Roles of METTL3 in cancer: mechanisms and therapeutic targeting

The m6A methyltransferase METTL3 contributes to Transforming Growth Factor-beta-induced epithelial-mesenchymal transition of lung cancer cells through the regulation of JUNB

(2020) Sasithorn Wanna-udom et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

miR24‐2 accelerates progression of liver cancer cells by activating Pim1 through tri‐methylation of Histone H3 on the ninth lysine

(2020) Yuxin Yang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Methyltransferase like 3 promotes colorectal cancer proliferation by stabilizing CCNE1 mRNA in an m6A‐dependent manner

(2020) Wei Zhu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

METTL3/YTHDF2 m 6 A axis promotes tumorigenesis by degrading SETD7 and KLF4 mRNAs in bladder cancer

(2020) Haiyun Xie et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

RNA m 6 A methylation regulates uveal melanoma cell proliferation, migration, and invasion by targeting c‐Met

(2020) Guangying Luo et al.   JOURNAL OF CELLULAR PHYSIOLOGY

M6A-mediated upregulation of LINC00958 increases lipogenesis and acts as a nanotherapeutic target in hepatocellular carcinoma

(2020) Xueliang Zuo et al.   Journal of Hematology & Oncology

The m6A reader YTHDF1 promotes ovarian cancer progression via augmenting EIF3C translation

(2020) Tao Liu et al.   NUCLEIC ACIDS RESEARCH

Progression of Thyroid Carcinoma Is Promoted by the m6A Methyltransferase METTL3 Through Regulating m6A Methylation on TCF1

(2020) Kejin Wang et al.   OncoTargets and Therapy

N6-methyladenosine modification enables viral RNA to escape recognition by RNA sensor RIG-I

(2020) Mijia Lu et al.   Nature Microbiology

METTL3 Promotes the Progression of Gastric Cancer via Targeting the MYC Pathway

(2020) Dong-Dong Yang et al.   Frontiers in Oncology

Silencing METTL3 inhibits the proliferation and invasion of osteosarcoma by regulating ATAD2

(2020) Lei Zhou et al.   BIOMEDICINE & PHARMACOTHERAPY

m6A-dependent up-regulation of DRG1 by METTL3 and ELAVL1 promotes growth, migration, and colony formation in osteosarcoma

(2020) Zhian Ling et al.   BIOSCIENCE REPORTS

m6A Modification in Coding and Non-coding RNAs: Roles and Therapeutic Implications in Cancer

(2020) Huilin Huang et al.   CANCER CELL

Small‐Molecule Inhibitors of METTL3, the Major Human Epitranscriptomic Writer

(2020) Rajiv K. Bedi et al.   ChemMedChem

The rRNA m6A methyltransferase METTL5 is involved in pluripotency and developmental programs

(2020) Valentina V. Ignatova et al.   GENES & DEVELOPMENT

m6A-binding proteins: the emerging crucial performers in epigenetics

(2020) Yanchun Zhao et al.   Journal of Hematology & Oncology

Epitranscriptomics in liver disease: Basic concepts and therapeutic potential

(2020) Zhicong Zhao et al.   JOURNAL OF HEPATOLOGY

m6A-dependent glycolysis enhances colorectal cancer progression

(2020) Chaoqin Shen et al.   Molecular Cancer

LNCAROD is stabilized by m6A methylation and promotes cancer progression via forming a ternary complex with HSPA1A and YBX1 in head and neck squamous cell carcinoma

(2020) Yuanyuan Ban et al.   Molecular Oncology

METTL3 Facilitates Oral Squamous Cell Carcinoma Tumorigenesis by Enhancing c-Myc Stability via YTHDF1-Mediated m6A Modification

(2020) Wei Zhao et al.   Molecular Therapy-Nucleic Acids

The m6A methyltransferase METTL3 promotes bladder cancer progression via AFF4/NF-κB/MYC signaling network

(2019) Maosheng Cheng et al.   ONCOGENE

miR-600 inhibits lung cancer via downregulating the expression of METTL3

(2019) Wenwen Wei et al.   Cancer Management and Research

METTL3 promotes the proliferation and mobility of gastric cancer cells

(2019) Sen Lin et al.   Open Medicine

Discovery of Small Molecules that Activate RNA Methylation through Cooperative Binding to the METTL3-14-WTAP Complex Active Site

(2019) Simona Selberg et al.   Cell Reports

Dynamic m6A mRNA methylation reveals the role of METTL3-m6A-CDCP1 signaling axis in chemical carcinogenesis

(2019) Fan Yang et al.   ONCOGENE

FTO controls reversible m6Am RNA methylation during snRNA biogenesis

(2019) Jan Mauer et al.   Nature Chemical Biology

Histone H3 trimethylation at lysine 36 guides m6A RNA modification co-transcriptionally

(2019) Huilin Huang et al.   NATURE

METTL3 mediated m6A modification plays an oncogenic role in cutaneous squamous cell carcinoma by regulating ΔNp63

(2019) Renpeng Zhou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Role of microRNAs, circRNAs and long noncoding RNAs in acute myeloid leukemia

(2019) Yan Liu et al.   Journal of Hematology & Oncology

m6A-induced lncRNA RP11 triggers the dissemination of colorectal cancer cells via upregulation of Zeb1

(2019) Yingmin Wu et al.   Molecular Cancer

RNA modifications regulating cell fate in cancer

(2019) Sylvain Delaunay et al.   NATURE CELL BIOLOGY

Hepatocellular Carcinoma

(2019) Augusto Villanueva   NEW ENGLAND JOURNAL OF MEDICINE

Mechanisms of hepatocellular carcinoma progression

(2019) Olorunseun O Ogunwobi et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Impaired autophagic degradation of lncRNA ARHGAP5-AS1 promotes chemoresistance in gastric cancer

(2019) Liyuan Zhu et al.   Cell Death & Disease

Excessive miR-25-3p maturation via N6-methyladenosine stimulated by cigarette smoke promotes pancreatic cancer progression

(2019) Jialiang Zhang et al.   Nature Communications

Deciphering the “m6A Code” via Antibody-Independent Quantitative Profiling

(2019) Miguel Angel Garcia-Campos et al.   CELL

METTL3 promote tumor proliferation of bladder cancer by accelerating pri-miR221/222 maturation in m6A-dependent manner

(2019) Jie Han et al.   Molecular Cancer

METTL3 facilitates tumor progression via an m6A-IGF2BP2-dependent mechanism in colorectal carcinoma

(2019) Ting Li et al.   Molecular Cancer

Nuclear TARBP2 Drives Oncogenic Dysregulation of RNA Splicing and Decay

(2019) Lisa Fish et al.   MOLECULAR CELL

The human 18S rRNA m6A methyltransferase METTL5 is stabilized by TRMT112

(2019) Nhan van Tran et al.   NUCLEIC ACIDS RESEARCH

m6A methyltransferase METTL3 suppresses colorectal cancer proliferation and migration through p38/ERK pathways

(2019) Ru Deng et al.   OncoTargets and Therapy

RNA m6A methylation regulates the epithelial mesenchymal transition of cancer cells and translation of Snail

(2019) Xinyao Lin et al.   Nature Communications

Detailed modeling of positive selection improves detection of cancer driver genes

(2019) Siming Zhao et al.   Nature Communications

The m6A methyltransferase METTL3 promotes osteosarcoma progression by regulating the m6A level of LEF1

(2019) Wujun Miao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

N6-methyladenosine Modulates Nonsense-mediated mRNA Decay in Human Glioblastoma

(2019) Fuxi Li et al.   CANCER RESEARCH

N6-methyladenosine METTL3 promotes the breast cancer progression via targeting Bcl-2

(2019) Hong Wang et al.   GENE

Upregulated METTL3 promotes metastasis of colorectal Cancer via miR-1246/SPRED2/MAPK signaling pathway

(2019) Wen Peng et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Reading, writing and erasing mRNA methylation

(2019) Sara Zaccara et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The RNA m6A methyltransferase METTL3 promotes pancreatic cancer cell proliferation and invasion

(2019) Tianfang Xia et al.   PATHOLOGY RESEARCH AND PRACTICE

N6-methyladenosine modification of ITGA6 mRNA promotes the development and progression of bladder cancer

(2019) Huan Jin et al.   EBioMedicine

MiR-4429 prevented gastric cancer progression through targeting METTL3 to inhibit m6A-caused stabilization of SEC62

(2019) Huabo He et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

LncRNA LINC00470 promotes the degradation of PTEN mRNA to facilitate malignant behavior in gastric cancer cells

(2019) Jijun Yan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

METTL3-mediated m6A modification of HDGF mRNA promotes gastric cancer progression and has prognostic significance

(2019) Qiang Wang et al.   GUT

The interplay between m6A RNA methylation and noncoding RNA in cancer

(2019) Shuai Ma et al.   Journal of Hematology & Oncology

METTL3-mediated N6-methyladenosine modification is critical for epithelial-mesenchymal transition and metastasis of gastric cancer

(2019) Ben Yue et al.   Molecular Cancer

m6A modification suppresses ocular melanoma through modulating HINT2 mRNA translation

(2019) Ruobing Jia et al.   Molecular Cancer

Targeted protein degradation: expanding the toolbox

(2019) Matthieu Schapira et al.   NATURE REVIEWS DRUG DISCOVERY

RNA m6A Methyltransferase METTL3 Promotes The Growth Of Prostate Cancer By Regulating Hedgehog Pathway

(2019) Jiarong Cai et al.   OncoTargets and Therapy

m6A in mRNA coding regions promotes translation via the RNA helicase-containing YTHDC2

(2019) Yuanhui Mao et al.   Nature Communications

Structure and regulation of ZCCHC4 in m6A-methylation of 28S rRNA

(2019) Wendan Ren et al.   Nature Communications

N6-methyladenosine modification of circNSUN2 facilitates cytoplasmic export and stabilizes HMGA2 to promote colorectal liver metastasis

(2019) Ri-Xin Chen et al.   Nature Communications

m6A mRNA methylation initiated by METTL3 directly promotes YAP translation and increases YAP activity by regulating the MALAT1-miR-1914-3p-YAP axis to induce NSCLC drug resistance and metastasis

(2019) Dan Jin et al.   Journal of Hematology & Oncology

N6-methyladenosine induced miR-143-3p promotes the brain metastasis of lung cancer via regulation of VASH1

(2019) Hongsheng Wang et al.   Molecular Cancer

m6A modification-mediated CBX8 induction regulates stemness and chemosensitivity of colon cancer via upregulation of LGR5

(2019) Yi Zhang et al.   Molecular Cancer

m6A mRNA methylation regulates CTNNB1 to promote the proliferation of hepatoblastoma

(2019) Li Liu et al.   Molecular Cancer

Loss of RDM1 enhances hepatocellular carcinoma progression via p53 and Ras/Raf/ERK pathways

(2019) Shi‐Lu Chen et al.   Molecular Oncology

The m6A epitranscriptome: transcriptome plasticity in brain development and function

(2019) Ido Livneh et al.   NATURE REVIEWS NEUROSCIENCE

The human methyltransferase ZCCHC4 catalyses N6-methyladenosine modification of 28S ribosomal RNA

(2019) Rita Pinto et al.   NUCLEIC ACIDS RESEARCH

Integrative network analysis identifies cell-specific trans regulators of m6A

(2019) Sanqi An et al.   NUCLEIC ACIDS RESEARCH

HBXIP-elevated methyltransferase METTL3 promotes the progression of breast cancer via inhibiting tumor suppressor let-7g

(2018) Xiaoli Cai et al.   CANCER LETTERS

Dynamic transcriptomic m6A decoration: writers, erasers, readers and functions in RNA metabolism

(2018) Ying Yang et al.   CELL RESEARCH

RNA N6-methyladenosine modification in cancers: current status and perspectives

(2018) Xiaolan Deng et al.   CELL RESEARCH

Meddling with METTLs in Normal and Leukemia Stem Cells

(2018) Gaëlle H. Martin et al.   Cell Stem Cell

METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m 6 A Modification

(2018) Hengyou Weng et al.   Cell Stem Cell

RNA N6-methyladenosine methyltransferase-like 3 promotes liver cancer progression through YTHDF2-dependent posttranscriptional silencing of SOCS2

(2018) Mengnuo Chen et al.   HEPATOLOGY

Multiple functions of m6A RNA methylation in cancer

(2018) Yutian Pan et al.   Journal of Hematology & Oncology

Zc3h13 Regulates Nuclear RNA m 6 A Methylation and Mouse Embryonic Stem Cell Self-Renewal

(2018) Jing Wen et al.   MOLECULAR CELL

Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation

(2018) Huilin Huang et al.   NATURE CELL BIOLOGY

RNA-modifying proteins as anticancer drug targets

(2018) P. Ann Boriack-Sjodin et al.   NATURE REVIEWS DRUG DISCOVERY

SUMOylation of the m6A-RNA methyltransferase METTL3 modulates its function

(2018) Yuzhang Du et al.   NUCLEIC ACIDS RESEARCH

The m6A reader protein YTHDC2 interacts with the small ribosomal subunit and the 5′-3′ exoribonuclease XRN1

(2018) Jens Kretschmer et al.   RNA

Reading m 6 A in the Transcriptome: m 6 A-Binding Proteins

(2018) Deepak P. Patil et al.   TRENDS IN CELL BIOLOGY

Solution structure of the RNA recognition domain of METTL3-METTL14 N6-methyladenosine methyltransferase

(2018) Jinbo Huang et al.   Protein & Cell

YTH Domain: A Family of N 6 -methyladenosine (m 6 A) Readers

(2018) Shanhui Liao et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

VIRMA mediates preferential m6A mRNA methylation in 3′UTR and near stop codon and associates with alternative polyadenylation

(2018) Yanan Yue et al.   Cell Discovery

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

METTL3 promotes ovarian carcinoma growth and invasion through the regulation of AXL translation and epithelial to mesenchymal transition

(2018) Wenfeng Hua et al.   GYNECOLOGIC ONCOLOGY

Methylation of Structured RNA by the m6A Writer METTL16 Is Essential for Mouse Embryonic Development

(2018) Mateusz Mendel et al.   MOLECULAR CELL

Differential m6A, m6Am, and m1A Demethylation Mediated by FTO in the Cell Nucleus and Cytoplasm

(2018) Jiangbo Wei et al.   MOLECULAR CELL

The SMAD2/3 interactome reveals that TGFβ controls m6A mRNA methylation in pluripotency

(2018) Alessandro Bertero et al.   NATURE

mRNA circularization by METTL3–eIF3h enhances translation and promotes oncogenesis

(2018) Junho Choe et al.   NATURE

m6A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer

(2018) Jun Liu et al.   NATURE CELL BIOLOGY

The Epitranscriptome in Translation Regulation

(2018) Eyal Peer et al.   Cold Spring Harbor Perspectives in Biology

N6-Methyladenosine methyltransferase ZCCHC4 mediates ribosomal RNA methylation

(2018) Honghui Ma et al.   Nature Chemical Biology

m6A-mediated ZNF750 repression facilitates nasopharyngeal carcinoma progression

(2018) Panpan Zhang et al.   Cell Death & Disease

Cross-talk among writers, readers, and erasers of m6A regulates cancer growth and progression

(2018) Subbarayalu Panneerdoss et al.   Science Advances

Promoter-bound METTL3 maintains myeloid leukaemia by m6A-dependent translation control

(2017) Isaia Barbieri et al.   NATURE

The N6-methyladenosine (m6A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells

(2017) Ly P Vu et al.   NATURE MEDICINE

N6-methyladenosine demethylase FTO targets pre-mRNAs and regulates alternative splicing and 3′-end processing

(2017) Marek Bartosovic et al.   NUCLEIC ACIDS RESEARCH

N 6-methyladenosine alters RNA structure to regulate binding of a low-complexity protein

(2017) Nian Liu et al.   NUCLEIC ACIDS RESEARCH

Essential role of METTL3-mediated m6A modification in glioma stem-like cells maintenance and radioresistance

(2017) A Visvanathan et al.   ONCOGENE

The M6A methyltransferase METTL3: acting as a tumor suppressor in renal cell carcinoma

(2017) Xiao Li et al.   Oncotarget

m 6 A RNA Methylation Regulates the Self-Renewal and Tumorigenesis of Glioblastoma Stem Cells

(2017) Qi Cui et al.   Cell Reports

YTHDC1 mediates nuclear export of N6-methyladenosine methylated mRNAs

(2017) Ian A Roundtree et al.   eLife

METTL14 suppresses the metastatic potential of hepatocellular carcinoma by modulatingN6-methyladenosine-dependent primary MicroRNA processing

(2016) Jin-zhao Ma et al.   HEPATOLOGY

Pancreatic cancer

(2016) Terumi Kamisawa et al.   LANCET

Nuclear m 6 A Reader YTHDC1 Regulates mRNA Splicing

(2016) Wen Xiao et al.   MOLECULAR CELL

Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases

(2016) Ping Wang et al.   MOLECULAR CELL

The m 6 A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells

(2016) Shuibin Lin et al.   MOLECULAR CELL

Structural basis of N6-adenosine methylation by the METTL3–METTL14 complex

(2016) Xiang Wang et al.   NATURE

m6A RNA methylation promotes XIST-mediated transcriptional repression

(2016) Deepak P. Patil et al.   NATURE

Small molecules, big targets: drug discovery faces the protein–protein interaction challenge

(2016) Duncan E. Scott et al.   NATURE REVIEWS DRUG DISCOVERY

YTHDF2 destabilizes m6A-containing RNA through direct recruitment of the CCR4–NOT deadenylase complex

(2016) Hao Du et al.   Nature Communications

Structural insights into the molecular mechanism of the m6A writer complex

(2016) Paweł Śledź et al.   eLife

Structural Chemistry of Human RNA Methyltransferases

(2015) Matthieu Schapira   ACS Chemical Biology

N6-methyladenosine Modulates Messenger RNA Translation Efficiency

(2015) Xiao Wang et al.   CELL

Coordination of m 6 A mRNA Methylation and Gene Transcription by ZFP217 Regulates Pluripotency and Reprogramming

(2015) Francesca Aguilo et al.   Cell Stem Cell

N6-methyladenosine-dependent RNA structural switches regulate RNA–protein interactions

(2015) Nian Liu et al.   NATURE

Acute Myeloid Leukemia

(2015) Hartmut Döhner et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase

(2014) Xiao-Li Ping et al.   CELL RESEARCH

Structures of Human ALKBH5 Demethylase Reveal a Unique Binding Mode for Specific Single-strandedN6-Methyladenosine RNA Demethylation

(2014) Chao Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structures of the Human RNA Demethylase Alkbh5 Reveal Basis for Substrate Recognition

(2014) Chong Feng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural basis for selective binding of m6A RNA by the YTHDC1 YTH domain

(2014) Chao Xu et al.   Nature Chemical Biology

Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma

(2014) A. P. Patel et al.   SCIENCE

N6-methyladenosine-dependent regulation of messenger RNA stability

(2013) Xiao Wang et al.   NATURE

A METTL3–METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation

(2013) Jianzhao Liu et al.   Nature Chemical Biology

Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons

(2012) Kate D. Meyer et al.   CELL

ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility

(2012) Guanqun Zheng et al.   MOLECULAR CELL

Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq

(2012) Dan Dominissini et al.   NATURE

Molecular Genetics of Colorectal Cancer

(2011) Eric R. Fearon   Annual Review of Pathology-Mechanisms of Disease

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO

(2011) Guifang Jia et al.   Nature Chemical Biology