Multiple target-centric strategy to tame inflammation

Design, synthesis and biological evaluation of novel analgesic agents targeting both cyclooxygenase and TRPV1

(2016) Lin Yan et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The Molecular Basis for Dual Fatty Acid Amide Hydrolase (FAAH)/Cyclooxygenase (COX) Inhibition

(2015) Giulia Palermo et al.   ChemMedChem

COX inhibitors: a patent review (2011 – 2014)

(2015) Sara Consalvi et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Multi-target drugs to address multiple checkpoints in complex inflammatory pathologies: evolutionary cues for novel “first-in-class” anti-inflammatory drug candidates: a reviewer’s perspective

(2015) Geetha Mathew et al.   INFLAMMATION RESEARCH

Design and Synthesis of N-Arylphthalimides as Inhibitors of Glucocorticoid-Induced TNF Receptor-Related Protein, Proinflammatory Mediators, and Cytokines in Carrageenan-Induced Lung Inflammation

(2015) Mashooq A. Bhat et al.   JOURNAL OF MEDICINAL CHEMISTRY

Multi-target pharmacology: possibilities and limitations of the “skeleton key approach” from a medicinal chemist perspective

(2015) Alan Talevi   Frontiers in Pharmacology

Benzo[d]isothiazole 1,1-dioxide derivatives as dual functional inhibitors of 5-lipoxygenase and microsomal prostaglandin E2 synthase-1

(2014) Erchang Shang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Molecular targets of aspirin and cancer prevention

(2014) L Alfonso et al.   BRITISH JOURNAL OF CANCER

Multi-target approach for natural products in inflammation

(2014) Andreas Koeberle et al.   DRUG DISCOVERY TODAY

Polypharmacology: the rise of multitarget drugs over combination therapies

(2014) Michela Rosini   Future Medicinal Chemistry

Benzimidazoles: An Ideal Privileged Drug Scaffold for the Design of Multitargeted Anti-inflammatory Ligands

(2014) Gaganpreet Kaur et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Targeting epigenetic mechanisms and microRNAs by aspirin and other non steroidal anti-inflammatory agents - implications for cancer treatment and chemoprevention

(2014) Eugenia Yiannakopoulou   CELLULAR ONCOLOGY

Design of Multifunctional Compounds for Cardiovascular Disease: From Natural Scaffolds to “Classical” Multitarget Approach

(2013) A. Bisi et al.   CURRENT MEDICINAL CHEMISTRY

Aminothiazole-Featured Pirinixic Acid Derivatives As Dual 5-Lipoxygenase and Microsomal Prostaglandin E2 Synthase-1 Inhibitors with Improved Potency and Efficiency in Vivo

(2013) Thomas Hanke et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and biological activity of NOSH-naproxen (AVT-219) and NOSH-sulindac (AVT-18A) as potent anti-inflammatory agents with chemotherapeutic potential

(2013) Ravinder Kodela et al.   MedChemComm

Challenges in the design of multitarget drugs against multifactorial pathologies: a new life for medicinal chemistry?

(2012) Luca Costantino et al.   Future Medicinal Chemistry

Dynamic Modeling of Human 5-Lipoxygenase–Inhibitor Interactions Helps To Discover Novel Inhibitors

(2012) Yiran Wu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, and Pharmacological Evaluation of Novel Hybrid Compounds to Treat Sickle Cell Disease Symptoms. Part II: Furoxan Derivatives

(2012) Jean Leandro Dos Santos et al.   JOURNAL OF MEDICINAL CHEMISTRY

Molecular Mechanism Underlying Anti-Inflammatory and Anti-Allergic Activities of Phytochemicals: An Update

(2012) Yuva Bellik et al.   MOLECULES

Dual-Target Virtual Screening by Pharmacophore Elucidation and Molecular Shape Filtering

(2012) Daniel Moser et al.   ACS Medicinal Chemistry Letters

NOSH-Aspirin: A Novel Nitric Oxide–Hydrogen Sulfide-Releasing Hybrid: A New Class of Anti-inflammatory Pharmaceuticals

(2012) Ravinder Kodela et al.   ACS Medicinal Chemistry Letters

Polypharmacology: drug discovery for the future

(2012) A Srinivas Reddy et al.   Expert Review of Clinical Pharmacology

Identification of 2-mercaptohexanoic acids as dual inhibitors of 5-lipoxygenase and microsomal prostaglandin E2 synthase-1

(2011) Christine Greiner et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Identification and development of mPGES-1 inhibitors: where we are at?

(2011) Hui-Hua Chang et al.   Future Medicinal Chemistry

Tryptamine-Gallic Acid Hybrid Prevents Non-steroidal Anti-inflammatory Drug-induced Gastropathy

(2011) Chinmay Pal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery and Biological Evaluation of a Novel Class of Dual Microsomal Prostaglandin E2Synthase-1/5-lipoxygenase Inhibitors Based on 2-[(4,6-Diphenethoxypyrimidin-2-yl)thio]hexanoic Acid

(2011) Martina Hieke et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Structure−Activity Relationship Studies of Urea-Containing Pyrazoles as Dual Inhibitors of Cyclooxygenase-2 and Soluble Epoxide Hydrolase

(2011) Sung Hee Hwang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Dual Target Inhibitors against Cyclooxygenases and Leukotriene A4Hydrolyase

(2011) Zheng Chen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Inflammation as “common soil” of the multifactorial diseases

(2010) Rossana Scrivo et al.   AUTOIMMUNITY REVIEWS

Anti-inflammatory Activity of New Compounds from Andrographis paniculata by NF-κB Transactivation Inhibition

(2010) Wen-Wan Chao et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Anti-Inflammatory Effects of Resveratrol, Curcumin and Simvastatin in Acute Small Intestinal Inflammation

(2010) Stefan Bereswill et al.   PLoS One

Therapeutic potential of new hydrogen sulfide-releasing hybrids

(2010) Anna Sparatore et al.   Expert Review of Clinical Pharmacology

Inhibition of soluble epoxide hydrolase enhances the anti-inflammatory effects of aspirin and 5-lipoxygenase activation protein inhibitor in a murine model

(2009) Jun-Yan Liu et al.   BIOCHEMICAL PHARMACOLOGY

Discovery of benzo[g]indol-3-carboxylates as potent inhibitors of microsomal prostaglandin E2 synthase-1

(2009) Andreas Koeberle et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Dinitroglyceryl and diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of aspirin, indomethacin and ibuprofen: Synthesis, biological evaluation and nitric oxide release studies

(2009) Khaled R.A. Abdellatif et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Bioactive Food Components, Inflammatory Targets, and Cancer Prevention

(2009) Y. S. Kim et al.   Cancer Prevention Research

Arylpyrrolizines as Inhibitors of Microsomal Prostaglandin E2Synthase-1 (mPGES-1) or as Dual Inhibitors of mPGES-1 and 5-Lipoxygenase (5-LOX)

(2009) Andy J. Liedtke et al.   JOURNAL OF MEDICINAL CHEMISTRY

Selectively Nonselective Kinase Inhibition: Striking the Right Balance

(2009) Richard Morphy   JOURNAL OF MEDICINAL CHEMISTRY

Curcumin and cancer: An “old-age” disease with an “age-old” solution

(2008) Preetha Anand et al.   CANCER LETTERS

Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases

(2008) Bharat B. Aggarwal et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Discovery of Multitarget Inhibitors by Combining Molecular Docking with Common Pharmacophore Matching

(2008) Dengguo Wei et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pirinixic Acid Derivatives as Novel Dual Inhibitors of Microsomal Prostaglandin E2Synthase-1 and 5-Lipoxygenase

(2008) Andreas Koeberle et al.   JOURNAL OF MEDICINAL CHEMISTRY

Multi-target-Directed Ligands To Combat Neurodegenerative Diseases

(2008) Andrea Cavalli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Licofelone Suppresses Prostaglandin E2 Formation by Interference with the Inducible Microsomal Prostaglandin E2 Synthase-1

(2008) A. Koeberle et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Finding multiple target optimal intervention in disease-related molecular network

(2008) Kun Yang et al.   Molecular Systems Biology