Design, synthesis, evaluation and molecular modelling studies of some novel 5,6-diphenyl-1,2,4-triazin-3(2H)-ones bearing five-member heterocyclic moieties as potential COX-2 inhibitors: A hybrid pharmacophore approach

标题
Design, synthesis, evaluation and molecular modelling studies of some novel 5,6-diphenyl-1,2,4-triazin-3(2H)-ones bearing five-member heterocyclic moieties as potential COX-2 inhibitors: A hybrid pharmacophore approach
作者
关键词
Molecular hybridisation, COX-2, 1,2,4-triazine, 1,3,4-oxadiazole, 1,3,4-thiadiazole, Cardiotoxicity
出版物
BIOORGANIC CHEMISTRY
Volume 69, Issue -, Pages 102-120
出版商
Elsevier BV
发表日期
2016-10-15
DOI
10.1016/j.bioorg.2016.10.003

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