Design, Synthesis, In Silico and In Vitro Studies for New Nitric Oxide-Releasing Indomethacin Derivatives with 1,3,4-Oxadiazole-2-thiol Scaffold

From inflammation to colitis-associated colorectal cancer in inflammatory bowel disease: Pathogenesis and impact of current therapies

(2021) Massimo Claudio Fantini et al.   DIGESTIVE AND LIVER DISEASE

New nitric oxide-releasing indomethacin derivatives with 1,3-thiazolidine-4-one scaffold: Design, synthesis, in silico and in vitro studies

(2021) Alexandru Sava et al.   BIOMEDICINE & PHARMACOTHERAPY

An ACE2 Triple Decoy that neutralizes SARS-CoV-2 shows enhanced affinity for virus variants

(2021) Shiho Tanaka et al.   Scientific Reports

Novel 1,3,4-oxadiazole thioether derivatives containing flexible-chain moiety: Design, synthesis, nematocidal activities, and pesticide-likeness analysis

(2020) Jixiang Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design, synthesis, and biological evaluation of dual targeting inhibitors of histone deacetylase 6/8 and bromodomain BRPF1

(2020) Ehab Ghazy et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Structure-Activity Relationship Studies of Hydrazide-Hydrazones as Inhibitors of Laccase from Trametes versicolor

(2020) Halina Maniak et al.   MOLECULES

Allyl 4-Chlorophenyl Sulfone as a Versatile 1,1-Synthon for Sequential α-Alkylation/Cobalt-Catalyzed Allylic Substitution

(2020) Masahiro Kojima et al.   SYNTHESIS-STUTTGART

Essential oil-based nanostructures for inflammation and rheumatoid arthritis

(2020) Vishal Tyagi et al.   JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

Toxic effects of NSAIDs in non-target species: a review from the perspective of the aquatic environment

(2020) Klaudia Świacka et al.   ENVIRONMENTAL POLLUTION

Combatting Inflammation in Cardiovascular Disease

(2020) Anver M. Sethwala et al.   Heart Lung and Circulation

Carcinogenesis: Failure of resolution of inflammation?

(2020) Anna Fishbein et al.   PHARMACOLOGY & THERAPEUTICS

Exploring the potential intracellular targets of vascular normalization based on active candidates

(2020) Yuanyuan Shan et al.   BIOORGANIC CHEMISTRY

Design, synthesis and molecular modeling of novel aryl carboximidamides and 3-aryl-1,2,4-oxadiazoles derived from indomethacin as potent anti-inflammatory iNOS/PGE2 inhibitors

(2020) Mamdouh F.A. Mohamed et al.   BIOORGANIC CHEMISTRY

Humanized COVID‐19 decoy antibody effectively blocks viral entry and prevents SARS‐CoV‐2 infection

(2020) Kuo‐Yen Huang et al.   EMBO Molecular Medicine

Indomethacin, a nonselective cyclooxygenase inhibitor, does not interact with MTEP in antidepressant-like activity, as opposed to imipramine in CD-1 mice

(2020) Katarzyna Stachowicz   EUROPEAN JOURNAL OF PHARMACOLOGY

New 1,3,4-Oxadiazole Derivatives of Pyridothiazine-1,1-Dioxide with Anti-Inflammatory Activity

(2020) Teresa Glomb et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Novel 3-Acetyl-2,5-disubstituted-1,3,4-oxadiazolines: Synthesis and Biological Activity

(2020) Kinga Paruch et al.   MOLECULES

Therapeutic potential of oxadiazole or furadiazole containing compounds

(2020) Ankit Siwach et al.   BMC Chemistry

Novel 1,3,4-oxadiazoles as antitubercular agents with limited activity against drug-resistant tuberculosis

(2019) Vitthal B Makane et al.   Future Medicinal Chemistry

Optimization of an azetidine series as inhibitors of colony stimulating factor-1 receptor (CSF-1R) Type II to lead to the clinical candidate JTE-952

(2019) Kazutaka Ikegashira et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and biological evaluation of coumarin-1,3,4-oxadiazole hybrids as selective carbonic anhydrase IX and XII inhibitors

(2019) Sridhar Goud Narella et al.   BIOORGANIC CHEMISTRY

Novel 1,3,4-thiadiazole conjugates derived from protocatechuic acid: Synthesis, antioxidant activity, and computational and electrochemical studies

(2019) Katarina Jakovljević et al.   COMPTES RENDUS CHIMIE

AICD: an integrated anti-inflammatory compounds database for drug discovery

(2019) Kun Wang et al.   Scientific Reports

Molecular Docking and In Silico Cogitation Validate Mefenamic Acid Prodrugs as Human Cyclooxygenase-2 Inhibitor

(2019) Kamal Shah et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Design, synthesis and molecular docking of benzophenone conjugated with oxadiazole sulphur bridge pyrazole pharmacophores as anti inflammatory and analgesic agents

(2019) Zabiulla et al.   BIOORGANIC CHEMISTRY

Chronic inflammation in the etiology of disease across the life span

(2019) David Furman et al.   NATURE MEDICINE

Synthesis and antinociceptive evaluation of bioisosteres and hybrids of naproxen, ibuprofen and paracetamol

(2018) María Eva González-Trujano et al.   BIOMEDICINE & PHARMACOTHERAPY

Incorporation of nitric oxide donor into 1,3-dioxyxanthones leads to synergistic anticancer activity

(2018) Jie Liu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Exploring 1,3,4-Oxadiazole Scaffold for Anti-inflammatory and Analgesic Activities: A Review of Literature From 2005-2016

(2018) Gita Chawla et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

A Comprehensive Review of Non-Steroidal Anti-Inflammatory Drug Use in The Elderly

(2018) Supakanya Wongrakpanich et al.   Aging and Disease

Novel 1,3,4-Oxadiazole Induces Anticancer Activity by Targeting NF-κB in Hepatocellular Carcinoma Cells

(2018) Chakrabhavi Dhananjaya Mohan et al.   Frontiers in Oncology

Synthesis and evaluation of thiazolidine-2,4-dione/benzazole derivatives as inhibitors of protein tyrosine phosphatase 1B (PTP-1B): Antihyperglycemic activity with molecular docking study

(2018) Sergio Hidalgo-Figueroa et al.   BIOMEDICINE & PHARMACOTHERAPY

Metabolic disorders and inflammation are associated with familial combined hyperlipemia

(2018) María Díaz-Ruiz et al.   CLINICA CHIMICA ACTA

Anti-Cancer Activity of Derivatives of 1,3,4-Oxadiazole

(2018) Teresa Glomb et al.   MOLECULES

Pharmacoepidemiology of non-steroidal anti-inflammatory drugs

(2018) Nicholas Moore et al.   THERAPIE

Relevance and Standardization of In Vitro Antioxidant Assays: ABTS, DPPH, and Folin–Ciocalteu

(2018) Helena Abramovič et al.   Journal of Chemistry

Design, Synthesis and Biological Evaluation of 2 (((5-aryl-1,2,4-oxadiazol-3-yl)methyl)thio)benzo[d]oxazoles: New Antiinflammatory and Antioxidant Agents

(2018) Satyanarayana Yatam et al.   ChemistrySelect

Novel hybrids of benzothiazole-1,3,4-oxadiazole-4-thiazolidinone: Synthesis, in silico ADME study, molecular docking and in vivo anti-diabetic assessment

(2018) Rubina Bhutani et al.   BIOORGANIC CHEMISTRY

Discovery of new indomethacin-based analogs with potentially selective cyclooxygenase-2 inhibition and observed diminishing to PGE2 activities

(2017) Shaymaa E. Kassab et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and biological evaluation of novel α-hederagenin derivatives with anticancer activity

(2017) Xian-xuan Liu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

S -substituted 3,5-dinitrophenyl 1,3,4-oxadiazole-2-thiols and tetrazole-5-thiols as highly efficient antitubercular agents

(2017) Galina Karabanovich et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Multiple target-centric strategy to tame inflammation

(2017) Gaganpreet Kaur et al.   Future Medicinal Chemistry

COX Inhibition Profile and Molecular Docking Studies of Some 2-(Trimethoxyphenyl)-Thiazoles

(2017) Smaranda Oniga et al.   MOLECULES

Validation of Structures in the Protein Data Bank

(2017) Swanand Gore et al.   STRUCTURE

Updates on synthesis and biological activities of 1,3,4-oxadiazole: A review

(2017) Salahuddin et al.   SYNTHETIC COMMUNICATIONS

Design, synthesis, evaluation and molecular modelling studies of some novel 5,6-diphenyl-1,2,4-triazin-3(2H)-ones bearing five-member heterocyclic moieties as potential COX-2 inhibitors: A hybrid pharmacophore approach

(2016) Anupam G. Banerjee et al.   BIOORGANIC CHEMISTRY

The Pharmacology of Indomethacin

(2016) Sylvia Lucas   HEADACHE

A concise review on advances in development of small molecule anti-inflammatory therapeutics emphasising AMPK: An emerging target

(2016) Chethan Gejjalagere Honnappa et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

A Proteomic Approach to Analyze the Aspirin-mediated Lysine Acetylome

(2016) Michael H. Tatham et al.   MOLECULAR & CELLULAR PROTEOMICS

Computational protein–ligand docking and virtual drug screening with the AutoDock suite

(2016) Stefano Forli et al.   Nature Protocols

Resolution of inflammation: a new therapeutic frontier

(2016) James N. Fullerton et al.   NATURE REVIEWS DRUG DISCOVERY

FDA labeling of NSAIDs: Review of nonsteroidal anti-inflammatory drugs in cardiovascular disease

(2016) Preethi Pirlamarla et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Non-steroidal anti-inflammatory drugs and risk of heart failure in four European countries: nested case-control study

(2016) Andrea Arfè et al.   BMJ-British Medical Journal

Non-steroidal anti-inflammatory drugs and risk of heart failure in four European countries: nested case-control study

(2016) Andrea Arfè et al.   BMJ-British Medical Journal

Molecular basis for nonspecificity of nonsteroidal anti-inflammatory drugs (NSAIDs)

(2015) Avaneesh K. Dwivedi et al.   DRUG DISCOVERY TODAY

Signaling and stress: The redox landscape in NOS2 biology

(2015) Douglas D. Thomas et al.   FREE RADICAL BIOLOGY AND MEDICINE

The nitric oxide donor cis-[Ru(bpy)2(SO3)NO](PF6) increases gastric mucosa protection in mice – Involvement of the soluble guanylate cyclase/KATP pathway

(2015) Ana Paula M. Santana et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Applicability of the DPPH Assay for Evaluating the Antioxidant Capacity of Food Additives ^|^ndash; Inter-laboratory Evaluation Study ^|^ndash;

(2014) Tomoko SHIMAMURA et al.   ANALYTICAL SCIENCES

Design and Synthesis of Benzimidazole Analogs Endowed with Oxadiazole as Selective COX-2 Inhibitor

(2014) Ankita Rathore et al.   ARCHIV DER PHARMAZIE

Molecular targets of aspirin and cancer prevention

(2014) L Alfonso et al.   BRITISH JOURNAL OF CANCER

Synthesis of Novel Pyrazolo[3,4-d][1,2,3]Triazines

(2014) A. O. Gurenko et al.   Chemistry of Heterocyclic Compounds

Investigation of DMSO-Induced Conformational Transitions in Human Serum Albumin Using Two-Dimensional Raman Optical Activity Spectroscopy

(2014) Andrea N. L. Batista et al.   CHIRALITY

Development of GI-safe NSAID; progression from the bark of willow tree to modern pharmacology

(2014) Napapan Kangwan et al.   CURRENT OPINION IN PHARMACOLOGY

Multi-target approach for natural products in inflammation

(2014) Andreas Koeberle et al.   DRUG DISCOVERY TODAY

Synthesis and anticancer properties of RGD peptides conjugated to nitric oxide releasing functional groups and abiraterone

(2014) Andrew Nortcliffe et al.   TETRAHEDRON

Design, synthesis and evaluation of tacrine–flurbiprofen–nitrate trihybrids as novel anti-Alzheimer’s disease agents

(2013) Yao Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Structural Transformation of Bovine Serum Albumin Induced by Dimethyl Sulfoxide and Probed by Fluorescence Correlation Spectroscopy and Additional Methods

(2013) Ashok Pabbathi et al.   CHEMPHYSCHEM

Angiogenesis inhibitors identified by cell-based high-throughput screening: Synthesis, structure–activity relationships and biological evaluation of 3-[(E)-styryl]benzamides that specifically inhibit endothelial cell proliferation

(2012) Kihito Hada et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Directory of Useful Decoys, Enhanced (DUD-E): Better Ligands and Decoys for Better Benchmarking

(2012) Michael M. Mysinger et al.   JOURNAL OF MEDICINAL CHEMISTRY

1,3,4-Oxadiazole: A Biologically Active Scaffold

(2012) H. Khalilullah et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Contributions of central and systemic inflammation to the pathophysiology of Parkinson's disease

(2012) Louise M. Collins et al.   NEUROPHARMACOLOGY

Synthesis of new 2′-deoxy-2′-fluoro-4′-azido nucleoside analogues as potent anti-HIV agents

(2011) Qiang Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Oxadiazoles in Medicinal Chemistry

(2011) Jonas Boström et al.   JOURNAL OF MEDICINAL CHEMISTRY

Functionalized Fullerenes in Self-Assembled Monolayers

(2011) Maria del Carmen Gimenez-Lopez et al.   LANGMUIR

Structure and Cytotoxicity of Phidianidines A and B: First Finding of 1,2,4-Oxadiazole System in a Marine Natural Product

(2011) Marianna Carbone et al.   ORGANIC LETTERS

A turbulent decade for NSAIDs: update on current concepts of classification, epidemiology, comparative efficacy, and toxicity

(2011) Philip G. Conaghan   RHEUMATOLOGY INTERNATIONAL

Synthesis and in vitro antibacterial activity of new oxoethylthio-1,3,4-oxadiazole derivatives

(2011) Jignesh P. Raval et al.   Journal of Saudi Chemical Society

Molecular Basis for Cyclooxygenase Inhibition by the Non-steroidal Anti-inflammatory Drug Naproxen

(2010) Kelsey C. Duggan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Design, synthesis and biological investigation of certain pyrazole-3-carboxylic acid derivatives as novel carriers for nitric oxide

(2009) El-Shimaa M.N. Abdel-Hafez et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Porphyrins containing nitric oxide donors: Synthesis and cancer cell-oriented NO release

(2009) Wukun Liu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

(Nitrooxyacyloxy)methyl Esters of Aspirin as Novel Nitric Oxide Releasing Aspirins

(2009) Loretta Lazzarato et al.   JOURNAL OF MEDICINAL CHEMISTRY

Does aspirin acetylate multiple cellular proteins? (Review)

(2009) Bhat   Molecular Medicine Reports

Control of conformational flexibility in calix[6]arenes: synthesis and characterisation of triply bridged calix[6]arene—10,15-dihydro-5H-tribenzo [a,d,g]cyclononene conjugates

(2009) H. Mohindra Chawla et al.   JOURNAL OF CHEMICAL RESEARCH

Design and synthesis of nitrate esters of aromatic heterocyclic compounds as pharmacological preconditioning agents

(2008) Theano Fotopoulou et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Origin and physiological roles of inflammation

(2008) Ruslan Medzhitov   NATURE

Role of nitric oxide in the gastrointestinal tract

(2008) Angel Lanas   ARTHRITIS RESEARCH & THERAPY