标题
Targeting the Wnt/β-catenin signaling pathway in cancer
作者
关键词
-
出版物
Journal of Hematology & Oncology
Volume 13, Issue 1, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2020-12-04
DOI
10.1186/s13045-020-00990-3
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Curcumin therapeutic modulation of the Wnt signaling pathway
- (2020) Amirhossein Sahebkar et al. CURRENT PHARMACEUTICAL BIOTECHNOLOGY
- Targeting Wnt/β‐catenin and PI3K/Akt/mTOR pathways in T‐cell acute lymphoblastic leukemia
- (2020) Cecilia Evangelisti et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Antiepileptic Drug Carbamazepine Binds to a Novel Pocket on the Wnt Receptor Frizzled-8
- (2020) Yuguang Zhao et al. JOURNAL OF MEDICINAL CHEMISTRY
- Chelerythrine Chloride Downregulates β-Catenin and Inhibits Stem Cell Properties of Non-Small Cell Lung Carcinoma
- (2020) Win Sen Heng et al. MOLECULES
- The m6A reader YTHDF1 promotes ovarian cancer progression via augmenting EIF3C translation
- (2020) Tao Liu et al. NUCLEIC ACIDS RESEARCH
- Inhibiting WNT and NOTCH in renal cancer stem cells and the implications for human patients
- (2020) Annika Fendler et al. Nature Communications
- Inhibition of Wnt signalling pathway by XAV939 enhances radiosensitivity in human cervical cancer HeLa cells
- (2020) Jinhua Zhang et al. Artificial Cells Nanomedicine and Biotechnology
- Echinacoside inhibits breast cancer cells by suppressing the Wnt/β-catenin signaling pathway
- (2020) Chenghuai Tang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Blockade of β-Catenin–Induced CCL28 Suppresses Gastric Cancer Progression via Inhibition of Treg Cell Infiltration
- (2020) Lu Ji et al. CANCER RESEARCH
- Destabilization of β-catenin and RAS by targeting the Wnt/β-catenin pathway as a potential treatment for triple-negative breast cancer
- (2020) Won-Ji Ryu et al. EXPERIMENTAL AND MOLECULAR MEDICINE
- Emerging agents that target signaling pathways in cancer stem cells
- (2020) Yue Yang et al. Journal of Hematology & Oncology
- Discovery of Novel Inhibitor for WNT/β-Catenin Pathway by Tankyrase 1/2 Structure-Based Virtual Screening
- (2020) Bo Li et al. MOLECULES
- Overcoming Wnt–β-catenin dependent anticancer therapy resistance in leukaemia stem cells
- (2020) John M. Perry et al. NATURE CELL BIOLOGY
- Targeting the β-catenin signaling for cancer therapy
- (2020) Xue Zhang et al. PHARMACOLOGICAL RESEARCH
- GDE2-Dependent Activation of Canonical Wnt Signaling in Neurons Regulates Oligodendrocyte Maturation
- (2020) Bo-Ran Choi et al. Cell Reports
- Targeting RSPO3-LGR4 Signaling for Leukemia Stem Cell Eradication in Acute Myeloid Leukemia
- (2020) Basit Salik et al. CANCER CELL
- Evolving functions of Dickkopf-1 in cancer and immunity
- (2020) Nikolai Jaschke et al. CANCER LETTERS
- Phase 1b study of Wnt inhibitor ipafricept (IPA) with gemcitabine and nab-paclitaxel in patients with previously untreated stage IV pancreatic cancer (mPDAC).
- (2020) Efrat Dotan et al. CLINICAL CANCER RESEARCH
- Targeting Wnt/β‐catenin by anthelmintic drug niclosamide overcomes paclitaxel resistance in esophageal cancer
- (2020) Wei Wei et al. FUNDAMENTAL & CLINICAL PHARMACOLOGY
- WNT Signaling in Melanoma
- (2020) Anna Gajos-Michniewicz et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Targeting the CBP/β-Catenin Interaction to Suppress Activation of Cancer-Promoting Pancreatic Stellate Cells
- (2020) Mingtian Che et al. Cancers
- Phase 1 study of CWP232291 in patients with relapsed or refractory acute myeloid leukemia and myelodysplastic syndrome
- (2020) Je-Hwan Lee et al. Blood Advances
- Assembly of lung progenitors into developmentally-inspired geometry drives differentiation via cellular tension
- (2020) John P. Soleas et al. BIOMATERIALS
- Combined treatment with CBP and BET inhibitors reverses inadvertent activation of detrimental super enhancer programs in DIPG cells
- (2020) Maria Wiese et al. Cell Death & Disease
- 5-FU promotes stemness of colorectal cancer via p53-mediated WNT/β-catenin pathway activation
- (2020) Yong-Hee Cho et al. Nature Communications
- Aspirin Rescues Wnt-Driven Stem-like Phenotype in Human Intestinal Organoids and Increases the Wnt Antagonist Dickkopf-1
- (2020) Karen Dunbar et al. Cellular and Molecular Gastroenterology and Hepatology
- Hepatocyte growth factor/MET and CD44 in colorectal cancer: partners in tumorigenesis and therapy resistance
- (2020) Sander P.J. Joosten et al. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
- WNT/β-catenin signaling in the development of liver cancers
- (2020) Shuai He et al. BIOMEDICINE & PHARMACOTHERAPY
- Frizzled-7 is required for Wnt signaling in gastric tumors with and without Apc mutations.
- (2019) Dustin Flanagan et al. CANCER RESEARCH
- Growth inhibition and apoptosis in colorectal cancer cells induced by Vitamin D-Nanoemulsion (NVD): involvement of Wnt/β-catenin and other signal transduction pathways
- (2019) Suhail Razak et al. Cell and Bioscience
- Gfi1b regulates the level of Wnt/β-catenin signaling in hematopoietic stem cells and megakaryocytes
- (2019) Peiman Shooshtarizadeh et al. Nature Communications
- Modulating Wnt signaling at the root: Porcupine and Wnt acylation
- (2019) Viviana I. Torres et al. PHARMACOLOGY & THERAPEUTICS
- Downregulation of RNF128 activates Wnt/β-catenin signaling to induce cellular EMT and stemness via CD44 and CTTN ubiquitination in melanoma
- (2019) Chuan-Yuan Wei et al. Journal of Hematology & Oncology
- Discovery and anticancer evaluation of a formononetin derivative against gastric cancer SGC7901 cells
- (2019) Jian-Ning Yao et al. INVESTIGATIONAL NEW DRUGS
- Inhibition of CBP/β-catenin and porcupine attenuates Wnt signaling and induces apoptosis in head and neck carcinoma cells
- (2019) Robert Kleszcz et al. CELLULAR ONCOLOGY
- Distinct CRC-associated APC mutations dictate response to Tankyrase inhibition
- (2019) Emma M Schatoff et al. Cancer Discovery
- MELK mediates the stability of EZH2 through site-specific phosphorylation in extranodal natural killer/T-cell lymphoma
- (2019) Boheng Li et al. BLOOD
- A phase 1b dose escalation study of ipafricept (OMP 54F28) in combination with paclitaxel and carboplatin in patients with recurrent platinum-sensitive ovarian cancer
- (2019) Kathleen N. Moore et al. GYNECOLOGIC ONCOLOGY
- Targeting Jak/Stat pathway as a therapeutic strategy against SP/CD44+ tumorigenic cells in Akt/β-catenin-driven hepatocellular carcinoma
- (2019) Tan Boon Toh et al. JOURNAL OF HEPATOLOGY
- PORCN inhibition synergizes with PI3K/mTOR inhibition in Wnt-addicted cancers
- (2019) Zheng Zhong et al. ONCOGENE
- Temozolomide induces activation of Wnt/β-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy
- (2019) Vivek Singh Tomar et al. CELL BIOLOGY AND TOXICOLOGY
- Combined treatment with cisplatin and the tankyrase inhibitor XAV-939 increases cytotoxicity, abrogates cancer-stem-like cell phenotype and increases chemosensitivity of head-and-neck squamous-cell carcinoma cells
- (2019) Souvick Roy et al. MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
- Repurposing antipsychotics of the diphenylbutylpiperidine class for cancer therapy
- (2019) Vikram Shaw et al. SEMINARS IN CANCER BIOLOGY
- USP7 inhibits Wnt/β-catenin signaling through promoting stabilization of Axin
- (2019) Lei Ji et al. Nature Communications
- An aggregon in conductin/axin2 regulates Wnt/β-catenin signaling and holds potential for cancer therapy
- (2019) Dominic B. Bernkopf et al. Nature Communications
- Emerging insights of tumor heterogeneity and drug resistance mechanisms in lung cancer targeted therapy
- (2019) Zuan-Fu Lim et al. Journal of Hematology & Oncology
- Biological activity of weekly ONC201 in adult recurrent glioblastoma patients
- (2019) Isabel Arrillaga-Romany et al. NEURO-ONCOLOGY
- In silico discovery of quinoxaline derivatives as novel LRP5/6-sclerostin interaction inhibitors
- (2018) Jiwon Choi et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Phase II trial to investigate the safety and efficacy of orally applied niclosamide in patients with metachronous or sychronous metastases of a colorectal cancer progressing after therapy: the NIKOLO trial
- (2018) Susen Burock et al. BMC CANCER
- A first-in-human study investigating biodistribution, safety and recommended dose of a new radiolabeled MAb targeting FZD10 in metastatic synovial sarcoma patients
- (2018) Anne-Laure Giraudet et al. BMC CANCER
- Gigantol inhibits Wnt/β-catenin signaling and exhibits anticancer activity in breast cancer cells
- (2018) Shubin Yu et al. BMC Complementary and Alternative Medicine
- IWR-1, a tankyrase inhibitor, attenuates Wnt/β-catenin signaling in cancer stem-like cells and inhibits in vivo the growth of a subcutaneous human osteosarcoma xenograft
- (2018) Sara R. Martins-Neves et al. CANCER LETTERS
- Targeting the Wnt/beta-catenin pathway in cancer: Update on effectors and inhibitors
- (2018) Nithya Krishnamurthy et al. CANCER TREATMENT REVIEWS
- Wnt signalling: conquering complexity
- (2018) Katrin E. Wiese et al. DEVELOPMENT
- Discovery and optimization of 1-(1 H -indol-1-yl)ethanone derivatives as CBP/EP300 bromodomain inhibitors for the treatment of castration-resistant prostate cancer
- (2018) Qiuping Xiang et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- miR-182-5p promotes hepatocellular carcinoma progression by repressing FOXO3a
- (2018) Man-Qing Cao et al. Journal of Hematology & Oncology
- A loss-of-function genetic screening reveals synergistic targeting of AKT/mTOR and WTN/β-catenin pathways for treatment of AML with high PRL-3 phosphatase
- (2018) Jianbiao Zhou et al. Journal of Hematology & Oncology
- Wnt signaling in multiple myeloma: a central player in disease with therapeutic potential
- (2018) Ingrid Spaan et al. Journal of Hematology & Oncology
- Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε
- (2018) Balbina García-Reyes et al. JOURNAL OF MEDICINAL CHEMISTRY
- ONC201 Targets AR and AR-V7 Signaling, Reduces PSA, and Synergizes with Everolimus in Prostate Cancer
- (2018) Avital Lev et al. MOLECULAR CANCER RESEARCH
- A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells
- (2018) Aaron H. Nile et al. Nature Chemical Biology
- Is β-Catenin a Druggable Target for Cancer Therapy?
- (2018) Can Cui et al. TRENDS IN BIOCHEMICAL SCIENCES
- JIB-04, A Small Molecule Histone Demethylase Inhibitor, Selectively Targets Colorectal Cancer Stem Cells by Inhibiting the Wnt/β-Catenin Signaling Pathway
- (2018) Min Seong Kim et al. Scientific Reports
- SCFβ-TRCP E3 ubiquitin ligase targets the tumor suppressor ZNRF3 for ubiquitination and degradation
- (2018) Yanpeng Ci et al. Protein & Cell
- Actinomycin-D and dimethylamino-parthenolide synergism in treating human pancreatic cancer cells
- (2018) Gauri Lamture et al. DRUG DEVELOPMENT RESEARCH
- The lncRNA NEAT1 activates Wnt/β-catenin signaling and promotes colorectal cancer progression via interacting with DDX5
- (2018) Meng Zhang et al. Journal of Hematology & Oncology
- Pimozide suppresses colorectal cancer via inhibition of Wnt/β-catenin signaling pathway
- (2018) Yonggang Ren et al. LIFE SCIENCES
- A synthetic anti-Frizzled antibody engineered for broadened specificity exhibits enhanced anti-tumor properties
- (2018) Zvezdan Pavlovic et al. mAbs
- Loss of RBMS3 Confers Platinum Resistance in Epithelial Ovarian Cancer via Activation of miR-126-5p/β-catenin/CBP signaling
- (2018) Geyan Wu et al. CLINICAL CANCER RESEARCH
- Inhibition of LEF1-Mediated DCLK1 by Niclosamide Attenuates Colorectal Cancer Stemness
- (2018) So-Yeon Park et al. CLINICAL CANCER RESEARCH
- A CK1α Activator Penetrates the Brain and Shows Efficacy Against Drug-resistant Metastatic Medulloblastoma
- (2018) Jezabel Rodriguez-Blanco et al. CLINICAL CANCER RESEARCH
- Wnt signaling dynamics in head and neck squamous cell cancer tumor-stroma interactions
- (2018) Phuong N. Le et al. MOLECULAR CARCINOGENESIS
- IC-2 Suppresses Proliferation and Induces Apoptosis of Bladder Cancer Cells via the Wnt/β-Catenin Pathway
- (2018) Lingfeng Wu et al. MEDICAL SCIENCE MONITOR
- USP25 regulates Wnt signaling by controlling the stability of tankyrases
- (2017) Daichao Xu et al. GENES & DEVELOPMENT
- Prostate apoptosis response 4 (PAR4) expression modulates WNT signaling pathways in MCF7 breast cancer cells: A possible mechanism underlying PAR4-mediated docetaxel chemosensitivity
- (2017) Simone Aparecida De Bessa Garcia et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- Therapeutic Potential of Targeting Wnt/β-Catenin Pathway in Treatment of Colorectal Cancer: Rational and Progress
- (2017) Afsane Bahrami et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Wnt/beta-catenin pathway: modulating anticancer immune response
- (2017) Sachin Gopalkrishna Pai et al. Journal of Hematology & Oncology
- GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP)
- (2017) F. Anthony Romero et al. JOURNAL OF MEDICINAL CHEMISTRY
- Differential abundance of CK1α provides selectivity for pharmacological CK1α activators to target WNT-dependent tumors
- (2017) Bin Li et al. Science Signaling
- The lichen secondary metabolite atranorin suppresses lung cancer cell motility and tumorigenesis
- (2017) Rui Zhou et al. Scientific Reports
- Targeting of Wnt/β-Catenin by Anthelmintic Drug Pyrvinium Enhances Sensitivity of Ovarian Cancer Cells to Chemotherapy
- (2017) Chongyuan Zhang et al. MEDICAL SCIENCE MONITOR
- Differential abundance of CK1α provides selectivity for pharmacological CK1α activators to target WNT-dependent tumors
- (2017) Bin Li et al. Science Signaling
- Targeting Signaling Pathways in Cancer Stem Cells for Cancer Treatment
- (2017) Jeffrey Koury et al. Stem Cells International
- WNT antagonists exhibit unique combinatorial antitumor activity with taxanes by potentiating mitotic cell death
- (2017) Marcus M. Fischer et al. Science Advances
- Cancer stem cell-related gene expression as a potential biomarker of response for first-in-class imipridone ONC201 in solid tumors
- (2017) Varun V. Prabhu et al. PLoS One
- Development of a triazole class of highly potent Porcn inhibitors
- (2016) Lin You et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Enhanced targeting of CML stem and progenitor cells by inhibition of porcupine acyltransferase in combination with TKI
- (2016) Puneet Agarwal et al. BLOOD
- Simultaneous destabilization of β-catenin and Ras via targeting of the axin-RGS domain as a potential therapeutic strategy for colorectal cancer
- (2016) Pu-Hyeon Cha et al. BMB Reports
- Tankyrase 1 inhibitior XAV939 increases chemosensitivity in colon cancer cell lines via inhibition of the Wnt signaling pathway
- (2016) XUEFANG WU et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- WNT pathway inhibitor pyrvinium pamoate inhibits the self-renewal and metastasis of breast cancer stem cells
- (2016) LIANG XU et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Ursolic acid inhibits proliferation and induces apoptosis by inactivating Wnt/β-catenin signaling in human osteosarcoma cells
- (2016) Ran-Xi Zhang et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Small-molecule binding of the axin RGS domain promotes β-catenin and Ras degradation
- (2016) Pu-Hyeon Cha et al. Nature Chemical Biology
- Discovery of Pyridinyl Acetamide Derivatives as Potent, Selective, and Orally Bioavailable Porcupine Inhibitors
- (2016) Dai Cheng et al. ACS Medicinal Chemistry Letters
- Preclinical evaluation of a nanoformulated antihelminthic, niclosamide, in ovarian cancer
- (2016) Chi-Kang Lin et al. Oncotarget
- Reduced CD146 expression promotes tumorigenesis and cancer stemness in colorectal cancer through activating Wnt/β-catenin signaling
- (2016) Dan Liu et al. Oncotarget
- Triptonide Effectively Inhibits Wnt/β-Catenin Signaling via C-terminal Transactivation Domain of β-catenin
- (2016) Jessica Chinison et al. Scientific Reports
- Wnts are dispensable for differentiation and self-renewal of adult murine hematopoietic stem cells
- (2015) Z. Kabiri et al. BLOOD
- A Small-Molecule Antagonist of the -Catenin/TCF4 Interaction Blocks the Self-Renewal of Cancer Stem Cells and Suppresses Tumorigenesis
- (2015) L. Fang et al. CANCER RESEARCH
- Tankyrase Inhibition Blocks Wnt/ -Catenin Pathway and Reverts Resistance to PI3K and AKT Inhibitors in the Treatment of Colorectal Cancer
- (2015) O. Arques et al. CLINICAL CANCER RESEARCH
- Targeting Wnt pathway in mantle cell lymphoma-initiating cells
- (2015) Rohit Mathur et al. Journal of Hematology & Oncology
- Discovery of Selective Small-Molecule Inhibitors for the β-Catenin/T-Cell Factor Protein–Protein Interaction through the Optimization of the Acyl Hydrazone Moiety
- (2015) J. Leon Catrow et al. JOURNAL OF MEDICINAL CHEMISTRY
- Dishevelled Promotes Wnt Receptor Degradation through Recruitment of ZNRF3/RNF43 E3 Ubiquitin Ligases
- (2015) Xiaomo Jiang et al. MOLECULAR CELL
- Wnt addiction of genetically defined cancers reversed by PORCN inhibition
- (2015) B Madan et al. ONCOGENE
- Therapeutic targets in the Wnt signaling pathway: Feasibility of targeting TNIK in colorectal cancer
- (2015) Mari Masuda et al. PHARMACOLOGY & THERAPEUTICS
- Targeting the Wnt pathway in human cancers: Therapeutic targeting with a focus on OMP-54F28
- (2015) Phuong N. Le et al. PHARMACOLOGY & THERAPEUTICS
- Tankyrase Inhibition Causes Reversible Intestinal Toxicity in Mice with a Therapeutic Index < 1
- (2015) Yu Zhong et al. TOXICOLOGIC PATHOLOGY
- Wnt-C59 arrests stemness and suppresses growth of nasopharyngeal carcinoma in mice by inhibiting the Wnt pathway in the tumor microenvironment
- (2015) Yue Cheng et al. Oncotarget
- Inhibition of Cyclic Adenosine Monophosphate (cAMP)-response Element-binding Protein (CREB)-binding Protein (CBP)/β-Catenin Reduces Liver Fibrosis in Mice
- (2015) Yosuke Osawa et al. EBioMedicine
- Wnt inhibition leads to improved chemosensitivity in paediatric acute lymphoblastic leukaemia
- (2014) Smita Dandekar et al. BRITISH JOURNAL OF HAEMATOLOGY
- Safely targeting cancer stem cells via selective catenin coactivator antagonism
- (2014) Heinz-Josef Lenz et al. CANCER SCIENCE
- Isoquercitrin Suppresses Colon Cancer Cell Growthin Vitroby Targeting the Wnt/β-Catenin Signaling Pathway
- (2014) Nathália G. Amado et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Salinomycin Suppresses LRP6 Expression and Inhibits Both Wnt/β-catenin and mTORC1 Signaling in Breast and Prostate Cancer Cells
- (2014) Wenyan Lu et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- High-Throughput Drug Screen Identifies Chelerythrine as a Selective Inducer of Death in a TSC2-null Setting
- (2014) Doug Medvetz et al. MOLECULAR CANCER RESEARCH
- Effect of Niclosamide on Basal-like Breast Cancers
- (2014) A. I. Londono-Joshi et al. MOLECULAR CANCER THERAPEUTICS
- Can we safely target the WNT pathway?
- (2014) Michael Kahn NATURE REVIEWS DRUG DISCOVERY
- The Anthelmintic Drug Niclosamide Induces Apoptosis, Impairs Metastasis and Reduces Immunosuppressive Cells in Breast Cancer Model
- (2014) Tinghong Ye et al. PLoS One
- Targeting the Wnt/β-Catenin Signaling Pathway in Liver Cancer Stem Cells and Hepatocellular Carcinoma Cell Lines with FH535
- (2014) Roberto Gedaly et al. PLoS One
- Roles of Wnt/β-catenin signaling in the gastric cancer stem cells proliferation and salinomycin treatment
- (2014) J Mao et al. Cell Death & Disease
- The EMT activator ZEB1 promotes tumor growth and determines differential response to chemotherapy in mantle cell lymphoma
- (2013) E Sánchez-Tilló et al. CELL DEATH AND DIFFERENTIATION
- Hematein, a casein kinase II inhibitor, inhibits lung cancer tumor growth in a murine xenograft model
- (2013) MING-SZU HUNG et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- XAV939, a tankyrase 1 inhibitior, promotes cell apoptosis in neuroblastoma cell lines by inhibiting Wnt/β-catenin signaling pathway
- (2013) Xiao-Hong Tian et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Wnt signaling blockage inhibits cell proliferation and migration, and induces apoptosis in triple-negative breast cancer cells
- (2013) Birdal Bilir et al. Journal of Translational Medicine
- Sulindac Selectively Inhibits Colon Tumor Cell Growth by Activating the cGMP/PKG Pathway to Suppress Wnt/ -Catenin Signaling
- (2013) N. Li et al. MOLECULAR CANCER THERAPEUTICS
- Wogonin induced G1 cell cycle arrest by regulating Wnt/β-catenin signaling pathway and inactivating CDK8 in human colorectal cancer carcinoma cells
- (2013) Licheng He et al. TOXICOLOGY
- Structural and molecular basis of ZNRF3/RNF43 transmembrane ubiquitin ligase inhibition by the Wnt agonist R-spondin
- (2013) Matthias Zebisch et al. Nature Communications
- The tankyrase-specific inhibitor JW74 affects cell cycle progression and induces apoptosis and differentiation in osteosarcoma cell lines
- (2013) Eva Wessel Stratford et al. Cancer Medicine
- Trifluoperazine, an Antipsychotic Agent, Inhibits Cancer Stem Cell Growth and Overcomes Drug Resistance of Lung Cancer
- (2012) Chi-Tai Yeh et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Inactivation of tankyrases reduces experimental fibrosis by inhibiting canonical Wnt signalling
- (2012) Alfiya Distler et al. ANNALS OF THE RHEUMATIC DISEASES
- Celecoxib Downregulates CD133 Expression Through Inhibition of the Wnt Signaling Pathway in Colon Cancer Cells
- (2012) Yanhong Deng et al. CANCER INVESTIGATION
- A Novel Tankyrase Inhibitor Decreases Canonical Wnt Signaling in Colon Carcinoma Cells and Reduces Tumor Growth in Conditional APC Mutant Mice
- (2012) J. Waaler et al. CANCER RESEARCH
- A molecular mechanism that links Hippo signalling to the inhibition of Wnt/β-catenin signalling
- (2012) Masamichi Imajo et al. EMBO JOURNAL
- Nimbolide, a neem limonoid abrogates canonical NF-κB and Wnt signaling to induce caspase-dependent apoptosis in human hepatocarcinoma (HepG2) cells
- (2012) Krishnamurthy Kavitha et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Tankyrase-targeted therapeutics: expanding opportunities in the PARP family
- (2012) Jenna L. Riffell et al. NATURE REVIEWS DRUG DISCOVERY
- Wnt pathway inhibition via the targeting of Frizzled receptors results in decreased growth and tumorigenicity of human tumors
- (2012) A. Gurney et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Hippo pathway in intestinal homeostasis and tumorigenesis
- (2012) Lanfen Chen et al. Protein & Cell
- Salinomycin inhibits osteosarcoma by targeting its tumor stem cells
- (2011) Qing-Lian Tang et al. CANCER LETTERS
- Phospho-Sulindac (OXT-328) Combined with Difluoromethylornithine Prevents Colon Cancer in Mice
- (2011) Gerardo G. Mackenzie et al. Cancer Prevention Research
- Novel Synthetic Antagonists of Canonical Wnt Signaling Inhibit Colorectal Cancer Cell Growth
- (2011) J. Waaler et al. CANCER RESEARCH
- Small molecule-based disruption of the Axin/β-catenin protein complex regulates mesenchymal stem cell differentiation
- (2011) Jungsug Gwak et al. CELL RESEARCH
- Attenuation of multi-targeted proliferation-linked signaling by 3,3′-diindolylmethane (DIM): From bench to clinic
- (2011) Sanjeev Banerjee et al. MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH
- Salinomycin inhibits Wnt signaling and selectively induces apoptosis in chronic lymphocytic leukemia cells
- (2011) Desheng Lu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Targeting Wnt Signaling: Can We Safely Eradicate Cancer Stem Cells?
- (2010) F. Takahashi-Yanaga et al. CLINICAL CANCER RESEARCH
- Role of Wnt canonical pathway in hematological malignancies
- (2010) Xueling GE et al. Journal of Hematology & Oncology
- Convergence between Wnt-β-catenin and EGFR signaling in cancer
- (2010) Tianhui Hu et al. Molecular Cancer
- Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α
- (2010) Curtis A Thorne et al. Nature Chemical Biology
- Targeting cancer stem cells by inhibiting Wnt, Notch and Hedgehog pathways
- (2010) Naoko Takebe et al. Nature Reviews Clinical Oncology
- Cellular signaling perturbation by natural products
- (2009) Fazlul H. Sarkar et al. CELLULAR SIGNALLING
- Discovery and Characterization of a Small Molecule Inhibitor of the PDZ Domain of Dishevelled
- (2009) David Grandy et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling
- (2009) Shih-Min A. Huang et al. NATURE
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started