期刊
IMMUNOLOGY AND CELL BIOLOGY
卷 96, 期 6, 页码 598-606出版社
WILEY
DOI: 10.1111/imcb.12039
关键词
Development of MAIT cells; mucosal-associated invariant T cells; T-cell receptor
资金
- National Health and Medical Research Council (NHMRC) Career Development Fellowship [1144308]
- NHMRC Senior Principal Research Fellowship [1020770, 1117766]
- NHMRC [1145373, 1122890, 1140126]
- Australian Research Council (ARC) [CE140100011]
- National Health and Medical Research Council of Australia [1145373, 1140126, 1122890, 1144308] Funding Source: NHMRC
Mucosal-associated invariant T (MAIT) cells develop in the thymus and migrate into the periphery to become the largest antigen-specific T-cell population in the human immune system. However, the frequency of MAIT cells varies widely between human individuals, and the basis for this is unclear. While MAIT cells are highly conserved through evolution and are phenotypically similar between humans and mice, they represent a much smaller proportion of total T cells in mice. In this review, we discuss how MAIT cells transition through a three-stage development pathway in both mouse and human thymus, and continue to mature and expand after they leave the thymus. Moreover, we will explore and speculate on how specific factors regulate different stages of this process.
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