Anti-Cancer Activity of Derivatives of 1,3,4-Oxadiazole

Rational design of bis -indolylmethane-oxadiazole hybrids as inhibitors of thymidine phosphorylase

(2018) Muhammad Taha et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design, synthesis and anticancer activities evaluation of novel 5 H -dibenzo[ b , e ]azepine-6,11-dione derivatives containing 1,3,4-oxadiazole units

(2018) Xin He et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of pyrazole acrylic acid based oxadiazole and amide derivatives as antimalarial and anticancer agents

(2018) Garima Verma et al.   BIOORGANIC CHEMISTRY

Synthesis, SAR elucidations and molecular docking study of newly designed isatin based oxadiazole analogs as potent inhibitors of thymidine phosphorylase

(2018) Muhammad Tariq Javid et al.   BIOORGANIC CHEMISTRY

Design, synthesis, in-vitro thymidine phosphorylase inhibition, in-vivo antiangiogenic and in-silico studies of C-6 substituted dihydropyrimidines

(2018) Fatima Iftikhar et al.   BIOORGANIC CHEMISTRY

Synthesis of benzimidazole-linked-1,3,4-oxadiazole carboxamides as GSK-3β inhibitors with in vivo antidepressant activity

(2018) Mushtaq A. Tantray et al.   BIOORGANIC CHEMISTRY

Synthesis, molecular docking study and in vitro thymidine phosphorylase inhibitory potential of oxadiazole derivatives

(2018) Hayat Ullah et al.   BIOORGANIC CHEMISTRY

Synthesis, thymidine phosphorylase inhibitory and computational study of novel 1,3,4-oxadiazole-2-thione derivatives as potential anticancer agents

(2018) Shalini Bajaj et al.   COMPUTATIONAL BIOLOGY AND CHEMISTRY

Design, synthesis and biological evaluation of N-phenyl-(2,4-dihydroxypyrimidine-5-sulfonamido)benzoyl hydrazide derivatives as thymidylate synthase (TS) inhibitors and as potential antitumor drugs

(2018) Xin-yang Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis, in vitro and in silico evaluation of a new series of oxadiazole-based anticancer agents as potential Akt and FAK inhibitors

(2018) Mehlika Dilek Altıntop et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, crystal structures, computational studies and antimicrobial activity of new designed bis((5-aryl-1,3,4-oxadiazol-2-yl)thio)alkanes

(2018) Muhammad Naeem Ahmed et al.   JOURNAL OF MOLECULAR STRUCTURE

Biomolecular study of human thymidylate synthase conformer-selective inhibitors: New chemotherapeutic approach

(2018) Hala O. El-Mesallamy et al.   PLoS One

Novel 1,3,4-Oxadiazole Induces Anticancer Activity by Targeting NF-κB in Hepatocellular Carcinoma Cells

(2018) Chakrabhavi Dhananjaya Mohan et al.   Frontiers in Oncology

Design, synthesis, docking and QSAR study of substituted benzimidazole linked oxadiazole as cytotoxic agents, EGFR and erbB2 receptor inhibitors

(2017) Md Jawaid Akhtar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Aberrant control of NF-κB in cancer permits transcriptional and phenotypic plasticity, to curtail dependence on host tissue: molecular mode

(2017) A. Vlahopoulos Spiros   Cancer Biology & Medicine

Design and synthesis of novel HDAC8 inhibitory 2,5-disubstituted-1,3,4-oxadiazoles containing glycine and alanine hybrids with anti cancer activity

(2016) Vijaya Rao Pidugu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and in vitro antiproliferative evaluation of novel nonsymmetrical disulfides bearing 1,3,4-oxadiazole moiety

(2016) Ji-Jun Zhao et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

NF-κB in cancer therapy

(2015) Feng Li et al.   ARCHIVES OF TOXICOLOGY

Analysis of the intricate relationship between chronic inflammation and cancer

(2015) Edna Zhi Pei Chai et al.   BIOCHEMICAL JOURNAL

Synthesis and broad-spectrum antiproliferative activity of diarylamides and diarylureas possessing 1,3,4-oxadiazole derivatives

(2015) Mahmoud M. Gamal El-Din et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and evaluation of benzosuberone embedded with 1,3,4-oxadiazole, 1,3,4-thiadiazole and 1,2,4-triazole moieties as new potential anti proliferative agents

(2015) Bandi Yadagiri et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and in vitro antiproliferative activity of new 1,3,4-oxadiazole derivatives possessing sulfonamide moiety

(2015) Mahmoud M. Gamal El-Din et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

FAK signaling in human cancer as a target for therapeutics

(2015) Brian Y. Lee et al.   PHARMACOLOGY & THERAPEUTICS

Synthesis and antitumor activities of novel hybrid molecules containing 1,3,4-oxadiazole and 1,3,4-thiadiazole bearing Schiff base moiety

(2014) Kai Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The necessity of and strategies for improving confidence in the accuracy of western blots

(2014) Rajeshwary Ghosh et al.   Expert Review of Proteomics

1,3,4-Oxadiazole-Containing Histone Deacetylase Inhibitors: Anticancer Activities in Cancer Cells

(2014) Sergio Valente et al.   JOURNAL OF MEDICINAL CHEMISTRY

Drug Resistance in Cancer: An Overview

(2014) Genevieve Housman et al.   Cancers

Structural basis for the design and synthesis of selective HDAC inhibitors

(2013) Simone Di Micco et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Novel 1,3,4-oxadiazole thioether derivatives targeting thymidylate synthase as dual anticancer/antimicrobial agents

(2013) Qian-Ru Du et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis, molecular modeling and biological evaluation of N-benzylidene-2-((5-(pyridin-4-yl)-1,3,4-oxadiazol-2-yl)thio)acetohydrazide derivatives as potential anticancer agents

(2013) Fei Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and antitumor activity of 1,3,4-oxadiazole possessing 1,4-benzodioxan moiety as a novel class of potent methionine aminopeptidase type II inhibitors

(2013) Juan Sun et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and bioactivities of novel thioether/sulfone derivatives containing 1,2,3-thiadiazole and 1,3,4-oxadiazole/thiadiazole moiety

(2013) Wei-Ming Xu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

2,5-Disubstituted-1,3,4-oxadiazoles: thymidine phosphorylase inhibitors

(2013) Khalid Mohammed Khan et al.   MEDICINAL CHEMISTRY RESEARCH

Efficacy of the Specific Endothelin A Receptor Antagonist Zibotentan (ZD4054) in Colorectal Cancer: A Preclinical Study

(2013) S.-u. Haque et al.   MOLECULAR CANCER THERAPEUTICS

Design, synthesis and biological evaluation of heterocyclic azoles derivatives containing pyrazine moiety as potential telomerase inhibitors

(2012) Yan-Bin Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis, molecular modeling and biological evaluation of 2-aminomethyl-5-(quinolin-2-yl)-1,3,4-oxadiazole-2(3H)-thione quinolone derivatives as novel anticancer agent

(2012) Juan Sun et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Vascular Endothelial Growth Factor (VEGF) Receptors: Drugs and New Inhibitors

(2012) Francesca Musumeci et al.   JOURNAL OF MEDICINAL CHEMISTRY

A New Strategy for Detection and Development of Tractable Telomerase Inhibitors

(2012) Elysia P. M. T. Cohn et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, biological evaluation, and molecular modeling studies of new 1,3,4-oxadiazole- and 1,3,4-thiadiazole-substituted 4-oxo-4H-pyrido[1,2-a]pyrimidines as anti-HIV-1 agents

(2012) Z. Hajimahdi et al.   MEDICINAL CHEMISTRY RESEARCH

Oxadiazoles in Medicinal Chemistry

(2011) Jonas Boström et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeting transcription factor NF-κB to overcome chemoresistance and radioresistance in cancer therapy

(2010) Feng Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Synthesis and biological evaluation of novel 2,4′-bis substituted diphenylamines as anticancer agents and potential epidermal growth factor receptor tyrosine kinase inhibitors

(2010) Sahar Mahmoud Abou-Seri   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and biological evaluation of some 1,3,4-oxadiazole derivatives

(2010) K. Manjunatha et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery and preclinical studies of 5-isopropyl-6-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(2-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine (BMS-645737), an in vivo active potent VEGFR-2 inhibitor

(2008) Réjean Ruel et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis, SAR, and Evaluation of 4-[2,4-Difluoro-5-(cyclopropylcarbamoyl)phenylamino]pyrrolo[2,1-f][1,2,4]triazine-based VEGFR-2 kinase inhibitors

(2008) Zhen-wei Cai et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

ZD4054: a specific endothelin A receptor antagonist with promising activity in metastatic castration-resistant prostate cancer

(2008) Ruth Warren et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS