期刊
CIRCULATION RESEARCH
卷 122, 期 9, 页码 1169-1171出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/CIRCRESAHA.117.310909
关键词
clinical decision-making; metabolomics; proteome transcriptome; whole exome sequencing
资金
- SNF Early Postdoctoral Mobility fellowship
- National Institutes of Health (NIH) Big Data To Knowledge Mobilize Center of Excellence Grant [U54 EB020405]
- Integrative Human Microbiome Project [NIH 8U54DK102556]
The convergence of scientific capability and technology that generates vast health data at diminishing cost has generated opportunities, challenges, and anticipation surrounding future data-centric healthcare models. Individualized health data spanning biomolecular, physiological, and environmental dimensions comprise a personal omics profile. Here, we discuss methods and opportunities to bridge genome and dynamic physiology, detect disease at an early stage, and uncover lifestyle and environmental patterns associated with the disease. Significant challenges exist to aggregate, integrate, and protect personal omics data to advance our understanding of the disease, enable data-driven clinical decisions, and motivate individuals to sustain behavioral change.
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