标题
N6-methyladenosine methyltransferases: functions, regulation, and clinical potential
作者
关键词
-
出版物
Journal of Hematology & Oncology
Volume 14, Issue 1, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2021-07-27
DOI
10.1186/s13045-021-01129-8
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- MiR‐103‐3p targets the m 6 A methyltransferase METTL14 to inhibit osteoblastic bone formation
- (2021) Zhongyang Sun et al. AGING CELL
- METTL3 promotes adriamycin resistance in MCF-7 breast cancer cells by accelerating pri-microRNA-221-3p maturation in a m6A-dependent manner
- (2021) Xiaoping Pan et al. EXPERIMENTAL AND MOLECULAR MEDICINE
- RNA methyltransferase METTL3 induces intrinsic resistance to gefitinib by combining with MET to regulate PI3K/AKT pathway in lung adenocarcinoma
- (2021) Fangyan Gao et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Metformin exhibits antiproliferation activity in breast cancer via miR-483-3p/METTL3/m6A/p21 pathway
- (2021) Lin Cheng et al. Oncogenesis
- N6-methyladenosine modification of MALAT1 promotes metastasis via reshaping nuclear speckles
- (2021) Xinyu Wang et al. DEVELOPMENTAL CELL
- RALYL increases hepatocellular carcinoma stemness by sustaining the mRNA stability of TGF-β2
- (2021) Xia Wang et al. Nature Communications
- RNA m6A methylation orchestrates cancer growth and metastasis via macrophage reprogramming
- (2021) Huilong Yin et al. Nature Communications
- Construction and Comprehensive Analyses of a METTL5-Associated Prognostic Signature With Immune Implication in Lung Adenocarcinomas
- (2021) Sijin Sun et al. Frontiers in Genetics
- Comprehensive Analysis of Expression Regulation for RNA m6A Regulators With Clinical Significance in Human Cancers
- (2021) Xiaonan Liu et al. Frontiers in Oncology
- Splice site m6A methylation prevents binding of U2AF35 to inhibit RNA splicing
- (2021) Mateusz Mendel et al. CELL
- A methionine-Mettl3-N-methyladenosine axis promotes polycystic kidney disease
- (2021) Harini Ramalingam et al. Cell Metabolism
- Dysregulation of LINC00470 and METTL3 promotes chemoresistance and suppresses autophagy of chronic myelocytic leukaemia cells
- (2021) Xun Lai et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Sec62 promotes stemness and chemoresistance of human colorectal cancer through activating Wnt/β-catenin pathway
- (2021) Xiaofeng Liu et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia
- (2021) Eliza Yankova et al. NATURE
- N6-methyladenosine modification of circCUX1 confers radioresistance of hypopharyngeal squamous cell carcinoma through caspase1 pathway
- (2021) Ping Wu et al. Cell Death & Disease
- Role of Hakai in m6A modification pathway in Drosophila
- (2021) Yanhua Wang et al. Nature Communications
- Pooled CRISPR screening identifies m6A as a positive regulator of macrophage activation
- (2021) Jiyu Tong et al. Science Advances
- Expression and clinical prognostic value of m6A RNA methylation modification in breast cancer
- (2021) Fangchao Zheng et al. Biomarker Research
- METTL3 Inhibitors for Epitranscriptomic Modulation of Cellular Processes
- (2021) Elena V. Moroz‐Omori et al. ChemMedChem
- Exosomal miR-4443 promotes cisplatin resistance in non-small cell lung carcinoma by regulating FSP1 m6A modification-mediated ferroptosis
- (2021) Zhiyu Song et al. LIFE SCIENCES
- The m6A methyltransferase METTL3 contributes to Transforming Growth Factor-beta-induced epithelial-mesenchymal transition of lung cancer cells through the regulation of JUNB
- (2020) Sasithorn Wanna-udom et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Cross talk between RNA N6‐methyladenosine methyltransferase‐like 3 and miR‐186 regulates hepatoblastoma progression through Wnt/β‐catenin signalling pathway
- (2020) Xichun Cui et al. CELL PROLIFERATION
- KIAA1429 regulates cell proliferation by targeting c‐Jun messenger RNA directly in gastric cancer
- (2020) Ran Miao et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Effect of m6A RNA Methylation Regulators on Malignant Progression and Prognosis in Renal Clear Cell Carcinoma
- (2020) Jiawu Wang et al. Frontiers in Oncology
- METTL3 Promotes the Progression of Gastric Cancer via Targeting the MYC Pathway
- (2020) Dong-Dong Yang et al. Frontiers in Oncology
- Dietary Approaches to Cancer Therapy
- (2020) Mylène Tajan et al. CANCER CELL
- m6A Modification in Coding and Non-coding RNAs: Roles and Therapeutic Implications in Cancer
- (2020) Huilin Huang et al. CANCER CELL
- Small‐Molecule Inhibitors of METTL3, the Major Human Epitranscriptomic Writer
- (2020) Rajiv K. Bedi et al. ChemMedChem
- RNA m 6 A methylation regulates sorafenib resistance in liver cancer through FOXO 3‐mediated autophagy
- (2020) Ziyou Lin et al. EMBO JOURNAL
- N6-methyladenosine mediates arsenite-induced human keratinocyte transformation by suppressing p53 activation
- (2020) Tianhe Zhao et al. ENVIRONMENTAL POLLUTION
- HBV‐Induced Increased N6 Methyladenosine Modification of PTEN RNA Affects Innate Immunity and Contributes to HCC
- (2020) Geon‐Woo Kim et al. HEPATOLOGY
- m6A-binding proteins: the emerging crucial performers in epigenetics
- (2020) Yanchun Zhao et al. Journal of Hematology & Oncology
- Emerging role of RNA methyltransferase METTL3 in gastrointestinal cancer
- (2020) Qiang Wang et al. Journal of Hematology & Oncology
- Cellular rewiring in lethal prostate cancer: the architect of drug resistance
- (2020) Marc Carceles-Cordon et al. Nature Reviews Urology
- TRIM11 facilitates chemoresistance in nasopharyngeal carcinoma by activating the β-catenin/ABCC9 axis via p62-selective autophagic degradation of Daple
- (2020) Runa Zhang et al. Oncogenesis
- Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion
- (2020) Rui Su et al. CANCER CELL
- Proteolysis targeting chimeras (PROTACs) are emerging therapeutics for hematologic malignancies
- (2020) Yonghan He et al. Journal of Hematology & Oncology
- RNA-binding proteins in tumor progression
- (2020) Hai Qin et al. Journal of Hematology & Oncology
- Principles and innovative technologies for decrypting noncoding RNAs: from discovery and functional prediction to clinical application
- (2020) Yu-Meng Sun et al. Journal of Hematology & Oncology
- The lncRNA LAMP5-AS1 drives leukemia cell stemness by directly modulating DOT1L methyltransferase activity in MLL leukemia
- (2020) Wen-Tao Wang et al. Journal of Hematology & Oncology
- METTL3 and N6-Methyladenosine Promote Homologous Recombination-Mediated Repair of DSBs by Modulating DNA-RNA Hybrid Accumulation
- (2020) Canfeng Zhang et al. MOLECULAR CELL
- Programmable m6A modification of cellular RNAs with a Cas13-directed methyltransferase
- (2020) Christopher Wilson et al. NATURE BIOTECHNOLOGY
- Structural analysis of the SARS-CoV-2 methyltransferase complex involved in RNA cap creation bound to sinefungin
- (2020) Petra Krafcikova et al. Nature Communications
- METTL3 Facilitates Oral Squamous Cell Carcinoma Tumorigenesis by Enhancing c-Myc Stability via YTHDF1-Mediated m6A Modification
- (2020) Wei Zhao et al. Molecular Therapy-Nucleic Acids
- Advances in targeted therapy for acute myeloid leukemia
- (2020) Jifeng Yu et al. Biomarker Research
- The emerging roles of N6-methyladenosine RNA methylation in human cancers
- (2020) Huafei Shen et al. Biomarker Research
- Oncogenic AURKA-enhanced N6-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells
- (2020) Fei Peng et al. CELL RESEARCH
- m 6 A RNA methyltransferases METTL3/14 regulate immune responses to anti‐PD‐1 therapy
- (2020) Lingling Wang et al. EMBO JOURNAL
- m 6 A methyltransferase METTL3 promotes retinoblastoma progression via PI3K/AKT/mTOR pathway
- (2020) Han Zhang et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- METTL3 potentiates resistance to cisplatin through m 6 A modification of TFAP2C in seminoma
- (2020) Jingchao Wei et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- RNA N6-methyladenosine reader IGF2BP3 regulates cell cycle and angiogenesis in colon cancer
- (2020) Zhou Yang et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Roles of METTL3 in cancer: mechanisms and therapeutic targeting
- (2020) Chengwu Zeng et al. Journal of Hematology & Oncology
- Cancer stem cell secretome in the tumor microenvironment: a key point for an effective personalized cancer treatment
- (2020) Julia López de Andrés et al. Journal of Hematology & Oncology
- Upregulation of METTL14 mediates the elevation of PERP mRNA N6 adenosine methylation promoting the growth and metastasis of pancreatic cancer
- (2020) Min Wang et al. Molecular Cancer
- CRISPR/Cas9: A preclinical and clinical perspective for the treatment of human diseases
- (2020) Garima Sharma et al. MOLECULAR THERAPY
- PI3K/AKT pathway as a key link modulates the multidrug resistance of cancers
- (2020) Rui Liu et al. Cell Death & Disease
- WTAP promotes osteosarcoma tumorigenesis by repressing HMBOX1 expression in an m6A-dependent manner
- (2020) Shijie Chen et al. Cell Death & Disease
- N6-methyladenosine-dependent pri-miR-17-92 maturation suppresses PTEN/TMEM127 and promotes sensitivity to everolimus in gastric cancer
- (2020) Yiting Sun et al. Cell Death & Disease
- Resistance to PD-1/PD-L1 blockade cancer immunotherapy: mechanisms, predictive factors, and future perspectives
- (2020) Jin-Yu Sun et al. Biomarker Research
- Advances in RNA cytosine-5 methylation: detection, regulatory mechanisms, biological functions and links to cancer
- (2020) Chen Xue et al. Biomarker Research
- m6A methyltransferase Wilms' tumor 1‐associated protein facilitates cell proliferation and cisplatin resistance in NK /T cell lymphoma by regulating dual‐specificity phosphatases 6 expression via m6A RNA methylation
- (2020) HongYan Ma et al. IUBMB LIFE
- Targeting the Wnt/β-catenin signaling pathway in cancer
- (2020) Ya Zhang et al. Journal of Hematology & Oncology
- Targeting autophagy to overcome drug resistance: further developments
- (2020) Haocai Chang et al. Journal of Hematology & Oncology
- N6-methyladenosine-modified CircRNA-SORE sustains sorafenib resistance in hepatocellular carcinoma by regulating β-catenin signaling
- (2020) Junjie Xu et al. Molecular Cancer
- Ribosome 18S m6A Methyltransferase METTL5 Promotes Translation Initiation and Breast Cancer Cell Growth
- (2020) Bowen Rong et al. Cell Reports
- RNA N6-Methyladenosine Methyltransferase METTL3 Facilitates Colorectal Cancer by Activating the m6A-GLUT1-mTORC1 Axis and Is a Therapeutic Target
- (2020) Huarong Chen et al. GASTROENTEROLOGY
- The m6A methyltransferase METTL3 promotes bladder cancer progression via AFF4/NF-κB/MYC signaling network
- (2019) Maosheng Cheng et al. ONCOGENE
- miR-600 inhibits lung cancer via downregulating the expression of METTL3
- (2019) Wenwen Wei et al. Cancer Management and Research
- Discovery of Small Molecules that Activate RNA Methylation through Cooperative Binding to the METTL3-14-WTAP Complex Active Site
- (2019) Simona Selberg et al. Cell Reports
- Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia
- (2019) Yue Huang et al. CANCER CELL
- Where, When, and How: Context-Dependent Functions of RNA Methylation Writers, Readers, and Erasers
- (2019) Hailing Shi et al. MOLECULAR CELL
- Impaired autophagic degradation of lncRNA ARHGAP5-AS1 promotes chemoresistance in gastric cancer
- (2019) Liyuan Zhu et al. Cell Death & Disease
- Noncoding RNAs in cancer therapy resistance and targeted drug development
- (2019) Wen-Tao Wang et al. Journal of Hematology & Oncology
- Tumor-associated macrophages in tumor metastasis: biological roles and clinical therapeutic applications
- (2019) Yuxin Lin et al. Journal of Hematology & Oncology
- The human 18S rRNA m6A methyltransferase METTL5 is stabilized by TRMT112
- (2019) Nhan van Tran et al. NUCLEIC ACIDS RESEARCH
- KIAA1429 acts as an oncogenic factor in breast cancer by regulating CDK1 in an N6-methyladenosine-independent manner
- (2019) Jia-Yi Qian et al. ONCOGENE
- N6-methyladenosine Modulates Nonsense-mediated mRNA Decay in Human Glioblastoma
- (2019) Fuxi Li et al. CANCER RESEARCH
- N6-methyladenosine METTL3 promotes the breast cancer progression via targeting Bcl-2
- (2019) Hong Wang et al. GENE
- Programmable RNA N6-methyladenosine editing by CRISPR-Cas9 conjugates
- (2019) Xiao-Min Liu et al. Nature Chemical Biology
- Reading, writing and erasing mRNA methylation
- (2019) Sara Zaccara et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- MiR-4429 prevented gastric cancer progression through targeting METTL3 to inhibit m6A-caused stabilization of SEC62
- (2019) Huabo He et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- The interplay between m6A RNA methylation and noncoding RNA in cancer
- (2019) Shuai Ma et al. Journal of Hematology & Oncology
- Chemical inhibitors make their RNA epigenetic mark
- (2019) Megan Cully NATURE REVIEWS DRUG DISCOVERY
- Emerging insights of tumor heterogeneity and drug resistance mechanisms in lung cancer targeted therapy
- (2019) Zuan-Fu Lim et al. Journal of Hematology & Oncology
- m6A mRNA methylation regulates CTNNB1 to promote the proliferation of hepatoblastoma
- (2019) Li Liu et al. Molecular Cancer
- HBXIP-elevated methyltransferase METTL3 promotes the progression of breast cancer via inhibiting tumor suppressor let-7g
- (2018) Xiaoli Cai et al. CANCER LETTERS
- METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m 6 A Modification
- (2018) Hengyou Weng et al. Cell Stem Cell
- Zc3h13 Regulates Nuclear RNA m 6 A Methylation and Mouse Embryonic Stem Cell Self-Renewal
- (2018) Jing Wen et al. MOLECULAR CELL
- Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation
- (2018) Huilin Huang et al. NATURE CELL BIOLOGY
- Interactions, localization, and phosphorylation of the m 6 A generating METTL3–METTL14–WTAP complex
- (2018) Eva Schöller et al. RNA
- VIRMA mediates preferential m6A mRNA methylation in 3′UTR and near stop codon and associates with alternative polyadenylation
- (2018) Yanan Yue et al. Cell Discovery
- mRNA circularization by METTL3–eIF3h enhances translation and promotes oncogenesis
- (2018) Junho Choe et al. NATURE
- m6A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer
- (2018) Jun Liu et al. NATURE CELL BIOLOGY
- N6-Methyladenosine methyltransferase ZCCHC4 mediates ribosomal RNA methylation
- (2018) Honghui Ma et al. Nature Chemical Biology
- Targeting macrophages: therapeutic approaches in cancer
- (2018) Luca Cassetta et al. NATURE REVIEWS DRUG DISCOVERY
- An N-methyladenosine at the transited codon 273 of p53 pre-mRNA promotes the expression of R273H mutant protein and drug resistance of cancer cells
- (2018) Mohammad B. Uddin et al. BIOCHEMICAL PHARMACOLOGY
- FOXO Signaling Pathways as Therapeutic Targets in Cancer
- (2017) Mohd Farhan et al. International Journal of Biological Sciences
- Tumor-associated macrophages: from basic research to clinical application
- (2017) Li Yang et al. Journal of Hematology & Oncology
- Genetic alterations of m6A regulators predict poorer survival in acute myeloid leukemia
- (2017) Chau-To Kwok et al. Journal of Hematology & Oncology
- RNA m6A methylation regulates the ultraviolet-induced DNA damage response
- (2017) Yang Xiang et al. NATURE
- The N6-methyladenosine (m6A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells
- (2017) Ly P Vu et al. NATURE MEDICINE
- Essential role of METTL3-mediated m6A modification in glioma stem-like cells maintenance and radioresistance
- (2017) A Visvanathan et al. ONCOGENE
- An interferon-independent lncRNA promotes viral replication by modulating cellular metabolism
- (2017) Pin Wang et al. SCIENCE
- Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases
- (2016) Ping Wang et al. MOLECULAR CELL
- The m 6 A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells
- (2016) Shuibin Lin et al. MOLECULAR CELL
- Structural basis of N6-adenosine methylation by the METTL3–METTL14 complex
- (2016) Xiang Wang et al. NATURE
- m6A RNA methylation promotes XIST-mediated transcriptional repression
- (2016) Deepak P. Patil et al. NATURE
- Therapeutic targeting of splicing in cancer
- (2016) Stanley Chun-Wei Lee et al. NATURE MEDICINE
- SAM/SAH Analogs as Versatile Tools for SAM-Dependent Methyltransferases
- (2015) Jing Zhang et al. ACS Chemical Biology
- N6-methyladenosine marks primary microRNAs for processing
- (2015) Claudio R. Alarcón et al. NATURE
- Single-nucleotide-resolution mapping of m6A and m6Am throughout the transcriptome
- (2015) Bastian Linder et al. NATURE METHODS
- The BCL2 Family: Key Mediators of the Apoptotic Response to Targeted Anticancer Therapeutics
- (2015) A. N. Hata et al. Cancer Discovery
- Development and Applications of CRISPR-Cas9 for Genome Engineering
- (2014) Patrick D. Hsu et al. CELL
- Crystal structure of the YTH domain of YTHDF2 reveals mechanism for recognition of N6-methyladenosine
- (2014) Tingting Zhu et al. CELL RESEARCH
- Drugging the p53 pathway: understanding the route to clinical efficacy
- (2014) Kian Hoe Khoo et al. NATURE REVIEWS DRUG DISCOVERY
- The new frontier of genome engineering with CRISPR-Cas9
- (2014) J. A. Doudna et al. SCIENCE
- Perturbation of m6A Writers Reveals Two Distinct Classes of mRNA Methylation at Internal and 5′ Sites
- (2014) Schraga Schwartz et al. Cell Reports
- The Sox Family of Transcription Factors: Versatile Regulators of Stem and Progenitor Cell Fate
- (2013) Abby Sarkar et al. Cell Stem Cell
- Targeting p53 by small molecules in hematological malignancies
- (2013) Manujendra N Saha et al. Journal of Hematology & Oncology
- A METTL3–METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation
- (2013) Jianzhao Liu et al. Nature Chemical Biology
- Pediatric acute lymphoblastic leukemia: where are we going and how do we get there?
- (2012) C.-H. Pui et al. BLOOD
- MYC on the Path to Cancer
- (2012) Chi V. Dang CELL
- Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons
- (2012) Kate D. Meyer et al. CELL
- ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility
- (2012) Guanqun Zheng et al. MOLECULAR CELL
- Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq
- (2012) Dan Dominissini et al. NATURE
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO
- (2011) Guifang Jia et al. Nature Chemical Biology
- The RNA-binding Motif Protein 15B (RBM15B/OTT3) Acts as Cofactor of the Nuclear Export Receptor NXF1
- (2009) Hiroaki Uranishi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Expression and mutational analysis ofMETin human solid cancers
- (2008) Patrick C. Ma et al. GENES CHROMOSOMES & CANCER
- Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses
- (2008) S. Jones et al. SCIENCE
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