Tissue mechanics in stem cell fate, development, and cancer

Trophectoderm mechanics direct epiblast shape upon embryo implantation

(2021) Antonia Weberling et al.   Cell Reports

Single-cell and spatial transcriptomics reveal somitogenesis in gastruloids

(2020) Susanne C. van den Brink et al.   NATURE

A tensile ring drives tissue flows to shape the gastrulating amniote embryo

(2020) Mehdi Saadaoui et al.   SCIENCE

Fibrosis and cancer: A strained relationship

(2020) Bram Piersma et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Branching morphogenesis

(2020) Katharine Goodwin et al.   DEVELOPMENT

Cell-cell junctions as sensors and transducers of mechanical forces

(2020) Ana Angulo-Urarte et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Stiff stroma increases breast cancer risk by inducing the oncogene ZNF217

(2020) Jason J. Northey et al.   JOURNAL OF CLINICAL INVESTIGATION

Alveolar cells under mechanical stressed niche: critical contributors to pulmonary fibrosis

(2020) Juntang Yang et al.   MOLECULAR MEDICINE

Mechanical Tension Promotes Formation of Gastrulation-like Nodes and Patterns Mesoderm Specification in Human Embryonic Stem Cells

(2020) Jonathon M. Muncie et al.   DEVELOPMENTAL CELL

Tension heterogeneity directs form and fate to pattern the myocardial wall

(2020) Rashmi Priya et al.   NATURE

Tumour-associated macrophages drive stromal cell-dependent collagen crosslinking and stiffening to promote breast cancer aggression

(2020) Ori Maller et al.   NATURE MATERIALS

Membrane Tension Gates ERK-Mediated Regulation of Pluripotent Cell Fate

(2020) Henry De Belly et al.   Cell Stem Cell

Cell Surface Mechanics Gate Embryonic Stem Cell Differentiation

(2020) Martin Bergert et al.   Cell Stem Cell

Integrins as biomechanical sensors of the microenvironment

(2019) Jenny Z. Kechagia et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Soft culture substrates favor stem-like cellular phenotype and facilitate reprogramming of human mesenchymal stem/stromal cells (hMSCs) through mechanotransduction

(2019) Heloísa Gerardo et al.   Scientific Reports

Targeting Cancer Stem Cells in Triple-Negative Breast Cancer

(2019) Park et al.   Cancers

Wnt4 from the Niche Controls the Mechano-Properties and Quiescent State of Muscle Stem Cells

(2019) Susan Eliazer et al.   Cell Stem Cell

Controlled modelling of human epiblast and amnion development using stem cells

(2019) Yi Zheng et al.   NATURE

Mammalian Mechanoelectrical Transduction: Structure and Function of Force-Gated Ion Channels

(2019) Dominique Douguet et al.   CELL

Solid Stress Facilitates Fibroblasts Activation to Promote Pancreatic Cancer Cell Migration

(2018) Maria Kalli et al.   ANNALS OF BIOMEDICAL ENGINEERING

The major β-catenin/E-cadherin junctional binding site is a primary molecular mechano-transductor of differentiation in vivo

(2018) Jens-Christian Röper et al.   eLife

A tension-mediated glycocalyx–integrin feedback loop promotes mesenchymal-like glioblastoma

(2018) J. Matthew Barnes et al.   NATURE CELL BIOLOGY

Tumor-Stroma Mechanics Coordinate Amino Acid Availability to Sustain Tumor Growth and Malignancy

(2018) Thomas Bertero et al.   Cell Metabolism

Tissue mechanics regulate brain development, homeostasis and disease

(2017) J. Matthew Barnes et al.   JOURNAL OF CELL SCIENCE

Integrin-mediated traction force enhances paxillin molecular associations and adhesion dynamics that increase the invasiveness of tumor cells into a three-dimensional extracellular matrix

(2017) Armen H. Mekhdjian et al.   MOLECULAR BIOLOGY OF THE CELL

Orientation and repositioning of chromosomes correlate with cell geometry–dependent gene expression

(2017) Yejun Wang et al.   MOLECULAR BIOLOGY OF THE CELL

Quantifying forces in cell biology

(2017) Pere Roca-Cusachs et al.   NATURE CELL BIOLOGY

Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells

(2017) Ilaria Elia et al.   Nature Communications

Mammary extracellular matrix directs differentiation of testicular and embryonic stem cells to form functional mammary glands in vivo

(2017) Robert D. Bruno et al.   Scientific Reports

Tissue Stiffness and Hypoxia Modulate the Integrin-Linked Kinase ILK to Control Breast Cancer Stem-like Cells

(2016) Mei-Fong Pang et al.   CANCER RESEARCH

Tissue Mechanics Orchestrate Wnt-Dependent Human Embryonic Stem Cell Differentiation

(2016) Laralynne Przybyla et al.   Cell Stem Cell

Forces and mechanotransduction in 3D vascular biology

(2016) Matthew L Kutys et al.   CURRENT OPINION IN CELL BIOLOGY

Obesity and Cancer: An Angiogenic and Inflammatory Link

(2016) Dai Fukumura et al.   MICROCIRCULATION

Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression

(2016) Hanane Laklai et al.   NATURE MEDICINE

Receptors, channels and signalling in the urothelial sensory system in the bladder

(2016) Liana Merrill et al.   Nature Reviews Urology

Chromosome intermingling—the physical basis of chromosome organization in differentiated cells

(2016) Shovamayee Maharana et al.   NUCLEIC ACIDS RESEARCH

Force Matters: Biomechanical Regulation of Cell Invasion and Migration in Disease

(2016) FuiBoon Kai et al.   TRENDS IN CELL BIOLOGY

Tumor Cell-Driven Extracellular Matrix Remodeling Drives Haptotaxis during Metastatic Progression

(2016) M. J. Oudin et al.   Cancer Discovery

Surface topography enhances differentiation of mesenchymal stem cells towards osteogenic and adipogenic lineages

(2015) Giulio Abagnale et al.   BIOMATERIALS

Genome-wide Maps of Nuclear Lamina Interactions in Single Human Cells

(2015) Jop Kind et al.   CELL

Different responses of articular cartilage to strenuous running and joint immobilization

(2015) Guo-Xin Ni et al.   CONNECTIVE TISSUE RESEARCH

Mammary gland development: cell fate specification, stem cells and the microenvironment

(2015) J. L. Inman et al.   DEVELOPMENT

Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy

(2015) Bryan W Miller et al.   EMBO Molecular Medicine

Cochlear hair cells: The sound-sensing machines

(2015) Juan D. Goutman et al.   FEBS LETTERS

Human breast cancer invasion and aggression correlates with ECM stiffening and immune cell infiltration

(2015) I. Acerbi et al.   Integrative Biology

Mechanical induction of the tumorigenic β-catenin pathway by tumour growth pressure

(2015) María Elena Fernández-Sánchez et al.   NATURE

Control of cell–cell forces and collective cell dynamics by the intercellular adhesome

(2015) Elsa Bazellières et al.   NATURE CELL BIOLOGY

Integration of actin dynamics and cell adhesion by a three-dimensional, mechanosensitive molecular clutch

(2015) Lindsay B. Case et al.   NATURE CELL BIOLOGY

Matrix stiffness drives epithelial–mesenchymal transition and tumour metastasis through a TWIST1–G3BP2 mechanotransduction pathway

(2015) Spencer C. Wei et al.   NATURE CELL BIOLOGY

Functional organization of the human 4D Nucleome

(2015) Haiming Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Obesity-dependent changes in interstitial ECM mechanics promote breast tumorigenesis

(2015) Bo Ri Seo et al.   Science Translational Medicine

Identification of aPrg4-Expressing Articular Cartilage Progenitor Cell Population in Mice

(2015) Elena Kozhemyakina et al.   Arthritis & Rheumatology

Blood Flow and Bmp Signaling Control Endocardial Chamber Morphogenesis

(2014) Ann-Christin Dietrich et al.   DEVELOPMENTAL CELL

The extracellular matrix modulates the hallmarks of cancer

(2014) M. W. Pickup et al.   EMBO REPORTS

Mechanical motion promotes expression of Prg4 in articular cartilage via multiple CREB-dependent, fluid flow shear stress-induced signaling pathways

(2014) H. Ogawa et al.   GENES & DEVELOPMENT

Biomechanical profile of cancer stem-like/tumor-initiating cells derived from a progressive ovarian cancer model

(2014) Hesam Babahosseini et al.   Nanomedicine-Nanotechnology Biology and Medicine

Cellular foundations of mammary tubulogenesis

(2014) Robert J. Huebner et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Repair of Segmental Load-Bearing Bone Defect by Autologous Mesenchymal Stem Cells and Plasma-Derived Fibrin Impregnated Ceramic Block Results in Early Recovery of Limb Function

(2014) Min Hwei Ng et al.   Biomed Research International

Hypoxia induces epithelial-mesenchymal transition via activation of SNAI1 by hypoxia-inducible factor -1α in hepatocellular carcinoma

(2013) Lin Zhang et al.   BMC CANCER

Pancreatic stellate cells promote hapto-migration of cancer cells through collagen I-mediated signalling pathway

(2013) J Lu et al.   BRITISH JOURNAL OF CANCER

Stromally Derived Lysyl Oxidase Promotes Metastasis of Transforming Growth Factor- -Deficient Mouse Mammary Carcinomas

(2013) M. W. Pickup et al.   CANCER RESEARCH

Patterned Collagen Fibers Orient Branching Mammary Epithelium through Distinct Signaling Modules

(2013) Douglas G. Brownfield et al.   CURRENT BIOLOGY

On the role of intrinsic and extrinsic forces in early cardiac S-looping

(2013) Ashok Ramasubramanian et al.   DEVELOPMENTAL DYNAMICS

The Role of Tight Junctions in Mammary Gland Function

(2013) Kerst Stelwagen et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Broken nuclei – lamins, nuclear mechanics, and disease

(2013) Patricia M. Davidson et al.   TRENDS IN CELL BIOLOGY

Evolutionary conservation of early mesoderm specification by mechanotransduction in Bilateria

(2013) Thibaut Brunet et al.   Nature Communications

Ultra-structural defects cause low bone matrix stiffness despite high mineralization in osteogenesis imperfecta mice

(2012) Maximilien Vanleene et al.   BONE

HIF1α induced switch from bivalent to exclusively glycolytic metabolism during ESC-to-EpiSC/hESC transition

(2012) Wenyu Zhou et al.   EMBO JOURNAL

Aligned Collagen Is a Prognostic Signature for Survival in Human Breast Carcinoma

(2011) Matthew W. Conklin et al.   AMERICAN JOURNAL OF PATHOLOGY

The influence of substrate creep on mesenchymal stem cell behaviour and phenotype

(2011) Andrew. R. Cameron et al.   BIOMATERIALS

Dissociation of Bimolecular αIIbβ3-Fibrinogen Complex under a Constant Tensile Force

(2011) Rustem I. Litvinov et al.   BIOPHYSICAL JOURNAL

Actomyosin-Mediated Cellular Tension Drives Increased Tissue Stiffness and β-Catenin Activation to Induce Epidermal Hyperplasia and Tumor Growth

(2011) Michael S. Samuel et al.   CANCER CELL

Primary breast cancer patients with high risk clinicopathologic features have high percentages of bone marrow epithelial cells with ALDH activity and CD44+CD24lo cancer stem cell phenotype

(2011) James M. Reuben et al.   EUROPEAN JOURNAL OF CANCER

In situ force mapping of mammary gland transformation

(2011) Jose I. Lopez et al.   Integrative Biology

Non-steroidal anti-inflammatory drugs target the pro-tumorigenic extracellular matrix of the postpartum mammary gland

(2011) Jenean OBrien et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Tamoxifen-Induced Reduction in Mammographic Density and Breast Cancer Risk Reduction: A Nested Case-Control Study

(2011) J. Cuzick et al.   JNCI-Journal of the National Cancer Institute

Pancreatic cancer in chronic pancreatitis; aetiology, incidence, and early detection

(2010) Sara Raimondi et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

Dynamic interplay between the collagen scaffold and tumor evolution

(2010) Mikala Egeblad et al.   CURRENT OPINION IN CELL BIOLOGY

Endogenous patterns of mechanical stress are required for branching morphogenesis

(2010) Nikolce Gjorevski et al.   Integrative Biology

Nanoparticle-induced unfolding of fibrinogen promotes Mac-1 receptor activation and inflammation

(2010) Zhou J. Deng et al.   Nature Nanotechnology

Geometric cues for directing the differentiation of mesenchymal stem cells

(2010) K. A. Kilian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Substrate Elasticity Regulates Skeletal Muscle Stem Cell Self-Renewal in Culture

(2010) P. M. Gilbert et al.   SCIENCE

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

Suppression of Erk signalling promotes ground state pluripotency in the mouse embryo

(2009) J. Nichols et al.   DEVELOPMENT

Myosin II Dynamics Are Regulated by Tension in Intercalating Cells

(2009) Rodrigo Fernandez-Gonzalez et al.   DEVELOPMENTAL CELL

Demonstration of catch bonds between an integrin and its ligand

(2009) Fang Kong et al.   JOURNAL OF CELL BIOLOGY

Clustering of  5 1 integrins determines adhesion strength whereas  v 3 and talin enable mechanotransduction

(2009) P. Roca-Cusachs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stretching Single Talin Rod Molecules Activates Vinculin Binding

(2009) A. del Rio et al.   SCIENCE

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

Collective Epithelial Migration and Cell Rearrangements Drive Mammary Branching Morphogenesis

(2008) Andrew J. Ewald et al.   DEVELOPMENTAL CELL

Laminin and biomimetic extracellular elasticity enhance functional differentiation in mammary epithelia

(2008) Jordi Alcaraz et al.   EMBO JOURNAL

Cyclic strain induces mouse embryonic stem cell differentiation into vascular smooth muscle cells by activating PDGF receptor β

(2008) Nobutaka Shimizu et al.   JOURNAL OF APPLIED PHYSIOLOGY

Tensile forces govern germ-layer organization in zebrafish

(2008) M. Krieg et al.   NATURE CELL BIOLOGY

Exercise-induced changes in proteoglycan metabolism of equine articular cartilage

(2007) J. L. E. Bird et al.   EQUINE VETERINARY JOURNAL