Receptors, channels and signalling in the urothelial sensory system in the bladder

ATP release from freshly isolated guinea-pig bladder urothelial cells: a quantification and study of the mechanisms involved

(2015) Linda M. McLatchie et al.   BJU INTERNATIONAL

Transient receptor potential channel modulators as pharmacological treatments for lower urinary tract symptoms (LUTS): myth or reality?

(2015) Yves Deruyver et al.   BJU INTERNATIONAL

TRPM2 Mediates Histone Deacetylase Inhibition-Induced Apoptosis in Bladder Cancer Cells

(2015) Qi-feng Cao et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

Essential Role of Transient Receptor Potential M8 (TRPM8) in a Model of Acute Cold-induced Urinary Urgency

(2015) Pieter Uvin et al.   EUROPEAN UROLOGY

Pain-enhancing mechanism through interaction between TRPV1 and anoctamin 1 in sensory neurons

(2015) Yasunori Takayama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intravesical TRPV4 blockade reduces repeated variate stress-induced bladder dysfunction by increasing bladder capacity and decreasing voiding frequency in male rats

(2014) Liana Merrill et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Bladder sensory physiology: neuroactive compounds and receptors, sensory transducers, and target-derived growth factors as targets to improve function

(2014) Eric J. Gonzalez et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Potential role of transient receptor potential (TRP) channels in bladder cancer cells

(2014) Hideki Mizuno et al.   Journal of Physiological Sciences

Urothelial mucosal signaling and the overactive bladder-ICI-RS 2013

(2014) Lori A. Birder et al.   NEUROUROLOGY AND URODYNAMICS

TRPA1 mediates bladder hyperalgesia in a mouse model of cystitis

(2014) Jennifer J. DeBerry et al.   PAIN

Anoctamin-1 in the Juvenile Rat Urinary Bladder

(2014) Dominika A. Bijos et al.   PLoS One

Repeated variate stress in male rats induces increased voiding frequency, somatic sensitivity, and urinary bladder nerve growth factor expression

(2013) Liana Merrill et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Neuropeptide/Receptor Expression and Plasticity in Micturition Pathways

(2013) Liana Merrill et al.   CURRENT PHARMACEUTICAL DESIGN

Extracellular UDP enhances P2X-mediated bladder smooth muscle contractility via P2Y6 activation of the phospholipase C/inositol trisphosphate pathway

(2013) Weiqun Yu et al.   FASEB JOURNAL

Increased TRPV4 Expression in Urinary Bladder and Lumbosacral Dorsal Root Ganglia in Mice with Chronic Overexpression of NGF in Urothelium

(2013) Beatrice M. Girard et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Increased mRNA Expression of Genes Involved in Pronociceptive Inflammatory Reactions in Bladder Tissue of Interstitial Cystitis

(2013) Yukio Homma et al.   JOURNAL OF UROLOGY

The role of transient receptor potential ankyrin 1 (TRPA1) channel in activation of single unit mechanosensitive bladder afferent activities in the rat

(2013) Tomonori Minagawa et al.   NEUROUROLOGY AND URODYNAMICS

Lamina propria: The functional center of the bladder?

(2013) Karl-Erik Andersson et al.   NEUROUROLOGY AND URODYNAMICS

Urothelial Signaling

(2013) Lori Birder et al.   PHYSIOLOGICAL REVIEWS

Urinary ATP May Be a Dynamic Biomarker of Detrusor Overactivity in Women with Overactive Bladder Syndrome

(2013) Miguel Silva-Ramos et al.   PLoS One

Crucial Role of TRPC1 and TRPC4 in Cystitis-Induced Neuronal Sprouting and Bladder Overactivity

(2013) Mathieu Boudes et al.   PLoS One

Purinergic signalling in the urinary tract in health and disease

(2013) Geoffrey Burnstock   Purinergic Signalling

Purinergic signalling in the lower urinary tract

(2012) G. Burnstock   Acta Physiologica

Expression and electrophysiological characteristics of P2X3receptors in interstitial cells of Cajal in rats with partial bladder outlet obstruction

(2012) Yuxin Li et al.   BJU INTERNATIONAL

The regulation of ATP release from the urothelium by adenosine and transepithelial potential

(2012) Bryony M. Dunning-Davies et al.   BJU INTERNATIONAL

4α-phorbol 12,13-didecanoate activates cultured mouse dorsal root ganglia neurons independently of TRPV4

(2012) R Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

Transcriptional and Translational Plasticity in Rodent Urinary Bladder TRP Channels with Urinary Bladder Inflammation, Bladder Dysfunction, or Postnatal Maturation

(2012) Liana Merrill et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

A modulating effect of epigallocatechin gallate (EGCG), a tea catechin, on the bladder of rats exposed to water avoidance stress

(2012) Tony Bazi et al.   NEUROUROLOGY AND URODYNAMICS

Functional roles of transient receptor potential melastatin 8 (TRPM8) channels in the cold stress-induced detrusor overactivity pathways in conscious rats

(2012) Zhang Lei et al.   NEUROUROLOGY AND URODYNAMICS

Effects of Combination Treatment of Intravesical Resiniferatoxin Instillation and Hydrodistention in Patients with Refractory Painful Bladder Syndrome/Interstitial Cystitis: A Pilot Study

(2012) Byeong Kuk Ham et al.   International Neurourology Journal

Therapeutic potential of purinergic signalling for diseases of the urinary tract

(2011) Geoffrey Burnstock   BJU INTERNATIONAL

An investigation of the safety and pharmacokinetics of the novel TRPV1 antagonist XEN-D0501 in healthy subjects

(2011) Patrick Round et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Therapeutic Targeting of TRP Channels - The TR(i)P to Pain Relief

(2011) Samer R. Eid   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Trpv1 Reporter Mice Reveal Highly Restricted Brain Distribution and Functional Expression in Arteriolar Smooth Muscle Cells

(2011) D. J. Cavanaugh et al.   JOURNAL OF NEUROSCIENCE

TRP Vanilloid 2 Knock-Out Mice Are Susceptible to Perinatal Lethality But Display Normal Thermal and Mechanical Nociception

(2011) U. Park et al.   JOURNAL OF NEUROSCIENCE

Transient receptor potential channels as therapeutic targets

(2011) Magdalene M. Moran et al.   NATURE REVIEWS DRUG DISCOVERY

From urgency to frequency: facts and controversies of TRPs in the lower urinary tract

(2011) Roman Skryma et al.   Nature Reviews Urology

Effects of TRPV4 cation channel activation on the primary bladder afferent activities of the rat

(2011) Naoki Aizawa et al.   NEUROUROLOGY AND URODYNAMICS

TRPV1, NK1 receptor and substance P immunoreactivity and gene expression in the rat lumbosacral spinal cord and urinary bladder after systemic, low dose vanilloid administration

(2011) Yujing J. Heng et al.   REGULATORY PEPTIDES

The role of the transient receptor potential (TRP) superfamily of cation-selective channels in the management of the overactive bladder

(2010) Karl-Erik Andersson et al.   BJU INTERNATIONAL

Functional TRPV4 channels and an absence of capsaicin-evoked currents in freshly-isolated, guinea-pig urothelial cells

(2010) Xiaoping Xu et al.   Channels

The P2Y2 Receptor Sensitizes Mouse Bladder Sensory Neurons and Facilitates Purinergic Currents

(2010) X. Chen et al.   JOURNAL OF NEUROSCIENCE

Endogenous Purinergic Control of Bladder Activity via Presynaptic P2X3 and P2X2/3 Receptors in the Spinal Cord

(2010) T. K. Y. Kaan et al.   JOURNAL OF NEUROSCIENCE

Differential purinergic signaling in bladder sensory neurons of naïve and bladder-inflamed mice

(2010) Xiaowei Chen et al.   PAIN

Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis

(2010) W. Everaerts et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Release of ATP from rat urinary bladder mucosa: role of acid, vanilloids and stretch

(2009) P Sadananda et al.   BRITISH JOURNAL OF PHARMACOLOGY

In Vitro Release of Adenosine Triphosphate from the Urothelium of Human Bladders with Detrusor Overactivity, Both Neurogenic and Idiopathic

(2009) Vivek Kumar et al.   EUROPEAN UROLOGY

The TRPV4 Cation Channel Mediates Stretch-evoked Ca2+Influx and ATP Release in Primary Urothelial Cell Cultures

(2009) Tsutomu Mochizuki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Medial Amygdala Modulates Body Weight but not Neuroendocrine Responses to Chronic Stress

(2009) M. B. Solomon et al.   JOURNAL OF NEUROENDOCRINOLOGY

Functional Transient Receptor Potential Vanilloid 1 is Expressed in Human Urothelial Cells

(2009) Ana Charrua et al.   JOURNAL OF UROLOGY

Purinergic Mechanosensory Transduction and Visceral Pain

(2009) Geoffrey Burnstock   Molecular Pain

Where is TRPV1 expressed in the bladder, do we see the real channel?

(2009) Wouter Everaerts et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Chronic stress increases pituitary adenylate cyclase-activating peptide (PACAP) and brain-derived neurotrophic factor (BDNF) mRNA expression in the bed nucleus of the stria terminalis (BNST): Roles for PACAP in anxiety-like behavior

(2009) Sayamwong E. Hammack et al.   PSYCHONEUROENDOCRINOLOGY

Differential Localizations of the Transient Receptor Potential Channels TRPV4 and TRPV1 in the Mouse Urinary Bladder

(2008) Takahiro Yamada et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

N-((1S)-1- -3-hydroxypropanoyl)-1-piperazinyl]carbonyl}-3-methylbutyl)-1-benzothiophene-2-carboxamide (GSK1016790A), a Novel and Potent Transient Receptor Potential Vanilloid 4 Channel Agonist Induces Urinary Bladder Contraction and Hyperactivity: Part I

(2008) K. S. Thorneloe et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The neural control of micturition

(2008) Clare J. Fowler et al.   NATURE REVIEWS NEUROSCIENCE

Effect of Menthol on Detrusor Smooth-Muscle Contraction and the Micturition Reflex in Rats

(2008) Yoshiko Nomoto et al.   UROLOGY

Differential Expression Profile of Cold (TRPA1) and Cool (TRPM8) Receptors in Human Urogenital Organs

(2008) Shuqi Du et al.   UROLOGY

Distribution and Function of the Hydrogen Sulfide–Sensitive TRPA1 Ion Channel in Rat Urinary Bladder

(2007) Tomi Streng et al.   EUROPEAN UROLOGY

On the origin of bladder sensing: Tr(i)ps in urology

(2007) Wouter Everaerts et al.   NEUROUROLOGY AND URODYNAMICS