标题
Structure-guided design of a selective BCL-XL inhibitor
作者
关键词
-
出版物
Nature Chemical Biology
Volume 9, Issue 6, Pages 390-397
出版商
Springer Nature
发表日期
2013-04-22
DOI
10.1038/nchembio.1246
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets
- (2013) Andrew J Souers et al. NATURE MEDICINE
- Bcl-2, Bcl-xL, and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells
- (2012) D. Merino et al. BLOOD
- Phase II Study of Single-Agent Navitoclax (ABT-263) and Biomarker Correlates in Patients with Relapsed Small Cell Lung Cancer
- (2012) C. M. Rudin et al. CLINICAL CANCER RESEARCH
- Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia
- (2012) S. P. Glaser et al. GENES & DEVELOPMENT
- Protein–protein interaction inhibitors get into the groove
- (2012) Asher Mullard NATURE REVIEWS DRUG DISCOVERY
- The role of Bcl-2 and its pro-survival relatives in tumourigenesis and cancer therapy
- (2011) P N Kelly et al. CELL DEATH AND DIFFERENTIATION
- Deciphering the rules of programmed cell death to improve therapy of cancer and other diseases
- (2011) Andreas Strasser et al. EMBO JOURNAL
- Phase I Study of Navitoclax (ABT-263), a Novel Bcl-2 Family Inhibitor, in Patients With Small-Cell Lung Cancer and Other Solid Tumors
- (2011) Leena Gandhi et al. JOURNAL OF CLINICAL ONCOLOGY
- Substantial Susceptibility of Chronic Lymphocytic Leukemia to BCL2 Inhibition: Results of a Phase I Study of Navitoclax in Patients With Relapsed or Refractory Disease
- (2011) Andrew W. Roberts et al. JOURNAL OF CLINICAL ONCOLOGY
- Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets
- (2011) Emma C. Josefsson et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Integration, scaling, space-group assignment and post-refinement
- (2010) Wolfgang Kabsch ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- PHENIX: a comprehensive Python-based system for macromolecular structure solution
- (2010) Paul D. Adams et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Bcl-2 Family Proteins as Therapeutic Targets
- (2010) Peter E. Czabotar et al. CURRENT PHARMACEUTICAL DESIGN
- New Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays
- (2010) Jonathan B. Baell et al. JOURNAL OF MEDICINAL CHEMISTRY
- Navitoclax, a targeted high-affinity inhibitor of BCL-2, in lymphoid malignancies: a phase 1 dose-escalation study of safety, pharmacokinetics, pharmacodynamics, and antitumour activity
- (2010) Wyndham H Wilson et al. LANCET ONCOLOGY
- The landscape of somatic copy-number alteration across human cancers
- (2010) Rameen Beroukhim et al. NATURE
- Still embedded together binding to membranes regulates Bcl-2 protein interactions
- (2010) B Leber et al. ONCOGENE
- Conformational Changes in Bcl-2 Pro-survival Proteins Determine Their Capacity to Bind Ligands
- (2009) Erinna F. Lee et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cell Death
- (2009) Richard S. Hotchkiss et al. NEW ENGLAND JOURNAL OF MEDICINE
- ABT-263: A Potent and Orally Bioavailable Bcl-2 Family Inhibitor
- (2008) C. Tse et al. CANCER RESEARCH
- Targeting the Bcl-2-regulated apoptosis pathway by BH3 mimetics: a breakthrough in anticancer therapy?
- (2008) V Labi et al. CELL DEATH AND DIFFERENTIATION
- Vaccinia virus anti-apoptotic F1L is a novel Bcl-2-like domain-swapped dimer that binds a highly selective subset of BH3-containing death ligands
- (2008) M Kvansakul et al. CELL DEATH AND DIFFERENTIATION
- A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation
- (2008) Erinna F. Lee et al. JOURNAL OF CELL BIOLOGY
- Discovery of an Orally Bioavailable Small Molecule Inhibitor of Prosurvival B-Cell Lymphoma 2 Proteins
- (2008) Cheol-Min Park et al. JOURNAL OF MEDICINAL CHEMISTRY
- Generation of a Set of Simple, Interpretable ADMET Rules of Thumb
- (2008) M. Paul Gleeson JOURNAL OF MEDICINAL CHEMISTRY
- BCL-2 family antagonists for cancer therapy
- (2008) Guillaume Lessene et al. NATURE REVIEWS DRUG DISCOVERY
- Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax
- (2008) J. I. Fletcher et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structural Plasticity Underpins Promiscuous Binding of the Prosurvival Protein A1
- (2008) Callum Smits et al. STRUCTURE
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