derived Xenografts

(2014) Fariba Némati et al.   PLoS One

BM-1197: A Novel and Specific Bcl-2/Bcl-xL Inhibitor Inducing Complete and Long-Lasting Tumor Regression In Vivo

(2014) Longchuan Bai et al.   PLoS One

A Multicenter Phase I/II Study of Obatoclax Mesylate Administered as a 3- or 24-Hour Infusion in Older Patients with Previously Untreated Acute Myeloid Leukemia

(2014) Aaron D. Schimmer et al.   PLoS One

Radiosensitization by a novel Bcl-2 and Bcl-XL inhibitor S44563 in small-cell lung cancer

(2014) Y Loriot et al.   Cell Death & Disease

Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity

(2014) Zhi-Fu Tao et al.   ACS Medicinal Chemistry Letters

Mcl-1 Ubiquitination: Unique Regulation of an Essential Survival Protein

(2014) Barbara Mojsa et al.   Cells

Targeting BCL-2 with the BH3 Mimetic ABT-199 in Estrogen Receptor-Positive Breast Cancer

(2013) François Vaillant et al.   CANCER CELL

Contribution of Bcl-2 Phosphorylation to Bak Binding and Drug Resistance

(2013) H. Dai et al.   CANCER RESEARCH

Premature senescence in human breast cancer and colon cancer cells by tamoxifen-mediated reactive oxygen species generation

(2013) Young-Hoon Lee et al.   LIFE SCIENCES

A Novel Small-Molecule Inhibitor of Mcl-1 Blocks Pancreatic Cancer Growth In Vitro and In Vivo

(2013) F. Abulwerdi et al.   MOLECULAR CANCER THERAPEUTICS

Structure-guided design of a selective BCL-XL inhibitor

(2013) Guillaume Lessene et al.   Nature Chemical Biology

ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

(2013) Andrew J Souers et al.   NATURE MEDICINE

Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy

(2013) Peter E. Czabotar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Multiple Functions of BCL-2 Family Proteins

(2013) J. M. Hardwick et al.   Cold Spring Harbor Perspectives in Biology

PKC signaling prevents irradiation-induced apoptosis of primary human fibroblasts

(2013) A Bluwstein et al.   Cell Death & Disease

Aging, Cellular Senescence, and Cancer

(2012) Judith Campisi   Annual Review of Physiology

Experience with obatoclax mesylate (GX15-070), a small molecule pan-Bcl-2 family antagonist in patients with relapsed or refractory classical Hodgkin lymphoma

(2012) Y. Oki et al.   BLOOD

Phase II Study of Single-Agent Navitoclax (ABT-263) and Biomarker Correlates in Patients with Relapsed Small Cell Lung Cancer

(2012) C. M. Rudin et al.   CLINICAL CANCER RESEARCH

Inhibition of Mcl-1 Promotes Senescence in Cancer Cells: Implications for Preventing Tumor Growth and Chemotherapy Resistance

(2012) E. Bolesta et al.   MOLECULAR AND CELLULAR BIOLOGY

Anti-apoptotic MCL-1 localizes to the mitochondrial matrix and couples mitochondrial fusion to respiration

(2012) Rhonda M. Perciavalle et al.   NATURE CELL BIOLOGY

Noxa/Bcl-2 Protein Interactions Contribute to Bortezomib Resistance in Human Lymphoid Cells

(2011) Alyson J. Smith et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Phase II Study of AT-101 (Gossypol) in Chemotherapy-Sensitive Recurrent Extensive-Stage Small Cell Lung Cancer

(2011) Maria Q. Baggstrom et al.   Journal of Thoracic Oncology

AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy

(2011) M V Astle et al.   ONCOGENE

Anti-apoptosis and cell survival: A review

(2010) Liam Portt et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Absence of p53-dependent apoptosis leads to UV radiation hypersensitivity, enhanced immunosuppression and cellular senescence

(2010) Omid Tavana et al.   CELL CYCLE

Polyploidy: The Link Between Senescence and Cancer

(2010) G. Mosieniak et al.   CURRENT PHARMACEUTICAL DESIGN

Mcl-1; the molecular regulation of protein function

(2010) Luke W. Thomas et al.   FEBS LETTERS

A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis

(2010) Andrea Alimonti et al.   JOURNAL OF CLINICAL INVESTIGATION

Therapy-Induced Senescence in Cancer

(2010) Jonathan A. Ewald et al.   JNCI-Journal of the National Cancer Institute

Additive effects of C2-ceramide on paclitaxel-induced premature senescence of human lung cancer cells

(2010) Jeff Yi-Fu Chen et al.   LIFE SCIENCES

The landscape of somatic copy-number alteration across human cancers

(2010) Rameen Beroukhim et al.   NATURE

Bcl2 family proteins in carcinogenesis and the treatment of cancer

(2009) Anna Frenzel et al.   APOPTOSIS

MCL-1ES, a novel variant of MCL-1, associates with MCL-1L and induces mitochondrial cell death

(2009) Jae-Hong Kim et al.   FEBS LETTERS

Modification of Alternative Splicing of Mcl-1 Pre-mRNA Using Antisense Morpholino Oligonucleotides Induces Apoptosis in Basal Cell Carcinoma Cells

(2009) Jeng-Jer Shieh et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Prevention of premature senescence requires JNK regulation of Bcl-2 and reactive oxygen species

(2009) J -J Lee et al.   ONCOGENE

ABT-263: A Potent and Orally Bioavailable Bcl-2 Family Inhibitor

(2008) C. Tse et al.   CANCER RESEARCH

Mcl-1 is a potential therapeutic target in multiple types of cancer

(2008) C. Akgul   CELLULAR AND MOLECULAR LIFE SCIENCES

Knockout of myeloid cell leukemia-1 induces liver damage and increases apoptosis susceptibility of murine hepatocytes

(2008) Binje Vick et al.   HEPATOLOGY

Identification of the Major Phosphorylation Site in Bcl-xL Induced by Microtubule Inhibitors and Analysis of Its Functional Significance

(2008) Meenakshi Upreti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Progressive apoptosis resistance prior to senescence and control by the anti-apoptotic protein BCL-xL

(2008) Patrick J. Rochette et al.   MECHANISMS OF AGEING AND DEVELOPMENT

ABT-263 and rapamycin act cooperatively to kill lymphoma cells in vitro and in vivo

(2008) Scott Ackler et al.   MOLECULAR CANCER THERAPEUTICS

BCL-2 family antagonists for cancer therapy

(2008) Guillaume Lessene et al.   NATURE REVIEWS DRUG DISCOVERY

Bcl-2 family proteins and cancer

(2008) K W Yip et al.   ONCOGENE

Cyclin-dependent kinase 9: a key transcriptional regulator and potential drug target in oncology, virology and cardiology

(2008) S WANG et al.   TRENDS IN PHARMACOLOGICAL SCIENCES