Article
Immunology
Rene Reitermaier, Thomas Krausgruber, Nikolaus Fortelny, Tanya Ayub, Pablo Augusto Vieyra-Garcia, Philip Kienzl, Peter Wolf, Anke Scharrer, Christian Fiala, Marita Kolz, Manuela Hiess, Martin Vierhapper, Christopher Schuster, Andreas Spittler, Christof Worda, Wolfgang Weninger, Christoph Bock, Rene Reitermaier, Adelheid Elbe-Buerger
Summary: Single-cell analyses identified a naive T cell population expressing specific T cell receptors enriched in fetal skin and intestine. These cells may contribute to early skin development and fetal immune defense, showing fundamental differences in immune surveillance between fetal and adult human skin.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Review
Medicine, General & Internal
Deepak K. Singh, Vaibhav G. Patel, William K. Oh, Julio A. Aguirre-Ghiso
Summary: Prostate cancer has a variable clinical course, with possibilities ranging from curable local disease to lethal metastatic spread. The dynamic interplay between dormant disseminated cancer cells (DCCs) and the primary tumor microenvironment (TME) as well as the secondary organ niche plays a crucial role in controlling the conversion between states of dormancy and activation.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biology
Chan Li, Zhaoya Liu, Mengshi Chen, Liyang Zhang, Ruizheng Shi, Hua Zhong
Summary: This study investigates the role of cathepsinL/V in endothelial cell senescence. It found that decreased cathepsinL/V levels in senescent endothelial cells contribute to cellular senescence through the activation of the AKT/ERK1/2-P21 pathway. These findings suggest that cathepsinL/V may be a potential therapeutic target for treating endothelial cell senescence.
Article
Endocrinology & Metabolism
Josefine Tratwal, Guillaume Falgayrac, Alexandrine During, Nicolas Bertheaume, Charles Bataclan, Daniel N. N. Tavakol, Vasco Campos, Ludovic Duponchel, George Q. Q. Daley, Guillaume Penel, Christophe Chauveau, Olaia Naveiras
Summary: BMAds are the most abundant stromal component of adult human bone marrow, consisting of two types: rBMAds and cBMAds, with distinct characteristics. An in vitro model of BM adipogenesis with differential rBMAd and cBMAd-like characteristics has been developed, showing differences in fatty acid composition and desaturase expression. This model is useful for discriminating cBMAds from rBMAd and studying adipocyte differentiation.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Athanasios Kousathanas, Erola Pairo-Castineira, Konrad Rawlik, Alex Stuckey, Christopher A. Odhams, Susan Walker, Clark D. Russell, Tomas Malinauskas, Yang Wu, Jonathan Millar, Xia Shen, Katherine S. Elliott, Fiona Griffiths, Wilna Oosthuyzen, Kirstie Morrice, Sean Keating, Bo Wang, Daniel Rhodes, Lucija Klaric, Marie Zechner, Nick Parkinson, Afshan Siddiq, Peter Goddard, Sally Donovan, David Maslove, Alistair Nichol, Malcolm G. Semple, Tala Zainy, Fiona Maleady-Crowe, Linda Todd, Shahla Salehi, Julian Knight, Greg Elgar, Georgia Chan, Prabhu Arumugam, Christine Patch, Augusto Rendon, David Bentley, Clare Kingsley, Jack A. Kosmicki, Julie E. Horowitz, Aris Baras, Goncalo R. Abecasis, Manuel A. R. Ferreira, Anne Justice, Tooraj Mirshahi, Matthew Oetjens, Daniel J. Rader, Marylyn D. Ritchie, Anurag Verma, Tom A. Fowler, Manu Shankar-Hari, Charlotte Summers, Charles Hinds, Peter Horby, Lowell Ling, Danny McAuley, Hugh Montgomery, Peter J. M. Openshaw, Paul Elliott, Timothy Walsh, Albert Tenesa, Angie Fawkes, Lee Murphy, Kathy Rowan, Chris P. Ponting, Veronique Vitart, James F. Wilson, Jian Yang, Andrew D. Bretherick, Richard H. Scott, Sara Clohisey Hendry, Loukas Moutsianas, Andy Law, Mark J. Caulfield, J. Kenneth Baillie
Summary: This study used whole-genome sequencing to compare the genomes of 7,491 critically ill individuals with 48,400 controls, and identified 23 independent variants associated with critical COVID-19. The research found multiple genes that are involved in interferon signaling, leukocyte differentiation, and blood-type antigen secretion to be associated with critical illness.
Review
Endocrinology & Metabolism
Rossella Labella, Sarah Little-Letsinger, Viktorjia Avilkina, Rita Sarkis, Michaela Tencerova, Annegreet Vlug, Biagio Palmisano
Summary: The first International Summer School on Bone Marrow Adiposity was organized virtually, bringing together young scientists interested in bone marrow adipose tissue biology and pathology. The school featured keynote lectures, scientific workshops, and motivational and career development lectures, providing a platform for participants to present their research.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cell Biology
Sandeep Gupta, Riki Kawaguchi, Eric Heinrichs, Salena Gallardo, Stephanie Castellanos, Igor Mandric, Bennett G. Novitch, Samantha J. Butler
Summary: This study successfully generated a large quantity of bona fide somatosensory interneurons using mouse embryonic stem cells. The findings suggest that retinoic acid and bone morphogenetic protein 4 can induce the differentiation of cells into different types of spinal interneurons, and activating Wnt signaling can enhance neural progenitor proliferation and yield.
Article
Immunology
Richard P. Ramonell, Margaret Brown, Matthew C. Woodruff, Joshua M. Levy, Sarah K. Wise, John DelGaudio, Meixue Duan, Celia L. Saney, Shuya Kyu, Kevin S. Cashman, Jennifer R. Hom, Christopher F. Fucile, Alexander F. Rosenberg, Christopher M. Tipton, Ignacio Sanz, Gregory C. Gibson, F. Eun-Hyung Lee
Summary: Immunoglobulin E (IgE) plays a central role in the development of allergic conditions, such as allergic fungal rhinosinusitis. However, there is limited understanding of IgE antibody secreting cells (ASCs). This study used single-cell RNA sequencing to analyze nasal polyps from patients with allergic fungal rhinosinusitis, revealing that nasal polyps were mostly enriched in CD19+ ASCs. IgE ASCs were rare but shared clones with certain B cell populations, indicating ontogeny from both IgD+ and memory B cells. These findings suggest that mucosal IgE ASCs have a more immature plasma cell phenotype and may have unique functional roles.
MUCOSAL IMMUNOLOGY
(2023)
Review
Cell Biology
Lipeng Wang, Hao Zhang, Sicheng Wang, Xiao Chen, Jiacan Su
Summary: BMAs, as a type of bone marrow adipocytes, play significant roles in hematopoiesis, osteogenesis, and immune regulation, and represent a novel target for the treatment of bone marrow-related diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Qi-Quan Huang, Renee Doyle, Shang-Yang Chen, Qicong Sheng, Alexander Misharin, Qinwen Mao, Deborah R. Winter, Richard M. Pope
Summary: Analysis of a novel mouse model of rheumatoid arthritis reveals the importance of the macrophage tissue-resident niche in suppressing chronic inflammation, potentially contributing to the pathogenesis of rheumatoid arthritis.
Article
Hematology
Huan Cai, Makoto Kondo, Lakshmi Sandhow, Pingnan Xiao, Anne-Sofie Johansson, Takako Sasaki, Joanna Zawacka-Pankau, Karl Tryggvason, Johanna Ungerstedt, Julian Walfridsson, Marja Ekblom, Hong Qian
Summary: This study demonstrates the critical role of Lama4 in impeding AML progression and chemoresistance. Lama4 deletion results in impaired hematopoiesis regeneration and accelerated AML progression and relapse.
Review
Cell Biology
Jaimar C. Rincon, Philip A. Efron, Lyle L. Moldawer
Summary: This article points out that critically ill sepsis survivor patients have specific immunologic endotypes, which are secondary to a persistent maladaptive reprioritization of myelopoiesis and pathologic activation of myeloid cells. Early recognition and intervention are crucial to interrupt the pathological activation of myeloid populations.
JOURNAL OF LEUKOCYTE BIOLOGY
(2022)
Article
Cell Biology
Siyu Wu, Lorenzo Romero-Ramirez, Jorg Mey
Summary: The study demonstrated that ligands of nuclear receptor families, such as RARs, can increase myelin phagocytosis by macrophages and Raw264.7 cells without affecting the expression of other receptor genes. This process led to reduced inflammation and increased expression of genes involved in lipid transport and metabolism. This suggests a potential therapeutic application of RA in CNS trauma.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Plant Sciences
Liangjie Lv, Ce Dong, Yuping Liu, Aiju Zhao, Yelun Zhang, Hui Li, Xiyong Chen
Summary: This study identified differentially expressed genes and differential accumulated metabolites in wheat under cold stress. The comprehensive analysis of metabolomics and transcriptome revealed that the cold resistance of wheat is closely related to several metabolites and key enzymes in specific biosynthesis pathways. Additionally, several candidate genes were found to be involved in the cold resistance of wheat.
Article
Medicine, Research & Experimental
M. Hope Robinson, Nancy Y. Villa, David L. Jaye, Ajay K. Nooka, Alyssa Duffy, Samuel S. McCachren, Julia Manalo, Jeffrey M. Switchenko, Sierra Barnes, Sayalee Potdar, Maryam I. Azeem, Ava A. Horvat, Vaunita C. Parihar, Jingjing Gong, Yan Liang, Geoffrey H. Smith, Vikas A. Gupta, Lawrence H. Boise, Jonathan L. Kaufman, Craig C. Hofmeister, Nisha S. Joseph, Sagar Lonial, Kavita M. Dhodapkar, Madhav V. Dhodapkar
Summary: This study investigates the mechanisms underlying immune infiltration in human multiple myeloma (MM) and its precursor monoclonal gammopathy of undetermined significance (MGUS) using high-dimensional spatial analyses and in vitro and in vivo modeling. The results suggest that MM exhibits clustered tumor growth and spatial heterogeneity with the coexistence of T cell-rich and T cell-sparse regions, as well as areas of T cell exclusion. T cell entry into MM clusters is regulated by agonistic signals and CD2-CD58 interactions, and CLEC9A+ DCs play a role in marking the portals of entry for T cell infiltration.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Gastroenterology & Hepatology
Yanbo Yu, Wenjing Yang, Yanqing Li, Yingzi Cong
INFLAMMATORY BOWEL DISEASES
(2020)
Article
Immunology
Kevin T. Kline, Haifeng Lian, Xiaoying S. Zhong, Xiuju Luo, John H. Winston, Yingzi Cong, Tor C. Savidge, Roderick H. Dashwood, Don W. Powell, Qingjie Li
JOURNAL OF IMMUNOLOGY
(2020)
Article
Immunology
Xiangsheng Huang, Wenjing Yang, Suxia Yao, Anthony J. Bilotta, Yao Lu, Zheng Zhou, Pawan Kumar, Sara M. Dann, Yingzi Cong
JOURNAL OF IMMUNOLOGY
(2020)
Review
Immunology
Wenjing Yang, Yingzi Cong
Summary: The gut microbiota and microbiota-derived metabolites play a critical role in maintaining immune homeostasis and are involved in the pathogenesis of various immune-related inflammatory disorders.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yu Yu, Wenjing Yang, Anthony J. Bilotta, Xiaojing Zhao, Yingzi Cong, Yanqing Li
Summary: The study found that host-derived L-lactate can promote intestinal epithelial cell (IEC) migration by increasing mitochondrial ATP production in IEC, aiding in promoting intestinal wound healing. Additionally, administering mice with L-lactate can suppress colitis induced by dextran sulfate sodium.
Article
Immunology
Yuejin Liang, Xiaofang Wang, Hui Wang, Wenjing Yang, Panpan Yi, Lynn Soong, Yingzi Cong, Jiyang Cai, Xuegong Fan, Jiaren Sun
Summary: IL-33 promotes activation and proliferation of CD8(+) T cells via mTORC1 in LCMV infection.
Article
Immunology
Wenjing Yang, Liang Chen, Leiqi Xu, Anthony J. Bilotta, Suxia Yao, Zhanju Liu, Yingzi Cong
Summary: This study demonstrates the role of miR-10a in regulating IL-10 production in CD4(+) T cells to maintain intestinal homeostasis. The deficiency of miR-10a in CD4(+) T cells led to increased resistance to intestinal inflammation, with increased IL-10 production. Blocking the IL-10/IL-10R pathway exacerbated colitis induced by miR-10a-deficient CD4(+)CD45Rb(hi) T cells.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Yi Li, Jianping Chen, Andrew A. Bolinger, Haiying Chen, Zhiqing Liu, Yingzi Cong, Allan R. Brasier, Irina Pinchuk, Bing Tian, Jia Zhou
Summary: Inflammatory bowel disease (IBD) is a serious chronic gastrointestinal disease, with long-term inflammation contributing to neoplastic transformation and colorectal cancer development. The discovery of new small molecule drugs targeting specific pathways in mucosal inflammation offers hope for the treatment of IBD.
INFLAMMATORY BOWEL DISEASES
(2021)
Article
Medicine, Research & Experimental
Wenjing Yang, Tianming Yu, Yingzi Cong
Summary: CD4(+) T cell metabolic pathways and gut microbiota play important roles in the pathogenesis of autoimmune disorders.
PRECISION CLINICAL MEDICINE
(2022)
Editorial Material
Gastroenterology & Hepatology
Wenjing Yang, Yingzi Cong
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Tianming Yu, Wenjing Yang, Suxia Yao, Yanbo Yu, Maki Wakamiya, George Golovko, Yingzi Cong
Summary: The STING pathway regulates intestinal IgA production by maintaining a group of acetate-producing bacteria, which is mediated by GPR43. The role of STING in intestinal IgA response is still not well understood.
INFLAMMATORY BOWEL DISEASES
(2023)
Editorial Material
Gastroenterology & Hepatology
Wenjing Yang, Yingzi Cong
Summary: Animal models of colitis have provided important insights into the underlying mechanisms of inflammatory bowel disease (IBD). T cell adoptive transfer models have become a valuable tool in investigating the immunopathogenesis of intestinal inflammation, with CD4(+) T cell responses playing a critical role in the development of IBD.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Ramasatyaveni Geesala, Ke Zhang, You-Min Lin, John C. Johnson, Yingzi Cong, Steven Cohn, Xuan-Zheng Shi
Summary: This study found that mechanical stress could induce the expression of Th17-polarizing cytokines in the colon, and exclusive enteral nutrition (EEN) attenuates Th17 immune response by reducing mechanical stress-induced IL-6 in Crohn's-like colitis.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Anthony J. Bilotta, Chunyan Ma, Wenjing Yang, Yanbo Yu, Yu Yu, Xiaojing Zhao, Zheng Zhou, Suxia Yao, Sara M. Dann, Yingzi Cong
Summary: The study revealed that propionate enhances intestinal epithelial cell migration by promoting cell spreading and polarization, leading to increased cell speed and persistence. This effect is mediated by inhibition of class I HDAC, GPR43, and STAT3 signaling. Propionate was also shown to promote cell migration under homeostatic conditions and protect against ulcer formation in experimental colitis.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Review
Immunology
Roberta Caruso, Bernard C. Lo, Gabriel Nunez
NATURE REVIEWS IMMUNOLOGY
(2020)