Dysregulation of LINC00470 and METTL3 promotes chemoresistance and suppresses autophagy of chronic myelocytic leukaemia cells

m 6 A methyltransferase METTL3 promotes retinoblastoma progression via PI3K/AKT/mTOR pathway

(2020) Han Zhang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

METTL3 and ALKBH5 oppositely regulate m6A modification of TFEB mRNA, which dictates the fate of hypoxia/reoxygenation-treated cardiomyocytes

(2019) Huiwen Song et al.   Autophagy

Long noncoding RNAs as potential biomarkers and therapeutic targets in gallbladder cancer: a systematic review and meta-analysis

(2019) Yuan Zhong et al.   Cancer Cell International

METTL3 promote tumor proliferation of bladder cancer by accelerating pri-miR221/222 maturation in m6A-dependent manner

(2019) Jie Han et al.   Molecular Cancer

Upregulated METTL3 promotes metastasis of colorectal Cancer via miR-1246/SPRED2/MAPK signaling pathway

(2019) Wen Peng et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Long Non-Coding RNA in the Pathogenesis of Cancers

(2019) Chi et al.   Cells

LncRNA LINC00470 promotes the degradation of PTEN mRNA to facilitate malignant behavior in gastric cancer cells

(2019) Jijun Yan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Maternally expressed gene 3 (MEG3): A tumor suppressor long non coding RNA

(2019) Soudeh Ghafouri-Fard et al.   BIOMEDICINE & PHARMACOTHERAPY

Comprehensive analysis the potential biomarkers for the high-risk of childhood acute myeloid leukemia based on a competing endogenous RNA network

(2019) Nan Zhang et al.   BLOOD CELLS MOLECULES AND DISEASES

METTL14 Suppresses CRC Progression via Regulating N6-Methyladenosine-Dependent Primary miR-375 Processing

(2019) Xiaoxiang Chen et al.   MOLECULAR THERAPY

KIAA1429 contributes to liver cancer progression through N6-methyladenosine-dependent post-transcriptional modification of GATA3

(2019) Tian Lan et al.   Molecular Cancer

m6A mRNA methylation regulates CTNNB1 to promote the proliferation of hepatoblastoma

(2019) Li Liu et al.   Molecular Cancer

METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m 6 A Modification

(2018) Hengyou Weng et al.   Cell Stem Cell

RNA N6-methyladenosine methyltransferase-like 3 promotes liver cancer progression through YTHDF2-dependent posttranscriptional silencing of SOCS2

(2018) Mengnuo Chen et al.   HEPATOLOGY

A cytoplasmic long noncoding RNA LINC00470 as a new AKT activator to mediate glioblastoma cell autophagy

(2018) Changhong Liu et al.   Journal of Hematology & Oncology

Long noncoding RNA HULC accelerates liver cancer by inhibiting PTEN via autophagy cooperation to miR15a

(2018) Xiaoru Xin et al.   Molecular Cancer

LINC00470 Coordinates the Epigenetic Regulation of ELFN2 to Distract GBM Cell Autophagy

(2018) Changhong Liu et al.   MOLECULAR THERAPY

The N6-methyladenosine (m6A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells

(2017) Ly P Vu et al.   NATURE MEDICINE

Indole-3-carbinol induces apoptosis of chronic myelogenous leukemia cells through suppression of STAT5 and Akt signaling pathways

(2017) Majid Safa et al.   TUMOR BIOLOGY

CASC2c as an unfavorable prognosis factor interacts with miR-101 to mediate astrocytoma tumorigenesis

(2017) Changhong Liu et al.   Cell Death & Disease

miR-18a promotes cell proliferation of esophageal squamous cell carcinoma cells by increasing cylin D1 via regulating PTEN-PI3K-AKT-mTOR signaling axis

(2016) Weiguo Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Notch promotes tumor metastasis in a prostate-specific Pten-null mouse model

(2016) Oh-Joon Kwon et al.   JOURNAL OF CLINICAL INVESTIGATION

AKT activation controls cell survival in response to HDAC6 inhibition

(2016) M Kaliszczak et al.   Cell Death & Disease

ATM-mediated PTEN phosphorylation promotes PTEN nuclear translocation and autophagy in response to DNA-damaging agents in cancer cells

(2015) Jing-Hong Chen et al.   Autophagy

LC3- and p62-based biochemical methods for the analysis of autophagy progression in mammalian cells

(2015) Peidu Jiang et al.   METHODS

Leukemia stem cells: the root of chronic myeloid leukemia

(2015) Hong Zhou et al.   Protein & Cell

PTEN

(2014) Carolyn A. Worby et al.   Annual Review of Biochemistry

Expression of LYN and PTEN genes in chronic myeloid leukemia and their importance in therapeutic strategy

(2014) Cristian Ferri et al.   BLOOD CELLS MOLECULES AND DISEASES

HMGB1-mediated autophagy promotes docetaxel resistance in human lung adenocarcinoma

(2014) Banzhou Pan et al.   Molecular Cancer

PTEN Regulates BCRP/ABCG2 and the Side Population through the PI3K/Akt Pathway in Chronic Myeloid Leukemia

(2014) Fang-Fang Huang et al.   PLoS One

A Unified Nomenclature and Amino Acid Numbering for Human PTEN

(2014) R. Pulido et al.   Science Signaling

PTEN function: the long and the short of it

(2014) Benjamin D. Hopkins et al.   TRENDS IN BIOCHEMICAL SCIENCES

Multidrug resistance in chronic myeloid leukaemia: how much can we learn from MDR–CML cell lines?

(2013) Vivian M. Rumjanek et al.   BIOSCIENCE REPORTS

The PTEN Long N-tail is intrinsically disordered: increased viability for PTEN therapy

(2013) Prerna Malaney et al.   Molecular BioSystems

Systemic Elevation of PTEN Induces a Tumor-Suppressive Metabolic State

(2012) Isabel Garcia-Cao et al.   CELL

The functions and regulation of the PTEN tumour suppressor

(2012) Min Sup Song et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

CREB Is a Novel Nuclear Target of PTEN Phosphatase

(2011) T. Gu et al.   CANCER RESEARCH

PTEN is a tumor suppressor in CML stem cells and BCR-ABL-induced leukemias in mice

(2009) C. Peng et al.   BLOOD

Role of the PI3K/AKT and mTOR signaling pathways in acute myeloid leukemia

(2009) S. Park et al.   HAEMATOLOGICA