Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression

Multiparametric MR Imaging in Abdominal Malignancies

(2016) Antonio Luna et al.   Magnetic Resonance Imaging Clinics of North America

MiR-1181 inhibits stem cell-like phenotypes and suppresses SOX2 and STAT3 in human pancreatic cancer

(2015) Jianxin Jiang et al.   CANCER LETTERS

RUNX3 Controls a Metastatic Switch in Pancreatic Ductal Adenocarcinoma

(2015) Martin C. Whittle et al.   CELL

Signal Transducer and Activator of Transcription 3, Mediated Remodeling of the Tumor Microenvironment Results in Enhanced Tumor Drug Delivery in a Mouse Model of Pancreatic Cancer

(2015) Nagaraj S. Nagathihalli et al.   GASTROENTEROLOGY

Detailed analysis of epithelial-mesenchymal transition and tumor budding identifies predictors of long-term survival in pancreatic ductal adenocarcinoma

(2015) Ilona Kohler et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Quantification of Extracellular Matrix Proteins from a Rat Lung Scaffold to Provide a Molecular Readout for Tissue Engineering

(2015) Ryan C. Hill et al.   MOLECULAR & CELLULAR PROTEOMICS

Virtual microdissection identifies distinct tumor- and stroma-specific subtypes of pancreatic ductal adenocarcinoma

(2015) Richard A Moffitt et al.   NATURE GENETICS

Structural determinants of Smad function in TGF-β signaling

(2015) Maria J. Macias et al.   TRENDS IN BIOCHEMICAL SCIENCES

The prognostic value of stroma in pancreatic cancer in patients receiving adjuvant therapy

(2015) Katherine M. Bever et al.   HPB

The Role of Mechanical Forces in Tumor Growth and Therapy

(2014) Rakesh K. Jain et al.   Annual Review of Biomedical Engineering

α-Smooth muscle actin expression and desmoplastic stromal reaction in pancreatic cancer: results from the CONKO-001 study

(2014) M Sinn et al.   BRITISH JOURNAL OF CANCER

Compression of Pancreatic Tumor Blood Vessels by Hyaluronan Is Caused by Solid Stress and Not Interstitial Fluid Pressure

(2014) Vikash P. Chauhan et al.   CANCER CELL

Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival

(2014) Berna C. Özdemir et al.   CANCER CELL

Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma

(2014) Andrew D. Rhim et al.   CANCER CELL

Stromal reengineering to treat pancreas cancer

(2014) I. M. Stromnes et al.   CARCINOGENESIS

KRAS and YAP1 Converge to Regulate EMT and Tumor Survival

(2014) Diane D. Shao et al.   CELL

Hippo Pathway Activity Influences Liver Cell Fate

(2014) Dean Yimlamai et al.   CELL

Multiplatform Analysis of 12 Cancer Types Reveals Molecular Classification within and across Tissues of Origin

(2014) Katherine A. Hoadley et al.   CELL

The cancer glycocalyx mechanically primes integrin-mediated growth and survival

(2014) Matthew J. Paszek et al.   NATURE

Comprehensive molecular profiling of lung adenocarcinoma

(2014) Eric A. Collisson et al.   NATURE

Tissue mechanics modulate microRNA-dependent PTEN expression to regulate malignant progression

(2014) Janna K Mouw et al.   NATURE MEDICINE

Hyaluronan, fluid pressure and stromal resistance in pancreas cancer

(2013) P P Provenzano et al.   BRITISH JOURNAL OF CANCER

Stromally Derived Lysyl Oxidase Promotes Metastasis of Transforming Growth Factor- -Deficient Mouse Mammary Carcinomas

(2013) M. W. Pickup et al.   CANCER RESEARCH

Collective Invasion in Breast Cancer Requires a Conserved Basal Epithelial Program

(2013) Kevin J. Cheung et al.   CELL

Oncogenic targeting of BRM drives malignancy through C/EBPβ-dependent induction of α5 integrin

(2013) L Damiano et al.   ONCOGENE

Intratumoral α-SMA Enhances the Prognostic Potency of CD34 Associated with Maintenance of Microvessel Integrity in Hepatocellular Carcinoma and Pancreatic Cancer

(2013) Wen-Quan Wang et al.   PLoS One

Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels

(2013) Vikash P. Chauhan et al.   Nature Communications

SOX2 promotes dedifferentiation and imparts stem cell-like features to pancreatic cancer cells

(2013) M Herreros-Villanueva et al.   Oncogenesis

Targeting Tumor Architecture to Favor Drug Penetration: A New Weapon to Combat Chemoresistance in Pancreatic Cancer?

(2012) Man Yu et al.   CANCER CELL

Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal Adenocarcinoma

(2012) Paolo P. Provenzano et al.   CANCER CELL

Clinical Significance of the Genetic Landscape of Pancreatic Cancer and Implications for Identification of Potential Long-term Survivors

(2012) S. Yachida et al.   CLINICAL CANCER RESEARCH

Rho-associated kinases in tumorigenesis: re-considering ROCK inhibition for cancer therapy

(2012) Nicola Rath et al.   EMBO REPORTS

What We Have Learned About Pancreatic Cancer From Mouse Models

(2012) Pedro A. Pérez–Mancera et al.   GASTROENTEROLOGY

MicroRNA expression profiles associated with pancreatic adenocarcinoma and ampullary adenocarcinoma

(2012) Nicolai A Schultz et al.   MODERN PATHOLOGY

Sonic Hedgehog in pancreatic cancer: From bench to bedside, then back to the bench

(2012) David E. Rosow et al.   SURGERY

ROCK and JAK1 Signaling Cooperate to Control Actomyosin Contractility in Tumor Cells and Stroma

(2011) Victoria Sanz-Moreno et al.   CANCER CELL

Stat3 and MMP7 Contribute to Pancreatic Ductal Adenocarcinoma Initiation and Progression

(2011) Akihisa Fukuda et al.   CANCER CELL

Stat3/Socs3 Activation by IL-6 Transsignaling Promotes Progression of Pancreatic Intraepithelial Neoplasia and Development of Pancreatic Cancer

(2011) Marina Lesina et al.   CANCER CELL

Actomyosin-Mediated Cellular Tension Drives Increased Tissue Stiffness and β-Catenin Activation to Induce Epidermal Hyperplasia and Tumor Growth

(2011) Michael S. Samuel et al.   CANCER CELL

In situ force mapping of mammary gland transformation

(2011) Jose I. Lopez et al.   Integrative Biology

Inhibiting Cxcr2 disrupts tumor-stromal interactions and improves survival in a mouse model of pancreatic ductal adenocarcinoma

(2011) Hideaki Ijichi et al.   JOURNAL OF CLINICAL INVESTIGATION

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy

(2011) Eric A Collisson et al.   NATURE MEDICINE

Tenascin-C Enhances Pancreatic Cancer Cell Growth and Motility and Affects Cell Adhesion through Activation of the Integrin Pathway

(2011) Igor Paron et al.   PLoS One

Three-Dimensional Collagen I Promotes Gemcitabine Resistance in Pancreatic Cancer through MT1-MMP-Mediated Expression of HMGA2

(2010) S. Dangi-Garimella et al.   CANCER RESEARCH

Constitutively Active Stat3 Enhances Neu-Mediated Migration and Metastasis in Mammary Tumors via Upregulation of Cten

(2010) I. Barbieri et al.   CANCER RESEARCH

Stromal biology and therapy in pancreatic cancer

(2010) A. Neesse et al.   GUT

Matrix stiffness modulates proliferation, chemotherapeutic response, and dormancy in hepatocellular carcinoma cells

(2010) Jörg Schrader et al.   HEPATOLOGY

SMAD4 Gene Mutations Are Associated with Poor Prognosis in Pancreatic Cancer

(2009) A. Blackford et al.   CLINICAL CANCER RESEARCH

Side population of pancreatic cancer cells predominates in TGF-β-mediated epithelial to mesenchymal transition and invasion

(2009) Ayano Kabashima et al.   INTERNATIONAL JOURNAL OF CANCER

DPC4 Gene Status of the Primary Carcinoma Correlates With Patterns of Failure in Patients With Pancreatic Cancer

(2009) Christine A. Iacobuzio-Donahue et al.   JOURNAL OF CLINICAL ONCOLOGY

Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer

(2009) K. P. Olive et al.   SCIENCE

The Activated Stroma Index Is a Novel and Independent Prognostic Marker in Pancreatic Ductal Adenocarcinoma

(2008) Mert Erkan et al.   Clinical Gastroenterology and Hepatology