Omics sciences for systems biology in Alzheimer’s disease: State-of-the-art of the evidence

Molecular subtyping of Alzheimer’s disease using RNA sequencing data reveals novel mechanisms and targets

(2021) Ryan A. Neff et al.   Science Advances

The multiplex model of the genetics of Alzheimer’s disease

(2020) Rebecca Sims et al.   NATURE NEUROSCIENCE

An atlas of the protein-coding genes in the human, pig, and mouse brain

(2020) Evelina Sjöstedt et al.   SCIENCE

Genome-Wide Association Study of Brain Connectivity Changes for Alzheimer’s Disease

(2020) Samar S. M. Elsheikh et al.   Scientific Reports

ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries

(2020) Paul M. Thompson et al.   Translational Psychiatry

Gut–Brain Axis and Neurodegeneration: State-of-the-Art of Meta-Omics Sciences for Microbiota Characterization

(2020) Bruno Tilocca et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Discriminative Accuracy of Plasma Phospho-tau217 for Alzheimer Disease vs Other Neurodegenerative Disorders

(2020) Sebastian Palmqvist et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Integrated proteomics reveals brain-based cerebrospinal fluid biomarkers in asymptomatic and symptomatic Alzheimer’s disease

(2020) Lenora Higginbotham et al.   Science Advances

Integrated lipidomics and proteomics network analysis highlights lipid and immunity pathways associated with Alzheimer’s disease

(2020) Jin Xu et al.   Translational Neurodegeneration

DIABLO: an integrative approach for identifying key molecular drivers from multi-omic assays

(2019) Amrit Singh et al.   BIOINFORMATICS

Changes in synaptic proteins precede neurodegeneration markers in preclinical Alzheimer’s disease cerebrospinal fluid

(2019) Alberto Lleó et al.   MOLECULAR & CELLULAR PROTEOMICS

Biomarker-Drug and Liquid Biopsy Co-development for Disease Staging and Targeted Therapy: Cornerstones for Alzheimer’s Precision Medicine and Pharmacology

(2019) Harald Hampel et al.   Frontiers in Pharmacology

Blood-based molecular biomarkers for Alzheimer’s disease

(2019) Henrik Zetterberg et al.   Molecular Brain

Revealing heterogeneity of brain imaging phenotypes in Alzheimer’s disease based on unsupervised clustering of blood marker profiles

(2019) Gerard Martí-Juan et al.   PLoS One

The Alzheimer Precision Medicine Initiative

(2019) Harald Hampel et al.   JOURNAL OF ALZHEIMERS DISEASE

The new genetic landscape of Alzheimer’s disease: from amyloid cascade to genetically driven synaptic failure hypothesis?

(2019) Pierre Dourlen et al.   ACTA NEUROPATHOLOGICA

Differential default mode network trajectories in asymptomatic individuals at risk for Alzheimer's disease

(2019) Patrizia A. Chiesa et al.   Alzheimers & Dementia

Plasma amyloid β 40/42 ratio predicts cerebral amyloidosis in cognitively normal individuals at risk for Alzheimer's disease

(2019) Andrea Vergallo et al.   Alzheimers & Dementia

Alzheimer’s Disease Microbiome Is Associated with Dysregulation of the Anti-Inflammatory P-Glycoprotein Pathway

(2019) John P. Haran et al.   mBio

Integrating imaging and omics data: A review

(2019) Laura Antonelli et al.   Biomedical Signal Processing and Control

A Systematic Review of MicroRNA Expression as Biomarker of Late-Onset Alzheimer’s Disease

(2019) Soraya Herrera-Espejo et al.   MOLECULAR NEUROBIOLOGY

Time for the systems-level integration of aging: Resilience enhancing strategies to prevent Alzheimer’s disease

(2019) Harald Hampel et al.   PROGRESS IN NEUROBIOLOGY

Breast cancer quantitative proteome and proteogenomic landscape

(2019) Henrik J. Johansson et al.   Nature Communications

Systems Biology and Multi-Omics Integration: Viewpoints from the Metabolomics Research Community

(2019) Farhana R. Pinu et al.   Metabolites

Ageing as a risk factor for neurodegenerative disease

(2019) Yujun Hou et al.   Nature Reviews Neurology

Alzheimer Disease: An Update on Pathobiology and Treatment Strategies

(2019) Justin M. Long et al.   CELL

Proteogenomics: From next-generation sequencing (NGS) and mass spectrometry-based proteomics to precision medicine

(2019) Mia Yang Ang et al.   CLINICA CHIMICA ACTA

AD biomarker discovery in CSF and in alternative matrices

(2019) Giulia Sancesario et al.   CLINICAL BIOCHEMISTRY

Biomarker-guided clustering of Alzheimer's disease clinical syndromes

(2019) Nicola Toschi et al.   NEUROBIOLOGY OF AGING

Untangling Genetic Risk for Alzheimer’s Disease

(2018) Anna A. Pimenova et al.   BIOLOGICAL PSYCHIATRY

Genetic study of multimodal imaging Alzheimer’s disease progression score implicates novel loci

(2018) Marzia A Scelsi et al.   BRAIN

Personal Omics for Precision Health

(2018) Ryan A. Kellogg et al.   CIRCULATION RESEARCH

Toward Reproducible Results from Targeted Metabolomic Studies: Perspectives for Data Pre-Processing and a Basis for Analytic Pipeline Development

(2018) Thomas Gross et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Revolution of Alzheimer Precision Neurology. Passageway of Systems Biology and Neurophysiology

(2018) Harald Hampel et al.   JOURNAL OF ALZHEIMERS DISEASE

Oxidative Stress, Amyloid-β Peptide, and Altered Key Molecular Pathways in the Pathogenesis and Progression of Alzheimer’s Disease

(2018) D. Allan Butterfield et al.   JOURNAL OF ALZHEIMERS DISEASE

Gut Microbiota is Altered in Patients with Alzheimer’s Disease

(2018) Zhen-Qian Zhuang et al.   JOURNAL OF ALZHEIMERS DISEASE

Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimer’s disease

(2018) Srikant Rangaraju et al.   Molecular Neurodegeneration

Quantitative proteomics of acutely-isolated mouse microglia identifies novel immune Alzheimer’s disease-related proteins

(2018) Srikant Rangaraju et al.   Molecular Neurodegeneration

High performance plasma amyloid-β biomarkers for Alzheimer’s disease

(2018) Akinori Nakamura et al.   NATURE

Susceptibility of brain atrophy toTRIB3in Alzheimer’s disease, evidence from functional prioritization in imaging genetics

(2018) Marco Lorenzi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Understanding Alzheimer Disease at the Interface between Genetics and Transcriptomics

(2018) Jan Verheijen et al.   TRENDS IN GENETICS

Discovery of coding regions in the human genome by integrated proteogenomics analysis workflow

(2018) Yafeng Zhu et al.   Nature Communications

Whole transcriptome profiling of Late-Onset Alzheimer’s Disease patients provides insights into the molecular changes involved in the disease

(2018) Anita Annese et al.   Scientific Reports

Brain and blood metabolite signatures of pathology and progression in Alzheimer disease: A targeted metabolomics study

(2018) Vijay R. Varma et al.   PLOS MEDICINE

Application of Metabolomics in Alzheimer’s Disease

(2018) Jordan Maximillian Wilkins et al.   Frontiers in Neurology

Global quantitative analysis of the human brain proteome in Alzheimer’s and Parkinson’s Disease

(2018) Lingyan Ping et al.   Scientific Data

Validation of AclarusDx™, a Blood-Based Transcriptomic Signature for the Diagnosis of Alzheimer's Disease

(2018) Pascale Fehlbaum-Beurdeley et al.   JOURNAL OF ALZHEIMERS DISEASE

Candidate Blood Proteome Markers of Alzheimer's Disease Onset and Progression: A Systematic Review and Replication Study

(2018) Steven J. Kiddle et al.   JOURNAL OF ALZHEIMERS DISEASE

Source Analysis of Spontaneous Magnetoencephalograpic Activity in Healthy Aging and Mild Cognitive Impairment: Influence of Apolipoprotein E Polymorphism

(2018) Pablo Cuesta et al.   JOURNAL OF ALZHEIMERS DISEASE

Redox Proteomics and Amyloid β-Peptide: Insights into Alzheimer Disease

(2018) D Allan Butterfield et al.   JOURNAL OF NEUROCHEMISTRY

Integrative transcriptome analyses of the aging brain implicate altered splicing in Alzheimer’s disease susceptibility

(2018) Towfique Raj et al.   NATURE GENETICS

Next-generation biomarker discovery in Alzheimer's disease using metabolomics – from animal to human studies

(2018) Marina Ollé Hurtado et al.   Bioanalysis

Using Multi-Scale Genetic, Neuroimaging and Clinical Data for Predicting Alzheimer’s Disease and Reconstruction of Relevant Biological Mechanisms

(2018) Shashank Khanna et al.   Scientific Reports

MicroRNAs and mild cognitive impairment: A systematic review

(2018) Paola Piscopo et al.   AGEING RESEARCH REVIEWS

Deep proteomic network analysis of Alzheimer’s disease brain reveals alterations in RNA binding proteins and RNA splicing associated with disease

(2018) Erik C. B. Johnson et al.   Molecular Neurodegeneration

Epigenome-wide study uncovers large-scale changes in histone acetylation driven by tau pathology in aging and Alzheimer’s human brains

(2018) Hans-Ulrich Klein et al.   NATURE NEUROSCIENCE

A histone acetylome-wide association study of Alzheimer’s disease identifies disease-associated H3K27ac differences in the entorhinal cortex

(2018) Sarah J. Marzi et al.   NATURE NEUROSCIENCE

Current and future perspectives of liquid biopsies in genomics-driven oncology

(2018) Ellen Heitzer et al.   NATURE REVIEWS GENETICS

Blood-based biomarkers for Alzheimer disease: mapping the road to the clinic

(2018) Harald Hampel et al.   Nature Reviews Neurology

Effects of APOE Genotype on Brain Proteomic Network and Cell Type Changes in Alzheimer's Disease

(2018) Jingting Dai et al.   Frontiers in Molecular Neuroscience

Proteomic studies of cerebrospinal fluid biomarkers of Alzheimer’s disease: an update

(2017) Erik Portelius et al.   Expert Review of Proteomics

The use of stable isotopes in the study of human pathophysiology

(2017) Evelina Charidemou et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Oxidative Stress, Synaptic Dysfunction, and Alzheimer’s Disease

(2017) Eric Tönnies et al.   JOURNAL OF ALZHEIMERS DISEASE

A systems pharmacology-based approach to identify novel Kv1.3 channel-dependent mechanisms in microglial activation

(2017) Srikant Rangaraju et al.   Journal of Neuroinflammation

High-Throughput Metabolomics for Discovering Potential Metabolite Biomarkers and Metabolic Mechanism from the APPswe/PS1dE9 Transgenic Model of Alzheimer’s Disease

(2017) Jingbo Yu et al.   JOURNAL OF PROTEOME RESEARCH

Neurology Individualized Medicine: When to Use Next-Generation Sequencing Panels

(2017) Christopher J. Klein et al.   MAYO CLINIC PROCEEDINGS

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

(2017) Rebecca Sims et al.   NATURE GENETICS

Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly

(2017) Annamaria Cattaneo et al.   NEUROBIOLOGY OF AGING

Imaging-wide association study: Integrating imaging endophenotypes in GWAS

(2017) Zhiyuan Xu et al.   NEUROIMAGE

Single-Cell Multiomics: Multiple Measurements from Single Cells

(2017) Iain C. Macaulay et al.   TRENDS IN GENETICS

mixOmics: An R package for ‘omics feature selection and multiple data integration

(2017) Florian Rohart et al.   PLoS Computational Biology

Association between fatty acid metabolism in the brain and Alzheimer disease neuropathology and cognitive performance: A nontargeted metabolomic study

(2017) Stuart G. Snowden et al.   PLOS MEDICINE

Secretory Products of the Human GI Tract Microbiome and Their Potential Impact on Alzheimer's Disease (AD): Detection of Lipopolysaccharide (LPS) in AD Hippocampus

(2017) Yuhai Zhao et al.   Frontiers in Cellular and Infection Microbiology

A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer’s Disease

(2017) Nicholas T. Seyfried et al.   Cell Systems

More Is Better: Recent Progress in Multi-Omics Data Integration Methods

(2017) Sijia Huang et al.   Frontiers in Genetics

Transcriptomic profiling of the human brain reveals that altered synaptic gene expression is associated with chronological aging

(2017) Allissa A. Dillman et al.   Scientific Reports

Gut microbiome alterations in Alzheimer’s disease

(2017) Nicholas M. Vogt et al.   Scientific Reports

The epigenome in Alzheimer’s disease: current state and approaches for a new path to gene discovery and understanding disease mechanism

(2016) Hans-Ulrich Klein et al.   ACTA NEUROPATHOLOGICA

Blood metabolite markers of preclinical Alzheimer's disease in two longitudinally followed cohorts of older individuals

(2016) Ramon Casanova et al.   Alzheimers & Dementia

Clinical implications from proteomic studies in neurodegenerative diseases: lessons from mitochondrial proteins

(2016) D. Allan Butterfield et al.   Expert Review of Proteomics

Plasma Phospholipid and Sphingolipid Alterations in Presenilin1 Mutation Carriers: A Pilot Study

(2016) Pratishtha Chatterjee et al.   JOURNAL OF ALZHEIMERS DISEASE

Unbiased Metabolomic Investigation of Alzheimer’s Disease Brain Points to Dysregulation of Mitochondrial Aspartate Metabolism

(2016) Giuseppe Paglia et al.   JOURNAL OF PROTEOME RESEARCH

Metabolomics enables precision medicine: “A White Paper, Community Perspective”

(2016) Richard D. Beger et al.   Metabolomics

Proteogenomics connects somatic mutations to signalling in breast cancer

(2016) Philipp Mertins et al.   NATURE

Metabolomics: beyond biomarkers and towards mechanisms

(2016) Caroline H. Johnson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Genetic variants in Alzheimer disease — molecular and brain network approaches

(2016) Chris Gaiteri et al.   Nature Reviews Neurology

The Image and Data Archive at the Laboratory of Neuro Imaging

(2016) Karen L. Crawford et al.   NEUROIMAGE

Predicting Alzheimer disease from a blood-based biomarker profile

(2016) Samantha C. Burnham et al.   NEUROLOGY

Gram-negative bacterial molecules associate with Alzheimer disease pathology

(2016) Xinhua Zhan et al.   NEUROLOGY

Biomarker Tests for Molecularly Targeted Therapies — The Key to Unlocking Precision Medicine

(2016) Gary H. Lyman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Transcriptomic Profiling of Extracellular RNAs Present in Cerebrospinal Fluid Identifies Differentially Expressed Transcripts in Parkinson’s Disease

(2016) Arash Hossein-nezhad et al.   Journal of Parkinsons Disease

Host response: A trigger for neurodegeneration?

(2016) Roman M. Stilling et al.   Nature Microbiology

Non-targeted lipidomics of CSF and frontal cortex grey and white matter in control, mild cognitive impairment, and Alzheimer’s disease subjects

(2015) Paul L. Wood et al.   ACTA NEUROPSYCHIATRICA

Integration of ‘omics’ data in aging research: from biomarkers to systems biology

(2015) Jonas Zierer et al.   AGING CELL

Convergent genetic and expression data implicate immunity in Alzheimer's disease

(2015) Lesley Jones et al.   Alzheimers & Dementia

Innovative diagnostic tools for early detection of Alzheimer's disease

(2015) Christoph Laske et al.   Alzheimers & Dementia

Explorative and targeted neuroproteomics in Alzheimer's disease

(2015) Ann Brinkmalm et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

MicroRNA Landscape in Alzheimer’s Disease

(2015) Carlo Cogoni et al.   CNS & Neurological Disorders-Drug Targets

Blood metabolite markers of cognitive performance and brain function in aging

(2015) Brittany N Simpson et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Application of metabolomics based on direct mass spectrometry analysis for the elucidation of altered metabolic pathways in serum from the APP/PS1 transgenic model of Alzheimer's disease

(2015) Raúl González-Domínguez et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Advances and Applications of Single-Cell Sequencing Technologies

(2015) Yong Wang et al.   MOLECULAR CELL

Electrophysiological, transcriptomic and morphologic profiling of single neurons using Patch-seq

(2015) Cathryn R Cadwell et al.   NATURE BIOTECHNOLOGY

Increased acetyl and total histone levels in post-mortem Alzheimer's disease brain

(2015) Pritika J. Narayan et al.   NEUROBIOLOGY OF DISEASE

Brain amyloidosis ascertainment from cognitive, imaging, and peripheral blood protein measures

(2015) L. G. Apostolova et al.   NEUROLOGY

A New Initiative on Precision Medicine

(2015) Francis S. Collins et al.   NEW ENGLAND JOURNAL OF MEDICINE

Correlated gene expression supports synchronous activity in brain networks

(2015) J. Richiardi et al.   SCIENCE

Epigenetic Alterations in Alzheimer’s Disease

(2015) Jose V. Sanchez-Mut et al.   Frontiers in Behavioral Neuroscience

Non-targeted lipidomics of CSF and frontal cortex grey and white matter in control, mild cognitive impairment, and Alzheimer’s disease subjects

(2015) Paul L. Wood et al.   ACTA NEUROPSYCHIATRICA

Association of Brain DNA Methylation inSORL1,ABCA7,HLA-DRB5,SLC24A4, andBIN1With Pathological Diagnosis of Alzheimer Disease

(2015) Lei Yu et al.   JAMA Neurology

Plasma lipidomics analysis finds long chain cholesteryl esters to be associated with Alzheimer’s disease

(2015) P Proitsi et al.   Translational Psychiatry

Plasma 24-metabolite Panel Predicts Preclinical Transition to Clinical Stages of Alzheimer’s Disease

(2015) Massimo S. Fiandaca et al.   Frontiers in Neurology

Blood-Based Proteomic Biomarkers of Alzheimer’s Disease Pathology

(2015) Alison L. Baird et al.   Frontiers in Neurology

microRNA-Based Biomarkers and the Diagnosis of Alzheimer’s Disease

(2015) Yuhai Zhao et al.   Frontiers in Neurology

Hippocampal transcriptome-guided genetic analysis of correlated episodic memory phenotypes in Alzheimer's disease

(2015) Jingwen Yan et al.   Frontiers in Genetics

Untargeted Metabolomic Analysis of Human Plasma Indicates Differentially Affected Polyamine and L-Arginine Metabolism in Mild Cognitive Impairment Subjects Converting to Alzheimer’s Disease

(2015) Stewart F. Graham et al.   PLoS One

The critical need for defining preclinical biomarkers in Alzheimer's disease

(2014) Massimo S. Fiandaca et al.   Alzheimers & Dementia

Plasma proteins predict conversion to dementia from prodromal disease

(2014) Abdul Hye et al.   Alzheimers & Dementia

The role of microRNAs in lymphopoiesis

(2014) Timothy M. Johanson et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Proteogenomic characterization of human colon and rectal cancer

(2014) Bing Zhang et al.   NATURE

An integrated catalog of reference genes in the human gut microbiome

(2014) Junhua Li et al.   NATURE BIOTECHNOLOGY

Plasma phospholipids identify antecedent memory impairment in older adults

(2014) Mark Mapstone et al.   NATURE MEDICINE

Proteogenomics: concepts, applications and computational strategies

(2014) Alexey I Nesvizhskii   NATURE METHODS

Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease

(2014) Katie Lunnon et al.   NATURE NEUROSCIENCE

Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci

(2014) Philip L De Jager et al.   NATURE NEUROSCIENCE

Regulation of microRNA biogenesis

(2014) Minju Ha et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Integrating Transcriptomics with Metabolic Modeling Predicts Biomarkers and Drug Targets for Alzheimer's Disease

(2014) Shiri Stempler et al.   PLoS One

A network approach to clinical intervention in neurodegenerative diseases

(2014) Jose A. Santiago et al.   TRENDS IN MOLECULAR MEDICINE

MicroRNAs in brain development and function: a matter of flexibility and stability

(2014) Philipp Follert et al.   Frontiers in Molecular Neuroscience

A review of multivariate analyses in imaging genetics

(2014) Jingyu Liu et al.   Frontiers in Neuroinformatics

Epigenetic studies in Alzheimer's disease: Current findings, caveats, and considerations for future studies

(2013) Katie Lunnon et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

On the outside, looking in: A review and evaluation of the comparability of blood and brain “-omes”

(2013) Daniel S. Tylee et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

miRNAs in development and pathogenesis of the nervous system: Table 1

(2013) Jakub S. Nowak et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Recent advances in the application of metabolomics to Alzheimer's Disease

(2013) Eugenia Trushina et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

iPOP Goes the World: Integrated Personalized Omics Profiling and the Road toward Improved Health Care

(2013) Jennifer Li-Pook-Than et al.   CHEMISTRY & BIOLOGY

Beyond modules and hubs: the potential of gene coexpression networks for investigating molecular mechanisms of complex brain disorders

(2013) C. Gaiteri et al.   GENES BRAIN AND BEHAVIOR

A blood-based predictor for neocortical Aβ burden in Alzheimer’s disease: results from the AIBL study

(2013) S C Burnham et al.   MOLECULAR PSYCHIATRY

Transcriptome and genome sequencing uncovers functional variation in humans

(2013) Tuuli Lappalainen et al.   NATURE

The Genotype-Tissue Expression (GTEx) project

(2013) John Lonsdale et al.   NATURE GENETICS

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

(2013) Jean-Charles Lambert et al.   NATURE GENETICS

Systems genetics approaches to understand complex traits

(2013) Mete Civelek et al.   NATURE REVIEWS GENETICS

Evidence of altered phosphatidylcholine metabolism in Alzheimer's disease

(2013) Luke Whiley et al.   NEUROBIOLOGY OF AGING

Relationship between Plasma Analytes and SPARE-AD Defined Brain Atrophy Patterns in ADNI

(2013) Jon B. Toledo et al.   PLoS One

Identification of Altered Metabolic Pathways in Plasma and CSF in Mild Cognitive Impairment and Alzheimer’s Disease Using Metabolomics

(2013) Eugenia Trushina et al.   PLoS One

Genome-wide scan of healthy human connectome discovers SPON1 gene variant influencing dementia severity

(2013) N. Jahanshad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcriptomics: Advances and approaches

(2013) ZhiCheng Dong et al.   Science China-Life Sciences

Clinical, imaging, and pathological heterogeneity of the Alzheimer's disease syndrome

(2013) Benjamin Lam et al.   Alzheimers Research & Therapy

Blood-Based Protein Biomarkers for Diagnosis of Alzheimer Disease

(2012) James D. Doecke   ARCHIVES OF NEUROLOGY

Personal Omics Profiling Reveals Dynamic Molecular and Medical Phenotypes

(2012) Rui Chen et al.   CELL

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

(2012) Konrad Talbot et al.   JOURNAL OF CLINICAL INVESTIGATION

Metabolomics: the apogee of the omics trilogy

(2012) Gary J. Patti et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A large scale multivariate parallel ICA method reveals novel imaging–genetic relationships for Alzheimer's disease in the ADNI cohort

(2012) Shashwath A. Meda et al.   NEUROIMAGE

Novel late-onset Alzheimer disease loci variants associate with brain gene expression

(2012) M. Allen et al.   NEUROLOGY

Serum ceramides increase the risk of Alzheimer disease: The Women's Health and Aging Study II

(2012) M. M. Mielke et al.   NEUROLOGY

Plasma multianalyte profiling in mild cognitive impairment and Alzheimer disease

(2012) W. T. Hu et al.   NEUROLOGY

HMDB 3.0—The Human Metabolome Database in 2013

(2012) David S. Wishart et al.   NUCLEIC ACIDS RESEARCH

Evaluation of a Previously Suggested Plasma Biomarker Panel to Identify Alzheimer's Disease

(2012) Maria Björkqvist et al.   PLoS One

Plasma Based Markers of [11C] PiB-PET Brain Amyloid Burden

(2012) Steven John Kiddle et al.   PLoS One

Expression of Novel Alzheimer’s Disease Risk Genes in Control and Alzheimer’s Disease Brains

(2012) Celeste M. Karch et al.   PLoS One

Targeted proteomics for quantification of histone acetylation in Alzheimer's disease

(2012) Kangling Zhang et al.   PROTEOMICS

NF-κB-regulated, proinflammatory miRNAs in Alzheimer's disease

(2012) Walter J Lukiw   Alzheimers Research & Therapy

Epigenetic modifications in frontal cortex from Alzheimer's disease and bipolar disorder patients

(2012) J S Rao et al.   Translational Psychiatry

NF-кB-regulated micro RNAs (miRNAs) in primary human brain cells

(2011) Walter J. Lukiw   EXPERIMENTAL NEUROLOGY

Metabolomics in Early Alzheimer's Disease: Identification of Altered Plasma Sphingolipidome Using Shotgun Lipidomics

(2011) Xianlin Han et al.   PLoS One

Plasma Biomarkers of Brain Atrophy in Alzheimer's Disease

(2011) Madhav Thambisetty et al.   PLoS One

Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma

(2011) J. D. Arroyo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Parkinson Progression Marker Initiative (PPMI)

(2011) Kenneth Marek et al.   PROGRESS IN NEUROBIOLOGY

Metabolome in progression to Alzheimer's disease

(2011) M Orešič et al.   Translational Psychiatry

A Serum Protein–Based Algorithm for the Detection of Alzheimer Disease

(2010) Sid E. O’Bryant   ARCHIVES OF NEUROLOGY

Lipidomics: New Tools and Applications

(2010) Markus R. Wenk   CELL

The Need for Precompetitive Integrative Bionetwork Disease Model Building

(2010) S H Friend   CLINICAL PHARMACOLOGY & THERAPEUTICS

Comprehensive proteomics

(2010) Martin Beck et al.   CURRENT OPINION IN BIOTECHNOLOGY

MicroRNA pathways in neural development and plasticity

(2010) Ngan K Vo et al.   CURRENT OPINION IN NEUROBIOLOGY

Lipidomics reveals a remarkable diversity of lipids in human plasma,

(2010) Oswald Quehenberger et al.   JOURNAL OF LIPID RESEARCH

Understanding the pathogenesis of Alzheimer’s disease: will RNA-Seq realize the promise of transcriptomics?

(2010) Greg T. Sutherland et al.   JOURNAL OF NEUROCHEMISTRY

Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease

(2010) S J Furney et al.   MOLECULAR PSYCHIATRY

The IMAGEN study: reinforcement-related behaviour in normal brain function and psychopathology

(2010) G Schumann et al.   MOLECULAR PSYCHIATRY

Transcriptome genetics using second generation sequencing in a Caucasian population

(2010) Stephen B. Montgomery et al.   NATURE

A human gut microbial gene catalogue established by metagenomic sequencing

(2010) Junjie Qin et al.   NATURE

Micro RNA-125b (miRNA-125b) function in astrogliosis and glial cell proliferation

(2010) A.I. Pogue et al.   NEUROSCIENCE LETTERS

Identifying Early Markers of Alzheimer's Disease using Quantitative Multiplex Proteomic Immunoassay Panels

(2009) Holly D. Soares et al.   Annals of the New York Academy of Sciences

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

Insights into the critical role of NADPH oxidase(s) in the normal and dysregulated pancreatic beta cell

(2009) P. Newsholme et al.   DIABETOLOGIA

Five out of 16 plasma signaling proteins are enhanced in plasma of patients with mild cognitive impairment and Alzheimer's disease

(2009) Josef Marksteiner et al.   NEUROBIOLOGY OF AGING

A Systems Level Analysis of Transcriptional Changes in Alzheimer's Disease and Normal Aging

(2008) J. A. Miller et al.   JOURNAL OF NEUROSCIENCE

Functional organization of the transcriptome in human brain

(2008) Michael C Oldham et al.   NATURE NEUROSCIENCE

Metabolomics: A Global Biochemical Approach to the Study of Central Nervous System Diseases

(2008) Rima Kaddurah-Daouk et al.   NEUROPSYCHOPHARMACOLOGY

Serum MicroRNAs Are Promising Novel Biomarkers

(2008) Shlomit Gilad et al.   PLoS One