Obesity-dependent changes in interstitial ECM mechanics promote breast tumorigenesis

Stiffening and unfolding of early deposited-fibronectin increase proangiogenic factor secretion by breast cancer-associated stromal cells

(2015) Karin Wang et al.   BIOMATERIALS

3D Collagen Alignment Limits Protrusions to Enhance Breast Cancer Cell Persistence

(2014) Kristin M. Riching et al.   BIOPHYSICAL JOURNAL

Effects of Obesity on Transcriptomic Changes and Cancer Hallmarks in Estrogen Receptor–Positive Breast Cancer

(2014) Enrique Fuentes-Mattei et al.   JNCI-Journal of the National Cancer Institute

Extracellular matrix stiffness and composition jointly regulate the induction of malignant phenotypes in mammary epithelium

(2014) Ovijit Chaudhuri et al.   NATURE MATERIALS

Strategies for High Resolution Imaging of Epithelial Ovarian Cancer by Laparoscopic Nonlinear Microscopy

(2014) Rebecca M. Williams et al.   Translational Oncology

Macrophage-inducible C-type lectin underlies obesity-induced adipose tissue fibrosis

(2014) Miyako Tanaka et al.   Nature Communications

Caloric Restriction Reverses Obesity-Induced Mammary Gland Inflammation in Mice

(2013) P. Bhardwaj et al.   Cancer Prevention Research

Permanence of molecular features of obesity in subcutaneous adipose tissue of ex-obese subjects

(2013) R Cancello et al.   INTERNATIONAL JOURNAL OF OBESITY

Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts

(2013) Fernando Calvo et al.   NATURE CELL BIOLOGY

Adipocytes: Impact on tumor growth and potential sites for therapeutic intervention

(2013) Simona Hefetz-Sela et al.   PHARMACOLOGY & THERAPEUTICS

The mechanical memory of lung myofibroblasts

(2012) Jenna L. Balestrini et al.   Integrative Biology

Adipocyte-derived endotrophin promotes malignant tumor progression

(2012) Jiyoung Park et al.   JOURNAL OF CLINICAL INVESTIGATION

Understanding Breast Density and Breast Cancer Risk

(2012) J. Peres   JNCI-Journal of the National Cancer Institute

Implanted adipose progenitor cells as physicochemical regulators of breast cancer

(2012) E. M. Chandler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aligned Collagen Is a Prognostic Signature for Survival in Human Breast Carcinoma

(2011) Matthew W. Conklin et al.   AMERICAN JOURNAL OF PATHOLOGY

Inflammation and Increased Aromatase Expression Occur in the Breast Tissue of Obese Women with Breast Cancer

(2011) Patrick G. Morris et al.   Cancer Prevention Research

Obesity Is Associated with Inflammation and Elevated Aromatase Expression in the Mouse Mammary Gland

(2011) K. Subbaramaiah et al.   Cancer Prevention Research

Protection from Obesity and Diabetes by Blockade of TGF-β/Smad3 Signaling

(2011) Hariom Yadav et al.   Cell Metabolism

The Single-Molecule Mechanics of the Latent TGF-β1 Complex

(2011) Lara Buscemi et al.   CURRENT BIOLOGY

Mechanical signaling through the cytoskeleton regulates cell proliferation by coordinated focal adhesion and Rho GTPase signaling

(2011) P. P. Provenzano et al.   JOURNAL OF CELL SCIENCE

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

Collagen I matrix turnover is regulated by fibronectin polymerization

(2010) Feng Shi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Assembly of Fibronectin Extracellular Matrix

(2010) Purva Singh et al.   Annual Review of Cell and Developmental Biology

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

Dynamic interplay between the collagen scaffold and tumor evolution

(2010) Mikala Egeblad et al.   CURRENT OPINION IN CELL BIOLOGY

Fibrosis in Human Adipose Tissue: Composition, Distribution, and Link With Lipid Metabolism and Fat Mass Loss

(2010) A. Divoux et al.   DIABETES

Matrix stiffness modulates proliferation, chemotherapeutic response, and dormancy in hepatocellular carcinoma cells

(2010) Jörg Schrader et al.   HEPATOLOGY

Obesity and Cancer

(2010) K. Y. Wolin et al.   ONCOLOGIST

Calorie restriction and cancer prevention: metabolic and molecular mechanisms

(2010) Valter D. Longo et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

Hypoxia-Inducible Factor 1  Induces Fibrosis and Insulin Resistance in White Adipose Tissue

(2009) N. Halberg et al.   MOLECULAR AND CELLULAR BIOLOGY

A mechanosensitive transcriptional mechanism that controls angiogenesis

(2009) Akiko Mammoto et al.   NATURE

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Matrix density-induced mechanoregulation of breast cell phenotype, signaling and gene expression through a FAK–ERK linkage

(2009) P P Provenzano et al.   ONCOGENE

Mechanically Activated Integrin Switch Controls  5 1 Function

(2009) J. C. Friedland et al.   SCIENCE

Collagen fibrillogenesis: fibronectin, integrins, and minor collagens as organizers and nucleators

(2008) Karl E Kadler et al.   CURRENT OPINION IN CELL BIOLOGY

Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity

(2008) Corneliu Henegar et al.   GENOME BIOLOGY