Gut microbiota-derived metabolites in the regulation of host immune responses and immune-related inflammatory diseases

Author Correction: Bile acid metabolites control TH17 and Treg cell differentiation

(2020) Saiyu Hang et al.   NATURE

B cell-intrinsic epigenetic modulation of antibody responses by dietary fiber-derived short-chain fatty acids

(2020) Helia N. Sanchez et al.   Nature Communications

Gut microbial metabolite trimethylamine N-oxide aggravates GVHD by inducing M1 macrophage polarization in mice

(2020) Kunpeng Wu et al.   BLOOD

Microbiota-Derived Metabolites Suppress Arthritis by Amplifying Aryl-Hydrocarbon Receptor Activation in Regulatory B Cells

(2020) Elizabeth C. Rosser et al.   Cell Metabolism

Intestinal microbiota-derived short-chain fatty acids regulation of immune cell IL-22 production and gut immunity

(2020) Wenjing Yang et al.   Nature Communications

The short-chain fatty acid pentanoate suppresses autoimmunity by modulating the metabolic-epigenetic crosstalk in lymphocytes

(2019) Maik Luu et al.   Nature Communications

Microbiota Metabolite Butyrate Differentially Regulates Th1 and Th17 Cells’ Differentiation and Function in Induction of Colitis

(2019) Liang Chen et al.   INFLAMMATORY BOWEL DISEASES

The Short Chain Fatty Acid Butyrate Imprints an Antimicrobial Program in Macrophages

(2019) Julie Schulthess et al.   IMMUNITY

Data-driven multiple-level analysis of gut-microbiome-immune-joint interactions in rheumatoid arthritis

(2019) QuanQiu Wang et al.   BMC GENOMICS

Microbiota Metabolite Short-Chain Fatty Acids Facilitate Mucosal Adjuvant Activity of Cholera Toxin through GPR43

(2019) Wenjing Yang et al.   JOURNAL OF IMMUNOLOGY

Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases

(2019) Jason Lloyd-Price et al.   NATURE

Polyamines in mammalian pathophysiology

(2019) Francisca Sánchez-Jiménez et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Microbiota-Derived Short-Chain Fatty Acids Promote the Memory Potential of Antigen-Activated CD8+ T Cells

(2019) Annabell Bachem et al.   IMMUNITY

The Intestine Harbors Functionally Distinct Homeostatic Tissue-Resident and Inflammatory Th17 Cells

(2019) Sara Omenetti et al.   IMMUNITY

Trimethylamine N-Oxide Binds and Activates PERK to Promote Metabolic Dysfunction

(2019) Sifan Chen et al.   Cell Metabolism

Aryl Hydrocarbon Receptor Contributes to the Transcriptional Program of IL-10-Producing Regulatory B Cells

(2019) Christopher J.M. Piper et al.   Cell Reports

Microbial bile acid metabolites modulate gut RORγ+ regulatory T cell homeostasis

(2019) Xinyang Song et al.   NATURE

Metabolic control of B cell immune responses

(2019) Julia Jellusova   CURRENT OPINION IN IMMUNOLOGY

Microbiota-Derived Indole Metabolites Promote Human and Murine Intestinal Homeostasis through Regulation of Interleukin-10 Receptor

(2018) Erica E. Alexeev et al.   AMERICAN JOURNAL OF PATHOLOGY

Dietary Fiber Confers Protection against Flu by Shaping Ly6c − Patrolling Monocyte Hematopoiesis and CD8 + T Cell Metabolism

(2018) Aurélien Trompette et al.   IMMUNITY

Immune regulation by microbiome metabolites

(2018) Chang H. Kim   IMMUNOLOGY

Development of mucosal-associated invariant T cells

(2018) Hui-Fern Koay et al.   IMMUNOLOGY AND CELL BIOLOGY

Polyamine patterns in plasma of patients with systemic lupus erythematosus and fever

(2018) H A Kim et al.   LUPUS

A screen of Crohn’s disease-associated microbial metabolites identifies ascorbate as a novel metabolic inhibitor of activated human T cells

(2018) Yu-Ling Chang et al.   Mucosal Immunology

Gut microbiome–mediated bile acid metabolism regulates liver cancer via NKT cells

(2018) Chi Ma et al.   SCIENCE

Associations of serum indolepropionic acid, a gut microbiota metabolite, with type 2 diabetes and low-grade inflammation in high-risk individuals

(2018) Marjo Tuomainen et al.   Nutrition & Diabetes

The Beauveria bassiana Gas3 β-Glucanosyltransferase Contributes to Fungal Adaptation to Extreme Alkaline Conditions

(2018) Zhibing Luo et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Microbiota-derived short-chain fatty acids promote Th1 cell IL-10 production to maintain intestinal homeostasis

(2018) Mingming Sun et al.   Nature Communications

Microbial tryptophan catabolites in health and disease

(2018) Henrik M. Roager et al.   Nature Communications

Regulation of the effector function of CD8+ T cells by gut microbiota-derived metabolite butyrate

(2018) Maik Luu et al.   Scientific Reports

Therapeutic benefits of Indole-3-Carbinol in adjuvant-induced arthritis and its protective effect against methotrexate induced-hepatic toxicity

(2018) Hiba Hasan et al.   BMC Complementary and Alternative Medicine

A Diet-Sensitive Commensal Lactobacillus Strain Mediates TLR7-Dependent Systemic Autoimmunity

(2018) Daniel F. Zegarra-Ruiz et al.   Cell Host & Microbe

Gut microbiome structure and metabolic activity in inflammatory bowel disease

(2018) Eric A. Franzosa et al.   Nature Microbiology

Anti-inflammatory and anti-genotoxic activity of branched chain amino acids (BCAA) in lipopolysaccharide (LPS) stimulated RAW 264.7 macrophages

(2017) Jae Hoon Lee et al.   FOOD SCIENCE AND BIOTECHNOLOGY

Increased Tryptophan Metabolism Is Associated With Activity of Inflammatory Bowel Diseases

(2017) Susanna Nikolaus et al.   GASTROENTEROLOGY

Control of immune-mediated pathology via the aryl hydrocarbon receptor

(2017) Michael A. Wheeler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Bile Acid Receptor GPBAR1 Regulates the M1/M2 Phenotype of Intestinal Macrophages and Activation of GPBAR1 Rescues Mice from Murine Colitis

(2017) Michele Biagioli et al.   JOURNAL OF IMMUNOLOGY

Aryl Hydrocarbon Receptor Activation Suppresses EBF1 and PAX5 and Impairs Human B Lymphopoiesis

(2017) Jinpeng Li et al.   JOURNAL OF IMMUNOLOGY

Interactions between gut bacteria and bile in health and disease

(2017) Sarah L. Long et al.   MOLECULAR ASPECTS OF MEDICINE

A gut bacterial pathway metabolizes aromatic amino acids into nine circulating metabolites

(2017) Dylan Dodd et al.   NATURE

Salt-responsive gut commensal modulates TH17 axis and disease

(2017) Nicola Wilck et al.   NATURE

Lactobacillus reuteriinduces gut intraepithelial CD4+CD8αα+T cells

(2017) Luisa Cervantes-Barragan et al.   SCIENCE

Gut Microbiota, Endocrine-Disrupting Chemicals, and the Diabetes Epidemic

(2017) Ganesan Velmurugan et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Slc3a2 Mediates Branched-Chain Amino-Acid-Dependent Maintenance of Regulatory T Cells

(2017) Kayo Ikeda et al.   Cell Reports

The TMAO-Producing Enzyme Flavin-Containing Monooxygenase 3 Regulates Obesity and the Beiging of White Adipose Tissue

(2017) Rebecca C. Schugar et al.   Cell Reports

The Microbial Metabolite Butyrate Induces Expression of Th1-Associated Factors in CD4+ T Cells

(2017) Meike Kespohl et al.   Frontiers in Immunology

Control of lupus nephritis by changes of gut microbiota

(2017) Qinghui Mu et al.   Microbiome

Dynamics of the human gut microbiome in inflammatory bowel disease

(2017) Jonas Halfvarson et al.   Nature Microbiology

Butyrate Supplementation at High Concentrations Alters Enteric Bacterial Communities and Reduces Intestinal Inflammation in Mice Infected with Citrobacter rodentium

(2017) Janelle A. Jiminez et al.   mSphere

The dual role of short fatty acid chains in the pathogenesis of autoimmune disease models

(2017) Miho Mizuno et al.   PLoS One

From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites

(2016) Ara Koh et al.   CELL

Gut Microbial Metabolites Fuel Host Antibody Responses

(2016) Myunghoo Kim et al.   Cell Host & Microbe

Increased Trimethylamine N- Oxide Portends High Mortality Risk Independent of Glycemic Control in Patients with Type 2 Diabetes Mellitus

(2016) W. H. Wilson Tang et al.   CLINICAL CHEMISTRY

Diabetes is Associated with Higher Trimethylamine N-oxide Plasma Levels

(2016) M. Dambrova et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Memory CD8 + T Cells Require Increased Concentrations of Acetate Induced by Stress for Optimal Function

(2016) Maria L. Balmer et al.   IMMUNITY

The aryl hydrocarbon receptor controls cell-fate decisions in B cells

(2016) Bharat Vaidyanathan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Microbiota metabolite short chain fatty acids, GPCR, and inflammatory bowel diseases

(2016) Mingming Sun et al.   JOURNAL OF GASTROENTEROLOGY

Microbiota metabolite short-chain fatty acid acetate promotes intestinal IgA response to microbiota which is mediated by GPR43

(2016) W Wu et al.   Mucosal Immunology

CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands

(2016) Bruno Lamas et al.   NATURE MEDICINE

IgA production requires B cell interaction with subepithelial dendritic cells in Peyers patches

(2016) A. Reboldi et al.   SCIENCE

Dietary Fiber and Bacterial SCFA Enhance Oral Tolerance and Protect against Food Allergy through Diverse Cellular Pathways

(2016) Jian Tan et al.   Cell Reports

Western diet induces a shift in microbiota composition enhancing susceptibility to Adherent-Invasive E. coli infection and intestinal inflammation.

(2016) Allison Agus et al.   Scientific Reports

Slc5a8, a Na+-coupled high-affinity transporter for short-chain fatty acids, is a conditional tumour suppressor in colon that protects against colitis and colon cancer under low-fibre dietary conditions

(2015) Ashish Gurav et al.   BIOCHEMICAL JOURNAL

Dietary Indoles Suppress Delayed-Type Hypersensitivity by Inducing a Switch from Proinflammatory Th17 Cells to Anti-Inflammatory Regulatory T Cells through Regulation of MicroRNA

(2015) Narendra P. Singh et al.   JOURNAL OF IMMUNOLOGY

Gut Bacteria Products Prevent AKI Induced by Ischemia-Reperfusion

(2015) V. Andrade-Oliveira et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment

(2015) Xuan Zhang et al.   NATURE MEDICINE

Systematic genome assessment of B-vitamin biosynthesis suggests co-operation among gut microbes

(2015) Stefanía Magnúsdóttir et al.   Frontiers in Genetics

Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles

(2015) Troy D. Hubbard et al.   Scientific Reports

The effect of short-chain fatty acids on human monocyte-derived dendritic cells

(2015) Claudia Nastasi et al.   Scientific Reports

Microbiota-Generated Metabolites Promote Metabolic Benefits via Gut-Brain Neural Circuits

(2014) Filipe De Vadder et al.   CELL

Discovery and Characterization of Gut Microbiota Decarboxylases that Can Produce the Neurotransmitter Tryptamine

(2014) Brianna B. Williams et al.   Cell Host & Microbe

γ-Butyrobetaine Is a Proatherogenic Intermediate in Gut Microbial Metabolism of L -Carnitine to TMAO

(2014) Robert A. Koeth et al.   Cell Metabolism

The cross talk between microbiota and the immune system: metabolites take center stage

(2014) Hagit Shapiro et al.   CURRENT OPINION IN IMMUNOLOGY

Symbiotic Bacterial Metabolites Regulate Gastrointestinal Barrier Function via the Xenobiotic Sensor PXR and Toll-like Receptor 4

(2014) Madhukumar Venkatesh et al.   IMMUNITY

Activation of Gpr109a, Receptor for Niacin and the Commensal Metabolite Butyrate, Suppresses Colonic Inflammation and Carcinogenesis

(2014) Nagendra Singh et al.   IMMUNITY

Phylogenetic distribution of three pathways for propionate production within the human gut microbiota

(2014) Nicole Reichardt et al.   ISME Journal

Dietary trimethylamine N-oxide exacerbates impaired glucose tolerance in mice fed a high fat diet

(2014) Xiang Gao et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Effects of individual branched-chain amino acids deprivation on insulin sensitivity and glucose metabolism in mice

(2014) Fei Xiao et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Metabonomics of human fecal extracts characterize ulcerative colitis, Crohn’s disease and healthy individuals

(2014) Jacob Tveiten Bjerrum et al.   Metabolomics

Short-chain fatty acids induce both effector and regulatory T cells by suppression of histone deacetylases and regulation of the mTOR–S6K pathway

(2014) J Park et al.   Mucosal Immunology

T-cell activation by transitory neo-antigens derived from distinct microbial pathways

(2014) Alexandra J. Corbett et al.   NATURE

Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis

(2014) Aurélien Trompette et al.   NATURE MEDICINE

The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition

(2014) Pamela V. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Carnitine metabolism to trimethylamine by an unusual Rieske-type oxygenase from human microbiota

(2014) Y. Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intestinal Dysbiosis Associated with Systemic Lupus Erythematosus

(2014) A. Hevia et al.   mBio

Plasma amino acid profiles are associated with insulin, C-peptide and adiponectin levels in type 2 diabetic patients

(2014) H Nakamura et al.   Nutrition & Diabetes

Adiposity, gut microbiota and faecal short chain fatty acids are linked in adult humans

(2014) J Fernandes et al.   Nutrition & Diabetes

Indoles mitigate the development of experimental autoimmune encephalomyelitis by induction of reciprocal differentiation of regulatory T cells and Th17 cells

(2013) Michael Rouse et al.   BRITISH JOURNAL OF PHARMACOLOGY

Trimethylamine-N-Oxide, a Metabolite Associated with Atherosclerosis, Exhibits Complex Genetic and Dietary Regulation

(2013) Brian J. Bennett et al.   Cell Metabolism

Tryptophan Catabolites from Microbiota Engage Aryl Hydrocarbon Receptor and Balance Mucosal Reactivity via Interleukin-22

(2013) Teresa Zelante et al.   IMMUNITY

Polyamines: Emerging players in bacteria–host interactions

(2013) Maria Letizia Di Martino et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Bile acids PKA-dependently induce a switch of the IL-10/IL-12 ratio and reduce proinflammatory capability of human macrophages

(2013) Katrin Haselow et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Branched chain amino acids are novel biomarkers for discrimination of metabolic wellness

(2013) Bryan C. Batch et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

(2013) Yukihiro Furusawa et al.   NATURE

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

(2013) Nicholas Arpaia et al.   NATURE

Gut metagenome in European women with normal, impaired and diabetic glucose control

(2013) Fredrik H. Karlsson et al.   NATURE

Human Trace Amine-Associated Receptor TAAR5 Can Be Activated by Trimethylamine

(2013) Ivonne Wallrabenstein et al.   PLoS One

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis

(2013) P. M. Smith et al.   SCIENCE

The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43

(2013) Ikuo Kimura et al.   Nature Communications

Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis

(2013) Jose U Scher et al.   eLife

Butyrate increases IL-23 production by stimulated dendritic cells

(2012) Bradford E. Berndt et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Protein kinase Cβ is critical for the metabolic switch to glycolysis following B-cell antigen receptor engagement

(2012) Derek Blair et al.   BIOCHEMICAL JOURNAL

Butyrate interferes with the differentiation and function of human monocyte-derived dendritic cells

(2012) Lu Liu et al.   CELLULAR IMMUNOLOGY

Bile acids induce monocyte differentiation toward interleukin-12 hypo-producing dendritic cells via a TGR5-dependent pathway

(2012) Riko Ichikawa et al.   IMMUNOLOGY

Short-Chain Fatty Acids Suppress Lipopolysaccharide-Induced Production of Nitric Oxide and Proinflammatory Cytokines Through Inhibition of NF-κB Pathway in RAW264.7 Cells

(2012) Tengfei Liu et al.   INFLAMMATION

A metagenome-wide association study of gut microbiota in type 2 diabetes

(2012) Junjie Qin et al.   NATURE

MR1 presents microbial vitamin B metabolites to MAIT cells

(2012) Lars Kjer-Nielsen et al.   NATURE

Butyrate and Propionate Protect against Diet-Induced Obesity and Regulate Gut Hormones via Free Fatty Acid Receptor 3-Independent Mechanisms

(2012) Hua V. Lin et al.   PLoS One

Microbial conversion of choline to trimethylamine requires a glycyl radical enzyme

(2012) S. Craciun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of Peyer’s patches in synchronizing gut IgA responses

(2012) Nils Y. Lycke et al.   Frontiers in Immunology

Type 1 diabetes: role of intestinal microbiome in humans and mice

(2011) Brian P. Boerner et al.   Annals of the New York Academy of Sciences

Intestinal absorption of water-soluble vitamins in health and disease

(2011) Hamid M. Said   BIOCHEMICAL JOURNAL

TGR5 Activation Inhibits Atherosclerosis by Reducing Macrophage Inflammation and Lipid Loading

(2011) Thijs W.H. Pols et al.   Cell Metabolism

Aryl Hydrocarbon Receptor-Induced Signals Up-regulate IL-22 Production and Inhibit Inflammation in the Gastrointestinal Tract

(2011) Ivan Monteleone et al.   GASTROENTEROLOGY

Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease

(2011) R. M. Gadaleta et al.   GUT

The Aryl Hydrocarbon Receptor Regulates Gut Immunity through Modulation of Innate Lymphoid Cells

(2011) Ju Qiu et al.   IMMUNITY

Metabolomics of Fecal Extracts Detects Altered Metabolic Activity of Gut Microbiota in Ulcerative Colitis and Irritable Bowel Syndrome

(2011) Gwénaëlle Le Gall et al.   JOURNAL OF PROTEOME RESEARCH

Microbiota–immune system interaction: an uneasy alliance

(2010) Nita H Salzman   CURRENT OPINION IN MICROBIOLOGY

A Pyrosequencing Study in Twins Shows That Gastrointestinal Microbial Profiles Vary With Inflammatory Bowel Disease Phenotypes

(2010) Ben P. Willing et al.   GASTROENTEROLOGY

Multi-tasking of helper T cells

(2010) Yisong Y. Wan   IMMUNOLOGY

Blockade of Dendritic Cell Development by Bacterial Fermentation Products Butyrate and Propionate through a Transporter (Slc5a8)-dependent Inhibition of Histone Deacetylases

(2010) Nagendra Singh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Generation of Mucosal Dendritic Cells from Bone Marrow Reveals a Critical Role of Retinoic Acid

(2010) T. Feng et al.   JOURNAL OF IMMUNOLOGY

IL-10 production by CD4+ effector T cells: a mechanism for self-regulation

(2010) D Jankovic et al.   Mucosal Immunology

Antimicrobial activity of mucosal-associated invariant T cells

(2010) Lionel Le Bourhis et al.   NATURE IMMUNOLOGY

Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species

(2010) K. Atarashi et al.   SCIENCE

Human Mucosal Associated Invariant T Cells Detect Bacterially Infected Cells

(2010) Marielle C. Gold et al.   PLOS BIOLOGY

GPR109A Is a G-protein-Coupled Receptor for the Bacterial Fermentation Product Butyrate and Functions as a Tumor Suppressor in Colon

(2009) M. Thangaraju et al.   CANCER RESEARCH

Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria

(2009) Ivaylo I. Ivanov et al.   CELL

A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance

(2009) Christopher B. Newgard et al.   Cell Metabolism

Butyrate Improves Insulin Sensitivity and Increases Energy Expenditure in Mice

(2009) Z. Gao et al.   DIABETES

Diversity of human colonic butyrate-producing bacteria revealed by analysis of the butyryl-CoA:acetate CoA-transferase gene

(2009) Petra Louis et al.   ENVIRONMENTAL MICROBIOLOGY

Deacetylase inhibition increases regulatory T cell function and decreases incidence and severity of collagen-induced arthritis

(2009) Sandra J. Saouaf et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

The Bile Acid Receptor FXR Is a Modulator of Intestinal Innate Immunity

(2009) P. Vavassori et al.   JOURNAL OF IMMUNOLOGY

Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43

(2009) Kendle M. Maslowski et al.   NATURE

Acetogenesis and the Wood–Ljungdahl pathway of CO2 fixation

(2008) Stephen W. Ragsdale et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Polyamine compound deoxyspergualin inhibits heat shock protein-induced activation of immature dendritic cells

(2008) Atsushi Sugawara et al.   CELL STRESS & CHAPERONES

A microbial symbiosis factor prevents intestinal inflammatory disease

(2008) Sarkis K. Mazmanian et al.   NATURE