A systems pharmacology-based approach to identify novel Kv1.3 channel-dependent mechanisms in microglial activation

A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer’s Disease

(2017) Nicholas T. Seyfried et al.   Cell Systems

Differential Kv1.3, KCa3.1, and Kir2.1 expression in “classically” and “alternatively” activated microglia

(2016) Hai M. Nguyen et al.   GLIA

Microglial Physiology and Pathophysiology: Insights from Genome-wide Transcriptional Profiling

(2016) Andrea Crotti et al.   IMMUNITY

Transcriptome sequencing reveals that LPS-triggered transcriptional responses in established microglia BV2 cell lines are poorly representative of primary microglia

(2016) Amitabh Das et al.   Journal of Neuroinflammation

Ionic immune suppression within the tumour microenvironment limits T cell effector function

(2016) Robert Eil et al.   NATURE

Mitonuclear communication in homeostasis and stress

(2016) Pedro M. Quirós et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Gene Regulatory Network Inference of Immunoresponsive Gene 1 (IRG1) Identifies Interferon Regulatory Factor 1 (IRF1) as Its Transcriptional Regulator in Mammalian Macrophages

(2016) Aravind Tallam et al.   PLoS One

Understanding the Role of T Cells in CNS Homeostasis

(2016) Erik Ellwardt et al.   TRENDS IN IMMUNOLOGY

KCa3.1 inhibition switches the phenotype of glioma-infiltrating microglia/macrophages

(2016) A Grimaldi et al.   Cell Death & Disease

The suitability of BV2 cells as alternative model system for primary microglia cultures or for animal experiments examining brain inflammation

(2016) Anja Henn   ALTEX-Alternatives to Animal Experimentation

Development of Highly Selective Kv1.3-Blocking Peptides Based on the Sea Anemone Peptide ShK

(2015) Michael Pennington et al.   Marine Drugs

Novel Molecular Insights into Classical and Alternative Activation States of Microglia as Revealed by Stable Isotope Labeling by Amino Acids in Cell Culture (SILAC)-based Proteomics

(2015) Harris Bell-Temin et al.   MOLECULAR & CELLULAR PROTEOMICS

The receptor TREML4 amplifies TLR7-mediated signaling during antiviral responses and autoimmunity

(2015) Zaida G Ramirez-Ortiz et al.   NATURE IMMUNOLOGY

Immune attack: the role of inflammation in Alzheimer disease

(2015) Frank L. Heppner et al.   NATURE REVIEWS NEUROSCIENCE

Identification of Glial Activation Markers by Comparison of Transcriptome Changes between Astrocytes and Microglia following Innate Immune Stimulation

(2015) Silvia Madeddu et al.   PLoS One

Comparison of microglia and infiltrating CD11c+ cells as antigen presenting cells for T cell proliferation and cytokine response

(2014) Agnieszka Wlodarczyk et al.   Journal of Neuroinflammation

Accurate Proteome-wide Label-free Quantification by Delayed Normalization and Maximal Peptide Ratio Extraction, Termed MaxLFQ

(2014) Jürgen Cox et al.   MOLECULAR & CELLULAR PROTEOMICS

Microglial priming in neurodegenerative disease

(2014) V. Hugh Perry et al.   Nature Reviews Neurology

Purinergic and Calcium Signaling in Macrophage Function and Plasticity

(2014) Bimal N. Desai et al.   Frontiers in Immunology

Identification of a unique TGF-β–dependent molecular and functional signature in microglia

(2013) Oleg Butovsky et al.   NATURE NEUROSCIENCE

The microglial sensome revealed by direct RNA sequencing

(2013) Suzanne E Hickman et al.   NATURE NEUROSCIENCE

Blockade of Kv1.3 channels ameliorates radiation-induced brain injury

(2013) Ying Peng et al.   NEURO-ONCOLOGY

Microglial TNF-α-Dependent Elevation of MHC Class I Expression on Brain Endothelium Induced by Amyloid-Beta Promotes T Cell Transendothelial Migration

(2013) Yi-Ming Yang et al.   NEUROCHEMICAL RESEARCH

Blockade of Kv1.3 Potassium Channels Inhibits Differentiation and Granzyme B Secretion of Human CD8+ T Effector Memory Lymphocytes

(2013) Lina Hu et al.   PLoS One

Integrated Expression Profiles of mRNA and miRNA in Polarized Primary Murine Microglia

(2013) Robert W. Freilich et al.   PLoS One

Methods and approaches in the topology-based analysis of biological pathways

(2013) Cristina Mitrea et al.   Frontiers in Physiology

GO-Elite: a flexible solution for pathway and ontology over-representation

(2012) Alexander C. Zambon et al.   BIOINFORMATICS

Neuronal RING finger protein 11 (RNF11) regulates canonical NF-κB signaling

(2012) Elaine L Pranski et al.   Journal of Neuroinflammation

Lipopolysaccharide-Induced Microglial Activation and Neuroprotection against Experimental Brain Injury Is Independent of Hematogenous TLR4

(2012) Z. Chen et al.   JOURNAL OF NEUROSCIENCE

Quantitative Proteomics Reveals Subset-Specific Viral Recognition in Dendritic Cells

(2010) Christian A. Luber et al.   IMMUNITY

Immunomodulation of voltage-dependent K+channels in macrophages: molecular and biophysical consequences

(2010) Núria Villalonga et al.   JOURNAL OF GENERAL PHYSIOLOGY

Minimal penetration of lipopolysaccharide across the murine blood–brain barrier

(2009) William A. Banks et al.   BRAIN BEHAVIOR AND IMMUNITY

Endothelial Ca2+-activated K+ channels in normal and impaired EDHF-dilator responses - relevance to cardiovascular pathologies and drug discovery

(2009) Ivica Grgic et al.   BRITISH JOURNAL OF PHARMACOLOGY

Kv1.3 potassium channels as a therapeutic target in multiple sclerosis

(2009) Srikant Rangaraju et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Regulation of interferon and Toll-like receptor signaling during macrophage activation by opposing feedforward and feedback inhibition mechanisms

(2009) Xiaoyu Hu et al.   IMMUNOLOGICAL REVIEWS

The functional network of ion channels in T lymphocytes

(2009) Michael D. Cahalan et al.   IMMUNOLOGICAL REVIEWS

Does neuroinflammation fan the flame in neurodegenerative diseases?

(2009) Tamy C Frank-Cannon et al.   Molecular Neurodegeneration

Predominant Functional Expression of Kv1.3 by Activated Microglia of the Hippocampus after Status epilepticus

(2009) Alexis Menteyne et al.   PLoS One

Mitochondrial potassium channel Kv1.3 mediates Bax-induced apoptosis in lymphocytes

(2008) I. Szabo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA