标题
The emerging roles of N6-methyladenosine RNA methylation in human cancers
作者
关键词
-
出版物
Biomarker Research
Volume 8, Issue 1, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2020-06-30
DOI
10.1186/s40364-020-00203-6
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- The N 6 -methyladenosine (m6 A) erasers alkylation repair homologue 5 (ALKBH5) and fat mass and obesity-associated protein (FTO) are prognostic biomarkers in patients with clear cell renal carcinoma
- (2020) Alexander Strick et al. BJU INTERNATIONAL
- Cancer statistics, 2020
- (2020) Rebecca L. Siegel et al. CA-A CANCER JOURNAL FOR CLINICIANS
- METTL3/YTHDF2 m 6 A axis promotes tumorigenesis by degrading SETD7 and KLF4 mRNAs in bladder cancer
- (2020) Haiyun Xie et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- M6A-mediated upregulation of LINC00958 increases lipogenesis and acts as a nanotherapeutic target in hepatocellular carcinoma
- (2020) Xueliang Zuo et al. Journal of Hematology & Oncology
- METTL14 suppresses proliferation and metastasis of colorectal cancer by down-regulating oncogenic long non-coding RNA XIST
- (2020) Xiao Yang et al. Molecular Cancer
- FTO Facilitates Lung Adenocarcinoma Cell Progression by Activating Cell Migration Through mRNA Demethylation
- (2020) Yudi Ding et al. OncoTargets and Therapy
- METTL3 Promotes the Progression of Gastric Cancer via Targeting the MYC Pathway
- (2020) Dong-Dong Yang et al. Frontiers in Oncology
- Long non-coding RNA RHPN1-AS1 promotes tumorigenesis and metastasis of ovarian cancer by acting as a ceRNA against miR-596 and upregulating LETM1
- (2020) Junrong Wang et al. Aging-US
- Leukemogenic Chromatin Alterations Promote AML Leukemia Stem Cells via a KDM4C-ALKBH5-AXL Signaling Axis
- (2020) Jiazhen Wang et al. Cell Stem Cell
- RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia
- (2020) Chao Shen et al. Cell Stem Cell
- Mechanistic insights into m6A modification of U6 snRNA by human METTL16
- (2020) Tomohiko Aoyama et al. NUCLEIC ACIDS RESEARCH
- VIRMA-Dependent N6-Methyladenosine Modifications Regulate the Expression of Long Non-Coding RNAs CCAT1 and CCAT2 in Prostate Cancer
- (2020) Daniela Barros-Silva et al. Cancers
- METTL3 promotes the proliferation and mobility of gastric cancer cells
- (2019) Sen Lin et al. Open Medicine
- Gene signatures and prognostic values of m6A regulators in clear cell renal cell carcinoma – a retrospective study using TCGA database
- (2019) Jingcheng Zhou et al. Aging-US
- KIAA1429 regulates the migration and invasion of hepatocellular carcinoma by altering m6A modification of ID2 mRNA
- (2019) Xiaoyu Cheng et al. OncoTargets and Therapy
- FOX-A1 contributes to acquisition of chemoresistance in human lung adenocarcinoma via transactivation of SOX5
- (2019) Dongqin Chen et al. EBioMedicine
- YTHDF1 Regulates Tumorigenicity and Cancer Stem Cell-Like Activity in Human Colorectal Carcinoma
- (2019) Yang Bai et al. Frontiers in Oncology
- Tracing Oncogene Rearrangements in the Mutational History of Lung Adenocarcinoma
- (2019) Jake June-Koo Lee et al. CELL
- ALKBH5 promotes invasion and metastasis of gastric cancer by decreasing methylation of the lncRNA NEAT1
- (2019) Jun Zhang et al. JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
- METTL3 facilitates tumor progression via an m6A-IGF2BP2-dependent mechanism in colorectal carcinoma
- (2019) Ting Li et al. Molecular Cancer
- KIAA1429 acts as an oncogenic factor in breast cancer by regulating CDK1 in an N6-methyladenosine-independent manner
- (2019) Jia-Yi Qian et al. ONCOGENE
- m6A methyltransferase METTL3 suppresses colorectal cancer proliferation and migration through p38/ERK pathways
- (2019) Ru Deng et al. OncoTargets and Therapy
- RNA m6A methylation regulates the epithelial mesenchymal transition of cancer cells and translation of Snail
- (2019) Xinyao Lin et al. Nature Communications
- N6-methyladenosine Modulates Nonsense-mediated mRNA Decay in Human Glioblastoma
- (2019) Fuxi Li et al. CANCER RESEARCH
- N6-methyladenosine METTL3 promotes the breast cancer progression via targeting Bcl-2
- (2019) Hong Wang et al. GENE
- WTAP facilitates progression of hepatocellular carcinoma via m6A-HuR-dependent epigenetic silencing of ETS1
- (2019) Yunhao Chen et al. Molecular Cancer
- N6-methyladenosine modification of ITGA6 mRNA promotes the development and progression of bladder cancer
- (2019) Huan Jin et al. EBioMedicine
- MiR-4429 prevented gastric cancer progression through targeting METTL3 to inhibit m6A-caused stabilization of SEC62
- (2019) Huabo He et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- METTL3-mediated m6A modification of HDGF mRNA promotes gastric cancer progression and has prognostic significance
- (2019) Qiang Wang et al. GUT
- Long noncoding RNA GAS5 inhibits progression of colorectal cancer by interacting with and triggering YAP phosphorylation and degradation and is negatively regulated by the m6A reader YTHDF3
- (2019) Wen Ni et al. Molecular Cancer
- Mettl14 inhibits bladder TIC self-renewal and bladder tumorigenesis through N6-methyladenosine of Notch1
- (2019) Chaohui Gu et al. Molecular Cancer
- YTHDF2 reduction fuels inflammation and vascular abnormalization in hepatocellular carcinoma
- (2019) Jiajie Hou et al. Molecular Cancer
- ALKBH5-m6A-FOXM1 signaling axis promotes proliferation and invasion of lung adenocarcinoma cells under intermittent hypoxia
- (2019) Yinghui Chao et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- m6A RNA methylation regulators can contribute to malignant progression and impact the prognosis of bladder cancer
- (2019) Mei Chen et al. BIOSCIENCE REPORTS
- IGF2BP2 regulates DANCR by serving as an N6-methyladenosine reader
- (2019) Xiaoge Hu et al. CELL DEATH AND DIFFERENTIATION
- Immune signature of T follicular helper cells predicts clinical prognostic and therapeutic impact in lung squamous cell carcinoma
- (2019) Feng Xu et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- N6-methyladenosine induced miR-143-3p promotes the brain metastasis of lung cancer via regulation of VASH1
- (2019) Hongsheng Wang et al. Molecular Cancer
- KIAA1429 contributes to liver cancer progression through N6-methyladenosine-dependent post-transcriptional modification of GATA3
- (2019) Tian Lan et al. Molecular Cancer
- m6A RNA modification modulates gene expression and cancer-related pathways in clear cell renal cell carcinoma
- (2019) Yimeng Chen et al. Epigenomics
- Treatment strategies for adolescent and young adult patients with acute myeloid leukemia
- (2018) Kristen O'Dwyer et al. BLOOD
- HBXIP-elevated methyltransferase METTL3 promotes the progression of breast cancer via inhibiting tumor suppressor let-7g
- (2018) Xiaoli Cai et al. CANCER LETTERS
- R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m 6 A/MYC/CEBPA Signaling
- (2018) Rui Su et al. CELL
- METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m 6 A Modification
- (2018) Hengyou Weng et al. Cell Stem Cell
- Zc3h13/Flacc is required for adenosine methylation by bridging the mRNA-binding factor Rbm15/Spenito to the m6A machinery component Wtap/Fl(2)d
- (2018) Philip Knuckles et al. GENES & DEVELOPMENT
- RNA N6-methyladenosine methyltransferase-like 3 promotes liver cancer progression through YTHDF2-dependent posttranscriptional silencing of SOCS2
- (2018) Mengnuo Chen et al. HEPATOLOGY
- Epidemiology of prostate cancer in Asian countries
- (2018) Takahiro Kimura et al. INTERNATIONAL JOURNAL OF UROLOGY
- FTO regulates the chemo-radiotherapy resistance of cervical squamous cell carcinoma (CSCC) by targeting β-catenin through mRNA demethylation
- (2018) Shun Zhou et al. MOLECULAR CARCINOGENESIS
- Zc3h13 Regulates Nuclear RNA m 6 A Methylation and Mouse Embryonic Stem Cell Self-Renewal
- (2018) Jing Wen et al. MOLECULAR CELL
- Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation
- (2018) Huilin Huang et al. NATURE CELL BIOLOGY
- ketu mutant mice uncover an essential meiotic function for the ancient RNA helicase YTHDC2
- (2018) Devanshi Jain et al. eLife
- VIRMA mediates preferential m6A mRNA methylation in 3′UTR and near stop codon and associates with alternative polyadenylation
- (2018) Yanan Yue et al. Cell Discovery
- Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
- (2018) Freddie Bray et al. CA-A CANCER JOURNAL FOR CLINICIANS
- mRNA circularization by METTL3–eIF3h enhances translation and promotes oncogenesis
- (2018) Junho Choe et al. NATURE
- m6A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer
- (2018) Jun Liu et al. NATURE CELL BIOLOGY
- Structural insights into the RNA methyltransferase domain of METTL16
- (2018) Agnieszka Ruszkowska et al. Scientific Reports
- Premature polyadenylation of MAGI3 is associated with diminished N6-methyladenosine in its large internal exon
- (2018) Thomas K. Ni et al. Scientific Reports
- N-methyladenine DNA Modification in Glioblastoma
- (2018) Qi Xie et al. CELL
- MicroRNA-145 ModulatesN6-Methyladenosine Levels by Targeting the 3′-Untranslated mRNA Region of theN6-Methyladenosine Binding YTH Domain Family 2 Protein
- (2017) Zhe Yang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Genetic alterations of m6A regulators predict poorer survival in acute myeloid leukemia
- (2017) Chau-To Kwok et al. Journal of Hematology & Oncology
- RNA Chemical Proteomics Reveals the N6-Methyladenosine (m6A)-Regulated Protein–RNA Interactome
- (2017) A. Emilia Arguello et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Circulating cell-free nucleic acids and platelets as a liquid biopsy in the provision of personalized therapy for lung cancer patients
- (2017) L. Sorber et al. LUNG CANCER
- m 6 A Facilitates eIF4F-Independent mRNA Translation
- (2017) Ryan A. Coots et al. MOLECULAR CELL
- m6A mRNA methylation controls T cell homeostasis by targeting the IL-7/STAT5/SOCS pathways
- (2017) Hua-Bing Li et al. NATURE
- Promoter-bound METTL3 maintains myeloid leukaemia by m6A-dependent translation control
- (2017) Isaia Barbieri et al. NATURE
- The N6-methyladenosine (m6A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells
- (2017) Ly P Vu et al. NATURE MEDICINE
- N6-methyladenosine (m6A) recruits and repels proteins to regulate mRNA homeostasis
- (2017) Raghu R Edupuganti et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- N 6-methyladenosine alters RNA structure to regulate binding of a low-complexity protein
- (2017) Nian Liu et al. NUCLEIC ACIDS RESEARCH
- Essential role of METTL3-mediated m6A modification in glioma stem-like cells maintenance and radioresistance
- (2017) A Visvanathan et al. ONCOGENE
- FTO expression is associated with the occurrence of gastric cancer and prognosis
- (2017) Dong Xu et al. ONCOLOGY REPORTS
- Implication of downregulation and prospective pathway signaling of microRNA-375 in lung squamous cell carcinoma
- (2017) Wen-jie Chen et al. PATHOLOGY RESEARCH AND PRACTICE
- ALKBH5-dependent m6A demethylation controls splicing and stability of long 3′-UTR mRNAs in male germ cells
- (2017) Chong Tang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- m 6 A in mRNA: An Ancient Mechanism for Fine-Tuning Gene Expression
- (2017) Jean-Yves Roignant et al. TRENDS IN GENETICS
- N6-methyladenosine (m6A) recruits and repels proteins to regulate mRNA homeostasis
- (2017) Raghu R Edupuganti et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Downregulation of N6-methyladenosine binding YTHDF2 protein mediated by miR-493-3p suppresses prostate cancer by elevating N6-methyladenosine levels
- (2017) Jiangfeng Li et al. Oncotarget
- m 6 A RNA Methylation Regulates the Self-Renewal and Tumorigenesis of Glioblastoma Stem Cells
- (2017) Qi Cui et al. Cell Reports
- The conserved RNA helicase YTHDC2 regulates the transition from proliferation to differentiation in the germline
- (2017) Alexis S Bailey et al. eLife
- YTHDC1 mediates nuclear export of N6-methyladenosine methylated mRNAs
- (2017) Ian A Roundtree et al. eLife
- AlkB homolog 3-mediated tRNA demethylation promotes protein synthesis in cancer cells
- (2017) Yuko Ueda et al. Scientific Reports
- METTL14 suppresses the metastatic potential of hepatocellular carcinoma by modulatingN6-methyladenosine-dependent primary MicroRNA processing
- (2016) Jin-zhao Ma et al. HEPATOLOGY
- Nuclear m 6 A Reader YTHDC1 Regulates mRNA Splicing
- (2016) Wen Xiao et al. MOLECULAR CELL
- The m 6 A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells
- (2016) Shuibin Lin et al. MOLECULAR CELL
- Structural basis of N6-adenosine methylation by the METTL3–METTL14 complex
- (2016) Xiang Wang et al. NATURE
- m6A RNA methylation promotes XIST-mediated transcriptional repression
- (2016) Deepak P. Patil et al. NATURE
- Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m6A-demethylation of NANOG mRNA
- (2016) Chuanzhao Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Messenger RNA modifications: Form, distribution, and function
- (2016) W. V. Gilbert et al. SCIENCE
- YTHDF2 destabilizes m6A-containing RNA through direct recruitment of the CCR4–NOT deadenylase complex
- (2016) Hao Du et al. Nature Communications
- N6-Methyladenosine: a conformational marker that regulates the substrate specificity of human demethylases FTO and ALKBH5
- (2016) Shui Zou et al. Scientific Reports
- A Clearer View of the Molecular Complexity of Clear Cell Renal Cell Carcinoma
- (2015) Ian J. Frew et al. Annual Review of Pathology-Mechanisms of Disease
- Global cancer statistics, 2012
- (2015) Lindsey A. Torre et al. CA-A CANCER JOURNAL FOR CLINICIANS
- HNRNPA2B1 Is a Mediator of m6A-Dependent Nuclear RNA Processing Events
- (2015) Claudio R. Alarcón et al. CELL
- N6-methyladenosine Modulates Messenger RNA Translation Efficiency
- (2015) Xiao Wang et al. CELL
- Coordination of m 6 A mRNA Methylation and Gene Transcription by ZFP217 Regulates Pluripotency and Reprogramming
- (2015) Francesca Aguilo et al. Cell Stem Cell
- RNAN6-methyladenosine methylation in post-transcriptional gene expression regulation
- (2015) Yanan Yue et al. GENES & DEVELOPMENT
- Colorectal cancer
- (2015) Herb Brody NATURE
- Dynamic m6A mRNA methylation directs translational control of heat shock response
- (2015) Jun Zhou et al. NATURE
- N6-methyladenosine-dependent RNA structural switches regulate RNA–protein interactions
- (2015) Nian Liu et al. NATURE
- PI3K/AKT signaling pathway and cancer: an updated review
- (2014) Miriam Martini et al. ANNALS OF MEDICINE
- The PRKCI and SOX2 Oncogenes Are Coamplified and Cooperate to Activate Hedgehog Signaling in Lung Squamous Cell Carcinoma
- (2014) Verline Justilien et al. CANCER CELL
- Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase
- (2014) Xiao-Li Ping et al. CELL RESEARCH
- Management of older or unfit patients with acute myeloid leukemia
- (2014) R B Walter et al. LEUKEMIA
- N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells
- (2014) Yang Wang et al. NATURE CELL BIOLOGY
- Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5
- (2014) Yue Huang et al. NUCLEIC ACIDS RESEARCH
- Perturbation of m6A Writers Reveals Two Distinct Classes of mRNA Methylation at Internal and 5′ Sites
- (2014) Schraga Schwartz et al. Cell Reports
- N6-methyladenosine-dependent regulation of messenger RNA stability
- (2013) Xiao Wang et al. NATURE
- A METTL3–METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation
- (2013) Jianzhao Liu et al. Nature Chemical Biology
- Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons
- (2012) Kate D. Meyer et al. CELL
- ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility
- (2012) Guanqun Zheng et al. MOLECULAR CELL
- Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq
- (2012) Dan Dominissini et al. NATURE
- Prediction of novel families of enzymes involved in oxidative and other complex modifications of bases in nucleic acids
- (2011) Lakshminarayan M. Iyer et al. CELL CYCLE
- N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO
- (2011) Guifang Jia et al. Nature Chemical Biology
- The YTH Domain Is a Novel RNA Binding Domain
- (2010) Zhaiyi Zhang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Malignant Gliomas in Adults
- (2008) Patrick Y. Wen et al. NEW ENGLAND JOURNAL OF MEDICINE
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